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Mongolian Spot

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41. Mongolian Blue Spots Full Text available with Trip Pro

Mongolian Blue Spots 19978274 2010 06 24 2010 06 24 0035-9157 7 Sect Study Dis Child 1914 Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Mongolian Blue Spots. 123 Cockayne E A EA eng Journal Article England Proc R Soc Med 7505890 0035-9157 2009 12 9 6 0 1914 1 1 0 0 1914 1 1 0 1 ppublish 19978274 PMC2003276

1914 Proceedings of the Royal Society of Medicine

42. Fluor Varnish With Silver Nanoparticles for Dental Remineralization in Patients With Trisomy 21

remineralization of the teeth. A split-plot randomized controlled trial will be performed to address this question. Condition or disease Intervention/treatment Phase Down Syndrome Drug: Fluor varnish Drug: Fluor varnish with nanoparticles Phase 2 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 20 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Triple (Participant, Care Provider, Investigator) Primary (...) doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 1 Year to 6 Years (Child) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients with trisomy 21 diagnosed through caryotype Age 1 to 6 years old Any sex White spot present

2013 Clinical Trials

43. Newborn blood spot screening

Newborn blood spot screening Newborn blood spot screening | Great Ormond Street Hospital Google Tag Manager Navigation Search Search You are here Newborn blood spot screening Newborn blood spot screening ). These include: Phenylketonuria (PKU) Congenital hypothyroidism (CHT) Sickle cell disease (SCD) Cystic fibrosis (CF) Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) Homocystinuria (HCU) Maple syrup urine disease (MSUD) Glutaric Acidemia Type 1 (GA1) Isovaleric Acidemia (IVA). The aim (...) 20) insufficient blood on the card (Rationale 21) layering of blood (Rationale 22) delay in laboratory receiving the sample (Rationale 22) taken before five days of age (Rationale 23) repeat samples taken at the wrong time (Rationale 22) contamination of the sample card (Rationale 24) Ensuring completeness of coverage of newborn screening Newborn screening is offered to all infants up to one year of age (Rationale 25) (blood spot screening for CF can only be carried out up until 56 days of age

2012 Publication 1593

44. In search of the sweet spot: the links between dysglycaemia and first episode psychosis

In search of the sweet spot: the links between dysglycaemia and first episode psychosis The links between dysglycaemia and first episode psychosis Search National Elf Service Search National Elf Service » » » » In search of the sweet spot: the links between dysglycaemia and first episode psychosis Jan 24 2017 Posted by Imagine, if you will, a whole world dusted with white powdery sugar, like a picturesque wintery scene from a postcard. Now, imagine an idea, teetering at the top of a great hill (...) . Except this idea is but a small, solid sugar cube. For many years, this lonely cube sits patiently at the top of the great hill, the world turning around it, waiting for just the right propelling gust of wind. Eventually, that long-awaited gust of wind arrives, tipping the cube from its resting point at the top, and into motion. Our cube begins to roll, at first haphazardly, down the powdery white hill. As it whirls, the sweet sticky powder sticks to the cube, growing not just in size but also

2017 The Mental Elf

45. Health aspects of Down syndrome Full Text available with Trip Pro

in 1965 after a request by the delegation from the . While the term mongoloid (also mongolism, ) continued to be used until the early 1980s, it is now considered unacceptable and is no longer in common use. In 1975, the United States (NIH) convened a conference to standardize the naming and recommended replacing the possessive form, "Down's syndrome" with "Down syndrome". However, both the possessive and nonpossessive forms remain in use by the general population. The term "trisomy 21" is also (...) dementia may not be present. Those with DS also lack a normal number of and produce less which contributes to their increased risk of infection. Epigenetics Down syndrome is associated with an increased risk of many chronic diseases that are typically associated with older age such as Alzheimer's disease. The accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis is sparse. According to a biomarker of tissue age known as , trisomy

2012 Wikipedia

46. Comparative transcriptome and potential antiviral signaling pathways analysis of the gills in the red swamp crayfish, Procambarus clarkii infected with White Spot Syndrome Virus (WSSV) Full Text available with Trip Pro

Comparative transcriptome and potential antiviral signaling pathways analysis of the gills in the red swamp crayfish, Procambarus clarkii infected with White Spot Syndrome Virus (WSSV) Red swamp crayfish is an important model organism for research of the invertebrate innate immunity mechanism. Its excellent disease resistance against bacteria, fungi, and viruses is well-known. However, the antiviral mechanisms of crayfish remain unclear. In this study, we obtained high-quality sequence reads (...) from normal and white spot syndrome virus (WSSV)-challenged crayfish gills. For group normal (GN), 39,390,280 high-quality clean reads were randomly assembled to produce 172,591 contigs; whereas, 34,011,488 high-quality clean reads were randomly assembled to produce 182,176 contigs for group WSSV-challenged (GW). After GO annotations analysis, a total of 35,539 (90.01%), 14,931 (37.82%), 28,221 (71.48%), 25,290 (64.05%), 15,595 (39.50%), and 13,848 (35.07%) unigenes had significant matches

2017 Genetics and molecular biology

47. Multi-omics Analysis Sheds Light on the Evolution and the Intracellular Lifestyle Strategies of Spotted Fever Group Rickettsia spp. Full Text available with Trip Pro

was observed only in the less pathogenic species. After infecting Xenopus laevis cells, the virulent agents displayed less up-regulated than down-regulated proteins, as well as less number of identified core proteins. Furthermore, their similar and distinct protein profiles did not contain some genes (e.g., ompA/B and rickA) known to be related to rickettsial adhesion, motility and/or virulence, but may include other putative virulence-, antivirulence-, and/or disease-related proteins. The identified (...) Multi-omics Analysis Sheds Light on the Evolution and the Intracellular Lifestyle Strategies of Spotted Fever Group Rickettsia spp. Arthropod-borne Rickettsia species are obligate intracellular bacteria which are pathogenic for humans. Within this genus, Rickettsia slovaca and Rickettsia conorii cause frequent and potentially severe infections, whereas Rickettsia raoultii and Rickettsia massiliae cause rare and milder infections. All four species belong to spotted fever group (SFG) rickettsiae

2017 Frontiers in microbiology

48. A Proteomic Study of Hemocyte Proteins from Mud Crab (Scylla paramamosain) Infected with White Spot Syndrome Virus or Vibrio alginolyticus Full Text available with Trip Pro

A Proteomic Study of Hemocyte Proteins from Mud Crab (Scylla paramamosain) Infected with White Spot Syndrome Virus or Vibrio alginolyticus In this study, we investigated the hemocytes' immune response to white spot syndrome virus (WSSV) or Vibrio alginolyticus infection at the protein level. The differential proteomes from crab hemocytes infected with WSSV or V. alginolyticus were analyzed using the isobaric tags for relative and absolute quantitation approach immediately after infection. Using (...) . alginolyticus challenge. The results showed that the knockdown of these genes led to an increase in the morbidity and mortality (P < 0.01) rate, and a decrease in infection time in WSSV-infected crabs. During the first 84 h, knockdown of these genes also led to an increase in the morbidity rates in V. alginolyticus -infected crabs, and results of four genes showed a higher mortality rate than that of the control after they were knocked down. This is the first report of the proteome response in crab

2017 Frontiers in immunology

49. A prospective clinical trial to compare the performance of dried blood spots prenatal screening for Down’s syndrome with conventional non-invasive testing technology Full Text available with Trip Pro

A prospective clinical trial to compare the performance of dried blood spots prenatal screening for Down’s syndrome with conventional non-invasive testing technology To evaluate, side by side, the efficiency of dried blood spots (DBSs) against serum screening for Down's syndrome, and then, to construct a two-tier strategy by topping up the fetal cell-free DNA (cfDNA) secondary screening over the high-risk women marked by the primary blood testing to build a practical screening tactic (...) is to evaluate the efficiency of dried blood spots against serum screening for Down's syndrome and to construct a two-tier strategy by topping up the fetal cell-free DNA (cfDNA) secondary screening over the high-risk women marked by the primary blood testing to build a practical screening tactic to identify fetal Down's syndrome. Results demonstrate that fetal cfDNA can significantly reduce false-positive rate close to none while distinguishing all true positives. Thus, we recommend that fetal cfDNA analysis

2017 Experimental Biology and Medicine

50. Md-miR156ab and Md-miR395 Target WRKY Transcription Factors to Influence Apple Resistance to Leaf Spot Disease Full Text available with Trip Pro

Md-miR156ab and Md-miR395 Target WRKY Transcription Factors to Influence Apple Resistance to Leaf Spot Disease MicroRNAs (miRNAs) are key regulators of gene expression that post-transcriptionally regulate transcription factors involved in plant physiological activities. Little is known about the effects of miRNAs in disease resistance in apple (Malus×domestica). We globally profiled miRNAs in the apple cultivar Golden Delicious (GD) infected or not with the apple leaf spot fungus Alternaria (...) increased, while MdWRKYN1 and MdWRKY26 expression decreased in ALT1-inoculated GD leaves; furthermore, the overexpression of Md-miR156ab and Md-miR395 resulted in a significant reduction in MdWRKYN1 and MdWRKY26 expression. To investigate whether these miRNAs and their targets play a crucial role in plant defense, we overexpressed MdWRKYN1 or knocked down Md-miR156ab activity, which in both cases enhanced the disease resistance of the plants by upregulating the expression of the WRKY-regulated

2017 Frontiers in plant science

51. Impact of Acute and Chronic Inflammation on Cytochromes P450 Activity Measured With Dried Blood Spot

Impact of Acute and Chronic Inflammation on Cytochromes P450 Activity Measured With Dried Blood Spot Impact of Acute and Chronic Inflammation on Cytochromes P450 Activity Measured With Dried Blood Spot - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Impact of Acute and Chronic Inflammation on Cytochromes P450 Activity Measured With Dried Blood Spot The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03262051 Recruitment

2017 Clinical Trials

52. Treatment of Postorthodontic White Spot Lesions

-mediated demineralization episodes (Dowker et al., 1999 and Robinson et al., 2000). The demineralization of enamel (white spot lesions) is a significant problem during and after orthodontic treatment with prevalence 71.1% and various preventive measures have been suggested to minimize the incidence (Derks et al., 2004 and Al Maaitah et al., 2011). Condition or disease Intervention/treatment Phase White Spot Lesion of Tooth Drug: MI varnish GC Drug: White varnish 3M Phase 4 Detailed Description (...) and Cochrane et al., 2010). Management of white spot lesion should involve methods of both preventing demineralization and encourage the remineralization of existing lesions. In both of these processes, the efficacy of fluoride is well established. Fluoride increases the initial rate of remineralization of early enamel lesions. Consequently, it slows down the caries process and arresting the lesion. Fluoride varnish provides a protective coat over the tooth which adheres longer to the tooth surface (Demito

2017 Clinical Trials

53. Seroconversion to Causes of Febrile Illness in Mongolian Peacekeepers Deployed to South Sudan. Full Text available with Trip Pro

Seroconversion to Causes of Febrile Illness in Mongolian Peacekeepers Deployed to South Sudan. Immediately before deployment (Fall 2012) and after deployment (Spring 2013) in support of United Nations peacekeeping operations, Mongolian Armed Forces medical personnel obtained serum samples from the first contingent of Mongolian peacekeepers deploying to South Sudan to monitor serologic evidence of exposure to diseases that cause acute febrile illness. A total of 632 paired samples were tested (...) for IgG antibody for the following (number of seroconversions in parentheses): Rickettsia (spotted fever and typhus groups) (25), West Nile fever virus (WNV) (23), Coxiella burnetii (causative agent of Q fever) (12), dengue virus (8), leptospirosis (6), chikungunya virus (0), Congo-Crimean hemorrhagic fever virus (0), Japanese encephalitis virus (0), and Rift Valley fever virus (0). There was also evidence of exposure to WNV, C. burnetii, leptospirosis, and Rickettsia before deployment.© The American

2016 American Journal of Tropical Medicine & Hygiene

54. Kids who spot bullshit, and the adults who get upset about it

Kids who spot bullshit, and the adults who get upset about it Kids who spot bullshit, and the adults who get upset about it – Bad Science Search TED Talk Collected Journalism This Nerdy Book This Great Book T-shirts Categories (3) (4) (6) (45) (28) (6) (16) (190) (5) (20) (52) (88) (2) (1) (2) (1) (677) (4) (14) (2) (37) (4) (9) (3) (11) (6) (3) (16) (13) (1) (6) (8) (6) (6) (3) (13) (2) (2) (27) (1) (2) (6) (1) (7) (8) (3) (1) (4) (12) (1) (3) (20) (2) (13) (1) (20) (15) (4) (1) (20) (1) (1 (...) ) (1) (1) (3) (25) (2) (2) (4) (2) (1) (9) (6) (6) (2) (4) (2) (1) (1) (5) (14) (1) (3) (1) (14) (2) (2) (3) (15) (18) (14) (2) (3) (20) (1) (9) (162) (35) (11) (4) (4) (20) (3) (21) (6) (45) (15) (1) (6) (30) (36) (2) (14) (3) (1) (2) (44) (1) (3) (6) (3) (2) (3) (4) (9) (11) (60) (1) (1) (9) (2) (14) (6) (4) (34) (4) (22) (18) (31) (6) (9) (5) (1) (3) (1) (1) (1) (2) (22) (1) (12) (1) (59) (2) (6) (34) (26) (1) (1) (1) (2) (2) (1) (52) (7) (2) (1) (2) (3) (1) (1) (1) (4) (2) (82) (1) (10) (6) (3

2011 Bad Science

55. How To Spot a Quack Health Site: Red Flag #1, Primary Goal Is Selling Supplements

for this product. There are definitely no studies showing any benefit of his supplements in preventing cardiovascular disease in humans. In putting the follow up post together I ended up going down a reservatrol rabbit hole. The reservatrol story is typical and fascinating for how a “natural” chemical shows some early promise in limited animal studies , becomes hyped and marketed on the internet and ultimately is found to be useless. Wow, what a fast response ! Thanks so much ! I will look forward (...) How To Spot a Quack Health Site: Red Flag #1, Primary Goal Is Selling Supplements How To Spot a Quack Health Site: Red Flag #1, Primary Goal Is Selling Supplements | The Skeptical Cardiologist Primary Menu Search for: , , , How To Spot a Quack Health Site: Red Flag #1, Primary Goal Is Selling Supplements During the process of compiling the Cardiology Quackery Hall of Shame, the skeptical cardiologist has recognized that the #1 red flag of quackery is the constant promotion of useless

2017 The Skeptical Cardiologist

56. Laminin Receptor in Shrimp Is a Cellular Attachment Receptor for White Spot Syndrome Virus Full Text available with Trip Pro

Laminin Receptor in Shrimp Is a Cellular Attachment Receptor for White Spot Syndrome Virus White spot syndrome virus (WSSV, genus Whispovirus, family Nimaviridae) is causing huge economic losses in global shrimp farming, but there is no effective control. Shrimp cell laminin receptor (Lamr) may have a role in WSSV infection. The objective was to characterize interactions between Penaeus monodon Lamr (PmLamr) and WSSV structural proteins. In this study, PmLamr interacted with nine WSSV (...) structural proteins (based on yeast two-hybrid screening), of which one (VP31) was characterized. Protein pull-down assay confirmed the interaction between PmLamr and VP31; the latter was an envelope protein exposed outside the WSSV virion (based on membrane topology assays). Furthermore, similar to mammalian Lamr, there were two major protein bands in shrimp cells. Cellular localization assay demonstrated VP31 co-localized with PmLamr on transfected cells. Enzyme-link immunosorbent assay (ELISA

2016 PloS one

57. Scavenger Receptor C Mediates Phagocytosis of White Spot Syndrome Virus and Restricts Virus Proliferation in Shrimp Full Text available with Trip Pro

japonicus, designated MjSRC, which was significantly upregulated after white spot syndrome virus (WSSV) challenge at the mRNA and protein levels in hemocytes. The quantity of WSSV increased in shrimp after knockdown of MjSRC, compared with the controls. Furthermore, overexpression of MjSRC led to enhanced WSSV elimination via phagocytosis by hemocytes. Pull-down and co-immunoprecipitation assays demonstrated the interaction between MjSRC and the WSSV envelope protein. Electron microscopy observation (...) Scavenger Receptor C Mediates Phagocytosis of White Spot Syndrome Virus and Restricts Virus Proliferation in Shrimp Scavenger receptors are an important class of pattern recognition receptors that play several important roles in host defense against pathogens. The class C scavenger receptors (SRCs) have only been identified in a few invertebrates, and their role in the immune response against viruses is seldom studied. In this study, we firstly identified an SRC from kuruma shrimp, Marsupenaeus

2016 PLoS pathogens

58. A white spot syndrome virus microRNA promotes the virus infection by targeting the host STAT Full Text available with Trip Pro

A white spot syndrome virus microRNA promotes the virus infection by targeting the host STAT JAK/STAT pathway plays an important role in invertebrates during virus infection. However the microRNA (miRNA)-mediated regulation of JAK/STAT is not intensively investigated. Viral miRNAs, encoded by virus genome, have emerged as important regulators in the virus-host interactions. In this study, a WSSV (white spot syndrome virus)-encoded miRNA (WSSV-miR-22) was characterized in shrimp during virus (...) infection. The results showed that the viral miRNA could promote WSSV infection in shrimp by targeting the host STAT gene. When the expression of JAK or STAT was knocked down by sequence-specific siRNA, the WSSV copies in shrimp were significantly increased, indicating that the JAK/STAT played positive roles in the antiviral immunity of shrimp. The further findings revealed that TEP1 and TEP2 were the effectors of JAK-STAT signaling pathway. The silencing of TEP1 or TEP2 led to an increase of WSSV

2015 Scientific reports

59. A unique blue spot. (Abstract)

A unique blue spot. We report the unusual case of a 3-year-old child with a Mongolian blue spot present both around the auricle externally and on the tympanic membrane itself. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

2015 International Journal of Pediatric Otorhinolaryngology

60. Giant Mongolian Macules with Bilateral Ocular Involvement: Case Report and Review. (Abstract)

Giant Mongolian Macules with Bilateral Ocular Involvement: Case Report and Review. Dermal melanocytosis is characterized by the presence of spindle-shaped melanocytes in the dermis. The most common form is Mongolian spots. A 15-month-old girl from Azerbaijan had a systematized dark blue-gray hyperpigmentation on her shoulder, back and extremities. The hyperpigmentation was also found on both sclera and choroidal areas, without any other facial involvement. On histopathological examination

2012 Dermatology

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