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Modified Checklist for Autism in Toddlers

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21. Support for a Dimensional View of Autism Spectrum Disorders in Toddlers (PubMed)

Support for a Dimensional View of Autism Spectrum Disorders in Toddlers We examined whether clinically distinct subgroups can be derived from a sample of toddlers (n = 186) who failed the Modified Checklist for Autism in Toddlers, received a comprehensive clinical evaluation, and were diagnosed with an autism spectrum disorder (ASD). Three subgroups emerged from cluster analysis distinguished by (a) social, communication, and intellectual skills and (b) the rate and intensity of repetitive (...) behaviors and abnormal sensory response. Preoccupations, compulsions, and rituals did not distinguish resultant subgroups. These results support a dimensional diagnostic view of ASDs in toddlers since subgroup differences were based on symptom severity rather than different symptom profiles. Results also identify specific types and levels of behavioral deficit relevant to toddler populations. Implications for early diagnosis are discussed.

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2012 Journal of autism and developmental disorders

22. Age-Related Differences in Prevalence of Autism Spectrum Disorder Symptoms in Children and Adolescents with Costello Syndrome (PubMed)

Age-Related Differences in Prevalence of Autism Spectrum Disorder Symptoms in Children and Adolescents with Costello Syndrome Dysregulation of the mitogen activated protein kinase (MAPK) pathway in Costello syndrome (CS) may contribute to increased risk for autism-spectrum disorder (ASD). We examined prevalence of ASD symptoms in 14 individuals (six females) age 1-18 years with molecularly confirmed CS. Caregivers completed the Modified Checklist for Autism in Toddlers (M-CHAT) for ages 0-4 (...) criteria had significantly lower adaptive functioning and were physically much more impaired. Among older participants, SCQ subscale scores in communication, socialization, and repetitive behavior domains were comparable to the typically-developing normative sample. ASD symptoms were highly elevated in younger CS individuals. Older children did not differ from typically developing samples in prevalence of ASD symptoms. CS individuals may appear to fall on the autism spectrum in early childhood due

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2017 American journal of medical genetics. Part A

23. Association between Beta-Sympathomimetic Tocolysis and Risk of Autistic Spectrum Disorders, Behavioural and Developmental Outcome in Toddlers (PubMed)

toddlers (n = 44) were tocolytic untreated. Treated and untreated groups were also divided into subgroups: term and preterm delivered. The gestational age of tocolytic treatment start, the dose and duration of exposure in hours were obtained from obstetric medical records. The Brief Infant-Toddler Social and Emotional Assessment (BITSEA), the Modified Checklist for Autism in Toddlers (M-CHAT) and the Denver Developmental Screening Test (DDST) tests were applied for evaluation of social, emotional (...) problems, autism and developmental disorders.Term and preterm born toddlers treated tocolytically in utero didn't demonstrate a higher risk of autistic disorders or poorer behavioural and developmental results than controls. In the preterm group, the earliest start of tocolytic treatment was correlated with toddlers lower score of the Competencies Scale (p = 0.009) and a higher score of the Problems Scale (p = 0.048). Also, we concluded that preterm membrane rupture was associated with higher ASD risk

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2017 Open access Macedonian journal of medical sciences

24. Autism Screening With Online Decision Support by Primary Care Pediatricians Aided by M-CHAT/F. (PubMed)

Autism Screening With Online Decision Support by Primary Care Pediatricians Aided by M-CHAT/F. Autism spectrum disorders (ASDs) often go undetected in toddlers. The Modified Checklist for Autism in Toddlers (M-CHAT) With Follow-up Interview (M-CHAT/F) has been shown to improve detection and reduce over-referral. However, there is little evidence supporting the administration of the interview by a primary care pediatrician (PCP) during typical checkups. The goal of this study was to evaluate (...) the feasibility, validity, and reliability of the M-CHAT/F by PCPs with online prompts at the time of a positive M-CHAT screen.Forty-seven PCPs from 22 clinics completed 197 M-CHAT/Fs triggered by positive M-CHAT screens via the same secure Web-based platform that parents used to complete M-CHATs before an 18- or 24-month well-child visit. A second M-CHAT/F was administered live or by telephone by trained research assistants (RAs) at the Kennedy Krieger Institute Center for Autism and Related Disorders

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2016 Pediatrics

25. Assessment of Autism Symptoms During the Neonatal Period: Is There Early Evidence of Autism Risk? (PubMed)

Assessment of Autism Symptoms During the Neonatal Period: Is There Early Evidence of Autism Risk? To define neonatal social characteristics related to autism risk.Sixty-two preterm infants underwent neonatal neurobehavioral testing. At age 2 yr, participants were assessed with the Modified Checklist for Autism in Toddlers and Bayley Scales of Infant and Toddler Development, 3rd edition.Positive autism screening was associated with absence of gaze aversion, χ=5.90, p=01, odds ratio=5.05 (...) , and absence of endpoint nystagmus, χ=4.78, p=.02, odds ratio=8.47. Demonstrating gaze aversion was related to better language outcomes, t(55)=-3.07, p≤.003. Displaying endpoint nystagmus was related to better language outcomes, t(61)=-3.06, p=.003, cognitive outcomes, t(63)=-5.04, p<.001, and motor outcomes, t(62)=-2.82, p=.006.Atypical social interactions were not observed among infants who later screened positive for autism. Instead, the presence of gaze aversion and endpoint nystagmus was related

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2015 The American Journal of Occupational Therapy

26. Rapid video-referenced ratings of reciprocal social behavior in toddlers: a twin study. (PubMed)

Checklist for Autism in Toddlers (M-CHAT) and the MacArthur Communicative Development Inventory Short Form (MCDI-s).Scores on the vrRSB were fully continuously distributed, with excellent 6-month test-retest reliability ([intraclass correlation coefficient] ICC = 0.704, p < .000). MZ twins displayed markedly greater trait concordance than DZ twins, (MZ ICC = 0.863, p < .000, DZ ICC = 0.231, p < .012). VrRSB score distributions were highly distinct for children passing versus failing the M-CHAT (t (...) Rapid video-referenced ratings of reciprocal social behavior in toddlers: a twin study. Reciprocal social behavior (RSB) is a developmental prerequisite for social competency, and deficits in RSB constitute a core feature of autism spectrum disorder (ASD). Although clinical screeners categorically ascertain risk of ASD in early childhood, rapid methods for quantitative measurement of RSB in toddlers are not yet established. Such measurements are critical for tracking developmental trajectories

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2015 Journal of Child Psychology and Psychiatry

27. Testing two screening instruments for autism spectrum disorder in UK community child health services. (PubMed)

Testing two screening instruments for autism spectrum disorder in UK community child health services. The aim of this study was to test the accuracy of two screening instruments in UK Community health services: Modified Checklist for Autism in Toddlers (M-CHAT) and Social Communication Questionnaire (SCQ) for autism spectrum disorder (ASD). A two-stage screening and in-depth assessment procedure, combined with sampling stratification and statistical weighting, allowed the accuracy

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2015 Developmental Medicine and Child Neurology

28. Implementation of Web-based Autism Screening in an Urban Clinic (PubMed)

Implementation of Web-based Autism Screening in an Urban Clinic Screening toddlers for autism spectrum disorder (ASD) with the Modified Checklist for Autism in Toddlers, Revised (M-CHAT-R) has been shown to lower age of diagnosis by 2 years. In order to streamline ASD screening, research is exploring the use of web-based screening during well-child checkups. The current study examined implementation of the web-based M-CHAT-R in an urban pediatric clinic in Atlanta, Georgia. Toddlers (N = 2557 (...) ; 87% African American) were screened during well-child visits (Mage = 22.43 months, SD = 3.65). Using the web-based version resulted in a 58.5% increase in the number of cases screened per month. A similar proportion of toddlers in each modality screened positive (P = .43), but significantly fewer children were missing "Follow-up" in the web-based administration (P < .001). These results suggest that it is feasible to implement web-based screening in underserved populations. Future research

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2015 Clinical pediatrics

29. Screening and Linkage to Services for Autism

Plan (IFSP) development [ Time Frame: 36 months of age ] Time from initial positive Modified Checklist for Autism in Toddlers, Revised (M-CHAT-R) screen to indicated IFSP development (days) Initiation of indicated early intervention (EI) services [ Time Frame: 36 months of age ] Initiation of at least one indicated EI service (Yes/No) Age at initiation of indicated early intervention services [ Time Frame: 36 months of age ] Age at initiation of any indicated EI service (months) Time to initiation (...) of indicated early intervention services [ Time Frame: 36 months of age ] Time from initial positive Modified Checklist for Autism in Toddlers, Revised (M-CHAT-R) screen to initiation of any indicated EI service (days) Referral for developmental evaluation / eligibility determination [ Time Frame: 36 months of age ] Referral for developmental evaluation / eligibility determination made (yes/no) Time to referral for and implementation of developmental evaluation / eligibility determination [ Time Frame: 36

2015 Clinical Trials

30. Routine developmental, autism, behavioral, and psychological screening in epilepsy care settings. (PubMed)

. The parent of the child completed screening evaluations for development (Ages and Stages Questionnaire [ASQ], 0-66mo), autism (Modified Checklist for Autism in Toddlers [mCHAT], 16-30mo), social communication (Social Communication Questionnaire [SCQ], ≥4y), and psychiatric concerns (Strengths and Difficulties Questionnaire [SDQ], 4-17y).We screened 236 children overall (136 males [58%], 100 females [42%]; mean age [SD] 6y 7mo [4y 6mo]). Of these, 176 children (75%) had established epilepsy diagnoses (...) Routine developmental, autism, behavioral, and psychological screening in epilepsy care settings. Screening for cognitive impairment, developmental delay, and neuropsychiatric problems is not always performed in children with epilepsy. The aim of this study was to assess the value of this screening and its validity for determining previously unidentified ('actionable') problems in children with epilepsy.New and existing patients with epilepsy were recruited from a hospital-based epilepsy center

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2014 Developmental Medicine and Child Neurology

31. Infants Born Late/Moderately Preterm Are at Increased Risk for a Positive Autism Screen at 2 Years of Age. (PubMed)

Infants Born Late/Moderately Preterm Are at Increased Risk for a Positive Autism Screen at 2 Years of Age. To assess the prevalence of positive screens using the Modified Checklist for Autism in Toddlers (M-CHAT) questionnaire and follow-up interview in late and moderately preterm (LMPT; 32-36 weeks) infants and term-born controls.Population-based prospective cohort study of 1130 LMPT and 1255 term-born infants. Parents completed the M-CHAT questionnaire at 2-years corrected age. Parents (...) %; relative risk [RR] 1.58; 95% CI 1.18, 2.11). After follow-up, significantly more LMPT infants than controls had a true positive screen (2.4% vs 0.5%; RR 4.52; 1.51, 13.56). This remained significant after excluding infants with neurosensory impairments (2.0% vs 0.5%; RR 3.67; 1.19, 11.3).LMPT infants are at significantly increased risk for positive autistic screen. An M-CHAT follow-up interview is essential as screening for autism spectrum disorders is especially confounded in preterm populations

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2014 Journal of Pediatrics

32. Identifying children with autism spectrum disorder at 18 months in a general population sample. (PubMed)

and Child Cohort (MoBa), a population-based longitudinal study, and the Autism Birth Cohort (ABC), a sub-study on ASD. Parents completed all 23 items from the Modified Checklist for Autism in Toddlers (M-CHAT) at 18 months.The M-CHAT 6-critical-item criterion and the 23-item criterion had a specificity of 97.9% and 92.7% and a sensitivity of 20.8% and 34.1%, respectively. In the 173 children diagnosed with ASD to date, 60 children (34.7%) scored above the cut-off on either of the screening criteria (...) Identifying children with autism spectrum disorder at 18 months in a general population sample. Previous research on clinical and high-risk samples suggests that signs of autism spectrum disorder (ASD) can be detected between 1 and 2 years of age. We investigated signs of ASD at 18 months in a population-based sample and the association with later ASD diagnosis.The study sample includes 52,026 children born 2003 through 2008 and is a subset of children that participated in the Norwegian Mother

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2014 Paediatric and perinatal epidemiology

33. ESAT and M-CHAT as screening instruments for autism spectrum disorders at 18 months in the general population: issues of overlap and association with clinical referrals. (PubMed)

ESAT and M-CHAT as screening instruments for autism spectrum disorders at 18 months in the general population: issues of overlap and association with clinical referrals. The Modified Checklist for Autism in Toddlers (M-CHAT) and the Early Screening of Autistic Traits (ESAT) were designed to screen for autism spectrum disorders in very young children. The aim of this study was to explore proportions of children that screened positive on the ESAT or the M-CHAT and to investigate if screening

2014 European child & adolescent psychiatry

34. Pervasive Developmental Disorder: Autism (Diagnosis)

Regular screening of infants and toddlers for symptoms and signs of autistic disorder is crucial because it allows for early referral of patients for further evaluation and treatment. Siblings of children with autism are at risk for developing traits of autism and even a full-blown diagnosis of autism. Therefore, siblings should also undergo screening not only for autism-related symptoms but also for language delays, learning difficulties, social problems, and anxiety or depressive symptoms (...) . [ ] Having parents fill out the Autism Screening Checklist can identify children who merit further assessment for possible autism. See the image below for a printable version of the checklist. The significance of answers to individual Autism Screening Checklist items is as follows: Item 1- A "yes" occurs in healthy children and children with some pervasive developmental disorders; a "no" occurs in children with autism, Rett syndrome, and other developmental disorders. Item 2 - A "yes" occurs in healthy

2014 eMedicine Pediatrics

35. Pervasive Developmental Disorder: Autism (Follow-up)

Information Corporation (PMIC); 1993: Canal-Bedia R, García-Primo P, Martín-Cilleros MV, Santos-Borbujo J, Guisuraga-Fernández Z, Herráez-García L, et al. Modified checklist for autism in toddlers: cross-cultural adaptation and validation in Spain. J Autism Dev Disord . 2011 Oct. 41(10):1342-51. . [Guideline] Cincinnati Children's Hospital Medical Center. Best evidence statement (BESt). Use of motor and self-care assessment tools for children with autism spectrum disorder (ASD). 2009 Jul. . Cincinnati (...) Behav Pediatr . 2011 Apr 15. . Allison C, Auyeung B, Baron-Cohen S. Toward brief "Red Flags" for autism screening: The Short Autism Spectrum Quotient and the Short Quantitative Checklist for Autism in toddlers in 1,000 cases and 3,000 controls [corrected]. J Am Acad Child Adolesc Psychiatry . 2012 Feb. 51(2):202-212.e7. . Allison C, Baron-Cohen S, Wheelwright S, Charman T, Richler J, Pasco G, et al. The Q-CHAT (Quantitative CHecklist for Autism in Toddlers): a normally distributed quantitative

2014 eMedicine Pediatrics

36. Pervasive Developmental Disorder: Autism (Overview)

Regular screening of infants and toddlers for symptoms and signs of autistic disorder is crucial because it allows for early referral of patients for further evaluation and treatment. Siblings of children with autism are at risk for developing traits of autism and even a full-blown diagnosis of autism. Therefore, siblings should also undergo screening not only for autism-related symptoms but also for language delays, learning difficulties, social problems, and anxiety or depressive symptoms (...) . [ ] Having parents fill out the Autism Screening Checklist can identify children who merit further assessment for possible autism. See the image below for a printable version of the checklist. The significance of answers to individual Autism Screening Checklist items is as follows: Item 1- A "yes" occurs in healthy children and children with some pervasive developmental disorders; a "no" occurs in children with autism, Rett syndrome, and other developmental disorders. Item 2 - A "yes" occurs in healthy

2014 eMedicine Pediatrics

37. Pervasive Developmental Disorder: Autism (Treatment)

Information Corporation (PMIC); 1993: Canal-Bedia R, García-Primo P, Martín-Cilleros MV, Santos-Borbujo J, Guisuraga-Fernández Z, Herráez-García L, et al. Modified checklist for autism in toddlers: cross-cultural adaptation and validation in Spain. J Autism Dev Disord . 2011 Oct. 41(10):1342-51. . [Guideline] Cincinnati Children's Hospital Medical Center. Best evidence statement (BESt). Use of motor and self-care assessment tools for children with autism spectrum disorder (ASD). 2009 Jul. . Cincinnati (...) Behav Pediatr . 2011 Apr 15. . Allison C, Auyeung B, Baron-Cohen S. Toward brief "Red Flags" for autism screening: The Short Autism Spectrum Quotient and the Short Quantitative Checklist for Autism in toddlers in 1,000 cases and 3,000 controls [corrected]. J Am Acad Child Adolesc Psychiatry . 2012 Feb. 51(2):202-212.e7. . Allison C, Baron-Cohen S, Wheelwright S, Charman T, Richler J, Pasco G, et al. The Q-CHAT (Quantitative CHecklist for Autism in Toddlers): a normally distributed quantitative

2014 eMedicine Pediatrics

38. CPG for the Management of Patients with Autism Spectrum Disorders in Primary Care

CPG for the Management of Patients with Autism Spectrum Disorders in Primary Care Clinical Practice Guideline for the Management of Patients with Autism Spectrum Disorders in Primary Care CLINICAL PRACTICE GUIDELINES IN THE SPANISH NATIONAL HEALTHCARE SYSTEM MINISTRY OF HEALTH, SOCIAL POLICY , AND EQUALITYClinical Practice Guideline for the Management of Patients with Autism Spectrum Disorders in Primary Care CLINICAL PRACTICE GUIDELINES IN THE SPANISH NHS MINISTRY OF HEALTH AND SOCIAL POLICIES (...) development Group of the Clinical Practice Guidelines for the Management of Patients with Autism Spectrum Disorders in Primary Care. Clinical Practice Guidelines for the Management of Patients with Autism Spectrum Disorders in Primary Care. Quality Plan for the National System of Health, Ministry of Health and Social Policy. Health Technology Assessment Unit. Laín Entralgo Agency, 2009. Clinical Practice Guidelines in the NHS: UETS No. 2007/5-3. It has been 5 years since the publication of this Clinical

2009 GuiaSalud

39. Prospective, blinded exploratory evaluation of the PlayWisely program in children with autism spectrum disorder. (PubMed)

developmental disorder - not otherwise specified (PDD-NOS), and Asperger syndrome (AS). Eighteen children, 1 to 10 years of age, were evaluated using the Childhood Autism Rating Scale, Second Edition (CARS2); the PlayWisely Interactive Test of Attention, Recognition, and Memory Skills; Autism Treatment Evaluation Checklist (ATEC), and the Modified Checklist for Autism in Toddlers (M-CHAT). There were significant treatment effects for the PlayWisely measure on the Yellow Sets that examine recognition; Purple (...) Prospective, blinded exploratory evaluation of the PlayWisely program in children with autism spectrum disorder. The purpose of the study was to explore a low-cost intervention that targets an increasingly common developmental disorder. The study was a blinded, exploratory evaluation of the PlayWisely program on autism symptoms and essential learning foundation skills (attention, recognition, and memory skills) in children with a diagnosis of autism, autism spectrum disorder (ASD), pervasive

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2013 The Yale journal of biology and medicine

40. Genetic variance for autism screening items in an unselected sample of toddler-age twins. (PubMed)

Genetic variance for autism screening items in an unselected sample of toddler-age twins. Twin and family studies of autistic traits and of cases diagnosed with autism suggest high heritability; however, the heritability of autistic traits in toddlers has not been investigated. Therefore, this study's goals were (1) to screen a statewide twin population using items similar to the six critical social and communication items widely used for autism screening in toddlers (Modified Checklist (...) for Autism in Toddlers); (2) to assess the endorsement rates of these items in a general population; and (3) to determine their heritability.Participants composed a statewide, unselected twin population. Screening items were administered to mothers of 1,211 pairs of twins between 2 and 3 years of age. Twin similarity was calculated via concordance rates and tetrachoric and intraclass correlations, and the contribution of genetic and environmental factors was estimated with single-threshold ordinal

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2010 Journal of the American Academy of Child and Adolescent Psychiatry

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