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8701. A Study of the Efficacy and Safety of Eliglustat Tartrate (Genz-112638) in Type 1 Gaucher Patients

tartrate becomes commercially available, or where applicable, specific regulatory requirements have been met). Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 26 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: A Phase 2, Open-Label, Multi-Center Study Evaluating the Efficacy, Safety and Pharmacokinetics of Genz-112638 in Gaucher Type 1 Patients Study (...) . Participants were categorized as none (no bone pain), very mild bone pain, mild bone pain and moderate bone pain. In this outcome, number of participants with different levels of bone pain at specified time points were reported. Number of Participants With Mobility Status (MS) at Baseline, Year 1, Year 2, Year 3, Year 4, Year 5, Year 6, Year 7, Year 8, Year 9 and at End of Study [ Time Frame: Baseline, Year 1, Year 2, Year 3, Year 4, Year 5, Year 6, Year 7, Year 8, Year 9 and at End of Study (Up to Year 9

2006 Clinical Trials

8702. A Comparison of Sequential Compression Devices and Foot Pumps in the Obstetric Population

Intervention/treatment Phase Thrombophilia Device: Kendall A-V foot impulse pump, model 6060 Device: Kendall sequential compression device, model 9525 Not Applicable Detailed Description: The investigators will be comparing sequential compression devices (SCDs) to foot pumps to determine if foot pumps will be better tolerated by obstetric patients, both antepartum and intrapartum. Patients in whom thromboembolic prophylaxis is deemed necessary and ordered by the treating physician, who agree to participate (...) Criteria: Active DVT Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its identifier (NCT number): NCT00356434 Locations Layout table for location information United States, Maryland Johns Hopkins Bayview Medical Center Baltimore, Maryland, United States, 21224 Johns Hopkins Hospital

2006 Clinical Trials

8703. Normal Values of Facial Thermography

: An objective of this study is to standardize temperature values derived from thermograms of the facial region. It is anticipated that the mean temperature of a defined region of interest, such as the eyes, nose, or sinuses, might be useful for future applications. The investigators will attempt to determine normal temperature ranges based on participants' age and gender. Condition or disease Intervention/treatment Healthy Allergy Allergic Rhinoconjunctivitis Procedure: Thermography Detailed Description (...) : Medical thermography is a noninvasive technique that allows an examiner to visualize and estimate the temperature of the skin surface. An infrared scanning device is used to convert infrared radiation emitted from the skin surface into electrical impulses that can be captured as an image called a thermogram. During the past 20 years medical thermography has been used to study the pathology in the vascular, muscular, neural and skeletal systems. An objective of this study is to standardize temperature

2006 Clinical Trials

8704. Endoscopic Stomach and Pouch Reduction in Patients With Weight Regain Following Roux-En-Y Bypass Surgery

: March 18, 2008 Sponsor: USGI Medical Information provided by: USGI Medical Study Details Study Description Go to Brief Summary: The Roux-En-Y gastric bypass procedure is the most commonly performed bariatric procedure in the United States. Despite initial weight loss, some patients experience weight regain that may be related to an increase in the size of the gastric pouch and/or stoma. A second surgical procedure to reduce the size of the pouch and/or stoma is typically associated with a higher (...) risk of death or complications than the original gastric bypass procedure. This study will evaluate a less invasive, endolumenal alternative to pouch and stoma revision as a means of producing weight loss in patients who have regained weight following gastric bypass. Condition or disease Intervention/treatment Phase Obesity Procedure: endolumenal surgery Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Allocation: Non-Randomized

2006 Clinical Trials

8705. Melphalan, Yttrium Y 90 Ibritumomab Tiuxetan, and Rituximab Followed by Autologous Stem Cell Transplant in Treating Older Patients With Non-Hodgkin's Lymphoma That Has Relapsed or Not Responded to Previous Treatment

Y 90 ibritumomab tiuxetan and rituximab as a conditioning regimen followed by vinorelbine ditartrate- and filgrastim (G-CSF)-mobilized autologous stem cell transplantation in elderly patients with relapsed or refractory CD20-positive non-Hodgkin's lymphoma. Evaluate the feasibility and safety of this regimen in these patients. Determine the feasibility of stem cell mobilization with vinorelbine ditartrate in patients treated with this regimen. OUTLINE: This is a multicenter, dose-escalation (...) study of high-dose melphalan. Stem cell harvest and mobilization: Patients receive vinorelbine ditartrate IV on day -36 and filgrastim (G-CSF) subcutaneously (SC) twice daily on days -33 to -29. Patients undergo peripheral blood stem cell harvest on days -29 to -26. Radioimmunotherapy: Patients receive rituximab IV. Within 4 hours after completion of rituximab, patients receive indium In 111 ibritumomab tiuxetan (imaging dose) IV over 10 minutes on day -25. Patients undergo assessment

2006 Clinical Trials

8706. Deep Vein Thrombosis (DVT) Prevention in Total Hip Arthroplasty: Continuous Enhanced Circulation Therapy (CECT) Versus Low Molecular Weight Heparin (LMWH)

Government. Read our for details. Identifier: NCT00358735 Recruitment Status : Completed First Posted : August 1, 2006 Results First Posted : October 21, 2014 Last Update Posted : October 30, 2014 Sponsor: Medical Compression Systems Information provided by (Responsible Party): Medical Compression Systems Study Details Study Description Go to Brief Summary: Evaluation of the safety and effectiveness of ActiveCare+ CECT device +/- baby dose aspirin (81 mg QD) for lowering the potential (...) risk for bleeding and of DVT during and after THA surgery in comparison with LMWH. Condition or disease Intervention/treatment Phase Deep Vein Thrombosis of Lower Limb Pulmonary Embolism (PE) Bleeding Device: ActiveCare CECT device Drug: Enoxaparin Not Applicable Detailed Description: Patients undergoing total hip arthroplasty surgery are at particular risk for Thromboembolic disease. To date two prophylactic modalities are being used: mechanical (intermittent pneumatic compression [IPC

2006 Clinical Trials

8707. Busulfan Monotherapy as Conditioning for Autologous Hematopoietic Progenitor Cell Transplantation

: Leukapheresis Drug: Busulfan Procedure: Stem cell reinfusion Not Applicable Detailed Description: Pre- Transplantation Phase - Twenty-four to 48 hours following completion of consolidation chemotherapy, patients will begin to receive G-CSF at 10 mcg/kg twice daily subcutaneously. Alternatively, patients may receive G-CSF alone (same dose) as mobilization therapy. Leukapheresis will begin day 4 of G-CSF administration and proceed according to institutional guidelines. Leukapheresis will continue until (...) support Transfusion support Prophylaxis for busulfan-induced seizures During follow-up, patients will be seen at least weekly for the first month and there after periodically out to 730 days posttransplant. The following medical procedures will be done: Medical history and physical exam (including concurrent meds, vital signs, performance status and weight) Standard labs Bone marrow aspirate and biopsy Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial

2006 Clinical Trials

8708. Characterizing Wheelchair-Related Falls in Elderly Veterans

are not applicable to persons who use a wheelchair for mobility. Specific objectives include: (1) Describe the incidence and prevalence of wheelchair tips (near falls), falls, and fall-related injuries, (2) Describe the epidemiology of the wheelchair tip or fall event. (3) Create models for predicting wheelchair tips, falls, and fall-related injuries for elderly persons who use a wheelchair for mobility. (4) Determine healthcare utilization and direct costs associated with wheelchair-related fall injuries. (5 (...) will be conducted with a subset of subjects at 6 months post fall, using open-ended questions to gather data about patient-perceived long-term consequences of falls. At the end of the 12-month data collection, we will reassess patient's functional status and cognition. Sample. Inclusion criterion includes all veterans who (1) are aged 62 and older, (2) use a wheelchair for their primary means of mobility, (3) have used a wheelchair for at least 12 months previous to enrollment, and (4) will be using

2006 Clinical Trials

8709. Comparison Study of Two Chiropractic Treatment Protocols for Knee Pain Due to Patellofemoral Pain Syndrome

Mobilization (GISTM) Not Applicable Detailed Description: Exercise is standard of care for PFPS but gives limited pain reduction and functional improvement. Previous manipulative therapy for PFPS (with and without exercise) has been limited to the patellofemoral joint alone. However, literature suggests additional manipulative therapy with exercise and soft-tissue treatment may give a better outcome. Further research is needed. Therefore, this project is a pilot study to inform a future randomized (...) measure (step-ups, step-downs and squats) and a Patient Satisfaction Scale (PSS - discharge or refer) as secondary outcome measures. This study will help establish the feasibility of conducting quality research at Cleveland Chiropractic College Los Angeles. In this pilot study there will be two groups of 10 subjects each Group A will receive CMT to the knee only, exercise and soft tissue treatment (Graston Instrument Soft Tissue Mobilization hereafter GISTM) Group B will receive CMT to the lumbosacral

2006 Clinical Trials

8710. Client Centred 'Tune-ups': do They Enhance Community Reintegration After Stroke?

University Collaborator: Heart and Stroke Foundation of Ontario Information provided by (Responsible Party): Dr. Brenda Brouwer, Queen's University Study Details Study Description Go to Brief Summary: Once discharged from hospital many stroke survivors deteriorate medically, physically and in their mobility function and many report their level of function and quality of life to be poor 12 months after inpatient rehabilitation. There is an identified need for follow-up examinations of community dwelling (...) rehabilitation Not Applicable Detailed Description: The extent to which impairment (physical capacity) and function influence community reintegration is unclear. One of the challenges is that physical parameters change over time as does the person's awareness and perception of what activities are important to be able to engage in at the community level. Interventions have led to gains in physical capacity, function and community reintegration, but the benefits have been shown to dissipate within three to six

2006 Clinical Trials

8711. Chromogranin-A-Derived Peptides and Periodontitis in Diabetic Patients

the antimicrobial activity of these peptides. Condition or disease Intervention/treatment Phase Periodontitis and Diabetitis Procedure: Gingival crevicular fluid samples (this procedure is added to the subject usual medical follow-up). Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 90 participants Allocation: Non-Randomized Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Diagnostic (...) : January 12, 2009 Sponsor: University Hospital, Strasbourg, France Information provided by: University Hospital, Strasbourg, France Study Details Study Description Go to Brief Summary: Periodontitis is a chronic disease of the supporting tissue of the teeth, characterized by bleeding and inflamed gingival, resorption of alveolar bone. This disease has a significant impact of the quality of life as the teeth become progressively mobile and may fall out spontaneously if no treatment is provided

2006 Clinical Trials

8712. Mini-incision for strictly retroperitoneal nephrectomy in living kidney donation vs flank incision. (Full text)

Mini-incision for strictly retroperitoneal nephrectomy in living kidney donation vs flank incision. Mini-incision donor nephrectomies (MIDNs) were established during the last decade, as an alternative to traditional open donor nephrectomy (ODN) via flank incision. In this study, we investigated intra-operative and post-operative data on outcome following MIDN in comparison with ODN data.Data of 70 living kidney donations, performed at the University of Regensburg Medical Center since 1996, were (...) evaluated. Donor operation was performed as either strictly retroperitoneal MIDN (n = 34) or as traditional ODN (n = 36) via flank incision. Total operation time, warm ischaemia time (WIT), perioperative pain-medication usage and creatinine levels as well as length of hospital stay, return to complete enteral nutrition and regular digestion were evaluated retrospectively.Total operation times were similar in MIDN, n = 34 (132 +/- 26 min) and in ODN, n = 36 (140 +/- 37 min) (P = 0.424). WIT was also

2006 Transplantation

8713. Efficacy and safety of balloon kyphoplasty in the treatment of vertebral compression fractures: a systematic review. (Full text)

effects model. Meta-regression analyses were carried out where required. A total of 26 studies met the inclusion criteria. Although studies displayed considerable methodological limitations, the results of the clinical series indicate significant improvements in pain intensity, vertebral height, sagittal alignment, functional capacity, and quality of life. Compared with conventional medical management, BK afforded significant improvement in pain intensity and mobility. Likewise, a significant (...) %. The available evidence suggests that BK can be effective and safe in application to VCFs. However, existing studies evince substantial methodological limitations and relatively short follow-up periods. Better clinical research is required to determine the capacity of BK to avoid the functional and physiological sequelae of VCFs and to define the true role of the technique among the existing therapeutic options.

2006 European Spine Journal

8714. Using the SF-36 measure to compare the health impact of multiple sclerosis and Parkinson's disease with normal population health profiles. (Full text)

Using the SF-36 measure to compare the health impact of multiple sclerosis and Parkinson's disease with normal population health profiles. To examine the relative impact of two chronic neurological disorders, multiple sclerosis and Parkinson's disease, by comparing patients' scores on the medical outcomes study 36-item short form health survey (SF-36) with the health profile of the United Kingdom population norms.638 people representing the full spectrum of multiple sclerosis and 227 patients (...) with Parkinson's disease were studied. Health status was measured by the SF-36. Scores for the eight health domains were compared after controlling for age, sex, disease duration, mobility, social class, ethnicity, education, marital status, and employment status.People with multiple sclerosis and those with Parkinson's disease had significantly worse health than the general population on all eight domains measured by the SF-36. The relative impact of multiple sclerosis and Parkinson's disease were similar

2003 Neurosurgery and Psychiatry

8715. Automated speech recognition for time recording in out-of-hospital emergency medicine-an experimental approach. (PubMed)

Automated speech recognition for time recording in out-of-hospital emergency medicine-an experimental approach. Precise documentation of medical treatment in emergency medical missions and for resuscitation is essential from a medical, legal and quality assurance point of view [Anästhesiologie und Intensivmedizin, 41 (2000) 737]. All conventional methods of time recording are either too inaccurate or elaborate for routine application. Automated speech recognition may offer a solution. A special (...) false recognition appear. Time recording with automated speech recognition seems to be possible in emergency medical missions. Although results show an average recognition of only 75%, it is possible that missing elements may be reconstructed more precisely. Future technology should integrate a secure wireless connection between microphone and mobile computer. The system could then prove its value for real out-of-hospital emergencies.

2004 Resuscitation

8716. Monitoring and telemedicine support in remote environments and in human space flight. (Full text)

communication technologies for telemedicine applications is still low, either for logistic, economic and political reasons, or because of limited knowledge about the available technology and procedures. Criteria for selection of portable telemedicine terminals in remote terrestrial places, characteristics of currently available mobile telecommunication systems, and the concept of integrated monitoring of physiological and environmental parameters are mentioned in the first section of this paper. The second (...) space flight, days for remote exploratory camp, weeks for polar bases and months to years for interplanetary exploration. The generic system architecture, used in any telematic support, consists of data acquisition, data-processing and storage, telecommunications links, decision-making facilities and the means of command execution. At the present level of technology, a simple data transfer and two-way voice communication could be established from any place on the earth, but the current use of mobile

2006 British Journal of Anaesthesia

8717. BLI-800-301: BLI-800 vs an Active Control Bowel Preparation in Adult Subjects Undergoing Colonoscopy

of unknown etiology Neoplastic disease surveillance Endosonography Inflammatory bowel disease Unknown diarrhea or constipation etiology Polypectomy Laser therapy Routine Screening At least 18 years of age Otherwise in good health, as determined by physical exam and medical history If female, and of child-bearing potential, is using an acceptable form of birth control (hormonal birth control, IUD, double-barrier method, depot contraceptive, abstinent, or vasectomized spouse) Negative urine pregnancy test (...) at screening, if applicable In the Investigator's judgment, subject is mentally competent to provide informed consent to participate in the study Exclusion Criteria: Subjects with known or suspected ileus, severe ulcerative colitis, gastrointestinal obstruction, gastric retention, bowel perforation, toxic colitis, or megacolon. Subjects with impaired consciousness that predisposes them to pulmonary aspiration. Subjects who are undergoing colonoscopy for foreign body removal and decompression. Subjects

2007 Clinical Trials

8718. Autologous or Donor Stem Cell Transplantation in Treating Patients With Recurrent Non-Hodgkin's Lymphoma

: Fludarabine, Cyclophosphamide, and Rituximab Fludara, Cytoxan®, and Rituxan Procedure: Allogeneic transplant Infusion of G-CSF mobilized allogeneic hematopoietic stem cells Other Name: HSCT Drug: GVHD Prophylaxis Tacrolimus 0.09 mg/kg/day PO, based on body weight formulas will start on Day -2 and continue until Day +90 post-HSCT. Tacrolimus (or cyclosporine, if applicable) will be given orally in a twice-daily divided dose. Methotrexate 5 mg/m2 Intravenous Pyelogram (IVP) will be administered on Days +1 (...) accrual) First Posted : November 10, 2004 Results First Posted : September 17, 2012 Last Update Posted : September 12, 2016 Sponsor: Medical College of Wisconsin Collaborators: National Heart, Lung, and Blood Institute (NHLBI) Blood and Marrow Transplant Clinical Trials Network National Cancer Institute (NCI) National Marrow Donor Program Information provided by (Responsible Party): Medical College of Wisconsin Study Details Study Description Go to Brief Summary: This study is designed as a Phase II

2004 Clinical Trials

8719. Aquatic Verses Land Exercise to Decrease Fall Risk

Details Study Description Go to Brief Summary: Compare the effect of aquatic,land and no exercise on fall risk factors in women diagnosed with osteoporosis Condition or disease Intervention/treatment Phase Osteoporosis Behavioral: exercise Not Applicable Detailed Description: Background and Purpose: Fall prevention through exercise is an ongoing goal of researchers and clinicians. This study compared the effects of aquatic exercise (AE), land exercise (LE) and no exercise (NE) on fall risk factors (...) . Subjects: Seventy-three women, 60 or older, with osteoporosis (OP). Method: Randomized clinical trial comparing balance, posture, strength, mobility, function, falls, and quality of life. Results: Significant differences (p<0.05) were found for participants’ ratings of global change (AE and LE > NE), tandem balance (AE > LE) and function (LE > AE). Joint pain and falls occurred more often during LE. Discussion and Conclusion: Participants experienced significant global improvement with both AE and LE

2005 Clinical Trials

8720. MTAS—where are we now? (Full text)

MTAS—where are we now? 17446610 2007 04 30 2016 11 24 1756-1833 334 7598 2007 Apr 21 BMJ (Clinical research ed.) BMJ MTAS--where are we now? 824-5 Shannon Colleen C eng Journal Article England BMJ 8900488 0959-8138 AIM IM Career Mobility Inservice Training organization & administration trends Job Application Medical Staff, Hospital education organization & administration State Medicine United Kingdom 2007 4 21 9 0 2007 5 1 9 0 2007 4 21 9 0 ppublish 17446610 334

2007 BMJ : British Medical Journal

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