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8601. Study of an Implantable Functional Neuromuscular Stimulation System for Patients With Spinal Cord Injuries

evaluations of system performance in these patients. III. Perform long term follow up and monitor system use outside of the laboratory. Condition or disease Intervention/treatment Phase Spinal Cord Injury Procedure: Surgery Device: IRS-8 Not Applicable Detailed Description: PROTOCOL OUTLINE: Patients undergo surgery in which electrodes are sutured into areas of the pelvis and legs. Electrode leads are inserted into a receiver/stimulator implanted in a subcutaneous pocket in the abdomen. Following (...) implantation, patients undergo training in standing, transfers, and other advanced mobility skills using the functional neuromuscular stimulation system. Restricted activity continues for 2 weeks after surgery, followed by 8 weeks of exercise. Standing training then begins, and continues for up to 6 weeks. Home-based training follows prior to discharge with the system for spontaneous use. Patients are followed at 3, 6, and 12 months, then annually thereafter. Study Design Go to Layout table for study

1999 Clinical Trials

8602. Fludarabine Phosphate, Low-Dose Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer

transplantation Procedure: peripheral blood stem cell transplantation Biological: therapeutic allogeneic lymphocytes Drug: cyclosporine Drug: mycophenolate mofetil Other: pharmacological study Other: laboratory biomarker analysis Not Applicable Detailed Description: PRIMARY OBJECTIVES: I. To determine whether stable allogeneic engraftment from unrelated hematopoietic stem cell donors can be safely established using a non-myeloablative conditioning regimen in patients with hematologic malignancies and renal (...) treatable by allogeneic hematopoietic stem cell transplant (HSCT) and all patients with B cell malignancies except those who may be cured by autologous stem cell transplantation (SCT) Age =< 50 years of age with hematologic diseases treatable by allogeneic HSCT who through pre-existing medical conditions or prior therapy are considered to be of high risk for regimen related toxicity associated with a conventional transplant or those patients who refuse a conventional SCT; transplants must be approved

2000 Clinical Trials

8603. Stem Cell (Modified Bone Marrow) Transplantation in HIV-Infected Patients With Blood Cancer

, and will not use radiation therapy; or A laboratory-manufactured gene designed to obstruct HIV reproduction will be inserted into the stem cells, rendering future cells that develop from resistance to the virus. Prospective patients will be tested for matching with an HIV-negative donor (family member) and will undergo a medical history, physical examination and several tests (e.g., breathing tests, X-rays, etc.) to determine eligibility for the study. Study participants will then undergo apheresis to collect (...) Neoplasm HIV Infection Drug: GCSF Mobilized Allogeneic PBSC Cultured w/Cytokines; Transduced w/RV Phase 1 Detailed Description: Adult patients with myelodysplasia, leukemia, and non-Hodgkin's lymphoma can be cured by allogeneic bone marrow transplantation (BMT). This curative effect has until now been ascribed to the intense chemoradiotherapy used to condition the recipient for transplantation. The assumption that the curative effect of allogeneic transplantation rests in the ability to deliver very

2000 Clinical Trials

8604. Urban African-American Community Hypertension Control

to help close the gap in health status for African Americans. The study was conducted in response to a demonstration and education initiative, "Improving Hypertensive Care for Inner City Minorities", which was reviewed and approved by the Clinical Applications and Prevention Advisory Committee in April 1992 and by the National Heart, Lung, and Blood Advisory Council in May 1992. The Request for Applications was released in October 1992. DESIGN NARRATIVE: The two and a half year intervention trial (...) assigned to a more or less intensive educational-behavioral intervention. Both groups received usual medical care, community HBP education, and HBP patient education materials. In addition, the more intensive group received 1) individualized educational counseling sessions with the CHW to increase understanding of HBP and to address barriers to control of HBP; 2) outreach and follow-up to address inadequate health care resources and health behavior related skills through interim monitoring

2000 Clinical Trials

8605. Decompression Coring Versus Conservative Therapy in Patients With Avascular Necrosis of the Hip Related to Sickle Cell Disease

if decompression coring results in a substantial improvement in pain and mobility compared to conservative therapy in patients with avascular necrosis of the hip related to sickle cell disease. Condition or disease Intervention/treatment Phase Bone Avascular Necrosis Sickle Cell Anemia Procedure: Core decompression Not Applicable Detailed Description: PROTOCOL OUTLINE: This is a randomized, multicenter study. Patients are stratified according to stage of avascular necrosis (I vs II vs III). Patients (...) : Completed First Posted : August 4, 2000 Last Update Posted : February 15, 2017 Sponsor: Children's Hospital & Research Center Oakland Information provided by: Children's Hospital & Research Center Oakland Study Details Study Description Go to Brief Summary: OBJECTIVES: I. Phase II trial to determine surgical morbidity of decompression coring, including any adverse events in the perioperative period and the rate of secondary medical or surgical interventions. II. Collect preliminary data to determine

2000 Clinical Trials

8606. STI571 Compared With Interferon Alfa Plus Cytarabine in Treating Patients With Newly Diagnosed Chronic Myelogenous Leukemia

of complete hematologic response (without progression to accelerated or blastic phase) discontinue treatment on the arm to which they were originally randomized and begin treatment on the other arm. Crossover courses repeat monthly in the absence of progression to accelerated phase or blast crisis, or unacceptable toxicity. Quality of life is assessed prior to study; monthly for the first 6 months of study; at 9, 12, 18, and 24 months; at time of crossover (if applicable); and at treatment discontinuation (...) before year 2 (if applicable). All patients are followed every 3 months for up to 8 years. PROJECTED ACCRUAL: A total of 850 patients (425 per arm) will be accrued for this study. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Primary Purpose: Treatment Official Title: A Phase III Study of STI571 Versus Interferon-a (IFN-a) Combined With Cytarabine (Ara-C) in Patients With Newly Diagnosed Previously Untreated Philadelphia Chromosome Positive (Ph

2000 Clinical Trials

8607. Monoclonal Antibody Therapy in Treating Patients With Lymphoma or Leukemia

cells. Patients undergo transplantation on day 0, according to applicable transplant protocols, one month after mobilization. Some patients may receive posttransplant interleukin-2 after achieving durable engraftment. Patients are followed at day 30, 80, 180, 365, and 395. PROJECTED ACCRUAL: A total of 20-30 patients will be accrued for this study. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Primary Purpose: Treatment Official Title: A Phase I (...) : monoclonal antibody CD19 Biological: monoclonal antibody CD20 Procedure: in vitro-treated peripheral blood stem cell transplantation Phase 1 Phase 2 Detailed Description: OBJECTIVES: I. Evaluate the efficiency of tumor cell removal by immunomagnetic technique in patients with B cell malignancies. II. Determine toxicity of mobilized peripheral blood stem cell (PBSC) components of enriched CD34+ and depleted B cells in this patient population. III. Compare recovery with the use of this treatment regimen

1999 Clinical Trials

8608. Perineal dermatitis risk factors: clinical validation of a conceptual framework. (PubMed)

of diapers and underpads for 166 adult patients hospitalized on medical and surgical floors who were incontinent of urine and/or feces. Variables related to skin breakdown were the number of incontinence episodes, fecal incontinence, poor skin condition, pain, poor oxygenation, fevers, and mobility problems. Results also suggest that older patients may not have the sensory perception to experience discomfort in the same intensity as younger patients. Based on the findings of this study, pressure ulcer (...) Perineal dermatitis risk factors: clinical validation of a conceptual framework. As part of a larger study previously published in December of 1994, the question was asked whether commonly used pressure ulcer assessment tools (the Braden and Medley) were applicable to a broader definition of "skin risk assessment" and altered skin integrity related to perineal dermatitis (PD), and, if so, which risk factors were actually related to PD. The three site randomized clinical trial compared the use

1996 Ostomy/wound management

8609. Using hypnosis to accelerate the healing of bone fractures: a randomized controlled pilot study. (PubMed)

Using hypnosis to accelerate the healing of bone fractures: a randomized controlled pilot study. Hypnosis has been used in numerous medical applications for functional and psychological improvement, but has been inadequately tested for anatomical healing.To determine whether a hypnotic intervention accelerates bodily tissue healing using bone fracture healing as a site-specific test.Randomized controlled pilot study.Massachusetts General Hospital, Boston, Mass, and McLean Hospital, Belmont (...) included improved ankle mobility; greater functional ability to descend stairs; lower use of analgesics in weeks 1, 3, and 9; and trends toward lower self-reported pain through 6 weeks.Despite a small sample size and limited statistical power, these data suggest that hypnosis may be capable of enhancing both anatomical and functional fracture healing, and that further investigation of hypnosis to accelerate healing is warranted.

1999 Alternative Therapies in Health & Medicine

8610. Chemotherapy and Progenitor Cell Transplantation to Treat Inflammatory Breast Cancer

). Patients 18 years of age or older with stage IIIB inflammatory breast cancer that has not metastasized (spread beyond the breast) may be eligible for this study. Candidates are screened with a medical history and physical examination, blood and urine tests, and chest x-ray. They have computed tomography (CT) of the head, chest, abdomen and pelvis as well as a bone scan to determine the extent of disease, and a nuclear medicine scan called MUGA to examine the heart's pumping ability. They may receive (...) a rehabilitation medicine evaluation. Participants undergo the following tests and procedures: Central venous line placement: Patients have a central venous line (plastic tube) placed into a major vein in the chest before beginning treatment. The line remains in the body throughout treatment and is used to give chemotherapy and other medications and to withdraw blood samples. The line is usually placed under local anesthesia in the radiology department or the operating room. Chemotherapy: Patients receive two

1999 Clinical Trials

8611. A Study of Stem Cells and Filgrastim

Study Description Go to Brief Summary: To determine the safety of stem cell harvesting after administration of filgrastim ( G-CSF ) to mobilize bone marrow stem cells into the peripheral blood in patients at various stages of HIV-1 infection as well as in HIV-negative volunteers. To determine the surface phenotypic and functional characteristics as well as the viral load in the stem cells obtained following this procedure. Condition or disease Intervention/treatment Phase HIV Infections Drug (...) : Filgrastim Not Applicable Detailed Description: Patients and volunteers receive seven daily subcutaneous injections of G-CSF. On days 5 and 6 of drug administration, patients have peripheral blood mononuclear cells harvested by leukapheresis. HIV-positive patients are stratified into three cohorts based on CD4 count and presence of symptoms. If no increase in number of harvested stem cells and no grade 4 bone pain toxicity occur in two of the first three patients in a cohort, then the last three patients

1999 Clinical Trials

8612. Gabapentin For the Control of Hot Flashes in Women With Breast Cancer

anticonvulsant medication No concurrent clonidine or venlafaxine Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00022074 Locations Layout table for location information United States, Alabama MBCCOP - Gulf Coast Mobile, Alabama, United States, 36688 United (...) Flashes Drug: gabapentin Procedure: quality-of-life assessment Not Applicable Detailed Description: OBJECTIVES: Compare the effectiveness and side effects of 2 different doses of gabapentin vs placebo for the control of hot flashes and other vasomotor symptoms in women with breast cancer. Compare quality of life, anxiety, and depression in patients treated with these regimens. OUTLINE: This is a randomized, double-blind, placebo-controlled, multicenter study. Patients are stratified according

2001 Clinical Trials

8613. Nurse Counseling for Physical Activity in Primary Care Patients

Chronic Disease Exercise Behavioral: Telephone Care Not Applicable Detailed Description: Background: Many elderly primary care patients are at high risk for health complications and functional impairment due to low levels of physical activity. Previous trials of counseling of elderly patients in primary care clinics have not demonstrated lasting physical activity change and have not evaluated fitness changes associated with any increased activity. Objectives: The primary objective was to determine (...) telephone message delivery system; or 3) no follow-up calls. All kept walking diaries and mailed these in to a data collector blinded to intervention group. Follow-up research visits were scheduled at six and 12 months. Self-reported walking, the primary outcome measure, was assessed from the walking diaries and validated by reports of significant others and accelerometer data. Improvement in fitness was assessed at 12 months with a standardized six minute walking test. Tinetti mobility scores, body

2001 Clinical Trials

8614. Study of Mast Cell Precursors

. There is no known cure for any form of the disease. A better understanding of mast cells and how they respond to certain substances may provide insights that will lead to effective treatments for mastocytosis. Patients with systemic mastocytosis and normal healthy volunteers between the ages of 20 and 60 may be eligible for this 8-day study. Participants will undergo the following procedures: Day 1 Medical history, physical examination, and blood tests to assess general health status Days 2 through 6 Daily (...) will be adults of both sexes from 18 to 70 years of age. Granulocyte colony stimulating factor (G-CSF) will be administered to healthy volunteers at dose of 10 mcg/kg/day as a subcutaneous dose daily for 5 days not to exceed 960mcg. Patients will receive Plerixafor at a dose of 0.24 mg/kg as a single subcutaneous dose not to exceed 24mg the night before leukapheresis as a mobilizing agent for CD34+ cells. In identified patients where leukapheresis yield is considered adequate without stimulation

1999 Clinical Trials

8615. Ticket on the Titanic. Perils and pitfalls of junior faculty development. (PubMed)

Ticket on the Titanic. Perils and pitfalls of junior faculty development. 8754691 1996 09 25 2018 11 13 0008-350X 42 1996 Jul Canadian family physician Medecin de famille canadien Can Fam Physician Ticket on the Titanic. Perils and pitfalls of junior faculty development. 1271-4, 1281-4 Graham J E JE eng fre Editorial Canada Can Fam Physician 0120300 0008-350X IM Adaptation, Psychological Career Mobility Faculty, Medical Humans Job Application Mentors Negotiating Time Management 1996 7 1 1996 7

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1996 Canadian Family Physician

8616. WEB-WAP based telecare. (PubMed)

WEB-WAP based telecare. We have developed two telecare applications based on mobile telephony (WAP) and WEB. The first can be used to request Basic Life Support (BLS) guidelines any time by using a WAP device and to teach people and non-professionals involved in health care emergency situations. The second is a WEB-WAP based tool for medical data retrieval and at-home health care monitoring of chronically ill patients with congestive heart failure (CHF) or diabetes. Medical education content (...) related to these diseases is available on the WEB and on the WAP device. The WAP application uses the features found in the last generation of mobile phones such as better multimedia information presentations, better interactivity capabilities, and enhanced ease of use. Based on these two applications, a promising platform is offered for developing applications in health care, home care, medical monitoring and health education ensuring continuity of care. In the paper we present the preliminary

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2002 Proceedings of the AMIA Symposium

8617. National Pharmaceutical Stockpile drill analysis using XML data collection on wireless Java phones. (PubMed)

-anthrax exposure scenario. The goal of the Public Health Informatics Group at the University of Washington (www.phig.washington.edu) was to use informatics approaches to monitor subject numbers and elapsed time. This study compares accuracy of time measurements using a mobile phone Java application to traditional paper recording in a live drill of the NPS. Pearson correlation = 1.0 in 2 of 3 stations. Differences in last station measurements can be explained by delay in recording of the exit time. We (...) National Pharmaceutical Stockpile drill analysis using XML data collection on wireless Java phones. This study describes an informatics effort to track subjects through a National Pharmaceutical Stockpile (NPS) distribution drill. The drill took place in Seattle on 1/24/2002. Washington and the State Department of Health are among the first in the nation to stage a NPS drill testing the distribution of medications to mock patients, thereby testing the treatment capacity of the plan given a post

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2002 Proceedings of the AMIA Symposium

8618. The Department of Veterans Affairs Optical Patient Card Workstation. (PubMed)

. The intent of this work is to study the potential benefits of this technology to the VA's distributed health care network, with a large mobile patient population. It is hoped that the use of optical cards and the OPCW will enhance clinicians ability to work with a timely composite health record, and expedite the administrative workload of the medical center. (...) The Department of Veterans Affairs Optical Patient Card Workstation. The Department of Veterans Affairs has developed an optical patient card application which will undergo alpha testing in 1991. The optical cards are carried by patients and contain administrative, clinical, and image information. An optical patient card workstation (OPCW) will read/write these cards and pass this information to the VA Decentralized Hospital Computer Program (DHCP), the VA's health care information system

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1991 Proceedings of the Annual Symposium on Computer Application in Medical Care

8619. Transfixation pinning and casting of radial-ulnar fractures in calves: A review of three cases (PubMed)

and judged to be excellent at follow-up evaluation five to nine months later.Advantages of transfixation pinning and casting in management of radial-ulnar fractures include flexibility in pin positioning, adequate maintenance of reduction, early return to weight-bearing status, preservation of joint mobility, and ease of ambulation. The inability to adjust fixation and alignment after cast application is a disadvantage of this technique compared with other external fixators. We concluded (...) Transfixation pinning and casting of radial-ulnar fractures in calves: A review of three cases We reviewed the medical records of three calves with radial-ulnar fractures which were reduced and stabilized by transfixation pinning and casting. Multiple Steinmann pins were placed transversely through proximal and distal fracture fragments and the pin ends were incorporated in fiberglass cast material after fracture reduction. Cast material was placed from proximal to distal radius and served

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1992 The Canadian Veterinary Journal

8620. Clinician advice, an interactive computer program, and motivational counselling during routine medical visits increased reported smoking abstinence among teens

Clinician advice, an interactive computer program, and motivational counselling during routine medical visits increased reported smoking abstinence among teens Clinician advice, an interactive computer program, and motivational counselling during routine medical visits increased reported smoking abstinence among teens | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time (...) during routine medical visits increased reported smoking abstinence among teens Article Text Treatment Clinician advice, an interactive computer program, and motivational counselling during routine medical visits increased reported smoking abstinence among teens Free Dawn Kingston , RN, MSc Statistics from Altmetric.com Hollis JF, Polen MR, Whitlock EP, et al . Teen reach: outcomes from a randomized, controlled trial of a tobacco reduction program for teens seen in primary medical care. Pediatrics

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2006 Evidence-Based Nursing

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