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8441. The Effect of Osteopathic Manipulative Treatment on Recovery of Coronary Bypass Patients

: The Effect of Osteopathic Manipulative Treatment on Post-Operative Medical and Functional Recovery of Coronary Artery Bypass Graft Patients Study Start Date : April 2001 Actual Study Completion Date : October 2005 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Outcome Measures Go to Primary Outcome Measures : Recovery of mobility, bowel function, and reduced length of hospital stay. Eligibility Criteria Go to Information from the National Library (...) , another received daily similar placebo treatment with conventional care, and a final group received only conventional post surgical care.The research hypothesis was that daily treatment with osteopathic manipulative treatment would reduce hospital stay and hasten recovery from surgery.Persons in the treatment group had earlier discharge, and faster recovery of bowel function and basic mobility. Condition or disease Intervention/treatment Phase Cardiovascular Disease Procedure: Osteopathic Manipulative

2007 Clinical Trials

8442. Enhancing Indoor, Community, and Advanced Wheelchair Skills in Spinal Cord Injury (SCI)

Criteria Inclusion Criteria: SCI for at least 1 year (neurologically stable) Level of injury: C6 and below who use manual wheelchair as a primary means of mobility Able to self-propel wheelchair Between the ages of 18-75 Able to follow simple instructions Exclusion Criteria: Progressive disease (e.g. spinal tumor) Extended bedrest for more than 30 days Ventilator-dependent Any cardiac or respiratory condition that would limit subject's physical performance Unstable medical conditions Use power (...) result in a total score. The WST provide a pass-fail score for each skill. Refusal to attempt a skill (e.g. because of fear) constitutes a failing grade. The numerator is the Total Raw Score (i.e., the number of individual skills awarded a passing score) and the denominator is the number of applicable skills (i.e., the total number of skills minus those awarded NP scores). 100% is the maximum possible percentage score. Secondary Outcome Measures : Craig Handicap Assessment and Reporting Technique

2007 Clinical Trials

8443. Life 2: Improving Fitness and Function in Elders

of Research and Development ( US Department of Veterans Affairs ) Study Details Study Description Go to Brief Summary: The purpose of this study is to determine whether a 12-month physical activity counseling program, compared to usual care, improves physical performance in a sample of older veterans. The primary physical performance outcome is change in gait speed. Condition or disease Intervention/treatment Phase Aging Mobility Limitations Behavioral: Multi-component physical activity counseling program (...) Not Applicable Detailed Description: Physical inactivity contributes greatly to the health care burden of older adults and is associated with a high prevalence of functional limitations, morbidity, and disability. Rates of physical inactivity are highest among older adults. Older veterans, compared non-veteran older adults, are more likely to be physically inactive and report more limitations in physical function. Increasing physical activity among older veterans is a promising approach to reduce the burden

2007 Clinical Trials

8444. A Multicenter Randomized Trial Comparing IM Nails and Plate Fixation in Distal Femur Fractures

Posted : May 11, 2017 Sponsor: Boston Medical Center Information provided by (Responsible Party): Paul Tornetta, III, M.D., Boston Medical Center Study Details Study Description Go to Brief Summary: This study looks at two (2) types of surgical treatments and hopes to answer the question, "which is the best way to surgically treat a distal femur fracture?" Both procedures being studied are standard of care (used routinely) and use FDA approved devices. All medical and surgical treatment (...) will be the same for participants as non-participants. Condition or disease Intervention/treatment Phase Femoral Fractures Device: reamed, interlocking intramedullary nail Device: locking periarticular plate Not Applicable Detailed Description: The study is a randomized controlled multicenter trial in which individuals sustaining a fracture of the supracondylar (metaphyseal) region of the distal femur will be operatively managed by one of two strategies. The first strategy involves fixation of the fracture

2007 Clinical Trials

8445. Rosiglitazone (Extended Release Tablets) As Monotherapy In Subjects With Mild To Moderate Alzheimer's Disease

consists of 40 questions assessing basic and instrumental ADLs. This scale assesses a participants' ability to initiate, plan, and perform activities related to hygiene, dressing, continence, eating, meal preparation, telephoning, going on an outing, finance and correspondence, medications, leisure, and housework. Each item was scored as yes: 1, no: 0 and N/A: not applicable. Higher scores indicate less disability with a score of 100 indicating no disability and 0 indicating no functional ability (...) . Change from Baseline was calculated as value at scheduled time point minus Baseline value. Baseline was defined as value at W0. The percentage score was calculated as (DAD total score/total number of applicable items) multiplied by 100. Endpoint treatment differences which were adjusted to take account of missing data are derived. Change From Baseline (W0) in Mean Short Term Memory Assessment Total Score (ADAS-Cog Q1 Plus Q7) at W8, W16, W24 [ Time Frame: Baseline (W0) and up to W24 ] Change from

2007 Clinical Trials

8446. Study Of Adjuvant Lapatinib In High-Risk Head And Neck Cancer Subjects After Surgery

measure and a visual analog rating scale. Change from Baseline was analyzed using parametric analysis of covariance (with the Baseline value as a covariate). The EQ-5D is a generic measure of self-reported health outcomes that is applicable to a wide range of health conditions and treatments. The EQ-5D covers health status in 5 domains (3 questions each): mobility, self-care, usual activities, pain or discomfort, and anxiety or depression. Each item is scored as follows: 1, no problems; 2, some (...) (SAE) [ Time Frame: From the first dose of lapatinib/placebo until 5 days after the last dose (average of 141 study weeks) ] An AE is defined as any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease (new or exacerbated) temporally associated with the use of a medicinal product. An SAE is defined as any untoward medical occurrence that, at any dose, results in death, is life threatening, requires hospitalization or prolongation of existing

2007 Clinical Trials

8447. Allogeneic Blood Stem Cell Transplantation

Procedure: Allogeneic Blood Stem Cell Transplantation Drug: Fludarabine Drug: Melphalan Not Applicable Detailed Description: All patients in this study must have a plastic tube (catheter) inserted into a vein under the collarbone. Drugs and stem cells will be given through this tube. Fludarabine will be given through the catheter once a day for four days. Patients will also receive melphalan for two days through the catheter. Patients receiving a transplant from a matched unrelated donor (i.e (...) weeks and sometimes longer. Patients with progressive ("growing") Hodgkin's disease after the transplant will initially be taken off their immunosuppressive medications (tacrolimus, corticosteroids). If there is no response to this maneuver, they will be considered for infusion of additional cells from their donors, with or without preceding chemotherapy Both these maneuvers may produce a response ("shrinkage") of the tumor. Patients with persistent but stable (not "growing") disease may also

2007 Clinical Trials

8448. Focus on Function Study for Children With Cerebral Palsy

interventions Not Applicable Detailed Description: Children with cerebral palsy commonly receive ongoing physical and occupational therapy to facilitate development and to enhance functional independence in movement, self-care, play, school activities and leisure. The primary objective of this project is to conduct a multi-site clinical trial to evaluate the efficacy of a context-focused approach in improving performance of functional tasks, mobility, participation in everyday activities and quality of life (...) to 5 years, 11 months Exclusion Criteria: children whose parents feel uncomfortable or unable to respond to interviews and questionnaires in English children with planned surgical or medication changes during the study period that may impact motor function parents and caregivers who state that they will not be able to comply with the treatment schedule Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact

2007 Clinical Trials

8449. Clinical Trial Comparing Three Anterior Cruciate Ligament Reconstructive Procedures

: Chinese University of Hong Kong Information provided by (Responsible Party): Pauline Lui, Chinese University of Hong Kong Study Details Study Description Go to Brief Summary: The objective of this prospective study is to assess the clinical, functional and radiological outcomes of three different ACL reconstruction procedures: Bone Patella Bone graft, Single bundle hamstring graft and anatomical Double bundle graft in terms of pain, swelling, mobility, quadriceps girth size, stability, proprioception (...) , bone mineral density and functional status. Condition or disease Intervention/treatment Phase Knee Injuries Procedure: Single bundle hamstring Procedure: Double bundle hamstring Procedure: Bone patellar tendon bone Not Applicable Detailed Description: Anterior cruciate ligament (ACL) reconstruction surgery is one of the common procedures performed by orthopedic surgeons with approximately 100,000 cases performed per year in the United States. A large amount of sports injuries were related to ACL

2007 Clinical Trials

8450. GEM05 for Patients With Multiple Myeloma Under 65 Years

Summary: The primary objective is to compare safety and efficacy of three induction treatments: VBMCP-VBAD / Velcade versus Thalidomide / Dexamethasone versus Velcade / Thalidomide / Dexamethasone. The second one is to evaluate the ability of stem cell mobilization after the treatments in order to do an autologous transplant. Otherwise this study wants to compare the safety and efficacy of the maintenance treatments: Interferón a-2b versus Thalidomide versus Thalidomide/Velcade. Condition or disease (...) and baseline visits. After providing informed consent, patients will be evaluated for study eligibility and then Patients will be randomized (1:1:1) to receive VBMCP-VBAD+Velcade (Group A) or Thalidomide+Dexamethasone (Group B) or Thalidomide+Dexamethasone+Velcade (Group C). All of them will received the induction treatment up to 24 weeks. After 4 weeks, without progression or unacceptable toxicity, There will be stem cell mobilization to do an autologous transplant. Three months after transplant, patients

2007 Clinical Trials

8451. Comparison of Ex-PRESSTM Mini Glaucoma Shunt to Trabeculectomy in Subjects With Open Angle Glaucoma

of a fornix or limbal based conjunctival flap in upper quadrants Creation of limbal-based scleral flap extending into clear cornea Delicate application of MMC solution onto sclerectomy bed. (MMC concentration 0.4mg/ml for 1-3 minutes) Penetration into anterior chamber using 23-25G needle, halfway between the white sclera and clear cornea (in the center of the grey zone);creation of track incision at limbus Prior to implantation, a thorough mobility check should be performed Implantation of Ex-PRESS (...) Sponsor: University of Virginia Information provided by (Responsible Party): University of Virginia Study Details Study Description Go to Brief Summary: A prospective randomized trial to compare the safety and efficacy of the Ex-PRESS to trabeculectomy in patients with open angle glaucoma who failed medical or are allergic to medical treatment and for which filtering surgery is indicated Condition or disease Intervention/treatment Phase Glaucoma Procedure: Trabeculectomy Device: Ex-PRESS mini shunt

2007 Clinical Trials

8452. Noise-Enhanced Sensory Function in Elders at Risk for Falls

Institute on Aging (NIA) Information provided by: National Institute on Aging (NIA) Study Details Study Description Go to Brief Summary: The long-term goal of this project is to develop a non-invasive, noise-based technique for enhancing somatosensation and thereby improving balance control in elderly fallers and older adults with somatosensory deficits. Condition or disease Intervention/treatment Phase Aging Somatosensory Deficit Device: Vibrating Insoles Not Applicable Detailed Description: Previous (...) to the development of a novel bioengineering technique for improving balance control in older adults and patients with somatosensory deficits. The work could thus serve to reduce the frequency, morbidity and cost of falling, and assist aged individuals in achieving maximal independence in activities of daily living and mobility. Two groups of participants will be recruited from the RNH Epidemiology Core: 85 elderly individuals with somatosensory deficits, and 85 elderly individuals with recurrent falls

2007 Clinical Trials

8453. Heart Rate Variability and Postoperative Pain

: Postoperative pain stimulates the autonomic nervous system, induces the production of pro-inflammatory substances, reduces patient mobility and impairs vital functions. The ECG spectral analysis (ECGs) is a non-invasive marker of the autonomic nervous system state. To our knowledge, the correlation between the sympathovagal activity quantified by a non invasive method and the postoperative pain, has not been studied before. Condition or disease Intervention/treatment Phase Pain Postoperative Procedure: ECG (...) spectral Not Applicable Detailed Description: Principal Objective : 1)To quantify postoperative pain by the ECGs technique. 2) To compare the ECGs parameters with the visual analog pain scale (VAS) results. Secondary Objective : To determine the influence of preoperative chronic pain and pathophysiological profiles on the correlation between postoperative ECGs and VAS. Study design : An observational, prospective, single arm, single center study. Inclusion criteria : ¨Patients over 18 years old

2007 Clinical Trials

8454. Reshaping Exercise Habits and Beliefs (REHAB)

. Condition or disease Intervention/treatment Phase Cerebrovascular Accident Stroke Behavioral: Exercise Other: Stroke education Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 90 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Official Title: Reshaping Exercise Habits and Beliefs (REHAB): Pilot Testing of a Behavioral Intervention to Improve Mobility After Stroke (...) to this study by its identifier (NCT number): NCT00431821 Locations Layout table for location information United States, Maryland Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD Baltimore, Maryland, United States, 21201 Sponsors and Collaborators US Department of Veterans Affairs Investigators Layout table for investigator information Principal Investigator: Marianne Shaughnessy, RN PhD Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD

2007 Clinical Trials

8455. Comprehensive Intervention for Falls Prevention in the Elderly

for Falls Prevention in the Elderly The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. Identifier: NCT00413933 Recruitment Status : Terminated (The study was stopped due to lack of funding) First Posted : December 20, 2006 Last Update Posted : April 21, 2016 Sponsor: Soroka University Medical Center Information provided (...) by (Responsible Party): Yan Press, Soroka University Medical Center Study Details Study Description Go to Brief Summary: The purpose of this study is to determine whether the comprehensive multidisciplinary intervention (geriatrician, physical therapist and occupational therapist falls risk assessment and intervention)is effective in the falls prevention in the community dwelling elderly. Condition or disease Intervention/treatment Phase Accidental Falls Procedure: Comprehensive Multidisciplinary Intervention

2006 Clinical Trials

8456. Home-Based Assessment for Alzheimer Disease Prevention

) Behavioral: Home-based Computer Kiosk Behavioral: Traditional Evaluation Instruments Not Applicable Detailed Description: There is an unmet need for effective, efficient, and economical methods for conducting AD prevention trials. Traditional in-person visits to clinical assessment sites are time consuming and costly and may exclude some people from participation, such as those who are older, or are less mobile or with significant medical illnesses. These may be the people who are at greatest risk (...) , functioning in daily life, affective symptoms, global change, quality of life and resource use will all be assessed in each method at each visit. The total time for the at-home assessments will be approximately 45 minutes. In addition, all participants will be provided a multi-vitamin to be taken twice a day, and a measure of medication adherence will be collected for each assessment method. Changes in certain cognitive measures may "trigger" an in-person assessment, in which participants may change from

2007 Clinical Trials

8457. Nutritional Intervention in Hip Fracture Patients

by: Maastricht University Medical Center Study Details Study Description Go to Brief Summary: Hip fractures are highly prevalent and are expected to increase due to the ageing population. Malnutrition is often present in these patients and is associated with prolonged convalescence, lower mobility, lower mental function, lower quality of life and higher complication rate. Nutritional intervention starting soon after hospital admission might reduce complication rate and total length-of-stay by improving (...) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. Identifier: NCT00523575 Recruitment Status : Completed First Posted : August 31, 2007 Last Update Posted : July 20, 2011 Sponsor: Maastricht University Medical Center Collaborator: ZonMw: The Netherlands Organisation for Health Research and Development Information provided

2007 Clinical Trials

8458. The Effectiveness of Behavioral Graded Activity in Patients With Osteoarthritis of the Hip and/or Knee

for Health Services Research. Recruitment status was: Active, not recruiting First Posted : August 29, 2007 Last Update Posted : August 29, 2007 Sponsor: Netherlands Instititute for Health Services Research Collaborators: VU University Medical Center UMC Utrecht Maastricht University Radboud University Information provided by: Netherlands Instititute for Health Services Research Study Details Study Description Go to Brief Summary: We performed a randomized controlled trial to study the effectiveness (...) of patients benefited more from BGA and which factors influenced the success of BGA-treatment. Also, it will be investigated whether differences exist in exercise adherence and whether there is a relationship between exercise adherence and long-term effectiveness. Condition or disease Intervention/treatment Phase Osteoarthritis Behavioral: Behavioral graded activity Other: Exercise therapy Not Applicable Detailed Description: The principle objectives of managing OA are to control pain adequately, improve

2007 Clinical Trials

8459. High-Dose Chemotherapy in Treating Patients Undergoing Stem Cell Transplant for Recurrent or Refractory Hodgkin's Lymphoma

First Posted : October 16, 2007 Last Update Posted : February 9, 2010 Sponsor: City of Hope Medical Center Collaborator: National Cancer Institute (NCI) Information provided by: City of Hope Medical Center Study Details Study Description Go to Brief Summary: RATIONALE: Giving high-dose chemotherapy before a peripheral blood stem cell transplant stops the growth of cancer cells by stopping them from dividing or by killing them. Giving colony-stimulating factors, such as G-CSF, helps stem cells move (...) : filgrastim Drug: carmustine Drug: cyclophosphamide Drug: etoposide Drug: melphalan Procedure: autologous hematopoietic stem cell transplantation Procedure: peripheral blood stem cell transplantation Radiation: radiation therapy Radiation: total-body irradiation Not Applicable Detailed Description: OBJECTIVES: To evaluate the feasibility and toxicity of high-dose sequential therapy comprising high-dose etoposide and cyclophosphamide with filgrastim (G-CSF) support followed by 2 courses of high-dose

2007 Clinical Trials

8460. Dulcolax vs Placebo in Functional Constipation

, or any other significant disease or intercurrent illness (e.g. abdominal/gastrointestinal surgery) that, in the Investigators opinion, would interfere with participation in the trial Patients with restricted mobility (e.g. wheelchair bound, or bed-ridden) that, in the Investigators opinion, would interfere with participation in the trial Patients with a known hypersensitivity to bisacodyl or any other ingredient in the study medication Patients with ileus, intestinal obstruction, acute surgical (...) Number of Complete Spontaneous Bowel Movements (CSBMs) Per Week Over the 4 Weeks Treatment Period [ Time Frame: 4 Weeks ] A Complete Spontaneous Bowel Movement (CSBM) is a complete non-rescue medication-induced stool. The number of CSBMs in each of the 4 weeks was divided by the number of days where data were available in this week, multiplied by 7 and rounded off to the next integer. The sum of the resulting numbers were divided by the number of weeks with data. Secondary Outcome Measures : Number

2007 Clinical Trials

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