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8301. Electrical Stimulation and Chemotherapy Induced Peripheral Neuropathy

Induced Peripheral Neuropathy (CIPN) Device: longwave diathermy on high power and interferential therapy Device: longwave diathermy on low power Not Applicable Detailed Description: A randomized controlled trial to investigate the effects of combination therapy longwave diathermy on high power and interferential currents, as compared to longwave diathermy at low power (control group) for sensory and motor symptoms in patients with CIPN in the feet and lower legs. Sensory and motor symptoms are defined (...) of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: IT and LWD on high power IT and LWD on high power Device: longwave diathermy on high power and interferential therapy Placebo Comparator: LWD on low power LWD on low power Device: longwave diathermy on low power Outcome Measures Go to Primary Outcome Measures : Change in numbness from baseline [ Time Frame: baseline and 12 weeks ] The definition of spreading of numbness was pins and needles, tingling

2014 Clinical Trials

8302. Total Ankle Replacement Versus Arthrodesis Trial

Replacement Procedure: Arthrodesis Not Applicable Detailed Description: This is a randomised, multi-centre, non-blinded, prospective, parallel-group trial of TAR versus ankle arthrodesis in patients with end-stage ankle osteoarthritis (OA) aged between 50 and 85 years, comparing clinical outcomes (pain-free function, quality of life (QoL), range of motion (ROM), and rate of post-procedural complications) and cost-effectiveness. TARVA is a clinician-led, pragmatic, superiority trial designed to compare (...) : January 2015 Estimated Primary Completion Date : November 2019 Estimated Study Completion Date : May 2020 Resource links provided by the National Library of Medicine related topics: related topics: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Arthrodesis Ankle arthrodesis (fusion) Procedure: Arthrodesis The remaining damaged cartilage is removed from the ends of the bone and the two bones are then held together in compression using screws, or plates until they join

2014 Clinical Trials

8303. Acute Care for Elders (ACE) Program at OHSU Hospital

in the investigators hospital by implementing focused interventions and recommendations specific to geriatric needs and syndromes, including: reduced fall rate, decreased incidence and duration of delirium, early recognition and treatment of impaired mobility and function, careful minimization of medication use, prevention of unnecessary catheter and restraint use, decreased hospital readmission rates, improved transitional care following hospital discharge, and high levels of patient and referring physician (...) University Information provided by (Responsible Party): Juliana Bernstein, Oregon Health and Science University Study Details Study Description Go to Brief Summary: The purpose of this investigation is to assess the effectiveness of a multi-disciplinary Acute Care for Elders (ACE) program dedicated to the care of patients age 70 and older admitted to Oregon Health & Science University's hospital medicine service. The ACE program will aim to improve the quality of care of older patients

2014 Clinical Trials

8304. Biomarkers of Orthodontic Tooth Movement With Fixed Appliances and Vibration Appliance Therapy

Disease Multiple Myeloma Osteogenesis Imperfecta History of Bone Metastasis Patients taking medications such as bisphosphonates, corticosteroids or any anti-inflammatory drug Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02119455 Locations Layout (...) movement in conjunction with vibration appliance therapy. Condition or disease Intervention/treatment Phase Tooth Movement Device: Vibration Device Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 40 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Outcomes Assessor) Primary Purpose: Treatment Official Title: Biomarkers of Orthodontic Tooth Movement With Fixed Appliances

2014 Clinical Trials

8305. High Versus Low Level of Lumbar Traction in Acute Lumbar Sciatica Due to Disc Herniation

, Strasbourg, France Information provided by (Responsible Party): University Hospital, Strasbourg, France Study Details Study Description Go to Brief Summary: The aim of this study is to compare two levels (high and low forces) of short term lumbar traction on pain and functional tests of the lower limbs in a specific population of patients presenting with acute lumbar sciatica secondary to disc herniation. The investigators hypothesize that, in this particular medical condition, high level of lumbar (...) traction might be more effective than low level lumbar traction in decreasing the pain associated with acute sciatica. Condition or disease Intervention/treatment Phase Acute Lumbar Sciatica Secondary to Disc Herniation Procedure: Traction sessions Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 17 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant, Investigator

2014 Clinical Trials

8306. Evaluation of an Oral Nutritional Supplement on Lean Body Mass in Healthy Older Subjects.

Information provided by (Responsible Party): Abbott Nutrition Study Details Study Description Go to Brief Summary: The study will evaluate the effects of oral nutritional supplements (ONS) on attenuating the lean body mass (LBM) loss that occurs after bed rest. Condition or disease Intervention/treatment Phase Healthy Other: ONS without AN777 Other: ONS containing AN777 Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 76 (...) participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Official Title: Evaluation of a Complete Oral Nutritional Supplement on Lean Body Mass in Healthy Older Subjects During Bed Rest and Recovery. Study Start Date : March 2014 Actual Primary Completion Date : April 2016 Actual Study Completion Date : April 2016 Resource links provided by the National Library of Medicine related topics: Arms

2014 Clinical Trials

8307. Effects of Whole-body Vibration in the Frail Elderly

Party): Li Zhang, Chinese PLA General Hospital Study Details Study Description Go to Brief Summary: Objective: To study the acute and chronic effects of whole-body vibration (WBV) exercises on the lower extremity blood flow, mobility function, balance, muscle strength, bone density, and general health status, and its feasibility as an intervention in frail elderly patients. Design: Randomized controlled trial. Subjects: The frail older persons meeting the Fried Frailty Criteria. Interventions: All (...) cell velocity of the common femoral artery), timed up and go test, 30-second chair stand test, five times sit to stand test, lower extremities muscle strength, balance function, balance confidence, bone density, and general health status was assessed at the beginning of the study, at instant, 12 weeks and 24 month after the intervention. Study hypothesis: Whole-body vibration exercise is a safe and effective method that can improve the lower extremity blood flow, mobility function, balance, muscle

2014 Clinical Trials

8308. Comparing Functional Outcomes in Individuals Using Micro-processor Controlled Orthosis Versus Stance Control Orthosis

Posted : March 18, 2014 Last Update Posted : April 5, 2018 Sponsor: Shirley Ryan AbilityLab Collaborator: Otto Bock Healthcare Products GmbH Information provided by (Responsible Party): Arun Jayaraman, Shirley Ryan AbilityLab Study Details Study Description Go to Brief Summary: The study will specifically evaluate the potential of the C-Brace to improve the functional mobility and quality of life in individuals with lower extremity impairments due to neurologic or neuromuscular disease, orthopedic (...) disease or trauma, as compared to the stance control orthosis. Condition or disease Intervention/treatment Phase Spinal Cord Injuries Poliomyelitis Post-polio Syndrome Arthritis Lower Motor Neurone Lesion Device: C-brace Device: Stance control orthosis Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 24 participants Allocation: Randomized Intervention Model: Crossover Assignment Masking: None (Open Label) Primary

2014 Clinical Trials

8309. Texting to Improve Adherence in HIV+ With Bipolar Disorder

in this population. Poor psychotropic medication adherence is also common among people with SMI - it has been estimated that 40% of those with BD do not take their mood stabilizer as prescribed. Among persons with BD, nonadherence to psychotropic medications can lead to greater risk for manic and depressive episodes, decreased quality of life, suicide attempts, and hospitalization. The utilization of mobile health (i.e., mHealth) technologies to improve everyday functioning is growing. mHealth interventions (...) to improve treatment for individuals with BD. Taken together, a distinct need for RCTs utilizing text messaging to improve medication adherence within an at-risk HIV population is warranted. Individualized Texting for Adherence Building (iTAB) is one such intervention. The investigators propose an intervention development study designed to address these potential mechanisms of nonadherence with the following Specific Aims: 1) To further develop and refine a personalized, automated, real-time, mobile

2014 Clinical Trials

8310. Nurse Management of Neuromodulation Therapy

minutes. Study group Parkinson's patients with DBS Systems Condition or disease Intervention/treatment Phase Parkinson's Device: Standard of Care Device: DBS using Clinical Support System. Not Applicable Detailed Description: In most cases these subjects have failed to maintain adequate control of their symptoms on medications alone. The Diagnosis of PD (Parkinson's Disease) and the decision to have DBS qualifies a subject for enrollment. Subjects would be selected because they will require DBS (...) : Interventional (Clinical Trial) Actual Enrollment : 0 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Outcomes Assessor) Primary Purpose: Health Services Research Official Title: Mobile Computing Platform to Improve Outcomes From Deep Brain Stimulation Therapy Study Start Date : February 2014 Estimated Primary Completion Date : January 2015 Estimated Study Completion Date : January 2015 Resource links provided by the National Library of Medicine related topics

2014 Clinical Trials

8311. Tayside Rehabilitation in Bronchiectasis Exacerbations (TRIBE) : a Randomized Controlled Trial

assign patients with bronchiectasis exacerbations to pulmonary rehabilitation or standard care. The hypothesis is that exercise capacity will be improved by pulmonary rehabilitation at 8 weeks. Condition or disease Intervention/treatment Phase Bronchiectasis Procedure: Pulmonary rehabilitation Not Applicable Detailed Description: Background: Pulmonary rehabilitation is an effective treatment after exacerbations of COPD to prevent future exacerbations and to improve breathlessness and quality of life (...) Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: A Randomized Controlled Trial of Pulmonary Rehabilitation After Exacerbations of Bronchiectasis Study Start Date : June 2014 Estimated Primary Completion Date : December 2018 Estimated Study Completion Date : December 2018 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment No Intervention

2014 Clinical Trials

8312. Role of Chewing Gum in Reducing Post Operative Ileus After Reversal of Ileostomy

, delay in postoperative mobilization, prolonged hospitalization, and increased health-care costs. The estimated economic impact of POI in the United States is $7.5 billion per year, excluding the expenses of work loss. In view of these complications and economic burden a number of pharmacologic and non-pharmacologic strategies have been adopted by the doctors all over the world to reduce the burden of postoperative ileus.These programs involve transverse or curved surgical incisions, removal (...) of nasogastric tubes at the end of anesthesia, intraoperative and postoperative analgesia, early postoperative feeding, mobilization, and gum chewing. The use of gum chewing has emerged as a new and simple modality for decreasing POI. And reviews have concluded that there is consistent benefit for patients from gum chewing after the intestinal surgery; colonic surgery and gynecological surgery. This study is based on the hypothesis that postoperative gum chewing is beneficial in prevention of postoperative

2014 Clinical Trials

8313. Enteral Feeding in Discharged Patients

Not Applicable Detailed Description: For patients undergoing upper gastrointestinal (GI) surgery for cancer: Because of the nature of upper gastrointestinal surgery these patients have been shown to suffer undernutrition and weight loss after hospital discharge (up to 3 months) and to a greater extent than other groups of surgical patients. Quality of life and fatigue is a major issue after upper GI surgery. Nutritional supplementation via a jejunostomy after hospital discharge is only done routinely for all (...) : January 2015 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Jejunal feeding Nutritional supplementation via their jejunostomies for six weeks post hospital discharge, with continued assessment for a further 18 weeks. Dietary Supplement: Jejunal feeding A feeding jejunostomy tube is inserted at the time of surgery to provide enteral nutritional support. No Intervention: No jejunal feeding No jejunal

2014 Clinical Trials

8314. Clinical and Radiographic Evaluation of Demineralized Freeze-Dried Bone Allograft Versus Platelet Rich Fibrin for the Treatment of Periodontal Intrabony Defects in Humans

reduction or recession at sites treated with PRF compared to sites treated with DFDBA. Condition or disease Intervention/treatment Phase Periodontitis Device: DFDBA Device: autologous platelet rich fibrin Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 44 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Outcomes Assessor) Primary Purpose: Treatment Official Title: Clinical (...) intervention will be compared with measurement of bone level 6 months after surgery Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages

2014 Clinical Trials

8315. Changes in Taste Perception and Preference in the Peri-operative Patient

we hope to describe this affect and consider the significance of any changes on the background of current hospital food options. We hypothesise that food preference and tastes and desires are altered in the early post operative period and this affects what patients eat at this critical time. Condition or disease Intervention/treatment Phase Post Operative Nutrition Behavioral: Questionnaire, taste test, visual food test Not Applicable Detailed Description: Nutrition is a vital component of good (...) in patient recovery or the development of complications has been highlighted. This has resulted in the development and near universal adoption of the 'Enhanced recovery programme (ERP)'. The ERP is a multidisciplinary initiative aiming to improve the patients' journey by: Optimizing pre-operative health status Reducing postoperative complications and the surgical and physiological stress responses by changing traditional surgical methods Early mobility Early feeding Post-operative nutrition is a key

2014 Clinical Trials

8316. Clinical Protocol

by fluoroscopic images or CT) (when applicable) Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (...) : Completed First Posted : June 3, 2014 Last Update Posted : May 17, 2018 Sponsor: Ancora Heart, Inc. Information provided by (Responsible Party): Ancora Heart, Inc. Study Details Study Description Go to Brief Summary: To assess the safety and performance of the GDS Accucinch System when used percutaneously to reduce functional mitral regurgitation. Condition or disease Intervention/treatment Phase Severe Functional Mitral Regurgitation and Heart Failure Device: GDS Accucinch System Not Applicable Study

2014 Clinical Trials

8317. Optimizing Patient Engagement in a Novel Pain Management Initiative (OPEN)

), then find out how useful this intervention is compared to a patient navigator intervention (OPENnav) for increasing patient engagement, improving patient's motivation to manage their chronic pain, and improving patient confidence in self-managing their chronic pain condition. Condition or disease Intervention/treatment Phase Chronic Pain Other: OPENtext Other: OPENnav Not Applicable Detailed Description: Chronic pain is a condition that affects the most fundamental aspects of quality of life. Treatment (...) for chronic pain is challenging and usually takes the form of opioid medication therapy. But chronic opioid therapy is also associated with high rates of emergency department use, drug diversion, addiction, and unintentional overdose deaths. The new RI Medicaid Chronic Pain Initiative (CPI) targets patients who are both high emergency department users and experiencing chronic pain. In the CPI, patients can be prescribed an integrated treatment plan of massage, chiropractic, or acupuncture therapies

2014 Clinical Trials

8318. Maintenance of Shoulder Health and Function After Spinal Cord Injury

to these activities, reaching from a wheelchair can put strain on the shoulder because many environments are not ideally set up for wheelchair users. These new stressors are believed by the medical community to lead to shoulder pain. The prevalence of shoulder pain for persons with spinal cord injury is 30-70%. Untreated, shoulder pain may lead to additional losses in function and community mobility. Previous research shows that shoulder exercises along with education on how to improve one's technique (...) Other: Shoulder home exercise program Not Applicable Detailed Description: All persons are at risk for shoulder pain from a shoulder injury or rotator cuff injury. Persons with SCI are at a greater risk because of the increased use of their shoulders. Lifestyle changes following SCI place a large demand on an individual's shoulders. Pushing a wheelchair, transferring, and performing pressure relief raises are three common activities that put added strain on the shoulders. In addition

2014 Clinical Trials

8319. Game Based Vestibular Exercise for Home Rehabilitation

an absolute frame of reference with respect to gravity, thus providing a vertical spatial reference for body orientation and balance. Disease or damage of the vestibular sense organs causes a range of distressing symptoms and functional problems for people that could include loss of balance, gaze instability, disorientation and dizziness. A novel computer based rehabilitation system with therapeutic gaming application has been developed. This method allows different gaze and head movement exercises (...) program will result in greater improvements in dynamic balance control, gaze control, and dizziness, in individuals with peripheral vestibular disorders as compared to a typical out-patient physical therapy regimen. Condition or disease Intervention/treatment Phase Peripheral Vestibular Disorders Dizziness Behavioral: Experimental group Behavioral: Control group Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 50

2014 Clinical Trials

8320. Non-neural Vocal Changes After Thyroidectomy

) or presence of severe (2) findings of each the following laryngoscopic findings: erythema, oedema, polyp or nodule, and reduced vocal mobility Objective vocal outcomes [ Time Frame: 3 weeks ] Grade, roughness, breathiness, aesthenia and strain (GRBAS) score Subjective vocal outcomes [ Time Frame: 3 weeks ] VHI (Voice Handicap Index) scores Other Outcome Measures: Pain [ Time Frame: 24 hours ] VAS score Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate (...) Details Study Description Go to Brief Summary: The purpose of this study is to test the investigators hypothesis that intubation with a smaller ETT would lead to reduced postoperative vocal impairment and laryngoscopic evidence of laryngeal trauma than intubation with a standard size ETT. Condition or disease Intervention/treatment Phase Thyroidectomy Other: Small Tube size Other: Large Tube size Not Applicable Detailed Description: The optimum size of endotracheal tube (ETT) for general anaesthesia

2014 Clinical Trials

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