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Mitral Valve Prolapse

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1. Mitral valve prolapse

Mitral valve prolapse Mitral valve prolapse - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Mitral valve prolapse Last reviewed: February 2019 Last updated: November 2018 Summary A common valvular heart condition. One or both leaflets of the mitral valve prolapse into the left atrium during systole. Diagnosis established by clinical examination and echocardiogram. Usually follows a benign course with a favourable (...) prognosis. Uncommonly, serious complications occur such as infective endocarditis, severe mitral regurgitation, or sudden cardiac death. Patients at increased risk identifiable by clinical and echocardiographical features. Mitral valve repair is the preferred treatment option in patients with mitral valve prolapse and severe mitral regurgitation. Definition Mitral valve prolapse (MVP) is defined as systolic prolapse or billowing of one or both mitral valve leaflets into the left atrium. Nishimura RA

2018 BMJ Best Practice

3. Mitral valve prolapse

Mitral valve prolapse Mitral valve prolapse - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Mitral valve prolapse Last reviewed: February 2019 Last updated: November 2018 Summary A common valvular heart condition. One or both leaflets of the mitral valve prolapse into the left atrium during systole. Diagnosis established by clinical examination and echocardiogram. Usually follows a benign course with a favourable (...) prognosis. Uncommonly, serious complications occur such as infective endocarditis, severe mitral regurgitation, or sudden cardiac death. Patients at increased risk identifiable by clinical and echocardiographical features. Mitral valve repair is the preferred treatment option in patients with mitral valve prolapse and severe mitral regurgitation. Definition Mitral valve prolapse (MVP) is defined as systolic prolapse or billowing of one or both mitral valve leaflets into the left atrium. Nishimura RA

2017 BMJ Best Practice

4. Mitral valve and left ventricular features in malignant mitral valve prolapse Full Text available with Trip Pro

Mitral valve and left ventricular features in malignant mitral valve prolapse Mitral valve prolapse is a benign condition, however with occasional reports of sudden cardiac death or out-of-hospital cardiac arrest in the absence of severe mitral regurgitation or coronary artery disease, suggesting the existence of a malignant form. The objective of our study was to contribute to the characterisation of malignant mitral valve prolapse.We performed a retrospective analysis of pathology findings (...) in 68 consecutive cases of sudden cardiac death with mitral valve prolapse as lone abnormal finding, reported as cause of death.All mitral valve prolapse sudden death cases had mitral valve characteristics of Barlow disease, with extensive bileaflet multisegmental prolapse and dilatation of the annulus. The majority of cases (80.9%) had microscopic left ventricular fibrosis with associated hypertrophy and degenerative features of the myocytes, and some cases (10.9%) had right ventricular fibrosis

2018 Open heart

5. Mitral valve repair results in suppression of ventricular arrhythmias and normalization of repolarization abnormalities in mitral valve prolapse Full Text available with Trip Pro

Mitral valve repair results in suppression of ventricular arrhythmias and normalization of repolarization abnormalities in mitral valve prolapse 29915716 2019 02 26 2214-0271 4 5 2018 May HeartRhythm case reports HeartRhythm Case Rep Mitral valve repair results in suppression of ventricular arrhythmias and normalization of repolarization abnormalities in mitral valve prolapse. 191-194 10.1016/j.hrcr.2018.02.012 Alqarawi Wael W Arrhythmia Service, Division of Cardiology, University of Ottawa (...) Heart Institute, Ottawa, Canada. Birnie David H DH Arrhythmia Service, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Canada. Burwash Ian G IG Echocardiography Laboratory, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Canada. eng Case Reports 2018 03 02 United States HeartRhythm Case Rep 101656239 2214-0271 Mitral regurgitation Mitral valve prolapse Mitral valve repair Sudden cardiac death Ventricular arrhythmias 2018 6 20 6 0 2018 6 20 6 0 2018 6 20 6

2018 HeartRhythm Case Reports

6. Usefulness of 3-Tesla Cardiac Magnetic Resonance to Detect Mitral Annular Disjunction in Patients With Mitral Valve Prolapse. (Abstract)

Usefulness of 3-Tesla Cardiac Magnetic Resonance to Detect Mitral Annular Disjunction in Patients With Mitral Valve Prolapse. Mitral annulus disjunction (MAD) is characterized by a separation between the atrial wall mitral junction and the left ventricular (LV) free wall. Little is known regarding cardiac magnetic resonance (CMR) performance to detect MAD and its prevalence in mitral valve prolapse (MVP). Based on 89 MVP patients (63 women; mean age 64 ± 13) referred for CMR assessment of MR (...) , either from myxomatous mitral valve disease (MMVP) (n = 40; 45%) or fibroelastic disease (n = 49; 55%), we sought to assess the frequency of MAD and its consequences on LV morphology. Patients were classified in 2 groups according to MAD presence (MAD+) or absence (MAD-). MAD (measuring 8 ± 4 mm) was diagnosed in 35% (31 of 89) of MVP patients, more frequently in MMVP than fibroelastic disease (60% vs 14%). MAD+ was associated with MMVP; bileaflet MVP and nonsustain ventricular tachycardia

2019 American Journal of Cardiology

7. Predictive Factors for Progression of Mitral Regurgitation in Asymptomatic Patients With Mitral Valve Prolapse. (Abstract)

Predictive Factors for Progression of Mitral Regurgitation in Asymptomatic Patients With Mitral Valve Prolapse. Risk factors predicting progression from low grade to severe mitral regurgitation (MR), which is a guideline criterion for surgical intervention, remain unknown. We hypothesized that abnormalities of cardiac structure and function may predict progression in MR severity. We followed 82 asymptomatic mitral valve prolapse (MVP) patients (65 ± 12 years, 51% men) with mild or moderate MR (...) for progression. Only mean mitral annulus diameter (apical 4 and 2 chamber) was predictive for progression to severe MR (hazards ratio 1.14, 95% confidence interval 1.03 to 1.26, p = 0.01). A cut-off annulus diameter of 39.6 mm had a good accuracy (area under the curve 0.78, sensitivity 100%, and specificity 63.8%) for progression to severe. In conclusion, over a 4.5-year period, 50% of asymptomatic MVP patients with moderate MR, but none with mild, progressed to severe MR. Only mitral annular dimension

2019 American Journal of Cardiology

8. Effect of Progressive Left Ventricular Dilatation on Degree of Mitral Regurgitation Secondary to Mitral Valve Prolapse. (Abstract)

Effect of Progressive Left Ventricular Dilatation on Degree of Mitral Regurgitation Secondary to Mitral Valve Prolapse. Described herein is a 71-year-old man who at age 61 was found by echocardiogram to have severe mitral regurgitation (MR) from mitral valve prolapse. During the subsequent 9 years the MR progressively lessened as his left ventricular cavity dilated and his ejection fraction progressively fell such that just before orthotopic heart transplantation the degree of MR was no longer (...) severe, and the prolapse of the mitral leaflets had disappeared. This report describes this unique patient.Copyright © 2019. Published by Elsevier Inc.

2019 American Journal of Cardiology

9. Identification of known and unknown genes associated with mitral valve prolapse using an exome slice methodology. (Abstract)

Identification of known and unknown genes associated with mitral valve prolapse using an exome slice methodology. Although a familial distribution has been documented, the genetic aetiology of mitral valve prolapse (MVP) is largely unknown, with only four genes identified so far: FLNA, DCHS1, DZIP1 and PLD1. The aim of this study was to evaluate the genetic yield in known causative genes and to identify possible novel genes associated with MVP using a heart gene panel based on exome (...) the importance to screen these patients and their family for the presence of arrhythmias and of 'disproportionate' LV remodelling as compared with the severity of mitral regurgitation, unravelling a possible coexistent cardiomyopathy.© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.

2020 Journal of Medical Genetics

10. MitraClip transcatheter mitral valve repair in patients with moderate-to-severe or severe mitral regurgitation who are not eligible for surgery

MitraClip transcatheter mitral valve repair in patients with moderate-to-severe or severe mitral regurgitation who are not eligible for surgery SHTG Advice | 1 SHTG Advice 05-19 August 2019 In response to an enquiry from the National Advisory Committee on Heart Disease MitraClip® transcatheter mitral valve repair in patients with moderate-to-severe or severe mitral regurgitation who are not eligible for surgery Advice for NHSScotland MitraClip® transcatheter mitral valve repair should (...) be considered for patients with moderate-to- severe (grade 3+) or severe (grade 4+) mitral regurgitation who are not eligible for open mitral valve repair surgery. Decisions should be made by a multi-disciplinary team with experience of performing this procedure, taking into account individual patients’ level of risk, comorbidities, preferences and quality of life. The annual procedure volume per centre for MitraClip® should be maximised to support optimal patient outcomes and ensure clinical experience

2019 SHTG Advice Statements

11. Right-Sided Heart Structural and Functional Remodeling in Mitral Regurgitation Secondary to Mitral Valve Prolapse. (Abstract)

Right-Sided Heart Structural and Functional Remodeling in Mitral Regurgitation Secondary to Mitral Valve Prolapse. Preoperative evaluation of the mitral valve but also of tricuspid valve and right ventricular (RV) function is mandatory in primary mitral regurgitation (MR) secondary to mitral valve prolapse (MVP). Tricuspid annulus (TA) diameter plays a pivotal role in the surgical decision to perform preventive combined tricuspid valve annuloplasty. Cardiac magnetic resonance (CMR) is the gold (...) = 0.0001) were independent predictors of TA diameter ≥40 or 21 mm/m². CMR provides accurate right-sided cardiac chambers assessment and may help surgical planning of concomitant tricuspid valve annuloplasty before mitral valve repair in severe MR secondary to MVP. In conclusion, TA dilatation, RV enlargement, and dysfunction are related to pulmonary pressure and left-sided cardiac chambers enlargement, reflecting the long-standing consequences of severe MR.Copyright © 2018. Published by Elsevier Inc.

2018 American Journal of Cardiology

12. Grading of mitral regurgitation in mitral valve prolapse using the average pixel intensity method. Full Text available with Trip Pro

Grading of mitral regurgitation in mitral valve prolapse using the average pixel intensity method. We recently reported the feasibility of the average pixel intensity (API) method for grading mitral regurgitation (MR) in a heterogeneous MR population. Since mitral valve prolapse (MVP) is an important cause of primary MR, we more specifically investigated the feasibility of the API method and the MR flow dynamics in patients with MVP.Transthoracic echocardiography was performed by a single

2018 International journal of cardiology

13. Association between mitral valve prolapse and sudden sensorineural hearing loss: A case-control population-based study. Full Text available with Trip Pro

Association between mitral valve prolapse and sudden sensorineural hearing loss: A case-control population-based study. This study aimed to evaluate the relationship between sudden sensorineural hearing loss (SSNHL) and MVP using a population-based dataset. Data for this case-control study were retrieved from the Taiwan Longitudinal Health Insurance Database. In total, 3399 cases of newly diagnosed SSNHL were identified. We used propensity score matching to select 3399 comparison patients (one

2018 PLoS ONE

14. Effect of Fluoxetine Administration on Clinical and Echocardiographic Findings in Patients with Mitral Valve Prolapse and Generalized Anxiety Disorder: Randomized Clinical Trial. Full Text available with Trip Pro

Effect of Fluoxetine Administration on Clinical and Echocardiographic Findings in Patients with Mitral Valve Prolapse and Generalized Anxiety Disorder: Randomized Clinical Trial. Mitral valve prolapse (MVP) is accompanied by mental disorders including anxiety, which has similar presentations as MVP. It is hypothesised that treatment of anxiety might reduce the symptoms of MVP.The aim of this study was to assess the clinical and echocardiographic effects of fluoxetine administration in patients (...) diameter, mitral annular diameter, left ventricular diameter or ejection fraction (p>0.05). Pain severity was reduced significantly more in control group (3.27 ± 1.26) compared to intervention group (2.80 ± 0.85) after treatment (p<0.001).This study revealed that the co-administration of fluoxetine and propranolol may not only have no effective in improving echocardiographic changes of MVP but may also aggravate subjective findings of patients with MVP and GAD.The trial is registered at the Iranian

2017 Electronic physician Controlled trial quality: uncertain

15. Mitral Valve Prolapse: A Disease of Valve and Ventricle Full Text available with Trip Pro

Mitral Valve Prolapse: A Disease of Valve and Ventricle 30115221 2018 11 14 1558-3597 72 8 2018 Aug 21 Journal of the American College of Cardiology J. Am. Coll. Cardiol. Mitral Valve Prolapse: A Disease of Valve and Ventricle. 835-837 S0735-1097(18)35451-2 10.1016/j.jacc.2018.07.006 Levine Robert A RA Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts. Electronic address: rlevine@partners.org. Jerosch-Herold Michael M Cardiovascular Division, Brigham and Women's (...) Hospital, Boston, Massachusetts. Hajjar Roger J RJ Cardiovascular Research Center, Mount Sinai Medical School, New York, New York. eng R01 HL128099 HL NHLBI NIH HHS United States R01 HL135093 HL NHLBI NIH HHS United States R01 HL141917 HL NHLBI NIH HHS United States Editorial United States J Am Coll Cardiol 8301365 0735-1097 cardiac magnetic resonance mitral regurgitation mitral valve prolapse myocardial fibrosis papillary muscle sudden cardiac arrest 2018 06 13 2018 07 02 2018 07 10 2018 8 18 6 0 2018

2018 Journal of the American College of Cardiology

16. Unusual combination of mitral valve prolapse, bicuspid aortic valve, and ventricular septal defect restricted by the tricuspid septal leaflet Full Text available with Trip Pro

Unusual combination of mitral valve prolapse, bicuspid aortic valve, and ventricular septal defect restricted by the tricuspid septal leaflet 29339711 2018 12 21 2149-2271 19 1 2018 Jan Anatolian journal of cardiology Anatol J Cardiol Unusual combination of mitral valve prolapse, bicuspid aortic valve, and ventricular septal defect restricted by the tricuspid septal leaflet. E1 10.14744/AnatolJCardiol.2017.8238 Kocabaş Umut U Department of Cardiology, Soma State Hospital; Manisa-Turkey

2018 Anatolian journal of cardiology

17. Infective Endocarditis in Patients With Bicuspid Aortic Valve or Mitral Valve Prolapse. Full Text available with Trip Pro

Infective Endocarditis in Patients With Bicuspid Aortic Valve or Mitral Valve Prolapse. There is little information concerning infective endocarditis (IE) in patients with bicuspid aortic valve (BAV) or mitral valve prolapse (MVP). Currently, IE antibiotic prophylaxis (IEAP) is not recommended for these conditions.This study sought to describe the clinical and microbiological features of IE in patients with BAV and MVP and compare them with those of IE patients with and without IEAP indication

2018 Journal of the American College of Cardiology

18. Long-Term Results of Mitral Valve Repair for Regurgitation Due to Leaflet Prolapse. (Abstract)

Long-Term Results of Mitral Valve Repair for Regurgitation Due to Leaflet Prolapse. Mitral valve (MV) repair has become the standard therapy for mitral regurgitation (MR) due to degenerative diseases, but information on late outcomes is limited.The purpose of this study was to examine the late results of MV repair for MR in a large cohort of patients.A total of 1,234 consecutive patients (median age 59 years; 70.4% men) had MV repair for MR due to leaflet prolapse and were followed (...) prospectively for a median of 13 years (interquartile range: 8 to 34 years) with periodical echocardiographic studies. There were 163 patients still at risk at 20 years. Cumulative incidences of adverse events and associated factors were examined with death as a competing outcome.At 20 years, reoperation-free survival was 60.4% (95% confidence interval: 56.2% to 64.2%) and the cumulative incidence of cardiac and valve-related deaths was 12%, noncardiac deaths 21.3%, reoperation on the MV 4.6%, infective

2019 Journal of the American College of Cardiology

19. Relation Between Mitral Valve Prolapse and Erectile Dysfunction (from a Nationwide Case-Control Study). (Abstract)

Relation Between Mitral Valve Prolapse and Erectile Dysfunction (from a Nationwide Case-Control Study). Some previous literature indicated an association between cardiovascular diseases and erectile dysfunction (ED). This case-control study purposed to evaluate the association between prior mitral valve prolapse (MVP) and ED using data from the Taiwan National Health Insurance Research Dataset. In this study, 48,755 patients with ED were identified as cases, and 195,020 propensity score-matched

2019 American Journal of Cardiology

20. Mitral Valve Prolapse, Ventricular Arrhythmias, and Sudden Death. (Abstract)

Mitral Valve Prolapse, Ventricular Arrhythmias, and Sudden Death. Despite a 2% to 3% prevalence of echocardiographically defined mitral valve prolapse (MVP) in the general population, the actual burden, risk stratification, and treatment of the so-called arrhythmic MVP are unknown. The clinical profile is characterized by a patient, usually female, with mostly bileaflet myxomatous disease, mid-systolic click, repolarization abnormalities in the inferior leads, and complex ventricular (...) tissue as ventricular fibrillation triggers have been documented by electrophysiologic studies in MVP patients with aborted sudden death. The genesis of malignant ventricular arrhythmias in MVP probably recognizes the combination of the substrate (regional myocardial hypertrophy and fibrosis, Purkinje fibers) and the trigger (mechanical stretch) eliciting premature ventricular beats because of a primary morphofunctional abnormality of the mitral valve annulus. The main clinical challenge is how

2019 Circulation

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