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Migraine Headache Prophylaxis

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1. Migraine headache in children

for the success of treatment should take account of the level to which psychological factors are contributing to symptoms. Not all treatments (acute or prophylactic) work for every patient. Spontaneous remission with increasing age may occur in 25% to 50% of children. Definition Migraine is defined by the International Headache Society (IHS) as a recurrent headache that occurs with or without aura and lasts for 2 to 48 hours. It is usually unilateral in nature, of gradual onset (15 to 30 minutes), pulsating (...) than those used for adults in relationship to both duration and localisation of pain. Many affected children do not fit the traditional diagnostic classifications that have been developed from practice in adults. Ryan S. Medicines for migraine. Arch Dis Child Educ Pract Ed. 2007 Apr;92(2):ep50-5. http://www.ncbi.nlm.nih.gov/pubmed/17430855?tool=bestpractice.com This should not exclude them from a trial of acute or prophylactic treatment, provided that alternative diagnoses have been carefully

2018 BMJ Best Practice

2. Migraine headache in adults

to light sensitivity to noise aura vomiting unilateral throbbing sensation family history of migraine high caffeine intake exposure to change in barometric pressure female sex obesity habitual snoring stressful life events overuse of headache medications lack of sleep low socio-economic status allergies or asthma hypertension hypothyroidism diet Diagnostic investigations clinical diagnosis erythrocyte sedimentation rate (ESR) lumbar puncture (LP) cerebrospinal fluid (CSF) culture CT head MRI brain (...) Migraine headache in adults Migraine headache in adults - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Migraine headache in adults Last reviewed: February 2019 Last updated: October 2018 Summary Migraine is a chronic, genetically determined, episodic, neurological disorder that usually presents in early-to-mid life. Patients complain of intermittent headache and associated symptoms, such as visual disturbance

2018 BMJ Best Practice

3. Migraine headache in adults

to light sensitivity to noise aura vomiting unilateral throbbing sensation family history of migraine high caffeine intake exposure to change in barometric pressure female sex obesity habitual snoring stressful life events overuse of headache medications lack of sleep low socio-economic status allergies or asthma hypertension hypothyroidism diet Diagnostic investigations clinical diagnosis erythrocyte sedimentation rate (ESR) lumbar puncture (LP) cerebrospinal fluid (CSF) culture CT head MRI brain (...) Migraine headache in adults Migraine headache in adults - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Migraine headache in adults Last reviewed: February 2019 Last updated: October 2018 Summary Migraine is a chronic, genetically determined, episodic, neurological disorder that usually presents in early-to-mid life. Patients complain of intermittent headache and associated symptoms, such as visual disturbance

2018 BMJ Best Practice

4. Migraine and Tension Headache

, Freitag FG. Ibuprofen plus caffeine in the treatment of tension-type headache. Cephalalgia. 2000 Jul;20(6):597-602. Facco E, Liguori A, Petti F, Fauci AJ, Cavallin F, Zanette G. Acupuncture versus valproic acid in the prophylaxis of migraine without aura: a prospective controlled study. Minerva Anestesiol. 2013 Jun;79(6):634-642. Fan W, Lv Y, Ying G, Li W, Zhou J. Pilot study of amitriptyline in the prophylactic treatment of medication-overuse headache: a 1-year follow-up. Pain Med. 2014 Oct;15(10 (...) headache medications that the patient has been taking. 2. Stop all acute headache medications. Tapering may be required. 3. Start a prophylactic medication at the same time or, ideally, prior to stopping acute headache medications. See “Options for migraine prophylaxis,” p. 8. 4. Treat symptoms during withdrawal of acute headache medications. 5. Use the SmartPhrase .AVSHEADACHEMEDOVERUSE to develop a written headache treatment plan that includes acute and prophylactic treatment as well as a plan

2018 Kaiser Permanente Clinical Guidelines

5. Monoclonal antibodies to prevent migraine headaches

recurrent attacks may benefit from prophylactic therapy. 26 Botulinum toxin has received regulatory approval for the prevention of chronic migraine headaches. This medication requires multiple injections into specific head and neck sites. 1,6,24 Topiramate is used for the prophylaxis of migraine headaches in adults experiencing four or more migraine attacks per month. 27 Other drugs used for migraine prevention are anti-epileptics (divalproex sodium, lamotrigine, gabapentin), antidepressants (...) into specific head and neck sites. Other drugs are used in migraine prevention but patient adherence and efficacy are issues. Anti-calcitonin gene-related peptide (anti-CGRP) monoclonal antibodies belong to a novel class of drugs that target CGRP — a potent vasodilator — which plays a role in pain and migraines. Four anti-CGRP monoclonal antibodies are currently in development for use in the prevention of episodic and chronic migraines: eptinezumab, erenumab, fremanezumab, and galcanezumab. They have

2018 CADTH - Issues in Emerging Health Technologies

6. Transcutaneous stimulation of the cervical branch of the vagus nerve for cluster headache and migraine

include changes in the number and severity of cluster headache or migraine episodes, medication use, quality of life in the short and long term, side effects, acceptability, and device durability. NICE may update this guidance on publication of further evidence. 2 2 Indications and current treatments Indications and current treatments 2.1 Cluster headaches are characterised by episodes of unilateral periorbital pain, conjunctival injection, lacrimation and rhinorrhoea. Attacks can last from a few (...) that are refractory to medical treatments. For patients with chronic cluster headache, these include deep brain stimulation to modulate central processing of pain signals. For patients with chronic migraine, these include treatments such as nerve blocks, botulinum toxin (see NICE's technology appraisal guidance on botulinum toxin type A for the prevention of headaches in adults with chronic migraine), acupuncture or nerve stimulation. 3 3 The procedure The procedure 3.1 Transcutaneous vagus nerve stimulation uses

2016 National Institute for Health and Clinical Excellence - Interventional Procedures

7. Botulinum toxin a for prophylactic treatment of migraine and tension headaches in adults: a meta-analysis

Botulinum toxin a for prophylactic treatment of migraine and tension headaches in adults: a meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2012 DARE.

8. Injection of Botulinum Toxin (Botox) for Prophylaxis of Headaches in Adults with Chronic Migraine

related to botulinum toxin type A (BOTOX ® ), lyophilised powder 100 units, for prophylaxis of headaches in adults with chronic migraine. The recommended dose is 155 units to 195 units, with injections divided across seven specific head and neck areas, and including fixed-site, fixed-dose injections at 31 sites, totalling 155 units and up to an additional 40 units to eight ‘follow the pain’ sites. The drug is administered using a 30-gauge, 0.5 inch needle as 0.1 mL (5 units) injections per site. BOTOX (...) TOXIN (Botox), injection of, for the prophylaxis of headaches in adults with chronic migraine who have failed at least three migraine prophylactic medications, in accordance with supply of the drug under instrument PB 122 of 2008 (Arrangements – Botulinum Toxin Program) made under Section 100 (1) (b) of the National Health Act 1953. • (See para T11.1 of explanatory notes to this Category) • Fee: $124.85 5. Consumer Impact Statement Nil 6. Proposed intervention’s place in clinical management

2013 Medical Services Advisory Committee

9. The cost effectiveness of onabotulinumtoxinA for the prophylaxis of headache in adults with chronic migraine in the UK Full Text available with Trip Pro

The cost effectiveness of onabotulinumtoxinA for the prophylaxis of headache in adults with chronic migraine in the UK The cost effectiveness of onabotulinumtoxinA for the prophylaxis of headache in adults with chronic migraine in the UK The cost effectiveness of onabotulinumtoxinA for the prophylaxis of headache in adults with chronic migraine in the UK Batty AJ, Hansen RN, Bloudek LM, Varon SF, Hayward EJ, Pennington BW, Lipton RB, Sullivan SD Record Status This is a critical abstract (...) treatment; three frequencies of headache, classified as episodic migraine; and three frequencies, classified as chronic migraine. The authors stated that the perspective was that of the UK NHS. Effectiveness data: The main effectiveness data were the probabilities of transition between each health state every 12 weeks. These data were from two randomised controlled trials, within the Phase III Research Evaluating Migraine Prophylaxis Therapy (PREEMPT) programme. They were multicentre trials of 1,384

2013 NHS Economic Evaluation Database.

10. Chronic migraine and chronic tension-type headache

is not a covered benefit. HTCC reimbursement determination: Limitations of coverage: For treatment of chronic migraine (as defined by the International Headache Society), OnabotulinumtoxinA is covered when the following criteria are met: 1) Has not responded to at least three prior pharmacological prophylaxis therapies from two different classes of drugs AND 2) Condition is appropriately managed for medication overuse OnabotulinumtoxinA injections must be discontinued when the condition has shown inadequate (...) with chronic migraine (defined as headaches on =15 days per month of which =8 days are with migraine) if: 1) They have not responded to at least three prior pharmacological prophylaxis therapies from two different classes of drugs AND 2) Their condition is appropriately managed for medication overuse OnabotulinumtoxinA injections must be discontinued in people whose condition: 1) Has shown inadequate response to treatment (defined as <50% reduction in headache days per month after two treatment cycles

2017 Washington Health Care Authority

11. Management of Childhood Migraine by Headache Specialist vs Non-Headache Specialists. (Abstract)

Management of Childhood Migraine by Headache Specialist vs Non-Headache Specialists. This study aims to compare the management practices of a headache specialist with non-headache specialists in the treatment of children with migraine. The use of appropriate rescue medications and prophylactic agents, application of neuroimaging, and short-term outcomes are compared in children treated by the two groups of physicians.A retrospective cohort study was conducted by utilizing the electronic medical (...) compared to non-headache specialists who prescribed them in 28.7% (96/334) of cases (P < .001). Of the children with chronic migraine, the headache specialist evaluated 135 patients while the non-headache specialists treated 334 children. Non-headache specialists prescribed prophylaxis in the form of natural supplements more frequently (63.8% of cases) compared to the headache specialist (38.5% of children) (P < .001). Moreover, prophylaxis with prescription drugs was utilized more often by headache

2019 Headache

12. Latest clinical recommendations on valproate use for migraine prophylaxis in women of childbearing age: overview from European Medicines Agency and European Headache Federation Full Text available with Trip Pro

Latest clinical recommendations on valproate use for migraine prophylaxis in women of childbearing age: overview from European Medicines Agency and European Headache Federation Migraine is a common and burdensome neurological condition which affects mainly female patients during their childbearing years. Valproate has been widely used for the prophylaxis of migraine attacks and is also included in the main European Guidelines. Previous (2014) European recommendations on limiting the use (...) , with the active participation of the European Headache Federation, concluded that not enough has been done to mitigate the risks associated with in utero exposure to valproate. The review called for more extensive restrictions to the conditions for prescribing, better public awareness, and a more effective education campaign in migrainous women.

2018 The journal of headache and pain

13. Interest of Auriculotherapy in Prophylaxis of Migraine and Headache in Patients With Migraines

Interest of Auriculotherapy in Prophylaxis of Migraine and Headache in Patients With Migraines Interest of Auriculotherapy in Prophylaxis of Migraine and Headache in Patients With Migraines - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Interest of Auriculotherapy in Prophylaxis of Migraine and Headache in Patients With Migraines (Migauric) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03036761 Recruitment Status

2017 Clinical Trials

14. Injection of botulinum toxin (Botox) for prophylaxis of headaches in adults with chronic migraine

Injection of botulinum toxin (Botox) for prophylaxis of headaches in adults with chronic migraine Injection of botulinum toxin (Botox) for prophylaxis of headaches in adults with chronic migraine Injection of botulinum toxin (Botox) for prophylaxis of headaches in adults with chronic migraine Medical Services Advisory Committee Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA (...) database. Citation Medical Services Advisory Committee. Injection of botulinum toxin (Botox) for prophylaxis of headaches in adults with chronic migraine. Canberra: Medical Services Advisory Committee (MSAC). MSAC application 1168. 2012 Authors' conclusions After considering the strength of the available evidence in relation to the safety, clinical effectiveness and cost-effectiveness of injecting botulinum toxin type A (Botox®) in refractory chronic migraine, MSAC supports its public funding via a new

2012 Health Technology Assessment (HTA) Database.

15. Randomised controlled trial: Acupuncture prophylaxis of migraine no better than sham acupuncture for decreasing frequency of headaches

Randomised controlled trial: Acupuncture prophylaxis of migraine no better than sham acupuncture for decreasing frequency of headaches Acupuncture prophylaxis of migraine no better than sham acupuncture for decreasing frequency of headaches | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your (...) username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Acupuncture prophylaxis of migraine no better than sham acupuncture for decreasing frequency of headaches Article Text Therapeutics Randomised controlled

2013 Evidence-Based Medicine

16. gammaCore for cluster headache

be used for acute treatment of cluster headache. It also recommends that verapamil is prescribed for long-term prophylaxis and that electrocardiogram monitoring may be necessary. Anticonvulsants may also be prescribed. The use of verapamil and anticonvulsants for cluster headache is outside their marketing authorisation. Specialist commentators have stated that many people with cluster headache do not get enough pain relief from current treatment options, which are often limited by side effects (...) the clinical evidence as well as its strengths and limitations. Overall assessment of the evidence The studies included in table 2 examine the use of gammaCore as a prophylactic treatment for preventing cluster headache and for treating acute pain after the onset of a cluster headache. Several of the studies also separate cohorts into those that have been diagnosed with chronic cluster headache and people diagnosed with episodic cluster headache. The studies recruited relatively large populations given

2018 National Institute for Health and Clinical Excellence - Advice

17. Open Label Study of BOTOX® (Botulinum Toxin Type A) as Headache Prophylaxis in Chinese Patients With Chronic Migraine

Open Label Study of BOTOX® (Botulinum Toxin Type A) as Headache Prophylaxis in Chinese Patients With Chronic Migraine Open Label Study of BOTOX® (Botulinum Toxin Type A) as Headache Prophylaxis in Chinese Patients With Chronic Migraine - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Open Label Study of BOTOX® (Botulinum Toxin Type A) as Headache Prophylaxis in Chinese Patients With Chronic Migraine The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03193359 Recruitment Status : Withdrawn (Corporate Decision

2017 Clinical Trials

18. BOTOX® (Botulinum Toxin Type A) as Headache Prophylaxis in Chinese Participants With Chronic Migraine

with brainstem aura, Migrainous infarction, Chronic tension-type headache, Hypnic headache, Hemicrania continua, New daily-persistent headache and Recurrent painful ophthalmoplegic neuropathy Participants with a confirmed history of medication overuse headache Participants with a diagnosis of retinal migraine, persistent aura without infarction or migraine-triggered seizure Headache attributable to another disorder (eg, cervical dystonia, craniotomy, head/neck trauma) Use of any headache prophylactic (...) BOTOX® (Botulinum Toxin Type A) as Headache Prophylaxis in Chinese Participants With Chronic Migraine BOTOX® (Botulinum Toxin Type A) as Headache Prophylaxis in Chinese Participants With Chronic Migraine - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2017 Clinical Trials

19. Levetiracetam in compare to Sodium Valproate for prophylaxis in Chronic Migraine Headache: A Randomized Double-blind Clinical Trial. (Abstract)

Levetiracetam in compare to Sodium Valproate for prophylaxis in Chronic Migraine Headache: A Randomized Double-blind Clinical Trial. Migraine is not curable, but preventive treatments are usually used to decrease the intensity and frequency of headache attacks. Different therapeutic options are widely studied for chronic migraine (CM), but all of them have different inefficacies.The aim of this study was to compare the efficacy of levetiracetam versus sodium valproate in the treatment of CM.A (...) randomized controlled clinical trial was conducted on 62 patients with chronic migraine (30 patients in intervention group-treated with levetiracetam and 32 patients in control group- treated with sodium valproate). The treatment regimen consisted of initial dose of levetiracetam or sodium valproate 500 mg daily which increased to 500 mg two times a day after two weeks. The treatment response was evaluated by measuring pain frequency, pain severity, and the MIDAS (migraine disability assessment) score

2017 Current clinical pharmacology Controlled trial quality: uncertain

20. Cluster headache

from the episodic form. History and exam presence of risk factors repeated attacks of unilateral pain excruciating pain lacrimation, rhinorrhoea, and partial Horner's syndrome agitation nausea, vomiting photophobia, phonophobia migrainous aura male sex family history head injury cigarette smoking heavy drinking Diagnostic investigations brain CT scan or MRI erythrocyte sedimentation rate pituitary function tests polysomnogram ECG Treatment algorithm ACUTE ONGOING Contributors Authors Clinical (...) declare that they have no competing interests. Peer reviewers Director of Headache and Pain Medicine Professor of Neurology, Anesthesiology, and Rehabilitation Medicine Icahn School of Medicine at Mount Sinai New York NY Disclosures MWG declares that he has no competing interests. Professor Family and Community Medicine University of Kansas School of Medicine Wichita KS Disclosures AW declares that she has no competing interests. Department Head Department of Neurology and Pain Medicine

2018 BMJ Best Practice

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