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Microsoft Asp.Net

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1. Chimeric Antigen Receptor T-Cell Therapy for B-Cell Cancers: Effectiveness and Value

for Healthcare Research and Quality ASP Average sales price B-ALL B-cell acute lymphoblastic leukemia Allo-SCT Allogeneic stem cell transplant ASP Average sales price Auto-SCT Autologous stem cell transplant CAR-T Chimeric antigen receptor T-cell CNS Central nervous system CR Complete remission CRi Complete remission with incomplete hematologic recovery (leukemia) CRS Cytokine release syndrome CSF Cerebrospinal fluid DLCBL Diffuse large B-cell lymphoma ECOG Eastern Cooperative Oncology Group Performance (...) , neurotoxicity, B-cell aplasia), but they are manageable and perceived by clinicians as arguably no worse than the serious AEs associated with chemotherapy in this patient population. Thus, the estimated net health benefit is substantial. However, the level of certainty about the magnitude of the net health benefit compared to other therapies (clofarabine, blinatumomab, etc.) is low because there are no comparative trials and the existing single-arm trials are small with relatively short follow-up (8.7

2018 California Technology Assessment Forum

2. Chimeric Antigen Receptor T-Cell Therapy for B-Cell Cancers: Effectiveness and Value

AIC Akaike information criterion AHRQ Agency for Healthcare Research and Quality B-ALL B-cell Acute lymphoblastic leukemia Allo-SCT Allogeneic stem cell transplant ASP Average sales price Auto-SCT Autologous stem cell transplant CAR-T Chimeric antigen receptor T-cell CNS Central nervous system CR Complete remission CRi Complete remission with incomplete hematologic recovery (leukemia) CRS Cytokine release syndrome CSF Cerebrospinal fluid DLCBL Diffuse large B-cell lymphoma ECOG Eastern Cooperative (...) pediatric patients with B-cell ALL. In addition, the disease-free survival and OS were also greater than those observed with other therapies, particularly in the earlier Phase I trials that have longer follow-up. There are important harms that occur commonly with tisagenlecleucel therapy (CRS, neurotoxicity, B-cell aplasia), but they are manageable and perceived by clinicians as arguably no worse than the serious AEs associated with chemotherapy in this patient population. Thus, the estimated net health

2018 California Technology Assessment Forum

3. Enabling medication management through health information technology

Information To Support Estimates of Cost, Benefit, Impact, and Net Value With Regard To Enabling Health vii IT Applications in Terms of Prescribing, Order Transmission, Dispensing, Administering, and Monitoring, as Well as Reconciliation, Education, and Adherence? Discuss Gaps in Research, Including Specific Areas That Should Be Addressed and Suggest Possible Public and Private Organizational Types To Perform the Research and/or Analysis 71 Introduction 71 General Gaps 73 Summary 79 KQ3. What Critical (...) depending on the type of medication (controlled or noncontrolled substance) or the form of the medication (e.g., oral, injection, intravenous)? KQ2. Gaps in Knowledge or Evidence What knowledge or evidence deficits exist to support estimates of cost, benefit, impact, and net value with regard to health IT applications in all phases of medication management? KQ3. Value Proposition for Implementers and Users What critical information regarding the impact of health IT applications implemented to support

2011 EvidenceUpdates

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