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229 results for

Microdermabrasion

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221. Microdermabrasion as a novel tool to enhance drug delivery via the skin: an animal study. (Abstract)

Microdermabrasion as a novel tool to enhance drug delivery via the skin: an animal study. Microdermabrasion is a widely performed skin rejuvenation procedure. It can partly ablate and homogenize the stratum corneum (SC) layers.The effect of microdermabrasion treatment on the skin permeation of hydrophilic and lipophilic drugs was examined in this study.5-Fluorouracil (5-FU) and clobetasol 17-propionate were used as the hydrophilic and lipophilic permeants, respectively. In vitro skin delivery (...) using porcine skin and in vivo topical application employing nude mouse as the animal model were both used to examine the effect of microdermabrasion. The vacuum pressures used in this study (15-25 cmHg) were much lower than those used for therapeutic purposes.The 5-FU permeation across microdermabrasion-treated skin was 8- to 24-fold higher than that across intact skin and depended on differences in treatment pressure and duration. An intensity of 15 cmHg for 10 seconds showed the greatest

2006 Dermatologic Surgery

222. Approaches to document the efficacy and safety of microdermabrasion procedure. (Abstract)

Approaches to document the efficacy and safety of microdermabrasion procedure. Microdermabrasion is a popular cosmetic procedure for skin rejuvenation, which is achieved by mechanical abrasion of the skin at a superficial level.The objective was to study the efficacy of microdermabrasion in photoaging and to investigate the compatibility of a cleanser and a lotion with microdermabrasion.Sixteen women underwent microdermabrasion to the face once a week for a total of six treatments. Subjects (...) treatments). Subjects perceived improvement in facial photoaging variables. Colorimetry showed increased brightness and decreased yellowness of target skin sites on the face throughout the study.Multiple microdermabrasions were effective in significantly improving various facial photoaging variables. The personal skin care regimen used was well tolerated by the subjects.

2006 Dermatologic Surgery

223. Microdermabrasion: a molecular analysis following a single treatment. (Abstract)

Microdermabrasion: a molecular analysis following a single treatment. Microdermabrasion is a popular method of superficial skin resurfacing. It is unclear if dermal remodeling actually occurs.To rigorously investigate the molecular alterations observed following a single microdermabrasion treatment.Forty-nine subjects received a single microdermabrasion treatment to buttock skin. Serial in vivo biochemical and immunohistological analyses were performed. Reverse transcriptase real-time (...) microdermabrasion treatment. Two of 11 subjects also demonstrated increased type I procollagen messenger RNA and protein levels 14 days after treatment. No alteration in stratum corneum thickness was detected.Microdermabrasion activates a dermal remodeling/wound healing cascade with minimal epidermal disruption. Evidence now exists to further study manipulation of variables such as number and timing of microdermabrasion sessions.

2005 Journal of American Academy of Dermatology

224. Microdermabrasion with and without aluminum oxide crystal abrasion: a comparative molecular analysis of dermal remodeling. (Abstract)

Microdermabrasion with and without aluminum oxide crystal abrasion: a comparative molecular analysis of dermal remodeling. Microdermabrasion is a popular method of superficial skin resurfacing with effects on dermal remodeling.The purpose of this study was to evaluate the relative importance of the two components of microdermabrasion, negative pressure and abrasion, in stimulating expression of key genes involved in dermal remodeling.Ten subjects were treated with a microdermabrasion machine (...) , tumor necrosis factor-alpha, MMP-1, MMP-3, and MMP-9 were found with crystal abrasion combined with negative pressure. Negative pressure alone resulted in increased gene expression of MMP-1 and MMP-3 but of a quantitatively reduced magnitude when compared with negative pressure with crystal abrasion.It is unclear that molecular changes seen with these treatments can result in clinical effect.The abrasive component of microdermabrasion is necessary for stimulating expression of key genes involved

2006 Journal of American Academy of Dermatology

225. Enhancement of topical 5-aminolaevulinic acid delivery by erbium:YAG laser and microdermabrasion: a comparison with iontophoresis and electroporation. (Abstract)

Enhancement of topical 5-aminolaevulinic acid delivery by erbium:YAG laser and microdermabrasion: a comparison with iontophoresis and electroporation. 5-aminolaevulinic acid (ALA) is used as a protoporphyrin IX-precursor for the photodynamic therapy of superficial skin cancer and cutaneous metastases of internal malignancies. However, the permeability of hydrophilic ALA across the skin is very low.The objective of this study was to optimize and enhance the in vitro skin permeation of ALA by two (...) resurfacing techniques: erbium:yttrium-aluminium-garnet (Erb:YAG) laser and microdermabrasion. Light microscopic changes in pig skin caused by these techniques were also compared. The electrically assisted methods, iontophoresis and electroporation, were also used to facilitate ALA permeation across laser- or microdermabrasion-treated skin.Among the modalities tested in this study the Erb:YAG laser showed the greatest enhancement of ALA permeation. The laser fluence was found to play an important role

2004 British Journal of Dermatology

226. Microdermabrasion. (Abstract)

Microdermabrasion. Microdermabrasion has become one of the most popular forms of superficial resurfacing. The benefits and efficacy of microdermabrasion remain an intensely debated topic among dermatologic surgeons.This article reviews the efficacy, safety, epidermal barrier function, histopathologic effects, complications, advantages, and disadvantages of microdermabrasion.In general, microdermabrasion studies have been conducted in small groups of patients. Protocols, units, and settings have (...) differed. There remains a major disparity between the popularity of microdermabrasion in the public sector and cohesive and comprehensive scientific data documenting the efficacy of the procedure.

2005 Dermatologic Surgery

227. Damage and recovery of skin barrier function after glycolic acid chemical peeling and crystal microdermabrasion. (Abstract)

Damage and recovery of skin barrier function after glycolic acid chemical peeling and crystal microdermabrasion. Superficial chemical peeling and microdermabrasion have become increasingly popular methods for producing facial rejuvenation. However, there are few studies reporting the skin barrier function changes after these procedures.To evaluate objectively the degree of damage visually and the time needed for the skin barrier function to recover after glycolic acid peeling and aluminum oxide (...) crystal microdermabrasion using noninvasive bioengineering methods.Superficial chemical peeling using 30%, 50%, and 70% glycolic acid and aluminum oxide crystal microdermabrasion were used on the volar forearm of 13 healthy women. The skin response was measured by a visual observation and using an evaporimeter, corneometer, and colorimeter before and after peeling at set time intervals.Both glycolic acid peeling and aluminum oxide crystal microdermabrasion induced significant damage to the skin

2004 Dermatologic Surgery

228. Glycolic acid peels compared to microdermabrasion: a right-left controlled trial of efficacy and patient satisfaction. (Abstract)

Glycolic acid peels compared to microdermabrasion: a right-left controlled trial of efficacy and patient satisfaction. Glycolic acid peels and microdermabrasion are widely recommended by dermatologists and others for facial skin rejuvenation, but few studies have assessed their clinical efficacy.To compare the relative efficacy of glycolic acid peels and microdermabrasion for facial skin rejuvenation.An unblinded, randomized controlled trial was used. Each of 10 patients received paired (...) treatments with glycolic acid peels (20%) and microdermabrasion (mild setting) for 6 consecutive weeks. The right and left sides of the face were treated with different modalities. Once a patient was assigned to receive a particular modality to a particular side of the face, all subsequent treatments were delivered in the same manner. Patient ratings, investigator ratings, and photographs were obtained before the first treatment and 1 week after the last treatment.In terms of overall preference

2002 Dermatologic Surgery Controlled trial quality: uncertain

229. Lasers and microdermabrasion enhance and control topical delivery of vitamin C. Full Text available with Trip Pro

Lasers and microdermabrasion enhance and control topical delivery of vitamin C. The objective of this study was to evaluate the ability of lasers and microdermabrasion, both of which are skin resurfacing modalities, to enhance and control the in vitro skin permeation and deposition of vitamin C. The topical delivery of magnesium ascorbyl phosphate, the pro-drug of vitamin C, was also examined in this study. All resurfacing techniques evaluated produced significant increases in the topical (...) laser. The CO2 laser at a lower fluence promoted vitamin C permeation with no ablation of the stratum corneum or epidermal layers. Further enhancement was observed with the CO2 laser at higher fluences, which was accompanied by a prominent ablation effect. Microdermabrasion ablated the stratum corneum layers with minimal disruption of the skin barrier properties according to transepidermal water loss levels. The flux and skin deposition of vitamin C across microdermabrasion-treated skin

2003 Journal of Investigative Dermatology

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