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Microangiopathic Anemia

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1. Disseminated gastric carcinoma in disguise—presentation as microangiopathic haemolytic anemia with bone marrow necrosis (PubMed)

Disseminated gastric carcinoma in disguise—presentation as microangiopathic haemolytic anemia with bone marrow necrosis Cancer related microangiopathic hemolytic anemia (MAHA) and bone marrow necrosis (BMN) are two rare and distinct clinicopathological entities reported in patients with disseminated malignancy. When they emerge as initial findings in a previously undetected case of malignancy, the diagnosis is often missed resulting in inappropriate management. We report the extremely rare

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2016 Translational gastroenterology and hepatology

2. R Inguinal/R Scrotum Extramammary Paget's Disease with Diffuse Spine Metastasis Complicated by Microangiopathic Hemolytic Anemia (PubMed)

R Inguinal/R Scrotum Extramammary Paget's Disease with Diffuse Spine Metastasis Complicated by Microangiopathic Hemolytic Anemia A 47-year-old male presented with a groin lesion in 2011. Initial treatment with antifungals and vinegar was unsuccessful. In 2016, biopsy of this lesion was pursued with diagnosis of extramammary Paget's disease (EMPD). Prior to the scheduled excision, he developed constant lower back pain with radiation to his lower extremities. MRI confirmed vertebral metastasis (...) . Despite surgical and radiation therapy, his back pain progressed, and repeat imaging showed epidural spread of tumor in the thoracic spine. Later, the patient was admitted to the hospital due to severe anemia and thrombocytopenia. Further work-up confirmed the diagnosis of microangiopathic hemolytic anemia (MAHA). As we know, there are only few reports of spinal metastases in patients with EMPD. To the best of our knowledge, this is the first case report of EMPD complicated by MAHA.

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2018 Case reports in hematology

3. Microangiopathic hemolytic anemia as initial presentation of recurrent colon cancer (PubMed)

Microangiopathic hemolytic anemia as initial presentation of recurrent colon cancer 29963526 2018 11 14 2287-979X 53 2 2018 Jun Blood research Blood Res Microangiopathic hemolytic anemia as initial presentation of recurrent colon cancer. 167-169 10.5045/br.2018.53.2.167 Park Joowon J Department of Laboratory Medicine, Dankook University Hospital, Cheonan, Korea. eng Journal Article 2018 06 25 Korea (South) Blood Res 101605247 2287-979X Authors' Disclosures of Potential Conflicts of Interest

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2018 Blood research

4. Acute Hepatitis Caused by Genotype 4 HCV Presenting with Microangiopathic Hemolytic Anemia (PubMed)

Acute Hepatitis Caused by Genotype 4 HCV Presenting with Microangiopathic Hemolytic Anemia Many cases have been reported about the role of chronic hepatitis C and interferon therapy in the development and recurrence of thrombotic thrombocytopenic purpura (TTP), but to our knowledge there is no previous report about the association between acute hepatitis C and any microangiopathic hemolytic anemia (MAHA) including TTP. We report a case of acute hepatitis C that presented with MAHA resembling

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2018 ACG case reports journal

5. Microangiopathic Hemolytic Anemia in Pregnancy. (PubMed)

Microangiopathic Hemolytic Anemia in Pregnancy. Thrombotic microangiopathies (TMAs) are associated with microangiopathic hemolytic anemia and thrombocytopenia, resulting in microvascular thrombosis and end-organ damage. In pregnancy, this may be the result of pregnancy-related TMAs such as preeclampsia; hemolysis, elevated liver enzymes, and low platelets; or pregnancy-associated TMAs, specifically thrombotic thrombocytopenic purpura (TTP) or complement-mediated hemolytic uremic syndrome (CM

2018 Transfusion medicine reviews

6. A new onset of thrombocytopenia and microangiopathic hemolytic anemia in the healthcare setting: A challenge for diagnosis. (PubMed)

A new onset of thrombocytopenia and microangiopathic hemolytic anemia in the healthcare setting: A challenge for diagnosis. 30264862 2018 12 18 1096-8652 94 1 2019 Jan American journal of hematology Am. J. Hematol. A new onset of thrombocytopenia and microangiopathic hemolytic anemia in the healthcare setting: A challenge for diagnosis. 145-148 10.1002/ajh.25298 Di Mengyang M https://orcid.org/0000-0001-6165-2617 Department of Medicine, Rhode Island Hospital, The Warren Alpert Medical School

2018 American journal of hematology

7. Microangiopathic hemolytic anemia due to ADAMTS-13 loss in idiopathic systemic capillary leak syndrome: comment. (PubMed)

Microangiopathic hemolytic anemia due to ADAMTS-13 loss in idiopathic systemic capillary leak syndrome: comment. 28122158 2018 02 23 2018 12 02 1538-7836 15 4 2017 04 Journal of thrombosis and haemostasis : JTH J. Thromb. Haemost. Microangiopathic hemolytic anemia due to ADAMTS-13 loss in idiopathic systemic capillary leak syndrome: comment. 826-827 10.1111/jth.13635 Thachil J J Department of Haematology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK. eng Letter (...) Comment 2017 03 06 England J Thromb Haemost 101170508 1538-7836 EC 3.4.24.87 ADAMTS13 Protein IM J Thromb Haemost. 2016 Dec;14 (12 ):2353-2355 27622772 J Thromb Haemost. 2017 Apr;15(4):827-828 28182327 ADAMTS13 Protein Anemia, Hemolytic Capillary Leak Syndrome Humans Purpura, Thrombotic Thrombocytopenic 2017 01 13 2017 1 26 6 0 2018 2 24 6 0 2017 1 26 6 0 ppublish 28122158 10.1111/jth.13635

2017 Journal of Thrombosis and Haemostasis

8. Microangiopathic hemolytic anemia due to ADAMTS-13 loss in idiopathic systemic capillary leak syndrome: reply. (PubMed)

Microangiopathic hemolytic anemia due to ADAMTS-13 loss in idiopathic systemic capillary leak syndrome: reply. 28182327 2018 02 23 2018 12 02 1538-7836 15 4 2017 04 Journal of thrombosis and haemostasis : JTH J. Thromb. Haemost. Microangiopathic hemolytic anemia due to ADAMTS-13 loss in idiopathic systemic capillary leak syndrome: reply. 827-828 10.1111/jth.13652 Moreira D C DC Department of Pediatrics, University of Colorado Anschutz Medical Campus (AMC), Aurora, CO, USA. Di Paola J J (...) Department of Pediatrics, University of Colorado Anschutz Medical Campus (AMC), Aurora, CO, USA. Human Medical Genetics and Genomics Program, University of Colorado, Aurora, CO, USA. eng Letter Comment 2017 03 14 England J Thromb Haemost 101170508 1538-7836 EC 3.4.24.87 ADAMTS13 Protein IM J Thromb Haemost. 2017 Apr;15(4):826-827 28122158 J Thromb Haemost. 2016 Dec;14 (12 ):2353-2355 27622772 ADAMTS13 Protein Anemia, Hemolytic Capillary Leak Syndrome Humans Purpura, Thrombotic Thrombocytopenic 2017 2 10

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2017 Journal of Thrombosis and Haemostasis

9. Granulomatosis with Polyangiitis Presenting as Pyrexia of Unknown Origin, Leukocytosis, and Microangiopathic Haemolytic Anemia (PubMed)

Granulomatosis with Polyangiitis Presenting as Pyrexia of Unknown Origin, Leukocytosis, and Microangiopathic Haemolytic Anemia A 66-year-old woman presented to the Emergency Department with a florid sepsis-like picture, a two-week history of fever, relative hypotension with end organ ischemia (unexplained liver enzyme and troponin elevations), and nonspecific constitutional symptoms. She was initially found to have a urinary tract infection but, despite appropriate treatment, her fever (...) persisted and her white blood cell count continued to rise. During her hospitalization the patient manifested leukocytosis to 47,000 WBC/μL, ESR 67 mm/hr (normal range 0-42 mm/hr), CRP 17.5 mg/dL (normal range 0.02-1.20 mg/dL), and microangiopathic haemolytic anemia, with declining haemoglobin and haematocrit. An infectious aetiology was not found despite extensive bacteriologic studies and radiographic imaging. The patient progressed to acute kidney injury with "active" urinary sediment and proteinuria

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2017 Case reports in rheumatology

10. Postoperative severe microangiopathic hemolytic anemia associated with a giant hepatic cavernous hemangioma. (PubMed)

Postoperative severe microangiopathic hemolytic anemia associated with a giant hepatic cavernous hemangioma. Complications related to liver hemangioma are rare. We herein describe the case of a patient with three giant cavernous hemangiomas of the liver, of which two were resected for symptoms. A significant microangiopathic hemolytic anemia occurred in the early postoperative period, leading to acute renal failure and necessitating blood transfusions. The systematic evaluation of hemolytic

2017 Journal of Gastrointestinal Surgery

11. Microangiopathic Hemolytic Anemia Due to Malignancy in Pregnancy. (PubMed)

Microangiopathic Hemolytic Anemia Due to Malignancy in Pregnancy. Microangiopathic disorders during pregnancy remain a diagnostic challenge because these conditions often imitate more common obstetric diseases.A 31-year-old multigravid woman delivered at term with a postpartum course complicated by laboratory indices consistent with hemolysis, elevated liver enzymes, and low platelet count syndrome. After clinical recovery, she was readmitted 2 weeks after delivery with presumptive (...) pyelonephritis. Persistent hemolysis and worsening thrombocytopenia suggested a diagnosis of thrombotic microangiopathy, which did not respond to plasma exchange. Directed bone biopsy revealed metastatic signet ring cell adenocarcinoma.Microangiopathic hemolytic anemia is rarely the initial clinical manifestation of malignancy. Given the similar features of several common obstetric complications, additional diagnostic measures may be necessary to refine the diagnosis in cases unresponsive to standard

2016 Obstetrics and Gynecology

12. Microangiopathic Hemolytic Anemia Due to ADAMTS-13 Loss in Idiopathic Systemic Capillary Leak Syndrome. (PubMed)

Microangiopathic Hemolytic Anemia Due to ADAMTS-13 Loss in Idiopathic Systemic Capillary Leak Syndrome. Essentials Idiopathic systemic capillary leak syndrome (SCLS) is characterized by episodes of vascular leakage. We present the case of a patient with SCLS who developed microangiopathic hemolytic anemia (MAHA). We propose that this anemia is the result of ADAMTS-13 loss in the third-space fluid. This suggests that MAHA can occur in patients with significant extravasation (...) of proteins.Idiopathic systemic capillary leak syndrome (SCLS) is a rare process characterized by acute and recurrent episodes of vascular leakage with severe hypotension, hypoalbuminemia, hemoconcentration and edema. Anemia and thrombocytopenia are not part of this syndrome, but here we present the case of a pediatric patient with a clinical presentation consistent with SCLS who subsequently developed microangiopathic hemolytic anemia at a time when she had significant fluid loss and anasarca. Based on serial

2016 Journal of Thrombosis and Haemostasis

13. Thrombotic Microangiopathic Hemolytic Anemia without Evidence of Hemolytic Uremic Syndrome (PubMed)

Thrombotic Microangiopathic Hemolytic Anemia without Evidence of Hemolytic Uremic Syndrome 27020728 2016 08 24 2018 12 02 1308-5263 33 1 2016 Mar 05 Turkish journal of haematology : official journal of Turkish Society of Haematology Turk J Haematol Thrombotic Microangiopathic Hemolytic Anemia without Evidence of Hemolytic Uremic Syndrome. 83 10.4274/tjh.2015.0301 Özsoylu Şinasi Ş Retired Professor of Pediatrics, Hematology and Hepatology, Honorary Fellow of American Academy of Pediatrics (...) , Honorary Member of American Pediatric Society. E-mail: sinasiozsoylu@hotmail.com. eng Letter Comment Turkey Turk J Haematol 9606065 1300-7777 IM Turk J Haematol. 2015 Sep;32(3):275-6 26376595 Anemia, Hemolytic Hemolytic-Uremic Syndrome Humans Purpura, Thrombotic Thrombocytopenic Thrombosis 2016 3 30 6 0 2016 3 30 6 0 2016 8 25 6 0 ppublish 27020728 10.4274/tjh.2015.0301 PMC4805349 Turk J Haematol. 2015 Mar 5;32(1):92 25805687 Turk J Haematol. 2015 Sep;32(3):279-80 26376598 Turk J Haematol. 2015 Sep;32

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2016 Turkish Journal of Hematology

14. Microangiopathic Anemia

Microangiopathic Anemia Microangiopathic Anemia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Microangiopathic Anemia (...) Microangiopathic Anemia Aka: Microangiopathic Anemia , Microangiopathic Hemolytic Anemia , Fragmentation Hemolysis , MAHA From Related Chapters II. Mechanism RBCs damaged by injured vessel endothelium Results in formation III. Causes Recent Bypass Surgery or Arteriovenous Malformation or Renal graft rejection Giant (TTP) (HUS) (DIC) (Marathon runners) (5% of MAHA causes) Most commonly due to Quinine, , IV. Exam V. Labs s s Tests (PT) (aPTT) VI. References Udden in Goldman (2000) Cecil Medicine. p. 882-4 Images

2018 FP Notebook

15. Microangiopathic hemolytic anemia associated with metastatic breast cancer: case report and literature review (PubMed)

Microangiopathic hemolytic anemia associated with metastatic breast cancer: case report and literature review Microangiopathic hemolytic anemia (MAHA) is a mechanical hemolytic anemia characterized by the emergence of fragmented red cells in peripheral blood. Here, we report a case of breast cancer associated with cancer-related (CR)-MAHA along with a literature review.The patient was a 54-year-old woman who made an emergency visit to our hospital because of low back pain, shoulder pain, visual (...) impairment, and anemia. She was diagnosed with stage IV, ER-positive, PgR-positive, HER2-negative left breast cancer (invasive lobular carcinoma), with left axillary adenopathy, metastasis to the soft tissue of the orbital region, multiple bone metastases, pleural dissemination, and metastasis to the stomach and para-aortic lymph nodes. Chemotherapy was initiated successfully; tumor marker levels normalized and the visceral metastases almost disappeared. Hormone therapy was administered for maintenance

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2016 SpringerPlus

16. A rare case of concurrent signet-ring carcinoma of breast and microangiopathic hemolytic anemia (PubMed)

A rare case of concurrent signet-ring carcinoma of breast and microangiopathic hemolytic anemia Microangiopathic hemolytic anemia (MAHA) can be an uncommon presentation of an underlying malignancy, most often due to signet-ring cell carcinoma (SRCC). Additionally, pure SRCC in a breast primary-tumor comprises <2% of all breast cancers (Shin SY, Park H, Chae SW, Woo HY. Microangiopathic hemolytic anemia as the first manifestation of metastatic signet-ring cell carcinoma of unknown origin: a case

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2016 Journal of surgical case reports

17. A Case of Microangiopathic Hemolytic Anemia after Myxoma Excision and Mitral Valve Repair Presenting as Hemolytic Uremic Syndrome (PubMed)

A Case of Microangiopathic Hemolytic Anemia after Myxoma Excision and Mitral Valve Repair Presenting as Hemolytic Uremic Syndrome Microangiopathic hemolytic anemia occurs in a diverse group of disorders, including thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, and prosthetic cardiac valves. Hemolytic anemia also occurs as a rare complication after mitral valve repair. In this report, we describe a case of microangiopathic hemolytic anemia following myxoma excision and mitral

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2016 Journal of cardiovascular ultrasound

18. CRACKCAST E121 – Anemia, Polycythemia, and White Blood Cell Disorders

(Microangiopathic hemolytic anemias (MAHA), prosthetic HVs) Environmental (Drugs, toxins, infections, thermal) Abnormal sequestration – hypersplenism [11] List two RBC enzyme deficiencies. How do they typically present? Pyruvate kinase deficiency – presents as hemolytic jaundice around infancy G6PD deficiency – presents as acute hemolytic episode 24-48 hours after ingestion of oxidant drug/material [12] What is the pathophysiology of G6PD? What triggers G6PD symptoms? Deficiency of an enzyme in the early steps (...) CRACKCAST E121 – Anemia, Polycythemia, and White Blood Cell Disorders CRACKCAST E121 - Anemia, Polycythemia, and White Blood Cell Disorders - CanadiEM CRACKCAST E121 – Anemia, Polycythemia, and White Blood Cell Disorders In , by Nathan Stefani October 26, 2017 This 121st episode of CRACKCast covers Rosen’s 9th edition, Chapter 112 and 113, Anemia, Polycythemia, and White Blood Cell Disorders. These blood disorders are numerous and this episode attempts to break their classification and approach

2017 CandiEM

19. Evaluation of patients with microangiopathic hemolytic anemia and thrombocytopenia. (PubMed)

Evaluation of patients with microangiopathic hemolytic anemia and thrombocytopenia. When a patient presents with unexpected microangiopathic hemolytic anemia and thrombocytopenia, the diagnosis of thrombotic thrombocytopenic purpura (TTP) is often considered. However, many different disorders, including many different systemic infections and malignancies, can cause thrombotic microangiopathy (TMA), with the clinical features of microangiopathic hemolytic anemia and thrombocytopenia. Other (...) etiologies include severe hypertension, preeclampsia, systemic lupus erythematosus, adverse drug reactions, allogeneic hematopoietic stem cell transplantation, and abnormalities of complement regulation. This article focuses on distinguishing TTP from other etiologies of microangiopathic hemolytic anemia and thrombocytopenia, because consideration of the diagnosis of TTP requires an urgent decision for the initiation of plasma exchange treatment. Awareness of the many etiologies of TMA is essential

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2013 Seminars In Thrombosis And Hemostasis

20. Relapsing catastrophic antiphospholipid syndrome potential role of microangiopathic hemolytic anemia in disease relapses. (PubMed)

Relapsing catastrophic antiphospholipid syndrome potential role of microangiopathic hemolytic anemia in disease relapses. To analyze the clinical and laboratory characteristics of patients with catastrophic antiphospholipid syndrome (APS) who suffer relapses.We analyzed the Web site--based international registry of patients with catastrophic APS ("CAPS Registry") http://infmed.fcrb.es/es/web/caps and selected those cases that relapsed.Relapses were reported in 9 of 282 (3.2%) patients (...) , was infection. Brain, kidney, heart, and lung were the most common organs involved. Laboratory features of microangiopathic hemolytic anemia (MHA) were present in 13 of 18 (72%) episodes (definitive in 9, corresponding to 4 patients, and probable in 4, corresponding to 2 patients). Three relapses did not present with features of MHA and in the remaining 2 these data were not reported. The mortality rate was 38%.Although relapses are rare in patients with catastrophic APS, these results support

2013 Seminars in arthritis and rheumatism

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