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Methoxetamine

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1. Methoxetamine affects brain processing involved in emotional response in rats (PubMed)

Methoxetamine affects brain processing involved in emotional response in rats Methoxetamine (MXE) is a novel psychoactive substance that is emerging on the Internet and induces dissociative effects and acute toxicity. Its pharmacological effects have not yet been adequately investigated.We examined a range of behavioural effects induced by acute administration of MXE (0.5-5 mg·kg-1 ; i.p.) in rats and whether it causes rapid neuroadaptive molecular changes.MXE (0.5-5 mg·kg-1 ) affected motor

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2017 British journal of pharmacology

2. Ketamine Analog Methoxetamine Induced Inflammation and Dysfunction of Bladder in Rats (PubMed)

Ketamine Analog Methoxetamine Induced Inflammation and Dysfunction of Bladder in Rats The novel synthetic psychoactive ketamine analog methoxetamine is reportedly being used for recreational purposes. As ketamine use can result in urinary dysfunction, we conducted the present study to investigate how methoxetamine affects the bladder. A cystometry investigation showed that female Sprague-Dawley rats experienced increased micturition frequency bladder dysfunction after receiving a daily (...) intraperitoneal injection of 30 mg/kg methoxetamine or ketamine for periods of 4 or 12 weeks. Histologic examinations of rat bladder tissue revealed damaged urothelium barriers, as well as evidence of inflammatory cell infiltration and matrix deposition. The drug-treated rats showed significantly upregulated levels of pro-inflammatory cytokines such as IL-1β, IL-6, CCL-2, CXCL-1, CXCL-10, NGF, and COX-2. In addition, interstitial fibrosis was confirmed by increased levels of collagen I, collagen III

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2017 International journal of molecular sciences

3. “Being with a Buddha”: A Case Report of Methoxetamine Use in a United States Veteran with PTSD (PubMed)

“Being with a Buddha”: A Case Report of Methoxetamine Use in a United States Veteran with PTSD Methoxetamine (MXE) is a ketamine analogue with a high affinity for the N-methyl-D-aspartate (NMDA) receptor. MXE is a newly emerging designer drug of abuse and is widely available through on-line sources and is not detected by routine urine drug screens. In this report, we describe a United States (US) veteran with posttraumatic stress disorder (PTSD) and heavy polysubstance use, who injected

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2017 Case reports in psychiatry

4. The novel ketamine analog methoxetamine produces dissociative-like behavioral effects in rodents (PubMed)

The novel ketamine analog methoxetamine produces dissociative-like behavioral effects in rodents Methoxetamine (MXE) is a ketamine analog sold online that has been subject to widespread abuse for its dissociative and hallucinogenic effects. Previous studies have shown that MXE has high affinity for the phencyclidine (PCP) binding site located within the channel pore of the NMDA receptor (NMDAR), but little is known about its behavioral effects. Dissociative anesthetics such as ketamine and PCP

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2016 Psychopharmacology

5. Methoxetamine

Methoxetamine Methoxetamine Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Methoxetamine Methoxetamine Aka: Methoxetamine , MXE (...) are a random sampling from a Bing search on the term "Methoxetamine." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Chemical Dependency About FPnotebook.com is a rapid access, point-of-care medical reference for primary care and emergency clinicians. Started in 1995, this collection now contains 6656 interlinked topic pages divided into a tree of 31 specialty books and 728 chapters. Content is with systematic

2018 FP Notebook

6. Methoxetamine toxicity reported to the National Poisons Information Service: clinical characteristics and patterns of enquiries (including the period of the introduction of the UK's first Temporary Class Drug Order). (PubMed)

Methoxetamine toxicity reported to the National Poisons Information Service: clinical characteristics and patterns of enquiries (including the period of the introduction of the UK's first Temporary Class Drug Order). To report the demographic and clinical characteristics of cases of methoxetamine toxicity reported to The National Poisons Information Service (NPIS) by healthcare professionals. To assess the pattern of enquiries from health professionals to the UK NPIS related to methoxetamine (...) , including the period of the making of the UK first Temporary Class Drug Order (TCDO).All telephone enquiries to and user sessions for TOXBASE, the NPIS on-line information resource, related to methoxetamine (and synonyms 'MXE', 'mket' and '2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone') were reviewed from 1 April 2010 to 1 August 2012. Data were compared for the 3 months before and after the TCDO.There were 47 telephone enquiries and 298 TOXBASE sessions regarding methoxetamine during the period

2013 Emergency Medicine Journal

7. Here Today, Gone Tomorrow…and Back Again? A Review of Herbal Marijuana Alternatives (K2, Spice), Synthetic Cathinones (Bath Salts), Kratom, Salvia divinorum, Methoxetamine, and Piperazines (PubMed)

Here Today, Gone Tomorrow…and Back Again? A Review of Herbal Marijuana Alternatives (K2, Spice), Synthetic Cathinones (Bath Salts), Kratom, Salvia divinorum, Methoxetamine, and Piperazines Despite their widespread Internet availability and use, many of the new drugs of abuse remain unfamiliar to health care providers. The herbal marijuana alternatives, like K2 or Spice, are a group of herbal blends that contain a mixture of plant matter in addition to chemical grade synthetic cannabinoids (...) its psychiatric effects. Methoxetamine has recently become available via the Internet and is marked as "legal ketamine." Moreover, the piperazine derivatives, a class of amphetamine-like compounds that includes BZP and TMFPP, are making a resurgence as "legal Ecstasy." These psychoactives are available via the Internet, frequently legal, and often perceived as safe by the public. Unfortunately, these drugs often have adverse effects, which range from minimal to life-threatening. Health care

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2012 Journal of Medical Toxicology

8. Methoxetamine

Methoxetamine Methoxetamine Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Methoxetamine Methoxetamine Aka: Methoxetamine , MXE (...) are a random sampling from a Bing search on the term "Methoxetamine." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Chemical Dependency About FPnotebook.com is a rapid access, point-of-care medical reference for primary care and emergency clinicians. Started in 1995, this collection now contains 6656 interlinked topic pages divided into a tree of 31 specialty books and 728 chapters. Content is with systematic

2015 FP Notebook

9. Ketamine-like Effects After Recreational Use of Methoxetamine. (PubMed)

Ketamine-like Effects After Recreational Use of Methoxetamine. Methoxetamine, the N-ethyl derivative of ketamine, is a novel recreational drug that is not at present subject to restrictive regulations in most countries. To our knowledge, no case of methoxetamine abuse has been published to date in the scientific literature, and the only sources of information are illegal drug users' Web discussion forums. We report the first case of analytically confirmed intravenous methoxetamine abuse in a 19 (...) -year-old man. Observed signs and symptoms such as tachycardia, hypertension, confusion, agitation, stupor, ataxia, mydriasis, and nystagmus were consistent with ketamine-induced adverse effects and resolved with symptomatic treatment. According to this case report, user Web reports, and the chemical structure, methoxetamine produces ketamine-like effects. Complete recovery can be expected with supportive care.Copyright © 2011. Published by Mosby, Inc.

2012 Annals of Emergency Medicine

10. CRACKCast E154 – Hallucinogens

hallucinogens continue to emerge and may have effects from hallucinogenic, serotonergic, and dissociative toxidromes. These drugs are rarely detected by screening tests, and cases of toxicity may occur in regional outbreaks. Patients with PCP toxicity can have unpredictable, violent behavior, and may sustain traumatic injuries. Extreme agitation, although possible, is less common with ketamine and methoxetamine. Extremely agitated, violent PCP-intoxicated patients may require rapid sedation to decrease

2018 CandiEM

11. Novel Psychoactive Substances: important information for health professionals

, and the use of local slang terms. The same but different Unsurprisingly, some important differences between Novel Psychoactive Substances and their traditional counterpart substances have been noted. Methoxetamine, which was originally marketed as an alternative to the dissociative agent ketamine, shares many of its acute harms including renal and bladder toxicity. However, it produces greater hypertension, and produces some unique stimulant effects not shared with ketamine, such as tachycardia (faster (...) heart rate) and ataxia (unsteadiness). Inclusion of specific NPS in guidance such as these is sometimes problematic though. Whilst methoxetamine was briefly popular earlier in this decade, after legal control (it is now a Class B drug under the 1971 MDA) it all but disappeared from retailers, and was soon replaced with other dissociative arylcyclohexylamine drugs, of which less is known. The cannabinoid group of NPS, widely known as SCRAs, are the most widely available. Although there are important

2017 The Mental Elf

12. A Study of Bryostatin in Moderately Severe to Severe Alzheimer's Disease Subjects Not On Memantine

(Stage 0) may be acceptable after review by the Medical Monitor. Creatinine clearance (CL) of <45ml/min Poorly controlled diabetes, at the discretion of the Principal Investigator Concomitant treatment with NMDA receptor antagonists such as but not limited to memantine or drug combinations containing memantine, dextromethorphan (a cough suppressant), ketamine, phencyclidine (PCP), methoxetamine (MXE), nitrous oxide (N2O) and the following synthetic opioids: penthidine, levorphanol, methadone

2018 Clinical Trials

13. Hair Testing for Drugs of Abuse and New Psychoactive Substances in a High-Risk Population (PubMed)

. Among these, 26 samples tested positive for at least one NPS-the most common being butylone (25 samples). Other new drugs detected include methylone, methoxetamine, 5/6-APB, α-PVP and 4-FA. Hair analysis proved a powerful tool to gain objective biological drug-prevalence information, free from possible biases of unintentional or unknown intake and untruthful reporting of use. Such testing can be used actively or retrospectively to validate survey responses and inform research on consumption patterns

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2017 Journal of analytical toxicology

14. Hair Testing to Assess Both Known and Unknown Use of Drugs amongst Ecstasy Users in the Electronic Dance Music Scene (PubMed)

). Half (51.1%) of participants tested positive for a drug not self-reported, with most testing positive for synthetic cathinones (72.0%), methamphetamine (69.0%), other NPS stimulants (e.g., 4-FA, 5/6-APB; 66.7%), or new dissociatives (e.g., methoxetamine, diphenidine; 60.0%). Attending parties every other week or more often, reporting higher-frequency ecstasy pill use, having tested one's ecstasy, and having found out one's ecstasy was adulterated, were risk factors for testing positive

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2017 The International journal on drug policy

15. Phencyclidine (PCP)-Related Psychiatric Disorders (Treatment)

such as desipramine for withdrawal when dependence is present. In recent times, PCP analog drugs such as methoxetamine have come to the attention of clinicians. Methoxetamine is a synthetic analog of PCP and acts in a similar manner through the NMDA receptor. Presently, the treatment for synthetic analogs of PCP is similar to that of PCP itself, including supportive care and benzodiazepine administration. As with PCP, management of potentially concomitant rhabdomyolinolysis and respiratory support when warranted

2014 eMedicine.com

16. Phencyclidine (PCP)-Related Psychiatric Disorders (Overview)

, and killer weed have been used. When PCP is combined with cocaine, the resultant concoction is sometimes called space base or tragic magic. In recent times, PCP analog drugs such as methoxetamine have come to the attention of clinicians. Methoxetamine is a synthetic analog of PCP and acts in a similar manner through the NMDA receptor. [ ] Case Vignette Jay, a 20-year-old man, is brought to the emergency department of an inner-city general hospital by the police after he is taken into custody for fighting

2014 eMedicine.com

17. Toxicity, Amphetamine (Diagnosis)

. J Neurosci . 2014 Nov 12. 34 (46):15150-8. . . Rosenbaum CD, Carreiro SP, Babu KM. Here today, gone tomorrow…and back again? A review of herbal marijuana alternatives (K2, Spice), synthetic cathinones (bath salts), kratom, Salvia divinorum, methoxetamine, and piperazines. J Med Toxicol . 2012 Mar. 8 (1):15-32. . . Prosser JM, Nelson LS. The toxicology of bath salts: a review of synthetic cathinones. J Med Toxicol . 2012 Mar. 8 (1):33-42. . Gibbons S. 'Legal highs'--novel and emerging

2014 eMedicine Emergency Medicine

18. Phencyclidine (PCP)-Related Psychiatric Disorders (Diagnosis)

, and killer weed have been used. When PCP is combined with cocaine, the resultant concoction is sometimes called space base or tragic magic. In recent times, PCP analog drugs such as methoxetamine have come to the attention of clinicians. Methoxetamine is a synthetic analog of PCP and acts in a similar manner through the NMDA receptor. [ ] Case Vignette Jay, a 20-year-old man, is brought to the emergency department of an inner-city general hospital by the police after he is taken into custody for fighting

2014 eMedicine.com

19. Toxicity, Amphetamine (Treatment)

alternatives (K2, Spice), synthetic cathinones (bath salts), kratom, Salvia divinorum, methoxetamine, and piperazines. J Med Toxicol . 2012 Mar. 8 (1):15-32. . . Prosser JM, Nelson LS. The toxicology of bath salts: a review of synthetic cathinones. J Med Toxicol . 2012 Mar. 8 (1):33-42. . Gibbons S. 'Legal highs'--novel and emerging psychoactive drugs: a chemical overview for the toxicologist. Clin Toxicol (Phila) . 2012 Jan. 50 (1):15-24. . Begeman A, Franssen EJF. Lack of Detection of New Amphetamine

2014 eMedicine Emergency Medicine

20. Toxicity, Amphetamine (Overview)

. J Neurosci . 2014 Nov 12. 34 (46):15150-8. . . Rosenbaum CD, Carreiro SP, Babu KM. Here today, gone tomorrow…and back again? A review of herbal marijuana alternatives (K2, Spice), synthetic cathinones (bath salts), kratom, Salvia divinorum, methoxetamine, and piperazines. J Med Toxicol . 2012 Mar. 8 (1):15-32. . . Prosser JM, Nelson LS. The toxicology of bath salts: a review of synthetic cathinones. J Med Toxicol . 2012 Mar. 8 (1):33-42. . Gibbons S. 'Legal highs'--novel and emerging

2014 eMedicine Emergency Medicine

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