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Methamphetamine

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1. Management of Acute Withdrawal and Detoxification for Adults who Misuse Methamphetamine: A Review of the Clinical Evidence and Guidelines

Management of Acute Withdrawal and Detoxification for Adults who Misuse Methamphetamine: A Review of the Clinical Evidence and Guidelines Management of Acute Withdrawal and Detoxification for Adults who Misuse Methamphetamine: A Review of the Clinical Evidence and Guidelines | CADTH.ca Find the information you need Management of Acute Withdrawal and Detoxification for Adults who Misuse Methamphetamine: A Review of the Clinical Evidence and Guidelines Management of Acute Withdrawal (...) and Detoxification for Adults who Misuse Methamphetamine: A Review of the Clinical Evidence and Guidelines Last updated: February 8, 2019 Project Number: RC1067-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical evidence regarding methods to manage acute detoxification or withdrawal for adults who misuse methamphetamine? What are the evidence-based guidelines regarding the management of acute detoxification

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

2. Treatment of Neonatal Abstinence Syndrome due to Crystal Methamphetamine: A Review of Clinical Effectiveness and Guidelines

Treatment of Neonatal Abstinence Syndrome due to Crystal Methamphetamine: A Review of Clinical Effectiveness and Guidelines Treatment of Neonatal Abstinence Syndrome due to Crystal Methamphetamine: A Review of Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Treatment of Neonatal Abstinence Syndrome due to Crystal Methamphetamine: A Review of Clinical Effectiveness and Guidelines Treatment of Neonatal Abstinence Syndrome due to Crystal Methamphetamine: A Review (...) of Clinical Effectiveness and Guidelines Last updated: June 7, 2019 Project Number: RC1129-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of interventions for the treatment of neonatal abstinence syndrome due to crystal methamphetamine? What is the comparative clinical effectiveness of tools for the diagnosis and monitoring of neonatal abstinence syndrome due to crystal methamphetamine? What

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

3. Treatment for Methamphetamine Addiction: A Review of Guidelines

Treatment for Methamphetamine Addiction: A Review of Guidelines Treatment for Methamphetamine Addiction: A Review of Guidelines | CADTH.ca Find the information you need Treatment for Methamphetamine Addiction: A Review of Guidelines Treatment for Methamphetamine Addiction: A Review of Guidelines Last updated: July 2, 2019 Project Number: RC1146-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What are the evidence (...) -based guidelines regarding the treatment for patients with methamphetamine addiction immediately after acute detoxification? What are the evidence-based guidelines regarding post-treatment care for patients with methamphetamine addiction? Key Message Three evidence-based guidelines were identified that addressed the research questions. Although published separately, all three publications represented one unique guideline; therefore, one evidence-based guideline is reported. A variety

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

4. Withdrawal Management and Treatment of Crystal Methamphetamine Addiction in Pregnancy: A Review of Clinical Effectiveness and Guidelines

Withdrawal Management and Treatment of Crystal Methamphetamine Addiction in Pregnancy: A Review of Clinical Effectiveness and Guidelines Withdrawal Management and Treatment of Crystal Methamphetamine Addiction in Pregnancy: A Review of Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Withdrawal Management and Treatment of Crystal Methamphetamine Addiction in Pregnancy: A Review of Clinical Effectiveness and Guidelines Withdrawal Management and Treatment of Crystal (...) Methamphetamine Addiction in Pregnancy: A Review of Clinical Effectiveness and Guidelines Last updated: June 17, 2019 Project Number: RC1130-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of interventions for the withdrawal management or treatment of persons who are pregnant and addicted to crystal methamphetamine? What are the evidence-based guidelines regarding withdrawal management

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

5. Sexualized drug use (chemsex and methamphetamine) and men who have sex with men

Sexualized drug use (chemsex and methamphetamine) and men who have sex with men Sexualized drug use (chemsex and methamphetamine) and men who have sex with men | The Ontario HIV Treatment Network The Ontario HIV Treatment Network Sexualized drug use (chemsex and methamphetamine) and men who have sex with men Sexualized drug use (chemsex and methamphetamine) and men who have sex with men , , , , , , , , , , Questions What is the impact of sexualized drug use (specifically of chemsex (...) and methamphetamine) on the health of men who have sex with men? What are effective interventions and/or services that address chemsex and methamphetamine use among men who have sex with men (including prevention, harm reduction, engagement in care and treatment)? Key take-home messages Chemsex (1, 2) and methamphetamine use (3, 4) are associated with sexual health-related harms among men who have sex with men. Methamphetamine is the most commonly reported drug in sexualized drug use among men who have sex

2019 Ontario HIV Treatment Network

6. Safe Rooms for the Management of Patients Experiencing Crystal Methamphetamine-Induced Psychosis: Clinical and Cost-Effectiveness and Guidelines

Safe Rooms for the Management of Patients Experiencing Crystal Methamphetamine-Induced Psychosis: Clinical and Cost-Effectiveness and Guidelines Safe Rooms for the Management of Patients Experiencing Crystal Methamphetamine-Induced Psychosis: Clinical and Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Safe Rooms for the Management of Patients Experiencing Crystal Methamphetamine-Induced Psychosis: Clinical and Cost-Effectiveness and Guidelines Safe Rooms (...) for the Management of Patients Experiencing Crystal Methamphetamine-Induced Psychosis: Clinical and Cost-Effectiveness and Guidelines Last updated: December 21, 2018 Project Number: RB1294-000 Product Line: Research Type: Devices and Systems Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of safe rooms to manage patients experiencing crystal methamphetamine-induced psychosis? What is the cost- effectiveness of safe rooms to manage patients experiencing crystal

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

8. Methamphetamine in Canada [infographic]

Methamphetamine in Canada [infographic] Methamphetamine in Canada Nationally, use is low among the general population National use of methamphetamine is low, but use and harms are on the rise in certain regions Source: Statistics Canada. (2018). Canadian Tobacco, Alcohol and Drugs Survey. proportion who ever used † Largely meth but also includes other amphetamines and prescription stimulants For more detailed information on these increases, see CCSA’s Methamphetamine Canadian Drug Summary (...) 600% in Manitoba 500% in B.C. 300% in B.C. (2012–2015) 500% in Saskatchewan (2012–2015) 2,400% in Manitoba (2013–2018) 300% in Ontario (2012–2017) 330% meth seizures (2015–2016) 550% possession charges (2010–2017) 300% trafficking charges (2010–2017) Demand for treatment and harm reduction services Hospitalizations due to stimulants † Law enforcement indicators What can we do about the increasing use and harms of methamphetamine

2019 Canadian Centre on Substance Abuse

9. Methamphetamine (Canadian Drug Summary)

Methamphetamine (Canadian Drug Summary) www.ccsa.ca • www.ccdus.ca November 2018 Canadian Drug Summary Canadian Centre on Substance Use and Addiction • Centre canadien sur les dépendances et l’usage de substances Page 1 Methamphetamine Introduction Methamphetamine is a synthetic drug classified as a central nervous system (CNS) stimulant or psychostimulant. CNS stimulants cover a wide range of substances that act on the body by increasing the level of activity of the CNS and include caffeine (...) , nicotine, amphetamine (e.g., Adderall®), methylphenidate (e.g., Ritalin®), MDMA (“ecstasy”), cocaine (including crack cocaine) and methamphetamine (including crystal meth). 1,2 While both methamphetamine and amphetamine are psychostimulants and often grouped together, they are different drugs. A slight chemical modification of amphetamine produces methamphetamine, which has a different pharmacological profile that results in a larger release of certain neurochemicals in the brain and a stronger

2018 Canadian Centre on Substance Abuse

10. Craving Responses to Methamphetamine and Sexual Visual Cues in Individuals With Methamphetamine Use Disorder After Long-Term Drug Rehabilitation Full Text available with Trip Pro

Craving Responses to Methamphetamine and Sexual Visual Cues in Individuals With Methamphetamine Use Disorder After Long-Term Drug Rehabilitation Studies utilizing functional magnetic resonance imaging (fMRI) cue-reactivity paradigms have demonstrated that short-term abstinent or current methamphetamine (MA) users have increased brain activity in the ventral striatum, caudate nucleus and medial frontal cortex, when exposed to MA-related visual cues. However, patterns of brain activity following

2018 Frontiers in Psychiatry

11. Epigenetic Effects Induced by Methamphetamine and Methamphetamine-Dependent Oxidative Stress Full Text available with Trip Pro

Epigenetic Effects Induced by Methamphetamine and Methamphetamine-Dependent Oxidative Stress Methamphetamine is a widely abused drug, which possesses neurotoxic activity and powerful addictive effects. Understanding methamphetamine toxicity is key beyond the field of drug abuse since it allows getting an insight into the molecular mechanisms which operate in a variety of neuropsychiatric disorders. In fact, key alterations produced by methamphetamine involve dopamine neurotransmission in a way (...) , which is reminiscent of spontaneous neurodegeneration and psychiatric schizophrenia. Thus, understanding the molecular mechanisms operated by methamphetamine represents a wide window to understand both the addicted brain and a variety of neuropsychiatric disorders. This overlapping, which is already present when looking at the molecular and cellular events promoted immediately after methamphetamine intake, becomes impressive when plastic changes induced in the brain of methamphetamine-addicted

2018 Oxidative medicine and cellular longevity

12. Parallel Effects of Methamphetamine on Anxiety and CCL3 in Humans and a Genetic Mouse Model of High Methamphetamine Intake Full Text available with Trip Pro

Parallel Effects of Methamphetamine on Anxiety and CCL3 in Humans and a Genetic Mouse Model of High Methamphetamine Intake Methamphetamine (MA) abuse causes immune dysfunction and neuropsychiatric impairment. The mechanisms underlying these deficits remain unidentified.The effects of MA on anxiety-like behavior and immune function were investigated in mice selectively bred to voluntarily consume high amounts of MA [i.e., MA high drinking (MAHDR) mice]. MA (or saline) was administered to mice

2018 Neuropsychobiology

13. A Research of Methamphetamine Induced Psychosis in 1,430 Individuals With Methamphetamine Use Disorder: Clinical Features and Possible Risk Factors Full Text available with Trip Pro

A Research of Methamphetamine Induced Psychosis in 1,430 Individuals With Methamphetamine Use Disorder: Clinical Features and Possible Risk Factors Background and Aims: Methamphetamine (MA) abuse is commonly associated with the development of psychotic symptoms. The predictors and related risk factors of MA induced psychosis (MIP) are poorly understood. We investigated the occurrence of MIP, and analyzed the clinical features and possible risk factors among individuals with MA use disorder

2018 Frontiers in Psychiatry

14. The effects of online brief interventions for the prevention and treatment of methamphetamine use

The effects of online brief interventions for the prevention and treatment of methamphetamine use The effects of online brief interventions for the prevention and treatment of methamphetamine use An Evidence Check rapid review brokered by the Sax Institute for the Centre for Population Health in the New South Wales (NSW) Ministry of Health. August 2015. An Evidence Check rapid review brokered by the Sax Institute for the Centre for Population Health in the New South Wales (NSW) Ministry (...) the copyright owners. Enquiries regarding this report may be directed to the: Manager Knowledge Exchange Program Sax Institute www.saxinstitute.org.au knowledge.exchange@saxinstitute.org.au Phone: +61 2 91889500 Suggested Citation: David R Skvarc, Jay Varcoe, Bosco Rowland, Matthew Fuller-Tyszkiewicz, David Austin, John W Toumbourou. The effects of online brief interventions for the prevention and treatment of methamphetamine use: a systematic review: an Evidence Check rapid review brokered by the Sax

2015 Sax Institute Evidence Check

15. Antagonism of Neurotensin Receptors in the Ventral Tegmental Area Decreases Methamphetamine Self-Administration and Methamphetamine Seeking in Mice Full Text available with Trip Pro

Antagonism of Neurotensin Receptors in the Ventral Tegmental Area Decreases Methamphetamine Self-Administration and Methamphetamine Seeking in Mice Neurotensin is a peptide that modulates central dopamine neurotransmission and dopamine-related behaviors. Methamphetamine self-administration increases neurotensin levels in the ventral tegmental area, but the consequences for self-administration behavior have not been described. Here we test the hypothesis that antagonizing neurotensin receptors (...) in the ventral tegmental area attenuates the acquisition of methamphetamine self-administration and methamphetamine intake.We implanted mice with an indwelling catheter in the right jugular vein and bilateral cannulae directed at the ventral tegmental area. Mice were then trained to nose-poke for i.v. infusions of methamphetamine (0.1 mg/kg/infusion) on a fixed ratio 3 schedule.Mice receiving microinfusions of the neurotensin NTS1/NTS2 receptor antagonist SR142948A in the ventral tegmental area (10 ng/side

2017 International Journal of Neuropsychopharmacology

16. Protocol for a systematic review of psychological treatment for methamphetamine use: an analysis of methamphetamine use and mental health symptom outcomes. Full Text available with Trip Pro

Protocol for a systematic review of psychological treatment for methamphetamine use: an analysis of methamphetamine use and mental health symptom outcomes. People who use methamphetamine (MA) regularly, often experience symptoms of mental ill health associated with the use of the drug. These include symptoms of psychosis, depression, anxiety and also cognitive deficits. Accordingly, psychological treatments aim to reduce MA use and related problems, including symptoms of mental ill health

2017 BMJ open

17. Comparison of demographic characteristics and psychiatric comorbidity among methamphetamine-, heroin- and methamphetamine-heroin co- dependent males in Hunan, China. Full Text available with Trip Pro

Comparison of demographic characteristics and psychiatric comorbidity among methamphetamine-, heroin- and methamphetamine-heroin co- dependent males in Hunan, China. There is little research of psychiatric comorbidity differences among people with different types of drug dependence in Chinese population. We explored demographic and comorbid psychiatric differences among methamphetamine- dependent males (MDs), heroin-dependent males (HDs) and methamphetamine and heroin co-dependent males (M/HDs (...) of drug use than HDs. Overall, methamphetamine-dependence related to higher rates of current and lifetime psychotic disorders, lifetime hallucinogen use disorders. Heroin-dependence related to higher rates of current and lifetime substance-induced mood disorders, sedative/hypnotic/anxiolytic and other drug use disorders and current alcohol use disorder. For M/HDs, they were more likely to have any other lifetime substance use disorders than MDs and HDs.There were substantial differences

2017 BMC Psychiatry

18. Psychomotor effect differences between l-methamphetamine and d-methamphetamine are independent of murine plasma and brain pharmacokinetics profiles Full Text available with Trip Pro

Psychomotor effect differences between l-methamphetamine and d-methamphetamine are independent of murine plasma and brain pharmacokinetics profiles l-Methamphetamine has been occasionally referred to as a stimulant similar to d-methamphetamine, probably owing to insufficient comparative studies. Here, we directly compared psychomotor efficacies and pharmacokinetics of methamphetamine enantiomers in mice. Only d-methamphetamine, but not l-methamphetamine, induced stereotypy and sensitization (...) at 1-10 mg/kg. However, plasma pharmacokinetic parameters of 10 mg/kg l-methamphetamine were ≥tenfold those of 1 mg/kg d-methamphetamine. These results clearly indicate that differential psychomotor efficacies of methamphetamine enantiomers are independent of their pharmacokinetic profiles.

2017 Journal of neural transmission

19. Recombinant Adeno-Associated Virus-Mediated Expression of Methamphetamine Antibody Attenuates Methamphetamine-Induced Hyperactivity in Mice Full Text available with Trip Pro

Recombinant Adeno-Associated Virus-Mediated Expression of Methamphetamine Antibody Attenuates Methamphetamine-Induced Hyperactivity in Mice Methamphetamine (Meth) is one of the most frequently abused drugs worldwide. Recent studies have indicated that antibodies with high affinity for Meth reduce its pharmacological effects. The purpose of this study was to develop a technique for virus-based passive immunization against Meth effects. We generated a recombinant adeno-associated virus serotype-8

2017 Scientific reports

20. Naltrexone moderates the relationship between cue-induced craving and subjective response to methamphetamine in individuals with methamphetamine use disorder Full Text available with Trip Pro

Naltrexone moderates the relationship between cue-induced craving and subjective response to methamphetamine in individuals with methamphetamine use disorder Reductions in cue-induced craving and subjective response to drugs of abuse are commonly used as initial outcome measures when testing novel medications for the treatment of addiction. Yet neither the relationship between these two measures at the individual level nor the moderating effects of pharmacotherapies on this relationship has (...) been examined.This secondary data analysis sought to examine (1) the predictive relationship between cue-induced craving and subsequent acute subjective response to methamphetamine (MA) and (2) whether the opioid-receptor antagonist naltrexone moderated this association in a sample of non-treatment-seeking individuals who met DSM-IV criteria for MA use disorder (abuse or dependence).Participants (n = 30) completed two 4-day medication regimens (oral naltrexone 50 mg or placebo, in a randomized

2017 Psychopharmacology

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