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Metabolic Syndrome

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181. The influence of the rs1137101 genotypes of leptin receptor gene on the demographic and metabolic profile of normal Saudi females and those suffering from polycystic ovarian syndrome. (PubMed)

The influence of the rs1137101 genotypes of leptin receptor gene on the demographic and metabolic profile of normal Saudi females and those suffering from polycystic ovarian syndrome. Polycystic ovarian syndrome (PCOS) is of frequent occurrence in Saudi females and is often associated with obesity, insulin resistance, hypogonadotropic hypogonadism, and infertility. Since these features are also associated with leptin receptor (LEP-R) deficiency, several studies have attempted to link LEP-R gene (...) polymorphisms to PCOS.The purpose of this study is to assess the possible association of LEP-R gene polymorphism (rs1137101) with the main obesity-linked metabolic parameters in Saudi female patients affected by PCOS. A cohort of 122 Saudi female subjects, attending the outpatient's clinics at Makkah, Saudi Arabia and diagnosed with PCOS was investigated. Metabolic parameters in serum samples, including lipidogram, glucose, leptin, ghrelin and insulin and obesity markers (BMI, W/H ratio, HOMA) were assayed

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2019 BMC Women's Health

182. Whole-body vibration improves the functional parameters of individuals with metabolic syndrome: an exploratory study. (PubMed)

Whole-body vibration improves the functional parameters of individuals with metabolic syndrome: an exploratory study. Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that increases the cardiovascular risk. Regular physical exercise can promote benefits, but the MetS individuals are demotivated to perform it. Thus, new possibilities are important as an alternative intervention. The whole-body vibration can be considered an exercise modality and would be a safe and low-cost

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2019 BMC Endocrine Disorders

183. Shedding Perspective on Extracellular Vesicle Biology in Diabetes and Associated Metabolic Syndromes. (PubMed)

Shedding Perspective on Extracellular Vesicle Biology in Diabetes and Associated Metabolic Syndromes. The etiology of diabetes and associated metabolic derailments is a complex process that relies on crosstalk between metabolically active tissues. Dysregulation of secreted factors and metabolites from islets, adipose tissue, liver, and skeletal muscle contributes to the overall progression of diabetes and metabolic syndrome. Extracellular vesicles (EVs) are circulating nanovesicles secreted (...) by most cell types and are comprised of bioactive cargoes that are horizontally transferred to targeted cells/tissues. Accumulating evidence from the past decade implicates the role of EVs as mediators of islet cell dysfunction, inflammation, insulin resistance, and other metabolic consequences associated with diabetes. This review covers a broad spectrum of basic EV biology (i.e., biogenesis, secretion, and uptake), including a comprehensive investigation of the emerging role of EVs in β-cell

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2019 Endocrinology

184. Metabolic disturbances in non-obese women with polycystic ovary syndrome: a systematic review and meta-analysis. (PubMed)

Metabolic disturbances in non-obese women with polycystic ovary syndrome: a systematic review and meta-analysis. To explore metabolic disturbances in nonobese women with polycystic ovary syndrome (PCOS) compared with nonobese healthy controls.Systematic review and meta-analysis.Not applicable.Nonobese women with PCOS and nonobese healthy controls.None.Prevalence of metabolic disturbances including hyperinsulinemia, insulin resistance (IR), impaired fasting glucose (IFG), impaired glucose (...) intolerance (IGT), prediabetes, dyslipidemia, hypercholesterolemia, hypertriglyceridemia, and low high-density lipoprotein (low-HDL), as well as other metabolic outcomes such as type 2 diabetes mellitus (T2DM), hypertension, metabolic syndrome (Mets), myocardial infarction, stroke, cerebrovascular accident, arterial occlusive disease, and coronary heart disease.Compared to nonobese controls, nonobese women with PCOS showed a higher prevalence of hyperinsulinemia (odds ratio [OR], 36.27; 95% confidence

2019 Fertility and Sterility

185. Development of in vitro three-dimensional co-culture system for metabolic syndrome therapeutic agents. (PubMed)

Development of in vitro three-dimensional co-culture system for metabolic syndrome therapeutic agents. There are many obstacles to overcome in the development of new drugs for metabolic diseases, including efficacy and toxicity problems in later stages of drug development. To overcome these problems and predict efficacy and toxicity in early stages, we constructed a new model of insulin resistance in terms of communication between 3T3-L1 adipocytes and RAW264.7 macrophages by three-dimensional (...) demonstrated that 3D co-culture model had functional metabolic similarity to adipose tissue in diabetic mice. We utilized this 3D co-culture system to screen PPARγ antagonists that might have potential as therapeutic agents for diabetes as demonstrated by an in vivo assay.This in vitro 3D co-culture system could serve as a next-generation platform to accelerate the development of therapeutics for metabolic diseases.© 2019 John Wiley & Sons Ltd.

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2019 obesity & metabolism

186. Prevalence of metabolic syndrome among HIV-positive and HIV-negative populations in sub-Saharan Africa-a systematic review and meta-analysis. (PubMed)

Prevalence of metabolic syndrome among HIV-positive and HIV-negative populations in sub-Saharan Africa-a systematic review and meta-analysis. Metabolic syndrome (MetS) is a constellation of conditions that increase the risk of cardiovascular diseases. It is an emerging concern in sub-Saharan African (SSA) countries, particularly because of an increasingly aging population and lifestyle changes. There is an increased risk of MetS and its components among people living with Human immune (...) deficiency syndrome (HIV) individuals; however, the prevalence of metabolic syndrome in the SSA population and its differential contribution by HIV status is not yet established. This systematic review and meta-analysis were conducted to estimate the pooled prevalence of metabolic syndrome in people living with HIV and uninfected populations, its variation by sub-components.We performed a comprehensive search on major databases-MEDLINE (PubMed), EBSCOhost, and Cochrane Database of Systematic Reviews

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2019 Systematic reviews

187. Vestronidase alfa-vjbk (Mepsevii) - To treat pediatric and adult patients with an inherited metabolic condition called mucopolysaccharidosis type VII (MPS VII), also known as Sly syndrome.

Vestronidase alfa-vjbk (Mepsevii) - To treat pediatric and adult patients with an inherited metabolic condition called mucopolysaccharidosis type VII (MPS VII), also known as Sly syndrome. Mepsevii (vestronidase alfa-vjbk) Injection U.S. Department of Health and Human Services Search FDA Submit search Mepsevii (vestronidase alfa-vjbk) Injection Mepsevii Company: Ultragenyx Pharmaceutical Inc. Application No.: 761047 Approval Date: 11/15/2017 Persons with disabilities having problems accessing

2018 FDA - Drug Approval Package

188. Impact of interactions among metabolic syndrome components on the development of cardiovascular disease among Kazakhs in Xinjiang. (PubMed)

Impact of interactions among metabolic syndrome components on the development of cardiovascular disease among Kazakhs in Xinjiang. Few prospective studies have explored the effect of interactions among metabolic syndrome (MS) components on the development of cardiovascular disease (CVD) in the Kazakh population in Xinjiang Province of China.As of December 2016, 2,644 participants who completed a baseline survey over a period of 5 years or more were included in the study. The multiplicative

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2018 PLoS ONE

189. Does prenatal alcohol exposure cause a metabolic syndrome? (Non-)evidence from a mouse model of fetal alcohol spectrum disorder. (PubMed)

Does prenatal alcohol exposure cause a metabolic syndrome? (Non-)evidence from a mouse model of fetal alcohol spectrum disorder. Although prenatal alcohol exposure (PAE) reduces offspring growth, it may increase obesity risk at adolescence. Animal models of PAE display glucose intolerance and increased adiposity, suggesting that PAE causes metabolic reprogramming. We tested this hypothesis in a mouse model of binge PAE, wherein pregnant C57Bl/6J females received 3 g/kg alcohol (ETOH) daily from (...) three caloric groups (MCT, MD, ETOH), such that caloric groups had greater post-weaning weight gain (both sexes), reduced gonadal fat weight (males), and reduced glucose clearance (males) compared against H2O offspring. PAE did not affect body composition, respiratory exchange ratio, metabolic adaption to high-fat or low-fat diet, eating behavior, and blood pressure, and ETOH values did not differ from those obtained from isocaloric controls. Exposure to a higher alcohol dose (4.5 g/kg) or a high

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2018 PLoS ONE

190. Exploring the association between thyroid- stimulating hormone and metabolic syndrome: A large population-based study. (PubMed)

Exploring the association between thyroid- stimulating hormone and metabolic syndrome: A large population-based study. A growing amount of evidence suggests that thyroid-stimulating hormone (TSH) is associated with cardiometabolic risk. However, there have been few longitudinal studies. The aim of this study was to explore the causal relationship between TSH and metabolic syndrome (MetS) in a large population-based longitudinal study. From 2010 to 2016 at the Health Management Center at Tri

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2018 PLoS ONE

191. Cytokine-mediated inflammation mediates painful neuropathy from metabolic syndrome. (PubMed)

Cytokine-mediated inflammation mediates painful neuropathy from metabolic syndrome. Painful neuropathy (PN) is a prevalent condition in patients with metabolic syndrome (MetS). However, the pathogenic mechanisms of metabolic syndrome-associated painful neuropathy (MetSPN) remain unclear. In the current study, high-fat-fed mice (HF mice) were used to study MetSPN. HF mice developed MetS phenotypes, including increased body weight, elevated plasma cholesterol levels, and insulin resistance

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2018 PLoS ONE

192. Prevalence of metabolic syndrome and its risk factors in Kerala, South India: Analysis of a community based cross-sectional study. (PubMed)

Prevalence of metabolic syndrome and its risk factors in Kerala, South India: Analysis of a community based cross-sectional study. Coronary Artery Disease (CAD) is a leading cause of death and disability in Kerala, India. Metabolic syndrome (MS) is a constellation of established risk factors for CAD. We aimed to estimate the prevalence of MS and evaluate the association between MS and CAD using a community-based sample population.A cross-sectional community based survey was conducted in urban (...) , the prevalence of metabolic syndrome in Kerala was 24%, 29% and 33% for the NCEP ATP III, IDF and AHA/NHLBI Harmonization definitions, respectively. The mean (SD) age of the participants was 51 (14) years, and 60% were women. Women had a higher prevalence of MS than men (28% versus 20% for ATP III, p<0.001). Similarly, participants living in urban areas had higher prevalence of MS than their rural counterparts (26% versus 22%, p<0.001). Elevated body mass index, older age, and female sex were associated

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2018 PLoS ONE

193. Cardiorespiratory fitness and the metabolic syndrome: Roles of inflammation and abdominal obesity. (PubMed)

Cardiorespiratory fitness and the metabolic syndrome: Roles of inflammation and abdominal obesity. Individuals with metabolic syndrome have increased risk of type 2 diabetes and cardiovascular disease. We aimed to test the hypothesis that a high level of cardiorespiratory fitness (CR-fitness), counteracts accumulation of visceral fat, decreases inflammation and lowers risk factors of the metabolic syndrome.The study sample included 1,293 Danes (age 49-52 years) who from 2009 to 2011 (...) participated in the Copenhagen Aging and Midlife Biobank, including a questionnaire, physical tests, and blood samples. Multiple linear regression models were performed with CR-fitness as exposure and plasma levels of cytokines and high sensitive C-reactive protein as outcomes and measures of abdominal obesity were added to test if they explained the potential association. Similarly, multiple linear regression models were performed with CR-fitness as exposure and factors of the metabolic syndrome

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2018 PLoS ONE

194. Metabolic Syndrome and cognitive decline in the elderly: A systematic review. (PubMed)

Metabolic Syndrome and cognitive decline in the elderly: A systematic review. Metabolic Syndrome (MetS) refers to a cluster of metabolic disturbances which is associated with increased risk for vascular and degenerative conditions in general population. Although the relationship between vascular risk factors and dementia is undisputable, additional hazard for cognitive decline in older population with concurrent metabolic disorders still waits to be demonstrated. The present review aims

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2018 PLoS ONE

195. Metabolic Syndrome and Meaningful Statistics. (PubMed)

Metabolic Syndrome and Meaningful Statistics. Much has been discussed about the effects of the obesity epidemic in the countries involved in the multi-national study by Grieger et al (BJOG, 2019 xxxx). Although obesity has been associated with impaired fertility, the impact of metabolic syndrome (MetS), a more specifically pointed measure, has rarely been assessed. From this very large multi-national study, it is apparent that MetS is associated with a longer time to pregnancy and infertility

2019 BJOG

196. Greater Susceptibility for Metabolic Syndrome in Pediatric Solid Organ and Stem Cell Transplant Recipients. (PubMed)

Greater Susceptibility for Metabolic Syndrome in Pediatric Solid Organ and Stem Cell Transplant Recipients. Cardiovascular (CV) comorbidity is of increasing importance after transplantation (Tx). Metabolic syndrome (MS) contributes to the risk for CV sequelae. Our aim was to assess the risk for MS in pediatric solid organ and stem cell transplant recipients by comparing them to matched untransplanted peers in a multicenter study.We prospectively assessed MS in 295 pediatric transplant (...) recipients and compared them to 1.475 age- and sex-matched controls.Post transplant metabolic syndrome (PTMS) was most frequent in lung (43%) and kidney (39%), followed by liver (16%) and stem cell (13%) recipients compared to non transplanted peers (4%; p<0.01). The risk of displaying PTMS was almost 22-fold higher after lung (95%CI 8.2-57.4), 16-fold higher after kidney (95%CI 9.1-28.9), 5-fold higher after liver (95%CI 2.1-10.1) and 4-fold higher after stem cell (95%CI 1.4-9.5) Tx. The contribution

2019 Transplantation

197. Association of metabolic syndrome and its components with suicidal ideation and depression in adults: A nationally representative sample of the Korean population. (PubMed)

Association of metabolic syndrome and its components with suicidal ideation and depression in adults: A nationally representative sample of the Korean population. Few studies have evaluated the association of depressive symptoms and suicidal ideation with metabolic syndrome (MetS) and its components. This study examined the associations of MetS and its components with suicidal ideation and depression and determined the mediation effect of self-rated health (SRH) on these associations.This study

2019 Journal of Affective Disorders

198. Correction to: Association of HIV-infection, antiretroviral treatment and metabolic syndrome with large artery stiffness: a cross-sectional study. (PubMed)

Correction to: Association of HIV-infection, antiretroviral treatment and metabolic syndrome with large artery stiffness: a cross-sectional study. Following publication of the original article [1], the authors reported that they have provided the wrong caption.

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2019 BMC Infectious Diseases

199. What is the impact of metabolic syndrome and its components on reflux esophagitis? A cross-sectional study. (PubMed)

What is the impact of metabolic syndrome and its components on reflux esophagitis? A cross-sectional study. The prevalence rate of reflux esophagitis (RE) in Asia, including Taiwan, has increased dramatically in recent years. However, few studies have discussed on its relationship with metabolic syndrome (MetS). This study aimed to evaluate the correlation between RE and MetS and its components.We conducted a cross-sectional study during 2013 to 2014 in Taiwan. A total of 4895 subjects who

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2019 BMC Gastroenterology

200. Prospective associations of adolescent conscientiousness with psychological resources and metabolic syndrome in Black and White men. (PubMed)

Prospective associations of adolescent conscientiousness with psychological resources and metabolic syndrome in Black and White men. Conscientiousness predicts better psychological resources as well as lower cardiovascular mortality and lower metabolic syndrome (MetS) risk. However, the benefits of conscientiousness might be amplified, disabled, or reversed in disadvantaged groups. This study is the first to test these competing hypotheses for prospective associations between adolescent

2019 Psychosomatic Medicine

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