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Metabolic Syndrome

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1. Vestronidase alfa-vjbk (Mepsevii) - To treat pediatric and adult patients with an inherited metabolic condition called mucopolysaccharidosis type VII (MPS VII), also known as Sly syndrome.

Vestronidase alfa-vjbk (Mepsevii) - To treat pediatric and adult patients with an inherited metabolic condition called mucopolysaccharidosis type VII (MPS VII), also known as Sly syndrome. Mepsevii (vestronidase alfa-vjbk) Injection U.S. Department of Health and Human Services Search FDA Submit search Mepsevii (vestronidase alfa-vjbk) Injection Mepsevii Company: Ultragenyx Pharmaceutical Inc. Application No.: 761047 Approval Date: 11/15/2017 Persons with disabilities having problems accessing

2018 FDA - Drug Approval Package

2. Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China Full Text available with Trip Pro

. The incidence of acute cardiac injury was about 13 folds higher in ICU/severe patients compared with the non-ICU/severe patients. Conclusion Patients with previous cardiovascular metabolic diseases may face a greater risk of developing into the severe condition and the comorbidities can also greatly affect the prognosis of the COVID-19. On the other hand, COVID-19 can, in turn, aggravate the damage to the heart. Introduction During the past two decades, the outbreak and prevalence of severe acute (...) Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China | SpringerLink Advertisement Search Search SpringerLink Search Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China , , , , , , , & ( 2020 ) 9984 Accesses 3 Citations 19 Altmetric Abstract Background Studies have reminded that cardiovascular metabolic comorbidities made patients more susceptible to suffer 2019

2020 Covid-19 Ad hoc papers

3. Metabolic syndrome

Metabolic syndrome Evidence Maps - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4 (...) . Also read , explaining issues with the system. NOTE : Chrome is the best browser to use! To get started, type a condition/disease into the search box above. Here are some examples to get you started: Building Evidence Map X Axis Alphabetically Risk of bias No. Articles Sample Size Risk of bias any low Minimum sample size Apply Follow us: © 2019 Trip Database Ltd. company number 04316414. Trip is proud to be made in the UK.

2018 Trip Evidence Maps

4. Supervised lifestyle intervention for people with metabolic syndrome improves outcomes and reduces individual risk factors of metabolic syndrome: A systematic review and meta-analysis Full Text available with Trip Pro

of life were not statistically significant.There is low to moderate quality evidence that supervised multifaceted lifestyle intervention improves multiple risk factors of metabolic syndrome, as well as reducing prevalence of the disease. Health services should consider implementing lifestyle intervention programs for people with metabolic syndrome to improve health outcomes and prevent progression to chronic disease.Crown Copyright © 2019. Published by Elsevier Inc. All rights reserved. (...) Supervised lifestyle intervention for people with metabolic syndrome improves outcomes and reduces individual risk factors of metabolic syndrome: A systematic review and meta-analysis Metabolic syndrome is characterised by a clustering of metabolic risk factors including abdominal obesity, raised triglycerides, lowered HDL cholesterol, hypertension and impaired glucose tolerance. Multifaceted lifestyle interventions including diet and exercise are recommended as the first-line treatment

2019 EvidenceUpdates

5. Metabolic syndrome

are overweight or obese, with one quarter of the Western population estimated to have the condition. Multiple criteria exist to define metabolic syndrome. Increases risk of cardiovascular disease and diabetes, although there are ethnic variations in the incidence of comorbidities associated with metabolic syndrome defined by the same criteria. The precise pathogenetic mechanisms unifying all of its components are as yet unknown, although insulin resistance certainly plays a key role. Obesity, an atherogenic (...) /reprint/106/25/3143 http://www.ncbi.nlm.nih.gov/pubmed/12485966?tool=bestpractice.com Reaven GM. Banting lecture 1988: role of insulin resistance in human disease. Diabetes. 1988;37:1595-1607. http://www.ncbi.nlm.nih.gov/pubmed/3056758?tool=bestpractice.com No known common cause unifies its components. The condition reflects the sedentary lifestyle, overnutrition, and resultant excess adiposity of the modern world. Metabolic syndrome is associated with endothelial dysfunction and atherosclerosis

2018 BMJ Best Practice

7. Transition from metabolically benign to metabolically unhealthy obesity and 10-year cardiovascular disease incidence: the ATTICA cohort study (Abstract)

Transition from metabolically benign to metabolically unhealthy obesity and 10-year cardiovascular disease incidence: the ATTICA cohort study Metabolically benign obesity remains a scientific field of considerable debate. The aim of the present work was to evaluate whether metabolically healthy obese (MHO) status is a transient condition which propagates 10-year cardiovascular disease (CVD) onset.A prospective longitudinal study was conducted during 2001-2012, the ATTICA study studying 1514 (...) (49.8%) men and 1528 (50.2%) women (aged >18 years old) free of CVD and residing in the greater Athens area, Greece. Follow-up assessment of first combined CVD event (2011-2012) was achieved in n = 2020 participants; of them, 317 (15.7%) incident cases were identified. Obesity was defined as body mass index ≥30 kg/m2 and healthy metabolic status as absence of all NCEP ATP III (2005) metabolic syndrome components (excluding waist circumference).The MHO prevalence was 4.8% (n = 146) with 28.2

2019 EvidenceUpdates

8. Which patients with metabolic syndrome benefit from metformin?

Which patients with metabolic syndrome benefit from metformin? Which patients with metabolic syndrome benefit from metformin? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Which patients with metabolic syndrome benefit from metformin? View/ Open Date 2016-11 Format Metadata Abstract Q Which patients with metabolic (...) syndrome benefit from metformin? Evidence-based answer: Patients at highest risk for progression to diabetes benefit from metformin. In patients with metabolic syndrome who are in the highest-risk quartile for progression to diabetes (predicted mean 3-year risk, 60%), metformin, 850 mg twice daily, reduces the absolute risk by about 20% over a 3-year period. Metformin doesn't reduce the incidence in patients at lower risk of progression (strength of recommendation [SOR]: C, post-hoc analysis

2017 Clinical Inquiries

9. Identification of female-specific genetic variants for metabolic syndrome and its component traits to improve the prediction of metabolic syndrome in females. Full Text available with Trip Pro

Identification of female-specific genetic variants for metabolic syndrome and its component traits to improve the prediction of metabolic syndrome in females. Metabolic syndrome (MetS), defined as a cluster of metabolic risk factors including dyslipidemia, insulin-resistance, and elevated blood pressure, has been known as partly heritable. MetS effects the lives of many people worldwide, yet females have been reported to be more vulnerable to this cluster of risks.To elucidate genetic variants

2019 BMC Medical Genetics

10. Interventions for metabolic bone disease in children with chronic kidney disease. (Abstract)

Interventions for metabolic bone disease in children with chronic kidney disease. Bone disease is common in children with chronic kidney disease (CKD) and when untreated may result in bone deformities, bone pain, fractures and reduced growth rates. This is an update of a review first published in 2010.This review aimed to examine the benefits (improved growth rates, reduced risk of bone fractures and deformities, reduction in PTH levels) and harms (hypercalcaemia, blood vessel calcification (...) , deterioration in kidney function) of interventions (including vitamin D preparations and phosphate binders) for the prevention and treatment of metabolic bone disease in children with CKD.We searched the Cochrane Kidney and Transplant Specialised Register to 8 September 2015 through contact with the Trial's Search Co-ordinator using search terms relevant for this review.We included randomised controlled trials (RCTs) comparing different interventions used to prevent or treat bone disease in children

2015 Cochrane

11. Fine-scale haplotype mapping of MUT, AACS, SLC6A15 and PRKCA genes indicates association with insulin resistance of metabolic syndrome and relationship with branched chain amino acid metabolism or regulation. Full Text available with Trip Pro

Fine-scale haplotype mapping of MUT, AACS, SLC6A15 and PRKCA genes indicates association with insulin resistance of metabolic syndrome and relationship with branched chain amino acid metabolism or regulation. Branched chain amino acids (BCAA) are essential elements of the human diet, which display increased plasma levels in obesity and regained particular interest as potential biomarkers for development of diabetes. To define determinants of insulin resistance (IR) we investigated 73 genes (...) involved in BCAA metabolism or regulation by fine-scale haplotype mapping in two European populations with metabolic syndrome. French and Romanians (n = 465) were genotyped for SNPs (Affymetrix) and enriched by imputation (BEAGLE 4.1) at 1000 genome project density. Initial association hits detected by sliding window were refined (HAPLOVIEW 3.1 and PHASE 2.1) and correlated to homeostasis model assessment (HOMAIR) index, in vivo insulin sensitivity (SI) and BCAA plasma levels (ANOVA). Four genomic

2019 PLoS ONE

12. A structural equation modeling approach for the association of a healthy eating index with metabolic syndrome and cardio-metabolic risk factors among obese individuals. Full Text available with Trip Pro

A structural equation modeling approach for the association of a healthy eating index with metabolic syndrome and cardio-metabolic risk factors among obese individuals. Numerous studies have evaluated the association between dietary factors and cardiovascular risk among patients with chronic disease. It is worthwhile to assess these associations in a combination model rather than in an isolated form. In the current study, we aimed to use structural equation modeling (SEM) to assess (...) the association of adherence to a healthy eating index (HEI)-2015 with socio-demographic factors, psychological characteristics, metabolic syndrome (MetS) and other cardio-metabolic risk factors among obese individuals.This cross-sectional study was conducted among 188 healthy obese adults (96 males and 92 females) aged 20-50 years in Tabriz. A validated semi-quantitative food frequency questionnaire (FFQ) was used to record dietary intake and to estimate HEI-2015. Anthropometric parameters, blood pressure

2019 PLoS ONE

13. Metabolically Healthy Obesity, Transition to Metabolic Syndrome, and Cardiovascular Risk Full Text available with Trip Pro

Metabolically Healthy Obesity, Transition to Metabolic Syndrome, and Cardiovascular Risk Debate over the cardiometabolic risk associated with metabolically healthy obesity (MHO) continues. Many studies have investigated this relationship by examining MHO at baseline with longitudinal follow-up, with inconsistent results.The authors hypothesized that MHO at baseline is transient and that transition to metabolic syndrome (MetS) and duration of MetS explains heterogeneity in incident (...) cardiovascular disease (CVD) and all-cause mortality.Among 6,809 participants of the MESA (Multi-Ethnic Study of Atherosclerosis) the authors used Cox proportional hazards and logistic regression models to investigate the joint association of obesity (≥30 kg/m2) and MetS (International Diabetes Federation consensus definition) with CVD and mortality across a median of 12.2 years. We tested for interaction and conducted sensitivity analyses for a number of conditions.Compared with metabolically healthy normal

2018 EvidenceUpdates

14. Metabolic syndrome and the skin: a more than superficial association. Reviewing the association between skin diseases and metabolic syndrome and a clinical decision algorithm for high risk patients Full Text available with Trip Pro

Metabolic syndrome and the skin: a more than superficial association. Reviewing the association between skin diseases and metabolic syndrome and a clinical decision algorithm for high risk patients There is ongoing scientific interest regarding comorbidities associated with the metabolic syndrome (MeTS). MeTS comprises a combination of parameters that predispose individuals to the development of type 2 diabetes and cardiovascular disease (CVD). Three or more of the following criteria (...) are necessary: fasting glucose > 110 mg/dl (5.6 mmol/l), hypertriglyceridemia > 150 mg/dl (1.7 mmol/l), HDL levels < 40 mg/dl (men)/< 50 mg/dl (women), blood pressure > 130/85 mmHg, waist circumference (values for Mediterranean populations > 94 cm (men)/> 89 cm (women). In this review we attempted to summarize relevant data by searching dermatological literature regarding associations between various skin conditions and MeTS. A multitude of studies was retrieved and a further goal of the present article

2018 Diabetology & metabolic syndrome

15. Risk factors associated with metabolic syndrome and cardiovascular disease among women with polycystic ovary syndrome in Tabuk, Saudi Arabia Full Text available with Trip Pro

Risk factors associated with metabolic syndrome and cardiovascular disease among women with polycystic ovary syndrome in Tabuk, Saudi Arabia Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder at a reproductive age. It is associated with a high risk of metabolic syndrome (MS) and cardiovascular diseases (CVD).To measure the prevalence of MS in women with PCOS and to assess the global cardiovascular risk (CVR) among them.This cross-sectional study was conducted at King Khalid (...) Hospital, Tabuk, Saudi Arabia during the period from February through December 2014. A total of 404 infertile women were randomly selected, and checked for diagnosing PCOS, MS and estimated CVD probability. Data were analyzed by IBM-SPSS version 22, using independent-samples t-test, Chi-square, and conditional logistic regression. A p-value of <0.05 was considered significant.MS was diagnosed in 58% and 32% of women with and without PCOS respectively (p<0.00). Results showed a statistically significant

2017 Electronic physician

16. Correction: Metabolic syndrome in Xinjiang Kazakhs and construction of a risk prediction model for cardiovascular disease risk. Full Text available with Trip Pro

Correction: Metabolic syndrome in Xinjiang Kazakhs and construction of a risk prediction model for cardiovascular disease risk. [This corrects the article DOI: 10.1371/journal.pone.0202665.].

2019 PLoS ONE

17. Metabolic syndrome and its components are associated with increased chronic kidney disease risk: Evidence from a meta-analysis on 11 109 003 participants from 66 studies Full Text available with Trip Pro

Metabolic syndrome and its components are associated with increased chronic kidney disease risk: Evidence from a meta-analysis on 11 109 003 participants from 66 studies Observational studies examining the relationship between metabolic syndrome and the risk of chronic kidney disease (CKD) have reported inconclusive results. This meta-analysis was performed to resolve these controversies.The MEDLINE, EMBASE, and PubMed databases were systematically searched from their inception until March 2016 (...) status. Moreover, all individual components of the MetS were significantly associated with CKD, and their coexistence resulted in an escalating dose-response relationship. The sensitivity and subgroup analyses established the stability of the findings.This meta-analysis strongly suggests that the metabolic syndrome and its components are independently associated with the increased risk of CKD.© 2018 John Wiley & Sons Ltd.

2018 EvidenceUpdates

18. Being overweight or obese is linked with heart disease even without other metabolic risk factors

obesity’, encouraging population-wide strategies to tackle obesity. The researchers defined obesity as a body mass index (BMI)> 30kg/m2 and being overweight as 25-30kg/m2. They defined metabolic syndrome as three or more of the following: high blood pressure, high waist circumference, raised triglyceride levels, raised blood sugar levels, and/or taking treatment for these conditions, and/or a self-reported history of these conditions. Expert commentary This study adds to the robust evidence base (...) Being overweight or obese is linked with heart disease even without other metabolic risk factors Being overweight or obese is linked with heart disease even without other metabolic risk factors Discover Portal Discover Portal Being overweight or obese is linked with heart disease even without other metabolic risk factors Published on 7 November 2017 doi: People with certain metabolic risk factors who are obese are two and a half times as likely to develop heart disease as healthy people

2019 NIHR Dissemination Centre

19. [Regulative effects of the acupuncture on glucose and lipid metabolism disorder in the patients of metabolic syndrome]. (Abstract)

[Regulative effects of the acupuncture on glucose and lipid metabolism disorder in the patients of metabolic syndrome]. To observe the regulative effects of the acupuncture on glucose and lipid metabolism disorder in the patients of metabolic syndrome.Seventy-six patients of metabolic syndrome were rando-mized into an acupuncture plus western medicine group (37 cases) and a western medicine group (39 cases). In the western medicine group, the conventional western medication was used for 40 days (...) P<0.05).On the basis of the conventional western medicine, the acupuncture relieves apparently the clinical symptoms and rectifies glucose and lipid metabolism disorder in the patients of metabolic syndrome.

2018 Zhongguo zhen jiu = Chinese acupuncture & moxibustion Controlled trial quality: uncertain

20. Impact of Metabolic Syndrome Factors on Testosterone and SHBG in Type 2 Diabetes Mellitus and Metabolic Syndrome Full Text available with Trip Pro

Impact of Metabolic Syndrome Factors on Testosterone and SHBG in Type 2 Diabetes Mellitus and Metabolic Syndrome Several studies have often reported low testosterone and SHBG to be associated with type 2 DM and the metabolic syndrome (MetS). Our objective was to determine the impact of metabolic syndrome and diabetic parameters on testosterone and SHBG in both MetS subjects and type 2 DM patients.In this study, 120 Yemeni male aged 30-70 years old were enrolled, 30 of whom were healthy subjects

2018 Journal of diabetes research

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