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141. Management of Spontaneous Labour at Term in Healthy Women

caregivers. (III-A) 8. When appropriate, health care providers should support women in their choice of analgesic options in labour. These may include pharmacological and non-pharmacological measures. (III-A) 9. Each woman should be provided with evidence-based information about labour analgesia options prior to the onset of labour and offered ample opportunity to discuss the risks and benefits of each option available at her planned site of delivery. (III-A) 10. The use of meperidine as labour analgesia

2016 Society of Obstetricians and Gynaecologists of Canada

142. Bupivacaine vs. Pethidine in Spinal Anesthesia of Old Patients: Haemodynamic Changes and Complications. (PubMed)

ischemia is vital. Various types of opioid analgesics have been used in order to pain control in these patients. We decided to conduct the present study in order to compare the hemodynamic changes of the old patients who undergo lower limbs orthopedic surgeries by applying subarachnoid bupivacaine and meperidine (pethidine).Sixty-six patients older than 60 years included according to inclusion and exclusion criteria and randomly allocated into two same groups, Then in the fi rst group in the sitting

2019 Asian journal of anesthesiology Controlled trial quality: uncertain

144. Side Effect Rates of Opioids in Equianalgesic Doses Via Intravenous Patient-Controlled Analgesia: A Systematic Review and Network Meta-analysis

on the primary outcomes (side effects), with some exceptions. Buprenorphine had a significantly higher RR of nausea and vomiting, whereas fentanyl had a lower RR of nausea and vomiting. Nalbuphine, butorphanol, methadone, and pethidine/meperidine had a lower risk of pruritus. Respiratory depression was rare (22 of 2452 patients). Pethidine/meperidine, fentanyl, and oxymorphone caused significantly lower sedation scores. Tramadol caused significantly lower satisfaction scores, whereas oxycodone, alfentanil (...) , remifentanil, fentanyl, and pethidine/meperidine caused significantly higher satisfaction scores.The opiate chosen for treatment most likely has little effect on the incidence of pruritus and nausea/vomiting, although considerable differences exist in terms of better and worse opioids in the presented rankings. Larger differences between drugs were observed with regard to sedation and patient satisfaction, and choosing the appropriate opioid may help to improve PCA in this regard.

2019 EvidenceUpdates

145. Usage of Intravenous Lidocaine Infusion with Enhanced Recovery Pathway in Patients Scheduled for Open Radical Cystectomy: A Randomized Trial

%. Postoperative pain scores, rescue analgesic consumption, times to return of bowel sounds, first flatus, first defecation, resuming of regular diet, length of hospital stay, in-hospital complications, and patient satisfaction were recorded.Patients in the lidocaine group experienced significantly lower pain scores after surgery at 6 hours (P = 0.005) and 12 hours (P = 0.001) at rest, and in the first 18 hours during mobilization (P < 0.05), with less paracetamol (P = 0.04) and meperidine (P = 0.02

2019 EvidenceUpdates

146. Management of Infusion Reactions to Systemic Anticancer Therapy: ESMO Clinical Practice Guidelines

severe reaction. [IV, B] Trastuzumab [1, 56, 89, 90] Humanised Anti-HER2 20%–40% on the ?rst infusion. Severe reactions<1%. Chills, fever, blood pressure changes, bronchospasm, itching, dyspnoea, wheez- ing, arrhythmia, angioedema. Loading dose in 90min. Subsequent doses in 30min. Premedication is not recommended. [IV, B] Grade 1/2: stop or slow the infusion rate. Symptomatic treatment. Meperidine for chills and rigours. Grade 3/4: stop the infusion. Aggressive symptomatic treat- ment. After

2017 European Society for Medical Oncology

148. Clinical Practice Guidelines for Sustained Neuromuscular Blockade in the Adult Critically Ill Patient

. However, related research in other populations may be extrapolated to the setting of therapeutic hypothermia following cardiac arrest. In an open-label randomized study of 20 patients following hypothermic cardiopulmonary bypass, vecuronium (0.1 mg/kg bolus followed by 1 µg·kg –1 ·min –1 for 4 hr) eliminated shivering in 100% of patients, compared with 50% of patients who received meperidine (25 mg every 15 min until no shivering was observed or a total dose of 75 mg was administered) ( p < 0.05 (...) ) ( ). Vecuronium eliminated shivering without lowering systolic blood pressure, as occurred with meperidine ( p < 0.02), and eliminated shivering in the five patients whose shivering was uncontrolled by meperidine. As was noted in nonrandomized studies involving pancuronium for the prevention of shivering in patients following cardiopulmonary bypass ( , ), vecuronium administration was associated with consistent and statistically significant decreases in oxygen consumption and CO 2 production, effects not seen

2016 Society of Critical Care Medicine

149. Perinatal substance use: maternal

to online version, destroy printed copies after use Page 7 of 29 1.2 Commonly used/misused substances Table 2. Substances commonly used/misused Opioids 5 (CNS depressants) Agonists 5 • Codeine 9 • Fentanyl • Heroin (Diacetyl morphine/Diamorphine) • Hydromorphone • Morphine • Methadone • Meperidine • Oxycodone • Propoxyphene Antagonists • Naltrexone Mixed agonist–antagonists • Buprenorphine (Subutex) 9 • Butorphanol • Nalbuphine • Pentazocine CNS stimulants Psycho stimulants • Caffeine 5 • Cocaine 5,9,10

2016 Queensland Health

151. Liver Disease and Pregnancy

recommendation, low level of evidence). Computed tomography scans carry a risk of teratogenesis and childhood hematologic malignancies but may be used judiciously with minimized radiation protocols (2–5 rads; conditional recommendation, very low level of evidence). Endoscopy in pregnancy Endoscopy is safe in pregnancy but should be deferred until the second trimester if possible (strong recommendation, low level of evidence). Meperidine and propofol can be used for endoscopic sedation (strong recommendation (...) trimester if possible (strong recommendation, low level of evidence). 6. Meperidine and propofol can be used for endoscopic seda- tion (strong recommendation, moderate level of evidence). Although clinical studies on the safety and eff ectiveness of endoscopy for the pregnant patient have been limited, endo- scopy can be safe and eff ective if careful assessment of the risks, benefi ts, and clinical rationale is performed. One of the most important clinical issues in endoscopy of the pregnant patient

2016 American College of Gastroenterology

152. Opioids for agitation in dementia. (PubMed)

Improvement Group Specialized Register, on 13 June 2014 using the terms: narcotic OR opioid OR opium OR morphine OR buprenorphine OR codeine OR dextromoramide OR diphenoxylate OR dipipanone OR dextropropoxyphene OR propoxyphene OR diamorphine OR dihydrocodeine OR alfentanil OR fentanyl OR remifentanil OR meptazinol OR methadone OR nalbuphine OR oxycodone OR papaveretum OR pentazocine OR meperidine OR pethidine OR phenazocine OR hydrocodone OR hydromorphone OR levorphanol OR oxymorphone OR butorphanol

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2015 Cochrane

154. Narcotics, Benzodiazepines, Stimulants, and Gabapentin: Policies, Initiatives, and Practices Across Canada, 2014

to the province’s PRP include, but are not limited to: select narcotic and controlled drugs, such as methadone and hydromorphone amphetamines anabolic steroids barbiturates benzodiazepines buprenorphine chloral hydrate codeine-containing products diethylpropion gabapentin. Increasing reports from law enforcement agencies on the sale and seizure of gabapentin prompted the addition of this substance to the list of monitored drugs. The province also identified safety concerns around meperidine and pentazocine

2015 Canadian Agency for Drugs and Technologies in Health - Environmental Scanning

155. Anaesthetic Agents in Pregnant Women Undergoing Non-Obstetric Surgical or Endoscopic Procedures

was performed during the first trimester of pregnancy. The non- randomized study concluded that regional anaesthesia for laparotomic adnexal mass surgery during pregnancy may be associated with an increased risk of preterm labour. However, it is difficult to elucidate the impact of anaesthesia alone on pregnancy outcomes due to the influence of several confounding factors present in the included studies. One evidence-based guideline was identified that recommends meperidine as the preferred agent (...) and lactating women, including recommendations for the use of analgesics and anaesthetic agents. Based on what was classified as very low quality evidence from “two large studies” otherwise undefined, ASGE recommends meperidine as the preferred agent for procedures on pregnant women requiring moderate sedation. They also recommend that deep sedation should be administered by an anaesthesia provider; however, no guidance on specific agents was included in this recommendation. A general procedural

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

157. Effectiveness of Sedoanalgesia in Percutaneous Liver Biopsy Premedication (PubMed)

were divided into three premedication groups as control, Meperidine, and Midazolam. Hospital Anxiety and Depression Scale (HADS) was used to measure each subject's anxiety level. Fifteen minutes before the biopsy, 1 mL 0.9% NaCl subcutaneously (sc), 1 mg/kg (max 100 mg) Meperidine sc, or 0.1 mg/kg (max 5 mg) Midazolam intravenously was administered to patients respectively. Then PLB was done with 16 G Menghini needle. The day after, the patients were asked about feelings regarding biopsy.Groups (...) were similar by gender and age. The HADS scores prior to PLB and on visual analog scale (VAS, 1-10 points) score during PLB were similar. In the three groups, 7, 12, and 7 patients, respectively, experienced no pain. Other patients explained pain as mild or moderate or severe. The number of patients who agreed for possible rebiopsy was higher in Meperidine and Midazolam groups than in the control group.Premedication with Meperidine or Midazolam in PLB would improve patients' tolerance, comfort

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2017 Euroasian journal of hepato-gastroenterology Controlled trial quality: uncertain

158. Effect of Different Sedation Regimes on Cognitive Functions in Colonoscopy (PubMed)

Effect of Different Sedation Regimes on Cognitive Functions in Colonoscopy To compare the effects of propofol/remifentanil and meperidine/midazolam on postprocedure cognitive function.A total of 100 American Society of Anesthesiologists (ASA) score I to III patients undergoing elective colonoscopy were taken into the study and divided into two groups. Exclusion criteria were patient refusal, mini mental test (MMT) <26, The Amsterdam Preoperative Anxiety and Information Scale (APAIS) >10 (...) , advanced cardiopulmonary or psychiatric disease, chronic alcohol abuse, morbid obesity, and known allergy to study drugs. In group MM, 2 mg midazolam and 20 mg meperidine was given intravenously and additional 1 to 2 mg midazolam and 20 mg meperidine (with a maximum total of 5 mg midazolam and 50 mg meperidine) was given when bispectral index (BIS) was >80. In group RP, 100 μg/kg/minute propofol infusion and 1 μg/kg remifentanil bolus was administered and additional 0.5 μg/kg remifentanil bolus

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2017 Euroasian journal of hepato-gastroenterology Controlled trial quality: uncertain

160. The effects of novel α (PubMed)

The effects of novel α Objective: Meperidine used to control shivering during perioperative period has associated side effects. The present study compared the safety of selective α2-adrenoreceptor agonist dexmedetomidine and meperidine for anti-shivering in primiparas after caesarean delivery under combined spinal-epidural anesthesia (CSEA).Methods: 100 primiparas scheduled for caesarean delivery were randomly allocated to dexmedetomidine group (Group D, n=50) and meperidine positive control (...) group (Group M, n=50). Primiparas experienced shivering that continued to cord clamping were treated with dexmedetomidine (0.5 μg/kg) or meperidine (0.5 mg/kg) after cord clamping. The primary outcome measures were incidence of nausea, vomiting, and respiratory depression. Secondary outcome measures were shivering score, vital signs including blood pressure, heart rate and O2 saturation, tympanic temperature, and sedation score.Results: Dexmedetomidine provided similar anti-shivering effects

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2019 Bioscience reports Controlled trial quality: uncertain

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