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Meperidine

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141. Usage of Intravenous Lidocaine Infusion with Enhanced Recovery Pathway in Patients Scheduled for Open Radical Cystectomy: A Randomized Trial (Abstract)

%. Postoperative pain scores, rescue analgesic consumption, times to return of bowel sounds, first flatus, first defecation, resuming of regular diet, length of hospital stay, in-hospital complications, and patient satisfaction were recorded.Patients in the lidocaine group experienced significantly lower pain scores after surgery at 6 hours (P = 0.005) and 12 hours (P = 0.001) at rest, and in the first 18 hours during mobilization (P < 0.05), with less paracetamol (P = 0.04) and meperidine (P = 0.02

2019 EvidenceUpdates

142. Opioids for agitation in dementia. (Abstract)

Improvement Group Specialized Register, on 13 June 2014 using the terms: narcotic OR opioid OR opium OR morphine OR buprenorphine OR codeine OR dextromoramide OR diphenoxylate OR dipipanone OR dextropropoxyphene OR propoxyphene OR diamorphine OR dihydrocodeine OR alfentanil OR fentanyl OR remifentanil OR meptazinol OR methadone OR nalbuphine OR oxycodone OR papaveretum OR pentazocine OR meperidine OR pethidine OR phenazocine OR hydrocodone OR hydromorphone OR levorphanol OR oxymorphone OR butorphanol

2015 Cochrane

143. Eptifibatide Accord

compatibility of Eptifibatide Accord when administered through an intravenous line with atropine sulfate, dobutamine, heparin, lidocaine, meperidine, metoprolol, midazolam, morphine, nitroglycerin, tissue plasminogen activator, or verapamil, is considered acceptable as well. Eptifibatide Accord is packaged in Type I glass containers with butyl rubber stoppers. The Type I glass complies with Ph. Eur. requirements. The stopper complies with Ph. Eur. requirements and appropriate compatibility studies have been

2016 European Medicines Agency - EPARs

144. Nitrous Oxide Use for Labor Pain Management

of women using 50% N2O/50% oxygen to epidural anesthesia. It found that 7% of the N2O group had Apgar scores less than or equal to seven at one minute after birth compared to 6% of infants of women who used epidurals. At five minutes, the proportions with low Apgar scores were 1% and 4%, respectively (p values not reported). There was a statistically significant finding in one study of lower arterial cord blood gasses among infants of primiparous women who used N2O plus meperidine (a parenteral opioid (...) ) compared to those who used an epidural (pH 7.21 vs. pH 7.29, p<0.01). Use of meperidine alone has been associated with lower umbilical cord gasses and so it is not clear whether this finding can be attributed to N2O use or only to use of meperidine. The AHRQ SR was unable to analyze neonatal intensive care unit admission because of the varying definitions of intensive care across countries and lack of reporting of this outcome. Only one study included in the AHRQ SR compared neonatal neurobehavioral

2016 Oregon Health Evidence Review Commission

145. Management of Spontaneous Labour at Term in Healthy Women

options in labour. These may include pharmacological and non-pharmacological measures. (III-A) 9. Each woman should be provided with evidence-based information about labour analgesia options prior to the onset of labour and offered ample opportunity to discuss the risks and benefits of each option available at her planned site of delivery. (III-A) 10. The use of meperidine as labour analgesia should be avoided due to its long-acting active metabolites and negative effects on neonatal behaviours. (II

2016 Society of Obstetricians and Gynaecologists of Canada

146. Management of Infusion Reactions to Systemic Anticancer Therapy: ESMO Clinical Practice Guidelines

severe reaction. [IV, B] Trastuzumab [1, 56, 89, 90] Humanised Anti-HER2 20%–40% on the ?rst infusion. Severe reactions<1%. Chills, fever, blood pressure changes, bronchospasm, itching, dyspnoea, wheez- ing, arrhythmia, angioedema. Loading dose in 90min. Subsequent doses in 30min. Premedication is not recommended. [IV, B] Grade 1/2: stop or slow the infusion rate. Symptomatic treatment. Meperidine for chills and rigours. Grade 3/4: stop the infusion. Aggressive symptomatic treat- ment. After

2017 European Society for Medical Oncology

151. Narcotics, Benzodiazepines, Stimulants, and Gabapentin: Policies, Initiatives, and Practices Across Canada, 2014

to the province’s PRP include, but are not limited to: select narcotic and controlled drugs, such as methadone and hydromorphone amphetamines anabolic steroids barbiturates benzodiazepines buprenorphine chloral hydrate codeine-containing products diethylpropion gabapentin. Increasing reports from law enforcement agencies on the sale and seizure of gabapentin prompted the addition of this substance to the list of monitored drugs. The province also identified safety concerns around meperidine and pentazocine

2015 Canadian Agency for Drugs and Technologies in Health - Environmental Scanning

152. Anaesthetic Agents in Pregnant Women Undergoing Non-Obstetric Surgical or Endoscopic Procedures

was performed during the first trimester of pregnancy. The non- randomized study concluded that regional anaesthesia for laparotomic adnexal mass surgery during pregnancy may be associated with an increased risk of preterm labour. However, it is difficult to elucidate the impact of anaesthesia alone on pregnancy outcomes due to the influence of several confounding factors present in the included studies. One evidence-based guideline was identified that recommends meperidine as the preferred agent (...) and lactating women, including recommendations for the use of analgesics and anaesthetic agents. Based on what was classified as very low quality evidence from “two large studies” otherwise undefined, ASGE recommends meperidine as the preferred agent for procedures on pregnant women requiring moderate sedation. They also recommend that deep sedation should be administered by an anaesthesia provider; however, no guidance on specific agents was included in this recommendation. A general procedural

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

154. The anaesthetist, opioid analgesic drugs, and serotonin toxicity: a mechanistic and clinical review. Full Text available with Trip Pro

The anaesthetist, opioid analgesic drugs, and serotonin toxicity: a mechanistic and clinical review. Most cases of serotonin toxicity are provoked by therapeutic doses of a combination of two or more serotonergic drugs, defined as drugs affecting the serotonin neurotransmitter system. Common serotonergic drugs include many antidepressants, antipsychotics, and opioid analgesics, particularly fentanyl, tramadol, meperidine (pethidine), and methadone, but rarely morphine and other related (...) . Opioids that are good inhibitors of SERT (tramadol, dextromethorphan, methadone, and meperidine) are most frequently associated with serotonin toxicity. Tramadol also has a direct serotonin-releasing action. Fentanyl produces an efflux of serotonin, and binds to 5-hydroxytryptamine (5-HT)1A and 5-HT2A receptors, whilst methadone, meperidine, and more weakly tapentadol, bind to 5-HT2A but not 5-HT1A receptors. The perioperative period is a time where opioids and other serotonergic drugs are frequently

2020 British Journal of Anaesthesia

156. Efficacy of Bispectral Index Monitoring for Midazolam and Meperidine Induced Sedation During Endoscopic Submucosal Dissection

Efficacy of Bispectral Index Monitoring for Midazolam and Meperidine Induced Sedation During Endoscopic Submucosal Dissection Efficacy of Bispectral Index Monitoring for Midazolam and Meperidine Induced Sedation During Endoscopic Submucosal Dissection - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. Efficacy of Bispectral Index Monitoring for Midazolam and Meperidine Induced Sedation During Endoscopic Submucosal Dissection The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01157598 Recruitment Status

2010 Clinical Trials

157. Meperidine Versus Drotaverine Regarding the Effect on the Duration of the First Stage of Labor in Full Term Primigravidae

Meperidine Versus Drotaverine Regarding the Effect on the Duration of the First Stage of Labor in Full Term Primigravidae Meperidine Versus Drotaverine Regarding the Effect on the Duration of the First Stage of Labor in Full Term Primigravidae - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Meperidine Versus Drotaverine Regarding the Effect on the Duration of the First Stage of Labor in Full Term Primigravidae The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01236651 Recruitment Status : Unknown Verified

2010 Clinical Trials

158. Synthesis and Structure-Activity Studies of Benzyl Ester Meperidine and Normeperidine Derivatives as Selective Serotonin Transporter Ligands Full Text available with Trip Pro

Synthesis and Structure-Activity Studies of Benzyl Ester Meperidine and Normeperidine Derivatives as Selective Serotonin Transporter Ligands A series of benzyl esters of meperidine and normeperidine were synthesized and evaluated for binding affinity at serotonin, dopamine and norepinephrine transporters. The 4-methoxybenzyl ester 8b and 4-nitrobenzyl ester 8c in the meperidine series and 4-methoxybenzyl ester 14a in the normeperidine series exhibited low nanomolar binding affinities

2010 Bioorganic & medicinal chemistry

159. Efficacy of tramadol vs meperidine in vasoocclusive sickle cell crisis. (Abstract)

Efficacy of tramadol vs meperidine in vasoocclusive sickle cell crisis. Despite progress in management, patients with sickle cell disease who are experiencing acute painful episode are often incompletely treated. We compared meperidine and tramadol with respect to their effects on the hemodynamics and pain relief in patients with sickle cell disease who were admitted to the emergency department with painful crisis. A total of 68 patients with sickle cell disease were randomly assigned (...) to receive either tramadol 1.5 mg/kg (n = 34) or meperidine 1 mg/kg (n = 34). Hemodynamic parameters were recorded at regular intervals after analgesic infusions. Pain intensity and relief were documented by visual analog and pain relief scale, respectively. Sedation level was defined according to Ramsay sedation scale. Both meperidine and tramadol administration resulted in a significant reduction in systolic and diastolic blood pressure after 2 hours (P < .05). Efficacy in pain relief between

2010 American Journal of Emergency Medicine Controlled trial quality: uncertain

160. Obstetric analgesia: a comparison of patient-controlled meperidine, remifentanil, and fentanyl in labour. Full Text available with Trip Pro

Obstetric analgesia: a comparison of patient-controlled meperidine, remifentanil, and fentanyl in labour. To compare the analgesic efficacy of remifentanil with meperidine and fentanyl in a patient-controlled setting (patient-controlled analgesia, PCA).Parturients (n=159) were randomly assigned to receive remifentanil (n=52), meperidine (n=53), or fentanyl (n=54). Pain scores and an observer sedation scores were assessed hourly. Fetal outcome was evaluated with Apgar score, cord blood gas (...) more parturients receiving meperidine crossed over to epidural analgesia. Overall satisfaction scores were higher with remifentanil, but remifentanil produced more sedation and itching. More periods of desaturation (Sa(o(2)) <95%) were observed during administration of remifentanil and fentanyl. There were no significant differences in fetal outcome between the three groups.The efficacy of meperidine, fentanyl, and remifentanil PCA for labour analgesia varied from mild to moderate. Remifentanil PCA

2010 British Journal of Anaesthesia Controlled trial quality: uncertain

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