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Meperidine

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81. Antishivering effects of two different doses of intrathecal meperidine in caesarean section: a prospective randomised blinded study. (PubMed)

Antishivering effects of two different doses of intrathecal meperidine in caesarean section: a prospective randomised blinded study. Shivering causes various adverse disturbances and interferes with monitoring. The optimal dose of intrathecal meperidine to prevent shivering without producing other side-effects remains unknown. This prospective randomised double-blinded study was conducted to compare the antishivering effects of two different doses of intrathecal meperidine.Seventy two (...) parturients, scheduled for elective caesarean section under spinal anaesthesia, were enrolled in three different groups. Spinal anaesthesia consisted of bupivacaine 0.5% (10 mg) for the control group (M0), and the same dose of bupivacaine with meperidine 12.5 or 25 mg for the experimental groups (M1, M2). Blood pressure, heart rate, skin and core temperatures, sensory level, capnometry, pulse oximetry, Apgar scores, shivering intensity and intrathecal opioid-related side-effects were evaluated

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2011 European Journal of Anaesthesiology

82. Efficacy of Bispectral Index Monitoring for Midazolam and Meperidine Induced Sedation during Endoscopic Submucosal Dissection: A Prospective, Randomized Controlled Study. (PubMed)

Efficacy of Bispectral Index Monitoring for Midazolam and Meperidine Induced Sedation during Endoscopic Submucosal Dissection: A Prospective, Randomized Controlled Study. Propofol induced sedation with bispectral index (BIS) monitoring has been reported to lead to higher satisfaction in patients and endoscopists during endoscopic submucosal dissection (ESD) procedures. There are no data, however, regarding the efficacy of midazolam and meperidine (M/M) induced sedation with BIS monitoring (...) between the BIS and non-BIS groups (92.3±16.3 vs 93.3±15.5, p=0.53) or endoscopists (83.1±15.4 vs 80.0±16.7, p=0.52). Although the mean meperidine dose did not differ (62.5±27.6 vs 51.0±17.3, p=0.18) between the two groups, the mean dose of midazolam in the non-BIS group was lower than in the BIS group (6.8±2.0 vs 5.4±2.1, p=0.01).BIS monitoring during ESD did not increase the satisfaction of endoscopists or patients and did not lead to an M/M dose reduction. These results demonstrate that BIS

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2011 Gut and liver

83. Preemptive peritonsillar ketamine infiltration: postoperative analgesic efficacy versus meperidine. (PubMed)

Preemptive peritonsillar ketamine infiltration: postoperative analgesic efficacy versus meperidine. The current study was planned to assess post-tonsillectomy analgesic efficacy of pre-emptive peritonsillar ketamine infiltration with or without bupivacaine in comparison to meperidine alone or in combination with bupivacaine.The study included 100 patients with mean age of 10.5 +/- 2.3 years assigned for adenotonsillectomy. Patients were randomly allocated into 4 groups (n = 25): Group K1 (...) : received peritonsillar infiltration of ketamine (0.5 mg/kg), Group M1: received peritonsillar infiltration ofmeperidine (1 mg/kg), and groups K2 and M2 received either ketamine (0.5 mg/kg) or meperidine (1 mg/kg) in combination with bupivacaine (5 mg/ml). All medications were prepared as 2 ml in volume and were applied as 1 ml per tonsil 3 min prior to tonsillectomy. On admission to the post-anesthesia care unit (PACU) pain was assessed using the objective pain scale (OPS) score which evaluates 5

2011 Middle East journal of anesthesiology

84. Ondansetron and meperidine prevent postoperative shivering after general anesthesia. (PubMed)

Ondansetron and meperidine prevent postoperative shivering after general anesthesia. Postoperative shivering is one of the common problems following general anesthesia and may lead to multiple complications. The aim of this study was to examine the preventive effects of Ondansetron and Meperidine on postoperative shivering.This randomized placebo-controlled double blind clinical trial included 90 patients scheduled for elective gynecologic operations, randomly divided to three groups (...) . Ondansetron (4 mg), Meperidine (0.4 mg/kg) and 2 cc normal saline (as a control group) were administered immediately before the induction of anesthesia. Anesthesia induced equivalently for all. Patients were observed in terms of vital signs, side effects and shivering.Postoperative shivering was observed in 13.3% of patients in Ondansetron group and 20% of Meperidine group, significantly lower than the controls (50%). The reduction of core and dermal temperature during the anesthesia and recovery, changes

2011 Middle East journal of anesthesiology

85. Comparison of prophylactic use of meperidine and two low doses of ketamine for prevention of post-anesthetic shivering: A randomized double-blind placebo controlled trial. (PubMed)

Comparison of prophylactic use of meperidine and two low doses of ketamine for prevention of post-anesthetic shivering: A randomized double-blind placebo controlled trial. Postanesthetic shivering is one of the most common complications of anesthesia. We compared the efficacy of meperidine and two low doses of ketamine with placebo to prevent postanesthetic shivering after general anesthesia.This was a prospective, randomized double-blind placebo controlled clinical trial involving 120 ASA I-II (...) patients aging 20-50 years, undergoing endoscopic sinus surgery with general anesthesia. Patients were randomly allocated to receive meperidine 0.4 mg/kg (Group M, n = 30), ketamine 0.3 mg/kg (Group K(1), n = 30), ketamine 0.5 mg/kg (Group K(2), n = 30), or normal saline (Group N, n = 30) 20 minutes before completion of the surgery. Tympanic temperature, blood pressure, and heart rate were measured before and immediately after induction of anesthesia, 30 minutes after induction, and before

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2011 Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

86. Is Meperidine the Drug That Just Won't Die? (PubMed)

Is Meperidine the Drug That Just Won't Die? 22479158 2012 08 23 2018 11 13 2331-348X 16 3 2011 Jul The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG J Pediatr Pharmacol Ther Is Meperidine the Drug That Just Won't Die? 167-9 10.5863/1551-6776-16.3.167 Buck Marcia L ML Department of Pharmacy Services, University of Virginia Children's Hospital, Charlottesville, Virginia, and Department of Pediatrics, School of Medicine, University of Virginia (...) , Charlottesville, Virginia. eng Journal Article United States J Pediatr Pharmacol Ther 101089851 1551-6776 adverse drug effect formulary hospital meperidine 2012 4 6 6 0 2012 4 6 6 0 2012 4 6 6 1 ppublish 22479158 10.5863/1551-6776-16.3.167 PMC3292527 J Pediatr Pharmacol Ther. 2011 Jul;16(3):185-90 22479160 Pharmacotherapy. 2004 Jun;24(6):776-83 15222668 Clin Pharm. 1990 May;9(5):337-8 2350937 Pediatrics. 2001 Sep;108(3):793-7 11533354 Anesth Analg. 2000 Feb;90(2):299-305 10648310 Am J Ther. 2002 Jan-Feb;9(1

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2011 The Journal of Pediatric Pharmacology and Therapeutics : JPPT

87. Meperidine Restriction in a Pediatric Hospital (PubMed)

Meperidine Restriction in a Pediatric Hospital Much has been published revealing concerns surrounding the use of meperidine due to associated toxicities, drug interactions, and lack of proven efficacy. Thus, many adult institutions have chosen to remove or limit the use of this agent, while little has been published about the restriction of meperidine in pediatrics. Many clinicians feel there are still clinical situations in which this agent may be useful.To describe methods taken (...) in a pediatric hospital to restrict the use of meperidine and review literature describing uses of meperidine as a second-line agent.In our pediatric institution, a policy to restrict the use of meperidine was developed, approved, and implemented. An assessment of meperidine's use 6 months prior to policy implementation was done, along with a postinitiation review of use.Data revealed that the use of meperidine dropped from 646 doses in 84 patients to 226 doses in 27 patients after restriction

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2011 The Journal of Pediatric Pharmacology and Therapeutics : JPPT

88. Double-blind comparison of butorphanol and meperidine in the treatment of post-surgical pain. (PubMed)

Double-blind comparison of butorphanol and meperidine in the treatment of post-surgical pain. 357232 1978 11 18 2017 02 14 0300-0605 6 4 1978 The Journal of international medical research J. Int. Med. Res. Double-blind comparison of butorphanol and meperidine in the treatment of post-surgical pain. 306-11 Stehling L C LC Zauder H L HL eng Clinical Trial Comparative Study Controlled Clinical Trial Journal Article Randomized Controlled Trial England J Int Med Res 0346411 0300-0605 0 Morphinans (...) 9E338QE28F Meperidine QV897JC36D Butorphanol IM Butorphanol adverse effects therapeutic use Clinical Trials as Topic Double-Blind Method Humans Meperidine adverse effects therapeutic use Morphinans therapeutic use Pain, Postoperative drug therapy 1978 1 1 1978 1 1 0 1 1978 1 1 0 0 ppublish 357232 10.1177/030006057800600408

1978 The Journal of international medical research

89. Two mechanisms for the meperidine block of action potential production in frog's skeletal muscle; non-specific and opiate drug receptor mediated blockade. (PubMed)

Two mechanisms for the meperidine block of action potential production in frog's skeletal muscle; non-specific and opiate drug receptor mediated blockade. The effects of meperidine and naloxone, and their interaction effects on action potential production in frog's sartorius muscle fibres, were studied with intracellular micro-electrode techniques. 1. Meperidine, a narcotic analgesic drug, depressed the rate of rise, the rate of fall and the amplitude of the action potentials. 2 (...) . At a meperidine concentration of 0-35 mM, the depression in the action potential maximum rate of rise followed a diphasic time course. At first there was a rapid reduction in the maximum rate of rise which was levelling off at about 60% of control 60-90 min after drug application. This was followed by the second phase during which there was an initial rapid decrease in the maximum rate of rise and all surface fibres were inexcitable by 180 min. 3. The addition of naloxone, a narcotic antagonist, in low

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1975 The Journal of physiology

90. Meperidine Idiosyncrasy (PubMed)

Meperidine Idiosyncrasy 19599069 2009 07 30 2009 07 30 12 9 1965 Nov Journal of the American Dental Society of Anesthesiology J Am Dent Soc Anesthesiol Meperidine Idiosyncrasy. 286 eng Journal Article United States J Am Dent Soc Anesthesiol 7505572 2009 7 15 9 0 1965 11 1 0 0 1965 11 1 0 1 ppublish 19599069 PMC2033287

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1965 Journal of the American Dental Society of Anesthesiology

91. Promazine and Meperidine (Sparidol 50), an Efficient Combination for Preoperative Medication (PubMed)

Promazine and Meperidine (Sparidol 50), an Efficient Combination for Preoperative Medication A number of elderly patients undergoing intraocular surgery were premedicated with a combination of promazine 50 mg. and meperidine 50 mg. Superior sedation and a smoother postoperative course were noted as compared to a control group premedicated with the usual high dosages of opiates and barbiturates. The incidence of nausea and vomiting, urinary retention, and postoperative disorientation was less

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1964 Canadian Medical Association Journal

92. An evaluation of the analgesic activity of meperidine and fentanyl. (PubMed)

An evaluation of the analgesic activity of meperidine and fentanyl. 4513853 1973 08 09 2018 11 13 0003-3006 20 3 1973 May-Jun Anesthesia progress Anesth Prog An evaluation of the analgesic activity of meperidine and fentanyl. 72-5 Allen G D GD Meyer R A RA eng Journal Article United States Anesth Prog 0043533 0003-3006 9E338QE28F Meperidine UF599785JZ Fentanyl D Analgesia Fentanyl pharmacology Meperidine pharmacology Pain prevention & control 1973 5 1 1973 5 1 0 1 1973 5 1 0 0 ppublish 4513853

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1973 Anesthesia progress

93. Paradoxical reaction to intravenous pentobarbital, meperidine and scopolamine. (PubMed)

Paradoxical reaction to intravenous pentobarbital, meperidine and scopolamine. 4525975 1974 09 03 2018 11 30 0003-3006 21 3 1974 May-Jun Anesthesia progress Anesth Prog Paradoxical reaction to intravenous pentobarbital, meperidine and scopolamine. 82-3 Hayden J J Jr Byrd B C BC Bunch F L FL eng Journal Article United States Anesth Prog 0043533 0003-3006 9E338QE28F Meperidine DL48G20X8X Scopolamine I4744080IR Pentobarbital K50XQU1029 Nitrous Oxide D Analgesia Injections, Intravenous Meperidine

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1974 Anesthesia progress

94. Letter: Psychotic symptoms due to meperidine intoxication. (PubMed)

Letter: Psychotic symptoms due to meperidine intoxication. 4834427 1974 08 23 2013 11 21 0008-4409 110 11 1974 Jun 08 Canadian Medical Association journal Can Med Assoc J Letter: Psychotic symptoms due to meperidine intoxication. 1237 MacVicar A A AA eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 9E338QE28F Meperidine U42B7VYA4P Chlorpromazine AIM IM Adult Aged Chlorpromazine therapeutic use Humans Meperidine adverse effects Middle Aged Psychoses, Substance-Induced drug therapy

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1974 Canadian Medical Association Journal

95. Comparative effects of morphine, meperidine and pentazocine on cardiocirculatory dynamics in patients with acute myocardial infarction. (PubMed)

Comparative effects of morphine, meperidine and pentazocine on cardiocirculatory dynamics in patients with acute myocardial infarction. The cardiocirculatory effects of the commonly used parenteral analgesics, morphine sulfate 15 mg, meperidine hydrochloride 100 mg and pentazocine 60 mg, each administered intravenously, were compared in 12 patients with acute myocardial infarction during cardiac catheterization and by echocardiogram. No untoward hemodynamic effects occurred following (...) the administration of morphine or meperidine. In contrast, pentazocine produced significant (p less than 0.01 to less than 0.05) increases in systemic and pulmonary arterial pressures, left ventricular filling pressure, systemic vascular resistance, and systolic and diastolic dimensions; and decreases in left ventricular ejection fraction and mean velocity of circumferential fiber shortening. These deleterious actions of pentazocine appeared due to peripheral vasoconstriction and negative inotropic properties

1976 The American journal of medicine

96. Double-blind comparison of butorphanol tartrate and meperidine hydrochloride in balanced anaesthesia. (PubMed)

Double-blind comparison of butorphanol tartrate and meperidine hydrochloride in balanced anaesthesia. Butorphanol tartrate, a synthetic morphinan which has analgesic agonist and antagonist properties, was compared with meperidine for balanced anaesthesia. The two agents were found to be comparable in efficacy, maintenance of cardiovascular stability, and incidence of side-effects. Butorphanol has the advantage of being non-narcotic and having a lower propensity for addiction. Because of its

1978 The Journal of international medical research

97. Double-blind comparison of maternal analgesia and neonatal neurobehaviour following intravenous butorphanol and meperidine. (PubMed)

Double-blind comparison of maternal analgesia and neonatal neurobehaviour following intravenous butorphanol and meperidine. Butorphanol (1 mg and 2 mg) and meperidine (40 mg and 80 mg), given intravenously, were evaluated for analgesic efficacy and safety in a double-blind randomized study employing 200 consenting pre-partum patients in moderate to severe pain during the late first stage of labour. Both drugs provided adequate relief of pain to the mothers. There was no significant difference (...) in the rate of cervical dilation, the foetal heart rate, the Apgar score, pain relief or neonatal neurobehavioural scores betweeen those receiving butorphanol and those receiving meperidine. Twenty-two mothers who received butorphanol and eleven who received meperidine nursed their infants with no adverse effects observed. Side-effects were generally infrequent in this study; however, more side-effects were reported by the patients and observed by the investigator in the meperidine-treated cases (13

1979 The Journal of international medical research

98. Pre-endoscopic medication. A randomized double-blind trial of atropine and meperidine as a supplement to diazepam. (PubMed)

Pre-endoscopic medication. A randomized double-blind trial of atropine and meperidine as a supplement to diazepam. The effects of an intramuscular injection of atropine (0.6 mg) and meperidine (1 mg/kg body weight) 30 min before topical benzocaine and intravenous diazepam administration were compared with those of a control group that received only benzocaine and intravenous diazepam in a randomized double-blind controlled trial of premedication for upper gastrointestinal endoscopy in 100 (...) consecutive patients. Atropine and meperidine decreased the amount of salivation and gastric secretion (p less than 0.001 and p less than 0.001, respectively) and increased the period of sedation (p less than 0.001). The patients' and examiners' evaluation of the procedure was the same with either premedication regimen. Neither regimen affected the success rate of the endoscopy. Regardless of the regimen used, every patient who underwent endoscopy stated that they would consent to another examination

1979 Scandinavian journal of gastroenterology

99. Butorphanol and meperidine compared in patients with acute ureteral colic. (PubMed)

Butorphanol and meperidine compared in patients with acute ureteral colic. Pain relief was evaluated in 81 patients with acute ureteral colic and the confirmed presence of a calculus. A randomized double-blind comparison of intramuscular 2 and 4 mg. butorphanol and 80 mg. meperidine was used. Pain intensity and pain relief were evaluated at half hour and hourly intervals for 4 hours. A 2 mg. dose of butorphanol was found to be analgesically equivalent to 80 mg. meperidine, while a 4 mg. dose (...) of butorphanol was found to be more effective than 80 mg. meperidine and 2 mg. butorphanol. Each patient received up to 2 doses of analgesic medication when necessary. There was no significant difference in the incidence of side effects among treatments. One patient had visual hallucinations after a 2 mg. dose of butorphanol, possibly owing to its antagonistic activity to significant narcotic experience given previously at another hospital. There was no other evidence of toxicity with butorphanol

1979 The Journal of urology

100. Remifentanil vs. meperidine for patient-controlled analgesia during colonoscopy: a randomized double-blind trial (PubMed)

Remifentanil vs. meperidine for patient-controlled analgesia during colonoscopy: a randomized double-blind trial The aim was to compare patients' and endoscopists' satisfaction in terms of efficacy and safety of remifentanil patient-controlled analgesia (PCA) during colonoscopy with that of a combination of midazolam and meperidine.Sixty patients undergoing colonoscopy were randomly assigned to two groups. All of the patients received midazolam 0.03 mg/kg intravenously for premedication (...) . In the remifentanil group, a bolus dose of remifentanil was given, and a patient-controlled sedation analgesia (PCSA) pump was set to inject further bolus doses with no "lockout" time. Patients in the meperidine group received a bolus of meperidine and sham PCSA. Non-invasive arterial blood pressure, electrocardiography, and pulse oximetry were monitored throughout the study. The Observer's Assessment of Alertness and Sedation Scale (OAA/S) was performed at baseline, every 5 min during, and after colonoscopy

2009 EvidenceUpdates

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