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Meperidine

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41. Comparison of meperidine alone with meperidine plus dexmedetomidine for postoperative patient-controlled analgesia. (PubMed)

Comparison of meperidine alone with meperidine plus dexmedetomidine for postoperative patient-controlled analgesia. To investigate if the addition of dexmedetomidine to meperidine in a patient-controlled analgesia (PCA) device would reduce postoperative meperidine consumption when compared with meperidine alone.Forty patients scheduled for elective abdominal surgery under general anesthesia in Suleyman Demirel University Medical School, Isparta, Turkey between February and September 2006, were (...) randomly allocated into 2 groups. Group I: meperidine 0.25 mg kg-1 intravenous bolus and dexmedetomidine 0.5 mcg kg-1 in 50 ml of saline solution infusion before the end of surgery. Group II: meperidine 0.25 mg kg-1 intravenous bolus and 50 ml of saline solution infusion. In the postanesthesia care unit (PACU) patients in both groups received intravenous meperidine 10 mg with 5-minutes intervals until the patient`s verbal pain score is lower than 2. Patients in both groups received PCA during the 24

2012 Neurosciences (Riyadh, Saudi Arabia)

42. Prophylactic effects of intrathecal Meperidine and intravenous Ondansetron on shivering in patients undergoing lower extremity orthopedic surgery under spinal anesthesia. (PubMed)

Prophylactic effects of intrathecal Meperidine and intravenous Ondansetron on shivering in patients undergoing lower extremity orthopedic surgery under spinal anesthesia. Intraoperative hypothermia is a common problem with anesthesia. Spinal anesthesia, the same as general anesthesia, affects the process of temperature regulation. The aim of this study was to compare the prophylactic effect of intravenous (IV) ondansetron with intrathecal (IT) meperidine on prevention of shivering during spinal (...) anesthesia in patients underwent orthopedic surgery of the lower limb.In this study, 120 patients with American Society of Anesthesiologists physical status I to II, between the ages 16 and 65 were randomized into three groups. Group O and Group M were given IV ondansetron 8 mg and IT meperidine 0.2 mg/kg, before spinal anesthesia, respectively. Group C received IV saline 0.9%. The core and ambient temperatures, the incidence and intensity of shivering, blood pressure, heart rate, and maximum level

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2014 Journal of research in pharmacy practice

43. Addition of intrathecal fentanyl or meperidine to lidocaine and epinephrine for spinal anesthesia in elective cesarean delivery. (PubMed)

Addition of intrathecal fentanyl or meperidine to lidocaine and epinephrine for spinal anesthesia in elective cesarean delivery. A common and useful approach to pain management is administration of neuraxial opioids.Whether addition of fentanyl or meperidine to lidocaine and epinephrine for spinal anesthesia in elective cesarean delivery has any effects on duration of postoperative pain.This was a clinical trial, conducted on 195 pregnant women candidates for elective cesarean section. All (...) patients were in ASA classes I, and II aged 17-45 years, and were randomly allocated to three groups named as meperidine (P), fentanyl (F), and placebo (S). In the three groups (P, F, and S), 25 mg meperidine, 25 µg fentanyl and 0.5 mL saline with lidocaine and epinephrine were injected into the subarachnoid space for spinal anesthesia, respectively. Perioperative complications and Apgar scores were recorded. Duration of analgesia was measured from the end of operation for 24 hours by using VAS

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2014 Anesthesiology and pain medicine

44. The safety of propofol infusion compared to midazolam and meperidine intravenous bolus for patients undergoing double balloon enteroscopy. (PubMed)

The safety of propofol infusion compared to midazolam and meperidine intravenous bolus for patients undergoing double balloon enteroscopy. The double balloon enteroscopy (DBE) procedure is long and requires moderate sedation. We aim to determine whether the administration of propofol infusion is safe by comparing it to intravenous midazolam/meperidine in patients undergoing DBE.A prospective study with 48 patients was conducted at King Chulalongkorn Hospital randomizing (block of four) patients (...) into two groups. In group 1, 28 patients were enrolled for intravenous midazolam/meperidine, and one patient was dropped out before underwent DBE due to hemodynamic instability. Therefore, 27 (n = 27) participants were included in Group 1. In group 2, 28 patients were enrolled for propofol infusion, and seven patients were dropped out before underwent DBE, five due to hemodynamic instability (n = 5), and two refused treatment (n = 2). Therefore, 1 (n = 21) participants were included in Group 2. Vital

2014 Journal of the Medical Association of Thailand = Chotmaihet thangphaet

45. Meperidine relieves pain during transrectal ultrasound-guided prostate biopsy. (PubMed)

Meperidine relieves pain during transrectal ultrasound-guided prostate biopsy. To compare the efficacy and safety of intramuscular meperidine injection with periprostatic nerve block (PNB) during transrectal ultrasound-guided prostate biopsy.This study was carried out from July 2010 to June 2012 at the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China. This controlled, double-blinded, randomized study included 186 patients. These patients were randomly assigned to 3 (...) treatment groups: PNB by injection 10 minutes prior to the prostate biopsy; intramuscular meperidine injection administered 30 minutes before the biopsy, and a control group (n = 62, each). At the time of ultrasound probe insertion, during biopsy, and 30 minutes after biopsy, patients graded their level of pain on a 10-point visual analog scale (VAS).There was no statistical difference in clinical features of the 3 groups. The patients administered meperidine had the minimum mean VAS score during probe

2014 Saudi medical journal

46. Comparison of ondansetron and meperidine for treatment of postoperative shivering: a randomized controlled clinical trial. (PubMed)

Comparison of ondansetron and meperidine for treatment of postoperative shivering: a randomized controlled clinical trial. The involved neurotransmitter pathways in the postoperative shivering (POS) are poorly understood. Recently, 5-hydroxytryptamine 3 (5-HT3) receptor antagonists have been reported to prevent POS. We investigated the effect of ondansetron, a 5-HT3 antagonist that is used to treat postoperative nausea and vomiting, on shivering.This study aimed to compare the efficacy (...) of ondansetron and meperidine in the treatment of shivering after general anesthesia.In this double-blinded randomized clinical trial, 83 patients (age range, 18-60 years) who had shivering after general anesthesia were randomly allocated to any of these three groups: Group A, (number = 27) received 4 mg of intravenous ondansetron, Group B, (number = 27) received 8 mg of intravenous ondansetron, and Group C, (number = 29) received 0.4 mg/kg of intravenous meperidine at recovery room. The surface temperatures

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2014 Iranian Red Crescent medical journal

47. Intrathecal Meperidine versus intrathecal Fentanyl for prevention of shivering in lower limb orthopedic surgeries under spinal anesthesia: A randomized double-blind placebo-controlled trial. (PubMed)

Intrathecal Meperidine versus intrathecal Fentanyl for prevention of shivering in lower limb orthopedic surgeries under spinal anesthesia: A randomized double-blind placebo-controlled trial. Shivering is an unpleasant sensation for patients who undergoing spinal anesthesia. This randomized double-blind clinical trial study was designed to compare the effect of intrathecal fentanyl with intrathecal meperidine for prevention of shivering in lower limb orthopedic surgeries under spinal (...) anesthesia.Ninety patients were randomly recruited to receive either 3 ml of 0.5% hyperbaric bupivacaine plus 20 μg of fentanyl (Group F), or 3 ml of 0.5% hyperbaric bupivacaine plus 0.2 mg/kg of meperidine (Group M), or 3 ml of 0.5% hyperbaric bupivacaine plus normal saline (Group S). The incidence and intensity of shivering were compared in three groups. Data were analyzed by analysis of variances, Mann-Whitney U-test followed by Chi-square test.There were not statistically differences in complications

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2014 Journal of research in pharmacy practice

48. Cardiopulmonary Safety of Propofol Versus Midazolam/Meperidine Sedation for Colonoscopy: A Prospective, Randomized, Double-Blinded Study (PubMed)

Cardiopulmonary Safety of Propofol Versus Midazolam/Meperidine Sedation for Colonoscopy: A Prospective, Randomized, Double-Blinded Study Different levels of pharmacological sedation ranging from minimal to general anesthesia are often used to increase patient tolerance for a successful colonoscopy. However, sedation increases the risk of respiratory depression and cardiovascular complications during colonoscopy.We aimed to compare the propofol and midazolam/meperidine sedation methods (...) for colonoscopy procedures with respect to cardiopulmonary safety, procedure-related times, and patient satisfaction.This was a prospective, randomized, double-blinded study, in which 124 consecutive patients undergoing elective outpatient diagnostic colonoscopies were divided into propofol and midazolam/meperidine sedation groups (n: 62, m/f ratio: 26/36, mean age: 46 ± 15 for the propofol group; n: 62, m/f ratio: 28/34, mean age: 49 ± 15 for the midazolam/meperidine group) by computer-generated

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2014 Iranian Red Crescent medical journal

49. Study to Determine if the Midazolam-Meperidine-Dexmedetomidine is Superior to the Midazolam-Meperidine for Sedation During ERCP

Study to Determine if the Midazolam-Meperidine-Dexmedetomidine is Superior to the Midazolam-Meperidine for Sedation During ERCP Study to Determine if the Midazolam-Meperidine-Dexmedetomidine is Superior to the Midazolam-Meperidine for Sedation During ERCP - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. Study to Determine if the Midazolam-Meperidine-Dexmedetomidine is Superior to the Midazolam-Meperidine for Sedation During ERCP (DEMMER) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01404689 Recruitment

2011 Clinical Trials

50. The relative efficacy of meperidine for the treatment of acute migraine: a meta-analysis of randomized controlled trials

The relative efficacy of meperidine for the treatment of acute migraine: a meta-analysis of randomized controlled trials The relative efficacy of meperidine for the treatment of acute migraine: a meta-analysis of randomized controlled trials The relative efficacy of meperidine for the treatment of acute migraine: a meta-analysis of randomized controlled trials Friedman B W, Kapoor A, Friedman M S, Hochberg M L, Rowe B H CRD summary The authors concluded that meperidine is less effective (...) for migraine headache than dihydroergotamine regimens and may be more likely to cause adverse events. Meperidine may also be less effective than antiemetics. A degree of caution may be necessary in interpreting these conclusions because the primary trials were small, their quality was mixed and there were marked differences between them. Authors' objectives To compare the efficacy and safety of injectable opioids versus other treatments for acute migraine headache. Searching The following databases were

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2008 DARE.

51. Meperidine as the single sedative agent during esophagogastroduodenoscopy, a double-blind, randomized, controlled study. (PubMed)

Meperidine as the single sedative agent during esophagogastroduodenoscopy, a double-blind, randomized, controlled study. In Taiwan, unsedated esophagogastroduodenoscopy (EGD) is widely used, but it is uncomfortable for some patients. While meperidine has been adopted in colonoscopy, its use in EGD has not received extensive attention. This was a prospective study to investigate the use of meperidine as a single sedative agent during EGD.One hundred and forty patients were randomized to receive (...) either 25-mg meperidine (n = 70) or placebo (n = 70) by intramuscular injection before EGD. The primary outcome was patient discomfort scores. The secondary outcomes included patient, endoscopist, and EGD-related variables.Patients in the meperidine group reported less discomfort during esophageal intubation (median score of 2.0 and interquartile range [IQR] of 0-4.0 vs median score of 4.8 and IQR of 1.7-7.0, respectively; P < 0.001) and during the procedure (median score of 1.0 [IQR 0-3.1] vs 3.5

2013 Journal of gastroenterology and hepatology

52. Efficacy of intramuscular meperidine hydrochloride versus placebo in experimental foot lameness in horses. (PubMed)

Efficacy of intramuscular meperidine hydrochloride versus placebo in experimental foot lameness in horses. There are no peer reviewed, blinded controlled studies regarding the skeletal analgesic efficacy of intramuscularly administered meperidine in horses.Using an adjustable heart bar shoe model of equine foot pain, the objective of this study was to test the hypothesis that meperidine (pethidine) administered intramuscularly would prove more efficacious in alleviating lameness than a saline (...) placebo.Crossover pharmacodynamic experiment.Eight healthy adult Thoroughbred horses randomly underwent weekly i.m. treatments 1 h after lameness induction: saline placebo (1 ml/45 kg bwt) or meperidine hydrochloride (1 mg/kg bwt i.m.). Heart rate (HR) and lameness score (LS) responses were assessed by a blinded observer every 20 min for 5 h after lameness induction and then hourly through 12 h after treatment. Jugular venous blood samples were obtained at -1, 0, 0:05, 1, 2, 4, 6, 8, 10 and 12 h and were

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2013 Equine veterinary journal. Supplement

53. Does dexamethasone prevent subarachnoid meperidin-induced nausea, vomiting and pruritus after cesarean delivery? (PubMed)

Does dexamethasone prevent subarachnoid meperidin-induced nausea, vomiting and pruritus after cesarean delivery? Opioid-induced side effects such as nausea and vomiting and pruritus are common and may be more debilitating than pain itself. We performed a study to assess the efficacy of dexamethasone in reducing postoperative nausea, vomiting, and pruritus in patients receiving neuraxial anesthesia with meperidine.Fifty-two women undergoing cesarean section were enrolled in the study (...) . Pruritus severity was significantly less in the dexamethasone group than in the saline group (P=0.019).Prophylactic dexamethasone does not reduce the incidence of subarachnoid meperidine-induced nausea, vomiting, and pruritus in women undergoing cesarean delivery.

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2013 Saudi journal of anaesthesia

54. Assessing the sedative effect of oral vs submucosal meperidine in pediatric dental patients. (PubMed)

Assessing the sedative effect of oral vs submucosal meperidine in pediatric dental patients. THE GOAL OF THIS INVESTIGATION WAS TO COMPARE THE BEHAVIORAL AND PHYSIOLOGICAL EFFECTS OF THREE SEDATIVE DRUG REGIMENS: oral meperidine (OM), submucosal meperidine (SM) and oral midazolam (M) in healthy pediatric patients.This study sample consisted of thirty children aged 24-72 months (mean = 41.1) exhibiting definitely negative behavior. Three sedative regimens including: Oral meperidine/hydroxyzine (...) , oral midazolam/hydroxyzine and submucosal meperidine/oral hydroxyzine were administered randomly during three consecutive appointments with a crossover design. Houpt behavioral scale was employed for evaluating the sedation effect of each regimen by a calibrated independent Pediatric dentist. Physiologic parameters were also recorded including blood oxygen saturation and pulse rate. Data was analyzed using Wilcoxon-signed ranked test, Mc-Nemar, GEE Logistic regression, Friedman, Fisher exact

2013 Dental research journal

55. Comparison of meperidine and nefopam for prevention of shivering during spinal anesthesia. (PubMed)

Comparison of meperidine and nefopam for prevention of shivering during spinal anesthesia. Shivering is a frequent event during spinal anesthesia and meperidine is a well-known effective drug for prevention and treatment of shivering. Nefopam is a non-opiate analgesic and also known to have an anti-shivering effect. We compared nefopam with meperidine for efficacy of prevention of shivering during spinal anesthesia.Sixty five patients, American Society of Anesthesiologists physical status I (...) or II, aged 20-65 years, scheduled for elective orthopedic surgery under spinal anesthesia were investigated. Patients were randomly divided into two groups, meperidine (Group M, n = 33) and nefopam (Group N, n = 32) groups. Group M and N received meperidine 0.4 mg/kg or nefopam 0.15 mg/kg, respectively, in 100 ml of isotonic saline intravenously. All drugs were infused for 15 minutes by a blinded investigator before spinal anesthesia. Blood pressures, heart rates, body temperatures and side effects

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2013 Korean journal of anesthesiology

56. Intra-Articular Bupivacaine Reduces Postoperative Pain and Meperidine Use After Total Hip Arthroplasty: A Randomized, Double-Blind Study. (PubMed)

Intra-Articular Bupivacaine Reduces Postoperative Pain and Meperidine Use After Total Hip Arthroplasty: A Randomized, Double-Blind Study. One hundred patients receiving unilateral total hip arthroplasty (THA) were randomized to receive an intra-articular injection of 300mg bupivacaine or normal saline after completion of surgery. Pain scores of the bupivacaine group were significantly lower than those of the control group the first 12hours postoperatively (all, P<0.001). A significantly lower (...) dose of meperidine was used in the study group than in the control group the first 24hours postoperatively (median, 25 vs. 45mg, P<0.001). Nineteen patients in the study group required meperidine the first day after surgery, as compared to 45 patients in the control group. We conclude that intra-articular injection of bupivacaine after THA reduces pain and meperidine use in the first 12hours after surgery.Copyright © 2014 Elsevier Inc. All rights reserved.

2013 Journal of Arthroplasty

57. The Effects of Meperidine Analgesia during Labor on Fetal Heart Rate. (PubMed)

The Effects of Meperidine Analgesia during Labor on Fetal Heart Rate. To estimate the effects of intramuscular meperidine analgesia on fetal heart rate (FHR) patterns compared with placebo. In a prospective randomized study, 150 healthy women with singleton term pregnancy requesting analgesia during active labor were planned to receive either intramuscular meperidin 50 mg (meperidin group) or normal saline (control group) when they requested analgesia. Fetal heart rate patterns occurring within (...) 40 minutes of initiation of labor analgesia were retrospectively read by maternal fetal medicine specialist who was blind to type of labor analgesia. Meperidine, compared with placebo, was associated with statistically significantly less beat to beat variability (absent or less than 5 beats per minute) (28% versus 5% of fetuses, P<0.05), lower proportion of accelerations (37.3% versus 17.3% P<0.05) and of the FHR. Also FHR deceleration was significantly more than control group (25.5% versus 4%, P

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2013 International journal of biomedical science : IJBS

58. Intrathecal Meperidine Plus Lidocaine for Prevention of Shivering during Cesarean Section. (PubMed)

Intrathecal Meperidine Plus Lidocaine for Prevention of Shivering during Cesarean Section. Shivering related to spinal anesthesia may interfere with monitoring and is uncomfortable. The aim of the present study was to investigate low-dose intrathecal meperidine for the prevention of shivering after induction of spinal anesthesia in parturients with cesarean section.This was a prospective randomized, double-blind, placebo-controlled trial including 100 parturients, of American Society (...) of Anesthesiologists (ASA) physical status I or II, scheduled for elective cesarean section under spinal anesthesia who were randomly assigned to a meperidine (0.2 mg/kg) plus hyperbaric lidocaine (5%, 75 mg, n = 50; group M) group or a placebo plus hyperbaric lidocaine (5%, 75 mg, n = 50; group L) group. Demographic and surgical data, adverse events, and the mean intensity for each parturient were assessed during the entire study period by a blinded observer.There were no significant differences between the two

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2013 The Korean journal of pain

59. Comparison of the Analgesic Efficacy of Dexketoprofen Trometamol and Meperidine HCl in the Relief of Renal Colic. (PubMed)

Comparison of the Analgesic Efficacy of Dexketoprofen Trometamol and Meperidine HCl in the Relief of Renal Colic. In this study, the analgesic effects of dexketoprofen trometamol and meperidine hydrochloride were compared in patients diagnosed with renal colic. This study was a prospective, randomized, double-blind study. Fifty-two patients, between the ages of 18 and 70 years who were diagnosed with renal colic, were enrolled in the study after obtaining ethics committee approval. Before drug (...) injection, dexketoprofen trometamol and meperidine hydrochloride were placed in closed envelopes, and the patients were randomly given a single dose of intravenous infusion for 20 minutes. Severity of pain and symptoms was evaluated with the numerical rating scale and renal colic symptom score for each patient immediately before administration of drugs and 30 minutes after the end of the application. At the same time, systolic arterial blood pressure, diastolic arterial pressure, respiratory rate, heart

2013 American journal of therapeutics

60. Comparison of effects of epidural bupivacaine and intravenous meperidine analgesia on patient recovery following elective abdominal aortic surgery. (PubMed)

Comparison of effects of epidural bupivacaine and intravenous meperidine analgesia on patient recovery following elective abdominal aortic surgery. The efficacy of epidural anesthesia and analgesia in management of perioperative stress has been established. Perioperative pain management strategies decrease surgical complications and aid recovery. In this study, we aimed to document and compare the efficacy of epidural bupivacaine and intravenous meperidine on recovery of patients with elective (...) abdominal aortic surgery performed under general anesthesia.Patients undergoing elective abdominal aortic surgery between February 2009 and November 2011 were studied prospectively. Patients were randomized into epidural bupivacaine (n=40) and intravenous meperidine (n=40) groups regarding postoperative analgesia strategy. The preoperative demographic characteristics, perioperative outcomes, postoperative adverse effects of analgesia strategy, time to initiate oral intake, sedation scores, visual

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2013 Medical science monitor : international medical journal of experimental and clinical research

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