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Meperidine

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184. Epacadostat and Pembrolizumab in Patients With Head and Neck Cancer That Have Failed Prior Immunotherapy

treatment. Has received prior therapy with an IDO inhibiting agent. Has a known history of Human Immunodeficiency Virus (HIV) (HIV 1/2 antibodies). Has known active Hepatitis B (e.g., HBsAg reactive) or Hepatitis C (e.g., HCV RNA [qualitative] is detected). Has received a live vaccine within 30 days of planned start of study therapy. Has received MAO-inhibitors (MAOI) or drug which has significant MAOI activity (meperidine, linezolid, methylene blue) within the 21 days before screening. History

2018 Clinical Trials

185. A Study of Epacadostat, an IDO1 Inhibitor, in Combination With Pembrolizumab in Patients With Metastatic and/or Locally Advanced Sarcoma

of the trial, starting with the pre-screening or screening visit through 120 days after the last dose of study treatment(s). Inability to comply with protocol required procedures Subjects receiving Monoamine Oxidase Inhibitors (MAOIs) or drug which has significant MAOI activity (meperidine, linezolid, methylene blue) within the 21 days before screening. Any history of Serotonin Syndrome (SS) after receiving serotonergic drugs. History or presence of an abnormal electrocardiogram (ECG

2018 Clinical Trials

186. Wound Infiltration With Ketorolac Versus Lidocaine for Postoperative Analgesia After Total Abdominal Hysterectomy

1, 2, 4, 6, 12, 18 and 24 h later. Patients will be instructed about the usage of VAS scalebefore the operation. The total analgesic consumption [ Time Frame: First 24 hours postoperatively ] Postoperative analgesia will be provided with intramuscular (IM) meperidine 50 mg to both groups when the VAS score is ≥4. The total meperidine consumption will be recorded. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important

2018 Clinical Trials

187. HIgh Dose Thymoglobulin Instead of Cyclosporine With a Low Dose of Thymoglobulin for GVHD Prophylaxis

in >5% difference from calculated dose. Foothills Medical Center Unit 57 standard practice followed for ATG infusion. ATG premeds include methylprednisolone 40 mg IVPB, acetaminophen 1000 mg PO & diphenhydramine 50 mg IVPB. Acetaminophen 1000 mg PO & diphenhydramine 50 mg IVPB can be repeated in 4-6 hrs PRN for flu-like symptoms/fever/chills. Meperidine 25-50 mg IVPB given PRN every 4 hrs for rigors. MTX is given 15 mg/m2 IV on day +1 & 10 mg/m2 on days +3, +6 & +11 posttransplant. First dose

2018 Clinical Trials

188. Ultrasound Guided Bilateral Erector Spinae Plane Block in Retropubic Radical Prostatectomy

routine analgesic protocol will be performed (consist of intravenous analgesics and intravenous patient controlled analgesia) with no additional intervention (block) Standard Pain Followup and Monitorization will be performed. Intervention: Other: Standard Pain Followup and Monitorization Other: Standard Pain Followup and Monitorization Numeric Rating Scale (NRS) pain score will be recorded from 20th minute in recovery room followed by 1.-3.-6.-12.-18.-24.hours. Intravenous meperidine administration (...) at 0.5 mg / kg rescue analgesia was determined in patients with a NSR score of 6 and over in the postoperative collection room. It is planned that the patient will continue to follow the hourly NRS score in ward. Intramuscular diclofenac will be administered in this period if NRS 6 and if it is over, intravenous 0.5 mg / kg meperidine will be administered if NRS score is 6 or more after 2 hours. Salvage analgesic needs and times will be noted in detail, and the use of rescue analgesics, as well

2018 Clinical Trials

189. Shivering prevention and treatment during cesarean delivery under neuraxial anesthesia: a systematic review. (PubMed)

. Intrathecal fentanyl, intrathecal sufentanil, intrathecal meperidine, intravenous ketamine and intravenous tramadol were beneficial for reducing shivering during CSs under NA. MgSO4 administered intrathecally resulted in transient alleviation of shivering, and the effect did not persist. Two trials investigated the antishivering effect of intravenous ondansetron. The medication appeared to be effective in one trial, but ineffective in the other.Appropriate use of dexmedetomidine, fentanyl, sufentanil (...) , ketamine, meperidine, tramadol and MgSO4 may effectively reduce the incidence and severity of shivering during CSs under NA, while trials on the effect of intravenous ondansetron reached inconclusive results.

2018 Minerva anestesiologica

190. Trends in Medical Use of Opioids in the U.S., 2006-2016. (PubMed)

by weight and converted to Morphine Milligram Equivalents. Geospatial and state-level analyses were also completed in 2017.The total for ten opioids peaked in 2011 (389.5 metric tons Morphine Milligram Equivalents) relative to both 2006 (286.1) and 2016 (364.6). Changes in the volume of opioids by weight over the decade were agent specific. Since 2011, there were decreases in hydrocodone (-28.4%); oxymorphone (-28.0%); fentanyl (-21.4%); morphine (-18.9%); oxycodone (-13.8%); and meperidine (-58.0

2018 American journal of preventive medicine

191. Postanaesthetic shivering – from pathophysiology to prevention (PubMed)

shivering exist and most are empiric. Unfortunately, the overall quality of the antishivering guidelines is low. Two main strategies are available: pharmacological and non-pharmacological antishivering methods. The combination of forced-air warming devices and intravenous meperidine is the most validated method. We also analysed different medications but final conclusion about the optimal antishivering medication is difficult to be drawn due to the lack of high-quality evidence. Nevertheless, control

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2018 Romanian Journal of Anaesthesia and Intensive Care

192. Placebo-Controlled, Randomized, SAD Study to Evaluate the Safety, Tolerability, and PK of TBI-223 in Healthy Adults

, sertraline, etc.), bupropion, agents known to prolong the QTc interval (erythromycin, clarithromycin, astemizole, type Ia [quinidine, procainamide, disopyramide] and III [amiodarone, sotalol] anti-arrhythmics, carbamazepine, sulfonylureas, and meperidine). Use of any over-the-counter (OTC) medication, including herbal products and vitamins, within 7 days prior to dosing, except acetaminophen. Up to 3 grams per day of acetaminophen is allowed at the discretion of the Investigator prior to dosing. Use

2018 Clinical Trials

193. Concomitant use of opioid medications with triptans or serotonergic antidepressants in US office-based physician visits (PubMed)

obtained for 2013 and 2014. Physician office visits that included the new or continued prescribing of ≥1 opioid medication with a triptan or an SSRI/SNRI were identified. Co-prescribed opioids were stratified by agent to determine the proportion of co-prescriptions with opioids posing a higher risk of serotonergic agonism (meperidine, tapentadol, and tramadol).Of an annualized mean 903.6 million office-based physician visits in 2013-2014, 17.7 million (2.0% of all US visits) resulted in the prescribing

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2018 Drug, healthcare and patient safety

194. Bilateral Ultrasound-Guided Erector Spinae Plane Block For Postoperative Analgesia in Breast Reduction Surgery

will receive intravenous patient controlled analgesia with morphine, and 1 g acetaminophen for supplemental analgesia if pain score raises over 5/10 on NRS and 50 mg meperidine for rescue analgesic for persistent pain. Interventions: Procedure: Ultrasound guided erector spinae plane block Other: Standard Pain Followup and Monitorization Procedure: Erector spinae plane block Ultrasound guided bilateral erector spinae plane block will be administered. An intravenous patient control analgesia device

2018 Clinical Trials

195. Project 2 Airway Potential Hydrogen (pH) in Asthma

-adrenergic blockers, tricyclic antidepressants, meperidine (or related central nervous system (CNS) agents), or nitrates Inherited or acquired blood coagulation disorder, congenital methemoglobinemia, or a familial hemoglobinopathy that impacts oxygen delivery (e.g., sickle cell) Any illness, condition or recent surgeries that may increase the risks associated with the study Participation in an investigational drug study within the 4 week period prior to screening (Visit 1) Severe Asthma specific

2018 Clinical Trials

196. Pharmacokinetic Study of Linezolid for TB Meningitis

than 3 days before admission History of TBM Current treatment with: MAO inhibitors, direct and indirect acting sympathomimetic drugs, vasopressive drugs, dopaminergic compounds, buspiron, serotonin reuptake inhibitors, tricyclic antidepressants, triptans, tramadol and meperidine History (< 2 weeks before start of linezolid) of taking any MAO inhibitors Pregnant or lactating females Hepatic insufficiency (ALT>5x upper normal limit) Kidney dysfunction (eGFR <50ml/min) Known hypersensitivity

2018 Clinical Trials

197. Comparison of Procedural Sequences in Same-day Painless Bidirectional Endoscopy With Colonoscopic Water Exchange Method

: Patients who < 18 years old, > 80 years old Without standard colon preparation Allergy to meperidine or propofol With a history of partial colectomy Refusal to provide written informed consent American Society of Anesthesiology (ASA) risk Class 3 or higher Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study

2018 Clinical Trials

198. Effect of Granisetron on Morphine Induced Pruritus in Cesarean Section

(meperidine) 1 mg/ kg IM when VAS is greater than 4. Perioperative adverse events [ Time Frame: 24 hours ] Nausea, vomiting, intraoperative shortness of breath and respiratory depression (RR < 8 breaths/ min), and postoperative headache in the first 24 hours postoperatively. Participants' satisfaction after end of the delivery [ Time Frame: 24 hours ] 1) not satisfied or 2) satisfied and willing to take the same medication and procedure in the future when indicated. Eligibility Criteria Go to Information

2018 Clinical Trials

199. Combining rTMS With Varenicline to Prevent Smoking Lapse in Schizophrenia

must meet SCID for DSM-5 diagnosis criteria for schizophrenia must be in stable remission from positive symptoms of psychosis as judged by a PANSS positive score total score <70 must be receiving a stable dose of antipsychotics for >1month. Exclusion Criteria: substance use (except nicotine or caffeine) in the last month a history of alcohol/drug abuse in the 3 months before study enrolment and use of opioids (e.g., meperidine, oxycodone, methadone) current use of smoking cessation aids (e.g

2018 Clinical Trials

200. Comparison of Transversus Abdominis Plane Block and Erector Spinae Plane Block in Inguinal Hernia Repair

will continue to follow the hourly NRS score in ward. Intramuscular diclofenac will be administered in this period if NRS 4 and if it is over, intravenous 0.5 mg / kg meperidine will be administered if NRS score is 4 or more after 2 hours. Salvage analgesic needs and times will be noted in detail, and the use of rescue analgesics, as well as NRS scores at designated hours, will be kept in a statistical evaluation. Active Comparator: TAP Block Ultrasound-guided Transversus abdominis plane (TAP) block (...) and Monitorization will be performed. Other: Standard Pain Followup and Monitorization Numeric Rating Scale (NRS) pain score will be recorded and followed by 0., 1.-3.-6.-12.-18.-24.hours. it is planned that the patient will continue to follow the hourly NRS score in ward. Intramuscular diclofenac will be administered in this period if NRS 4 and if it is over, intravenous 0.5 mg / kg meperidine will be administered if NRS score is 4 or more after 2 hours. Salvage analgesic needs and times will be noted in detail

2018 Clinical Trials

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