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1. Analgesic Efficacy and Adverse Effects of Meperidine in Managing Postoperative or Labor Pain: A Narrative Review of Randomized Controlled Trials

Analgesic Efficacy and Adverse Effects of Meperidine in Managing Postoperative or Labor Pain: A Narrative Review of Randomized Controlled Trials Analgesic Efficacy and Adverse Effects of Meperidine in Managing Postoperative or Labor Pain: A Narrative Review of Randomized Controlled Trials - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily (...) Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Pain Physician Actions . 2020 Mar;23(2):175-201. Analgesic Efficacy and Adverse Effects of Meperidine in Managing Postoperative or Labor Pain: A Narrative Review of Randomized Controlled Trials , Affiliations Expand Affiliation 1 Laboratory and Clinical Research Institute for Pain, Dept of Anesthesiology, The University of Hong Kong. PMID

2020 EvidenceUpdates

2. Patterns of opioid use (codeine, morphine or meperidine) in the Canadian population over time: analysis of the Longitudinal National Population Health Survey 1994-2011. Full Text available with Trip Pro

Patterns of opioid use (codeine, morphine or meperidine) in the Canadian population over time: analysis of the Longitudinal National Population Health Survey 1994-2011. This study aimed to investigate cohort effects in selected opioids use and determine whether cohort differences were associated with changes in risk factors for use over time.This study presents secondary analyses of a longitudinal survey panel of the general population that collected data biannually.Data from the Canadian (...) Longitudinal National Population Health Survey 1994-2011.This study included 12 542 participants from the following birth cohorts: post-World War I (born 1915-1924), pre-World War II (born 1925-1934), World War II (born 1935-1944), Older Baby Boom (born 1945-1954), Younger Baby Boom (born 1955-1964), Older Generation X (born 1965-1974) and Younger Generation X (born 1975-1984).Responses to a single question asking about the use of codeine, morphine or meperidine in the past month (yes/no) were

2019 BMJ open

3. Effect of Intrapleural Meperidine on Post-Operative Pain after Open Cholecystectomy. (Abstract)

Effect of Intrapleural Meperidine on Post-Operative Pain after Open Cholecystectomy. Post-operative pain after open cholecystectomy can result in increased oxygen consumption, atelectasis, pneumonia, decreased vital capacity, and increased morbidity and mortality. The aim of this study was to compare the analgesic effects of intrapleural meperidine and intravenous morphine in controlling post-cholecystectomy pain.In a double-blinded randomized clinical trial, 72 patients who were candidate (...) for elective open cholecystectomy, were divided randomly into two groups based on accidental randomized numbers. Anesthesia technique was precisely the same for all patients. At the end of surgery, 50 mg of meperidine (diluted in 20 cc normal saline) was injected intrapleurally for meperidine group patients; whereas, 0.1 mg/kg intravenous morphine was injected intravenously in control group. Onset of pain and total dose of rescue analgesic were measured.In order to obtain a Numerical Rating Scale (NRS) <3

2019 Tanaffos Controlled trial quality: uncertain

4. Meperidine to Relieve Shivering or Bladder Spasm: Clinical Effectiveness

Meperidine to Relieve Shivering or Bladder Spasm: Clinical Effectiveness Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid responses should (...) study only. It may not be copied, posted on a web site, redistributed by email or stored on an electronic system without the prior written permission of CADTH or applicable copyright owner. Links: This report may contain links to other information available on the websites of third parties on the Internet. CADTH does not have control over the content of such sites. Use of third party sites is governed by the owners’ own terms and conditions. TITLE: Meperidine to Relieve Shivering or Bladder Spasm

2013 Canadian Agency for Drugs and Technologies in Health - Rapid Review

5. Meperidine to relieve shivering or bladder spasm: clinical effectiveness

Meperidine to relieve shivering or bladder spasm: clinical effectiveness Meperidine to relieve shivering or bladder spasm: clinical effectiveness Meperidine to relieve shivering or bladder spasm: clinical effectiveness CADTH Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation CADTH. Meperidine to relieve shivering or bladder spasm: clinical (...) effectiveness. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). Rapid Response - Summary of Abstracts. 2013 Authors' conclusions One randomized controlled trial and one non-randomized study regarding the clinical effectiveness of meperidine for the relief of shivering in adults with brain injury undergoing hypothermia protocol were identified. No literature regarding the clinical effectiveness of meperidine for the relief of bladder spasm in adult patients following urinary catheter

2014 Health Technology Assessment (HTA) Database.

6. Comparison of preemptive effect of intravenous ketorolac versus meperidine on postoperative shivering and pain  in patients undergoing cesarean section under spinal anesthesia: A prospective, randomized, double-blind study. Full Text available with Trip Pro

Comparison of preemptive effect of intravenous ketorolac versus meperidine on postoperative shivering and pain  in patients undergoing cesarean section under spinal anesthesia: A prospective, randomized, double-blind study. Pain and shivering are two unpleasant problems in postoperative period. Various techniques are used to alleviate the postoperative shivering and pain. We compared the preemptive prescription of a single dose of intravenous meperidine and ketorolac on postoperative pain (...) and shivering in patients undergoing cesarean section with spinal anesthesia.One hundred and fifty patients who were scheduled for elective cesarean section under spinal anesthesia were randomly allocated to one of three study groups to receive intravenous ketorolac (group K), meperidine (group M) or normal saline (group P). Time to first analgesic request, analgesic requirement in the first 24 hours after surgery, body tympanic temperature, hemodynamic variables and incidence of shivering were assessed

2018 Caspian journal of internal medicine Controlled trial quality: predicted high

7. Comparison of the effectiveness of dexmedetomidine, meperidine and ketamine in the prevention of postoperative shivering. (Abstract)

Comparison of the effectiveness of dexmedetomidine, meperidine and ketamine in the prevention of postoperative shivering. To compare the prophylactic effectiveness of dexmedetomidine, meperidine, and ketamine for postoperative shivering.A randomized, controlled, double-blind, clinical trial, including 160 patients (ASA I - II) undergoing surgical procedures under general anaesthesia for longer than one hour. They were randomly assigned to four groups to receive a single intravenous dose (...) : Dexmedetomidine 1ug/kg (group A, n=33), meperidine 0.4mg/kg (group B, n=38), ketamine 0.5mg/kg (groupC, n=40), or 0.9% saline solution (group D, n=45), administered 20min before the skin suture. To avoid bias, the anaesthetic induction and maintenance technique, as well as postoperative follow-up was standardised.For any level of shivering, the greatest incidence was observed in the placebo group (47%) (P<.01). The greatest effect on shivering level 3 and 4 occurred in the placebo group (22% and 18

2018 Revista Espanola De Anestesiologia Y Reanimacion Controlled trial quality: predicted high

8. Meperidine for patients expected to have poor tolerance to esophagogastroduodenoscopy: A double-blind, randomized, controlled study Full Text available with Trip Pro

Meperidine for patients expected to have poor tolerance to esophagogastroduodenoscopy: A double-blind, randomized, controlled study Anxious patients and those with poor tolerance to previous esophagogastroduodenoscopy (EGD) usually have poor tolerance for EGD.To investigate the effect of meperidine on these patients during EGD.A total of 110 patients undergoing diagnostic EGD were randomized to receive either meperidine (n = 55) or placebo (n = 55) before EGD. The primary outcome was patient (...) discomfort scores during esophageal intubation.Patients in the meperidine group reported less discomfort during esophageal intubation (median score of 5.0 and interquartile range (IQR) 1.5-7.0) compared with the control (median score of 6.0, IQR 5.0-8.5, P = .003). Patients in the meperidine group had better tolerance during the procedure (median score of 2 (IQR 1.0-3.0) versus 3 (IQR 1.0-4.0), P = .048), and the endoscopists reported higher overall satisfaction scores (median score of 9 (IQR 7.0-9.0

2018 United European gastroenterology journal Controlled trial quality: predicted high

9. A comparison of prophylactic use of meperidine, meperidine plus dexamethasone, and ketamine plus midazolam for preventing of shivering during spinal anesthesia: a randomized, double-blind, placebo-controlled study. (Abstract)

A comparison of prophylactic use of meperidine, meperidine plus dexamethasone, and ketamine plus midazolam for preventing of shivering during spinal anesthesia: a randomized, double-blind, placebo-controlled study. The aim of this study is to compare the efficacy of combination of meperidine and dexamethasone with that of placebo, meperidine alone, and the combination of ketamine and midazolam in preventing shivering during spinal anesthesia.This is a prospective, placebo-controlled study.The (...) setting is at an operating room of a university-based teaching hospital.Two hundred American Society of Anesthesiologists I and II patients undergoing orthopedic and urologic surgery under spinal anesthesia were included.Subarachnoid anesthesia was performed by using 15mg of 0.5% hyperbaric bupivacaine. Patients were randomly allocated to receive saline (placebo, group C), meperidine 0.4mg/kg (group Me), ketamine 0.25mg/kg plus midazolam 37.5μg/kg (group KMi), and meperidine 0.2mg/kg plus

2016 Journal of clinical anesthesia Controlled trial quality: predicted high

10. Famotidine-induced reversal of meperidine-related serotonin syndrome: a case report Full Text available with Trip Pro

Famotidine-induced reversal of meperidine-related serotonin syndrome: a case report Serotonin syndrome is an unexpected fatal adverse event related to serotonergic medication. This case report is the first report describing the possible treatment effect of famotidine on serotonin syndrome. Furthermore, this is the first case report of serotonin syndrome induced by meperidine alone in a patient with no previous history suggesting a susceptibility to serotonin syndrome. A 70-year-old male (...) with no recent history of serotonergic drug use presented with severe serotonin syndrome following ureteroscopy, possibly due to postoperative meperidine administration. The patient's symptoms included hypertension, tachycardia, tachypnea, hyperthermia, myoclonus, diaphoresis, retching, nausea, agitation, and semicoma mentality with no pupillary light reflex. Symptoms began to subside immediately after the administration of intravenous famotidine for prevention of aspiration pneumonia, with mental

2017 Korean journal of anesthesiology

11. Sedation and use of analgesics in endoscopic retrograde cholangiopancreatography: a double-blind comparison study of meperidine/midazolam, remifentanil/ midazolam, and remifentanil alone. (Abstract)

Sedation and use of analgesics in endoscopic retrograde cholangiopancreatography: a double-blind comparison study of meperidine/midazolam, remifentanil/ midazolam, and remifentanil alone. To compare the efficacy and remifentanil with midazolam for conscious sedation during endoscopic retrograde cholangiopancreatography (ERCP).99 patients scheduled for ERCP were randomly allocated to be treated with either meperidine/midazolam (group C, n = 33), remifentanil (group R, n = 33 (...) ), or the remifentanil plus midazolam (group RM, n = 33). In group C, intermittent intravenous meperidine and midazolam were administrated during the procedure; in group R, remifentanil was infused continuously at a rate of 0.2 μg/kg/min for 5 minutes preoperatively, and decreased to 0.15 μg/kg/min when the procedure began; in group RM, midazolam 0.02 mg/kg was administered preoperatively, and remifentanil was administered in the same manner as in group R. Blood pressure, heart rate, respiratory rate, O2

2017 International journal of clinical pharmacology and therapeutics Controlled trial quality: uncertain

12. Shivering Treatment After Cesarean Delivery: Meperidine vs. Dexmedetomidine

Shivering Treatment After Cesarean Delivery: Meperidine vs. Dexmedetomidine Shivering Treatment After Cesarean Delivery: Meperidine vs. Dexmedetomidine - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Shivering Treatment After Cesarean Delivery: Meperidine vs. Dexmedetomidine The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03115047 Recruitment Status : Recruiting First Posted : April 14, 2017 Last Update Posted : June 21

2017 Clinical Trials

13. Comparison of efficacy of meperidine and fentanyl in terms of pain management and quality of life in patients with cervical cancer receiving intracavitary brachytherapy: a double-blind, randomized controlled trial. (Abstract)

Comparison of efficacy of meperidine and fentanyl in terms of pain management and quality of life in patients with cervical cancer receiving intracavitary brachytherapy: a double-blind, randomized controlled trial. The aim of this study was to compare the effectiveness of two sedative regimens, a benzodiazepine with either meperidine or fentanyl, in relieving pain in patients with cervical cancer undergoing intracavitary brachytherapy in terms of pain score and quality of life.Forty unselected (...) outpatients undergoing brachytherapy (160 fractions) were enrolled with informed consent and randomized to receive a benzodiazepine with either meperidine or fentanyl. The perceived pain score according to a standard 10-item numeric rating scale was collected every 15 min during the procedure, and the perceived quality of life was determined at the end of each procedure using the EuroQol five-dimension questionnaire. The patients and medical staff members directly involved with the procedure were blinded

2017 Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer Controlled trial quality: uncertain

14. The Effect of Paracetamol versus Meperidine on Postoperative Pain of Cesarean Section. Full Text available with Trip Pro

The Effect of Paracetamol versus Meperidine on Postoperative Pain of Cesarean Section. Meperidine and paracetamol are frequently used in postoperative pain control. We evaluated the effect of paracetamol versus meperidine on postoperative pain control of elective cesarean section in patients under general anesthesia.In this randomized double-blind study, seventy mothers' candidate for cesarean section under general anesthesia were randomized in paracetamol group (n = 35), received 1 g (...) paracetamol in 100 ml normal saline, and meperidine group (n = 35), received 25 mg meperidine in 100 ml normal saline and then compared regarding the pain and vomiting severity based on visual analog scale (VAS).Two groups did not show significant difference regarding pain score based on VAS during 30 min after surgery in the recovery room, however, the pain score after 30 min in paracetamol group was significantly more than meperidine group. The difference between two groups regarding pain score

2017 Anesthesia, essays and researches Controlled trial quality: uncertain

15. Intrathecal dexamethasone vs. meperidine for prevention of shivering during transurethral prostatectomy: a randomized controlled trial. (Abstract)

Intrathecal dexamethasone vs. meperidine for prevention of shivering during transurethral prostatectomy: a randomized controlled trial. Shivering is a common complication after spinal anesthesia. Also, during transurethral prostatectomy a large amount of irrigating fluids is used which may cause hypothermia and shivering. We hypothesized that intrathecal dexamethasone could effectively attenuate post-spinal shivering following transurethral prostatectomy as intrathecal meperidine.Ninety male (...) patients, ASA II-III, 50-75 years old were included in this prospective and randomized double-blind study. Patients were divided into three equal groups; Group D received 8 mg dexamethasone, Group M received 0.2 mg/kg meperidine, and Group C received 2 ml of normal saline, each in addition to intrathecal hyperbaric bupivacaine 0.5%. Shivering incidence, intensity and recurrence, dose of IV meperidine required to treat shivering, and adverse events were recorded for 150 min after the start of spinal

2017 Acta Anaesthesiologica Scandinavica Controlled trial quality: predicted high

16. Midazolam With Meperidine and Dexmedetomidine vs. Midazolam With Meperidine and Propofol for Sedation During ERCP

Midazolam With Meperidine and Dexmedetomidine vs. Midazolam With Meperidine and Propofol for Sedation During ERCP Midazolam With Meperidine and Dexmedetomidine vs. Midazolam With Meperidine and Propofol for Sedation During ERCP - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Midazolam With Meperidine and Dexmedetomidine vs. Midazolam With Meperidine and Propofol for Sedation During ERCP The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02475824 Recruitment Status : Completed First Posted : June 19, 2015

2015 Clinical Trials

17. Meperidine

Meperidine Meperidine Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Meperidine Meperidine Aka: Meperidine , Demerol From Related (...) over intramuscular No dosing adjustment needed for IV versus IM Dosing frequency is often dosed too infrequently Duration of action is only 3 hours Avoid more than 2-3 doses due to accumulation Often administered with ( ) 25 to 50 mg (0.5 mg/kg) IM q4-6 hours no longer routinely recommended Does not potentiate Meperidine requires intramuscular dosing (sclerosing) Only indicated for Meperidine induced (20%) Consider alternative intravenous Example: Dose only as needed for or VI. Disadvantages Toxic

2018 FP Notebook

18. Midazolam with meperidine and dexmedetomidine vs. midazolam with meperidine for sedation during ERCP: prospective, randomized, double-blinded trial. (Abstract)

Midazolam with meperidine and dexmedetomidine vs. midazolam with meperidine for sedation during ERCP: prospective, randomized, double-blinded trial. The combination of midazolam and opioid has been widely used as a standard sedative regimen for endoscopic retrograde cholangiopancreatography (ERCP). Following recent evidence that dexmedetomidine may exert a synergistic effect in combination with midazolam, this study compared the sedative effect and adverse events of midazolam - meperidine (...)  - dexmedetomidine (MMD) and midazolam - meperidine during ERCP.A total of 110 patients who were scheduled for ERCP were prospectively enrolled and randomly assigned, in a double-blind manner, to the MMD (n = 53) or midazolam - meperidine (n = 57) groups. Each patient received an intravenous (IV) bolus dose of midazolam and meperidine (0.06 mg/kg and 50 mg, 30 % reduction and 25 mg for patients aged ≥ 65 years, respectively). To this dose, a continuous IV infusion of dexmedetomidine (1 μg/kg/h; MMD group

2014 Endoscopy Controlled trial quality: predicted high

19. Infra-Additive Effects of Nefopam and Meperidine on Shivering in Humans Nefopam and Meperidine Are Infra-Additive on the Shivering Threshold in Humans. (Abstract)

Infra-Additive Effects of Nefopam and Meperidine on Shivering in Humans Nefopam and Meperidine Are Infra-Additive on the Shivering Threshold in Humans. Induction of therapeutic hypothermia is often complicated by shivering. Nefopam, a nonsedative benzoxazocine analgesic, reduces the shivering threshold (triggering core temperature) with minimal side effects. Consequently, nefopam is an attractive drug for inducing therapeutic hypothermia. However, nefopam alone is insufficient and thus needs (...) to be combined with another drug. Meperidine also reduces the shivering threshold. We therefore determined whether the combination of nefopam and meperidine is additive, infra-additive, or synergistic on the shivering threshold.Ten volunteers were each studied on 4 randomly assigned days. In random order, they were given the following treatments: (1) control, no drug; (2) nefopam to a target concentration of 0.1 μg/mL; (3) meperidine to a target concentration of 0.1 μg/mL; and (4) both nefopam and meperidine

2014 Anesthesia and Analgesia Controlled trial quality: uncertain

20. Prophylactic Effects of Doxapram, Ketamine and Meperidine in Postoperative Shivering. Full Text available with Trip Pro

Prophylactic Effects of Doxapram, Ketamine and Meperidine in Postoperative Shivering. Postanaesthetic shivering is one of the most common unpleasant complications in patients.The aim of this study was to compare the efficacy of doxapram, ketamine and meperidine in prevention of shivering after anaesthesia.In this randomized, double-blind clinical trial, 120 patients aged between 20 - 45 years old under general anaesthesia were enrolled. The patients were randomly allocated into one of three (...) groups: group M received 20 mg meperidine (n = 40), group K received 0.25 mg/kg ketamine (n = 40) and group D received 0.25 mg/kg doxapram (n = 40). All of the drugs were administered intravenously. The core temperature, shivering, time of the first postoperative analgesic requirement, and some of the other side effects were recorded. Obtained data from the three groups were compared using one-way ANOVA and chi-square test.Three patients (7.5%) of group K, four patients (10%) of group D and one

2016 Anesthesiology and pain medicine Controlled trial quality: uncertain

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