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Menstrual Migraine

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1. Epidemiology and Treatment of Menstrual Migraine and Migraine During Pregnancy and Lactation: A Narrative Review. (Abstract)

Epidemiology and Treatment of Menstrual Migraine and Migraine During Pregnancy and Lactation: A Narrative Review. The peak prevalence of migraine occurs in women of reproductive age, and women experience a higher burden of migraine symptoms and disability compared to men. This increased burden of migraine in women is related to both developmental and temporally variable activational effects of female sex hormones. Changing levels of female sex hormones affect the expression of migraine during (...) pregnancy, and, to a lesser degree, lactation, and are the mechanism underlying menstrual migraine. This review describes the evidence for sex differences in the expression of migraine across the reproductive epoch; reviews the epidemiology of migraine during pregnancy, lactation, and menses; and summarizes the available evidence for safety and efficacy of acute treatments during pregnancy and lactation and for menstrual migraine. Areas of controversy in treatment of migraine during pregnancy, including

2019 Headache

2. Characteristics of menstrual versus non-menstrual migraine during pregnancy: a longitudinal population-based study Full Text available with Trip Pro

Characteristics of menstrual versus non-menstrual migraine during pregnancy: a longitudinal population-based study Migraine is a common headache disorder that affects mostly women. In half of these, migraine is menstrually associated, and ranges from completely asymptomatic to frequent pain throughout pregnancy.The aim of the study was to define the pattern (frequency, intensity, analgesics use) of migrainous headaches among women with and without menstural migraine (MM) during pregnancy (...) , and define how hormonally-related factors affect its intensity.The analysis was based upon data from 280 women, 18.6% of them having a self-reported MM. Women with MM described a higher headache intensity during early pregnancy and postpartum compared those without MM, but both groups showed improvement during the second half of pregnancy and directly after delivery. Hormonal factors and pre-menstrual syndrome had no effect upon headache frequency, but may affect headache intensity.Individual treatment

2018 The journal of headache and pain

3. The NRP1 migraine risk variant shows evidence of association with menstrual migraine Full Text available with Trip Pro

The NRP1 migraine risk variant shows evidence of association with menstrual migraine In 2016, a large meta-analysis brought the number of susceptibility loci for migraine to 38. While sub-type analysis for migraine without aura (MO) and migraine with aura (MA) found some loci showed specificity to MO, the study did not test the loci with respect to other subtypes of migraine. This study aimed to test the hypothesis that single nucleotide polymorphisms (SNPs) robustly associated with migraine (...) are individually or collectively associated with menstrual migraine (MM).Genotyping of migraine susceptibility SNPs was conducted using the Agena MassARRAY platform on DNA samples from 235 women diagnosed with menstrual migraine as per International Classification for Headache Disorders II (ICHD-II) criteria and 140 controls. Alternative genotyping methods including restriction fragment length polymorphism, pyrosequencing and Sanger sequencing were used for validation. Statistical analysis was performed using

2018 The journal of headache and pain

4. Comparison of the Prophylactic Effect Between Acupuncture and Acupressure on Menstrual Migraine: Results of a Pilot Study. Full Text available with Trip Pro

Comparison of the Prophylactic Effect Between Acupuncture and Acupressure on Menstrual Migraine: Results of a Pilot Study. To compare between acupuncture and acupressure for preventing menstrual migraine (MM).MM is one kind of migraine associated with menses in female. It is often associated with increased menstrual distress and disability, leading to decreased daily activity and quality of life. A randomized and controlled pilot study was conducted with three groups: verum acupuncture (VA (...) ) group, acupressure (AP) group, and control acupuncture (CA) group. The study lasted for 7 cycle-months, with a 1 cycle-month baseline observation (T1), a 3 cycle-month intervention (3 times per cycle-month) (T2-T4), and a 3 cycle-month follow-up (T5-T7). Outcome measures were number of migraine days, average and peak pain, total duration period of MM, and percentage of patients with ≥50% reduction in the number of MM days.A total of 18 participants were included in the analysis (VA, n = 7; AP, n = 6

2018 Journal of acupuncture and meridian studies Controlled trial quality: uncertain

5. Understanding Menstrual Migraine. (Abstract)

Understanding Menstrual Migraine. Menstrual-related migraine is very prevalent, very disabling, yet very easy to manage given a good understanding of its cause.This article is intended to help with that understanding and to enable headache specialists to prescribe or create effective hormonal preventives of menstrual-related migraine.© 2018 American Headache Society.

2018 Headache

6. Treatment of menstrual migraine; multidisciplinary or mono-disciplinary approach Full Text available with Trip Pro

Treatment of menstrual migraine; multidisciplinary or mono-disciplinary approach The aim of this study was to compare a multidisciplinary approach of menstrual (related) migraine, combining the neurological and gynaecological consultation, to a mono-disciplinary approach involving neurological treatment. There is a clear relationship between the menstruation cycle and the occurrence of migraine (menstrual migraine). Nowadays the treatment of menstrual (related) migraine is performed (...) by a neurologist. A treatment with attention to hormonal treatment seems more convenient.This retrospective study was performed in a cohort using data of 88 women with menstrual (related) migraine who visited the menstrual migraine clinic between 2012 and 2014 (intervention group). The results were compared to a historical control group, which consisted of women with menstrual (related) migraine who were treated before 2012 and received a mono-disciplinary approach.In the intervention group the Headache Impact

2017 The journal of headache and pain

7. Acupuncture for menstrual migraine: a systematic review

Acupuncture for menstrual migraine: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith

2019 PROSPERO

8. Galcanezumab (migraine) - Benefit assessment according to §35a Social Code Book V

? cannabis/cannabinoids ? non-drug interventions: ? acupuncture ? chiropractic, physiotherapy, TENS or other electrical procedures on the head and neck ? herbs with anti-inflammatory or sympathomimetic effect ? flunarizine ? triptans for the treatment of menstrual migraine: frovatriptan, naratriptan, zolmitriptan ? antidepressants (TCAs, MAO inhibitors, 5HT 2a/2c antagonists, venlafaxine) Permitted pretreatment ? failed migraine prevention with 2x/month d in more than 2 of the last 6 months before (...) : Antiepileptics (divalproex sodium, sodium valproate, topiramate), beta-blockers (metoprolol, propranolol, timolol, atenolol, nadolol), only for the prevention of menstruation-associated migraine: triptans (frovatriptan, naratriptan, zolmitriptan), antidepressants (amitriptyline, venlafaxine). c: Treatment = 2 months in the maximum tolerated dose; lack of response due to lack of tolerability was not rated as treatment failure. d: Study REGAIN: > 3x/months 5-HT: 5-hydroxytryptamine; BSC: best supportive care

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

9. Menstrual Migraine

Menstrual Migraine Menstrual Migraine Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Menstrual Migraine Menstrual Migraine Aka (...) : Menstrual Migraine , Migraine Headache in Women II. Pathophysiology withdrawal precipitates s s often improve in pregnancy III. Symptoms onset 2 days prior to lasts until final day of IV. Associated conditions V. Management: Acute See Most effective agents used to abort Menstrual Migraine s (with current body of evidence) Mefanamic Acid ( tel) VI. Prevention Protocol: Standard See s Protocol: "Mini-Prophylaxis" Start 3 days prior to expected first day Continue until is finished (up to 5-6 days total

2018 FP Notebook

10. Acute Treatments for Migraine

Acute Treatments for Migraine ©Institute for Clinical and Economic Review, 2020 Acute Treatments for Migraine Evidence Report January 10, 2020 Prepared for ©Institute for Clinical and Economic Review, 2020 Page i Evidence Report- Acute Treatments for Migraine ICER Staff and Consultants The University of Illinois at Chicago College of Pharmacy’s Center for Pharmacoepidemiology and Pharmacoeconomic Research* Steven J. Atlas, MD, MPH Associate Professor of Medicine Harvard Medical School, Boston (...) , and the resulting ICER reports do not necessarily represent the views of the UIC. DATE OF PUBLICATION: January 10, 2020 How to cite this document: Atlas S, Touchette D, Agboola F, Lee T, Chapman R, Pearson S D, Rind D M. Acute Treatments for Migraine: Effectiveness and Value. Institute for Clinical and Economic Review, January 8,2020. http://icer-review.org/material/acute-migraine-evidence-report/ Steven Atlas served as the lead author for the report. Foluso Agboola led the systematic review and authorship

2020 California Technology Assessment Forum

11. Acute Treatments for Migraine

Acute Treatments for Migraine ©Institute for Clinical and Economic Review, 2020 Acute Treatments for Migraine Final Evidence Report February 25, 2020 Prepared for ©Institute for Clinical and Economic Review, 2020 Page i Final Evidence Report- Acute Treatments for Migraine ICER Staff and Consultants The University of Illinois at Chicago College of Pharmacy’s Center for Pharmacoepidemiology and Pharmacoeconomic Research* Steven J. Atlas, MD, MPH Associate Professor of Medicine Harvard Medical (...) of the University of Illinois at Chicago College of Pharmacy’s Center for Pharmacoepidemiology and Pharmacoeconomic Research is limited to the development of the cost-effectiveness model, and the resulting ICER reports do not necessarily represent the views of the UIC. DATE OF PUBLICATION: February 25, 2020 How to cite this document: Atlas S, Touchette D, Agboola F, Lee T, Chapman R, Pearson S D, Rind D M. Acute Treatments for Migraine: Effectiveness and Value. Institute for Clinical and Economic Review

2020 California Technology Assessment Forum

12. Pharmacological management of migraine

4.14 Occipital nerve block 19 4.15 Calcitonin gene-related peptide 19 4.16 Menstrual migraine prophylaxis 19 Pharmacological management of migraine Contents5 Medication-overuse headache 21 6 Devices for migraine therapy 23 6.1 Vagus nerve stimulation 23 6.2 Transcutaneous supraorbital nerve stimulation 23 6.3 Transcranial magnetic stimulation 23 7 Provision of information 24 7.1 Publications from SIGN 24 7.2 Sources of further information 24 7.3 Checklist for provision of information to patients 25 (...) in hormone levels during the menstrual cycle, which can be more pronounced at puberty and perimenopause. Before puberty migraine frequency is the same in boys and girls. 11 Following the menopause migraine often improves. 11,12 Migraine is often underdiagnosed, misdiagnosed (eg as sinusitis) and undertreated in both primary and secondary care. 13 In a multicentre primary care-based study more than 90% of patients presenting to primary care with headache had migraine. 14 In recent years there have been

2018 SIGN

13. Non-invasive Vagus Nerve Stimulation (nVNS) as mini-prophylaxis for menstrual/menstrually related migraine: an open-label study Full Text available with Trip Pro

Non-invasive Vagus Nerve Stimulation (nVNS) as mini-prophylaxis for menstrual/menstrually related migraine: an open-label study Menstrual migraine and menstrually related migraine attacks are typically longer, more disabling, and less responsive to medications than non-menstrual attacks. The aim of this study was to evaluate the efficacy, safety, and tolerability of non-invasive vagus nerve stimulation for the prophylactic treatment of menstrual migraine/menstrually related migraine.Fifty-six (...) enrolled subjects (menstrual migraine, 9 %; menstrually related migraine, 91 %), 33 (59 %) of whom were receiving other prophylactic therapies, entered a 12-week baseline period. Fifty-one subjects subsequently entered a 12-week treatment period to receive open-label prophylactic non-invasive vagus nerve stimulation adjunctively (31/51; 61 %) or as monotherapy (20/51; 39 %) on day -3 before estimated onset of menses through day +3 after the end of menses.The number of menstrual migraine/menstrually

2016 The journal of headache and pain

14. Migraine and Tension Headache

-related migraine headache Source: International Headache Society 2013 Episodes of migraine without aura (as defined in Table 1) occurring in the window of 2 days before to 3 days after menstruation, in at least two out of three menstrual cycles. (Menstruation is endometrial bleeding resulting from either the normal menstrual cycle or from the withdrawal of exogenous progestogens, as in the use of combined oral contraceptives or cyclical hormone replacement therapy.) 4 Tension Headache Acute treatment (...) Migraine and Tension Headache ? 2018 Kaiser Foundation Health Plan of Washington. All rights reserved. 1 Migraine and Tension Headache Guideline Background 2 Diagnosis Red flag warning signs 2 Differential diagnosis 2 Imaging 3 Migraine versus tension headache 3 Medication overuse headache 3 Menstruation-related migraine 3 Tension Headache Acute treatment 4 Prophylaxis 5 Migraine Headache Acute treatment 6 Treatment of refractory migraine 7 Prophylaxis 8 Menstruation-related migraine

2018 Kaiser Permanente Clinical Guidelines

15. Migraine

Guideline Background 2 Diagnosis Red flag warning signs 2 Differential diagnosis 2 Imaging 3 Migraine versus tension headache 3 Medication overuse headache 3 Menstruation-related migraine 3 Tension Headache Acute treatment 4 Prophylaxis 5 Migraine Headache Acute treatment 6 Treatment of refractory migraine 7 Prophylaxis 8 Menstruation-related migraine (...) Background This guideline includes diagnosis and treatment of the most common headache types that are managed in primary care: • Tension headache (...) • Migraine headache, including menstrual migraine • Medication overuse headache (also known as rebound headache) Cluster headaches are excluded from this guideline because of their low prevalence in the general population and the severity of the symptoms. For patients with suspected cluster headaches, consider consulting with Neurology for evaluation 2018 11. Migraine in adults: preventive pharmacologic treatments Migraine in adults: preventive pharmacologic treatments Migraine in adults: preventive

2018 Trip Latest and Greatest

16. Menstrual-Cycle and Menstruation Disorders in Episodic vs Chronic Migraine: An Exploratory Study. Full Text available with Trip Pro

Menstrual-Cycle and Menstruation Disorders in Episodic vs Chronic Migraine: An Exploratory Study. Migraine is a chronic condition of recurring moderate-to-severe headaches that affects an estimated 6% of men and 18% of women. The highest prevalence is in those 18-49 years of age, generally when women menstruate. It is divided into episodic and chronic migraine depending on the total number of headache days per month being 14 or less or 15 or more, respectively. Migraine has been associated (...) with menorrhagia, dysmenorrhea, and endometriosis, the latter particularly in chronic migraine.We conducted a questionnaire survey of 96 women with migraine, 18-45 years old, to determine the occurrence of the menstrual-cycle disorders, oligomenorrhea, polymenorrhea, and irregular cycle, and the menstruation disorders, dysmenorrhea and menorrhagia, in episodic vs chronic migraine.The prevalence of menstrual-cycle disorders in general (41.2 vs 22.2%) and dysmenorrhea (51.0 vs 28.9%) was statistically

2015 Pain Medicine

17. Migraine and HRT

Migraine and HRT BRITISH MENOPAUSE SOCIETY T ool for clinicians Information for GPs and other health professionals 1 of 3 Migraine and HRT Introduction Fluctuating estrogen levels and menstrual disorders are associated with increased migraine prevalence during the perimenopause. However, effective management of vasomotor symptoms can also result in improvement in migraine. What are the key points about managing perimenopausal women with migraine? • Perimenopausal women with no history (...) of migraine aura may benefit from continuous combined hormonal contraception until age 50 • Migraine aura does not contraindicate HRT • Use non-oral bio-identical estrogen (patch or gel) • Use the lowest estrogen dose that effectively controls vasomotor symptoms • Where progestogen is required continuous delivery is recommended, with preparations such as: – levonorgestrel intrauterine system – transdermal norethisterone (as in combined patches) – micronised progesterone • Women with migraine and vasomotor

2018 British Menopause Society

18. Menstrual Migraine and Treatment Options: Review. (Abstract)

Menstrual Migraine and Treatment Options: Review. A review of treatment options for menstrual migraine.Migraine affects ∼30 million people in the US. A subset of female migraineurs have migraines that are mainly associated with menstruation. Menstrual migraine (MM) is divided into pure MM and menstrually related migraine. Pure MM attacks occur only with menstruation and have a prevalence of 1%. Menstrually related migraine has a prevalence of 6-7%, and occurs both during menstruation as well (...) as during the rest of the cycle. MM is usually without aura and is more severe, longer lasting, and more resistant to treatment due to the effects of ovarian hormones, specifically estrogen. MM treatment is divided into acute, short-term prophylaxis, and daily prevention. The best-studied acute treatments are triptans. For short-term prophylaxis, triptans, non-triptans, or combinations are used. Some preventive medications may be used daily to prevent MM. Many anti-epileptic medications used in migraine

2016 Headache

19. Women Living Together Have a Higher Frequency of Menstrual Migraine. (Abstract)

. After binary logistic regression analysis, this finding was not related to the main influencing factors detected, that is, use of a contraceptive, test stress, or sleep deprivation (P = .03, adjusted odds ratio: 7.87; 1.23-50.36). These women also showed menstrual cycle synchrony with their roommates (8, 44.4%) and the presence of headache crises during the menstruation of their colleagues (11, 61.1%).The present study detected a higher occurrence of menstrual migraine among women who lived together (...) Women Living Together Have a Higher Frequency of Menstrual Migraine. Menstrual migraine is a highly prevalent disorder among adult women, resulting in disability and loss of quality of life. Some studies have reported menstrual cycle synchrony among women living together. No study has reported whether there may also be a higher prevalence of menstrual migraine among these women. Thus, they reported here the prevalence of menstrual migraine in a group of women living together compared

2016 Headache

20. Menstrual migraines: Which options and when? (Abstract)

Menstrual migraines: Which options and when? Would your patient benefit from abortive therapy or prophylactic treatment? And which regimen is likely to provide the best--and safest--relief?

2016 Journal of Family Practice

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