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Menstrual Cycle

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1. The cycling brain: menstrual cycle related fluctuations in hippocampal and fronto-striatal activation and connectivity during cognitive tasks. (PubMed)

The cycling brain: menstrual cycle related fluctuations in hippocampal and fronto-striatal activation and connectivity during cognitive tasks. Estradiol and progesterone vary along the menstrual cycle and exert opposite effects on a variety of neurotransmitter systems. However, few studies have addressed menstrual cycle-dependent changes in the brain. In the present study we investigate menstrual cycle changes in brain activation and connectivity patterns underlying cognition. Thirty-six (...) naturally cycling women underwent functional MRI during two cognitive tasks: spatial navigation and verbal fluency. While no significant performance differences were observed along the menstrual cycle, the changes in brain activation patterns are strikingly similar during both tasks. Irrespective of the task, estradiol boosts hippocampal activation during the pre-ovulatory cycle phase and progesterone boosts fronto-striatal activation during the luteal cycle phase. Connectivity analyses suggest

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2019 Neuropsychopharmacology

2. The effect of the menstrual cycle on dichotic listening. (PubMed)

The effect of the menstrual cycle on dichotic listening. The purpose of this study was to determine the effect of the menstrual cycle on responses to a dichotic listening task. It was hypothesized that participants would exhibit a stronger right ear advantage during the menstrual cycle days when estrogen levels are at their peak. It was also hypothesized that the women not taking oral contraceptives would exhibit greater variations in ear advantage over the course of their menstrual cycle than (...) those taking oral contraceptives. Finally, it was hypothesized that the error response rates would remain similar across different listening conditions and over the menstrual cycle. The participants were 30 women who took oral contraceptives and 15 who did not. They completed nine listening sessions comprised of three dichotic listening tasks: forced-left, forced-right, and open. The data were analyzed using a mixed effects models. The participants exhibited a reduction in right ear responses

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2019 PLoS ONE

3. Voice in different phases of menstrual cycle among naturally cycling women and users of hormonal contraceptives. (PubMed)

Voice in different phases of menstrual cycle among naturally cycling women and users of hormonal contraceptives. Previous studies have shown changes in women's behavior and physical appearance between the non-fertile and fertile phases of the menstrual cycle. It is assumed that these changes are regulated by fluctuations in sex hormone levels across the cycle. Receptors for sex hormones have been found on the vocal folds, suggesting a link between hormone levels and vocal fold function, which (...) might cause changes in voice production. However, attempts to identify changes in voice production across the menstrual cycle have produced mixed results. Therefore, the purpose of this study was to investigate changes in sexually dimorphic vocal characteristics and quality of women's voices in different phases of the cycle and to compare these with users of monophasic hormonal contraception. Voice samples (vowel phonation) of 44 naturally cycling women were obtained in the menstrual, late

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2017 PLoS ONE

4. Induced endometrial trauma (endometrial scratch) in the mid-luteal menstrual cycle phase preceding first cycle IVF/ICSI versus usual IVF/ICSI therapy: study protocol for a randomised controlled trial. (PubMed)

Induced endometrial trauma (endometrial scratch) in the mid-luteal menstrual cycle phase preceding first cycle IVF/ICSI versus usual IVF/ICSI therapy: study protocol for a randomised controlled trial. Endometrial trauma commonly known as endometrial scratch (ES) has been shown to improve pregnancy rates in women with a history of repeated implantation failure undergoing in vitro fertilisation (IVF), with or without intracytoplasmic sperm injection (ICSI). However, the procedure has not yet been (...) fully explored in women having IVF/ICSI for the first time. This study aims to examine the effect of performing an ES in the mid-luteal phase prior to a first-time IVF/ICSI cycle on the chances of achieving a clinical pregnancy and live birth. If ES can influence this success rate, there would be a significant cost saving to the National Health Service through decreasing the number of IVF/ICSI cycles necessary to achieve a pregnancy, increase the practice of single embryo transfer and consequently

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2018 BMJ open

5. A systematic review and meta-analysis of the factors associated with the resumption of the menstrual cycle in females with anorexia nervosa after weight restoration

A systematic review and meta-analysis of the factors associated with the resumption of the menstrual cycle in females with anorexia nervosa after weight restoration Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g

2019 PROSPERO

6. The Response of the Menstrual Cycle to Initiation of Hormonal Therapy in Transgender Men (PubMed)

The Response of the Menstrual Cycle to Initiation of Hormonal Therapy in Transgender Men Purpose: Transition from female to male gender after initiation of hormonal therapy involves both phenotypic and physiological changes. The response to treatment can vary widely from person to person. In this study, we looked at the response of the menstrual cycle after the initiation of testosterone therapy and we wished to determine the time period and dose of testosterone leading to the cessation (...) to moderate testosterone was sufficient in leading to menstrual cessation in the majority of patients by 6 months and nearly all by 1 year. There was individual variability in the time to cessation with little correlation to testosterone dose.

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2017 Transgender health

7. Menstrual cycle impact on thermoregulation during aerobic exercise in the heat in active individuals: a systematic review and meta-analysis

Menstrual cycle impact on thermoregulation during aerobic exercise in the heat in active individuals: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration

2019 PROSPERO

8. Variations in strength-related status across the menstrual cycle in eumenorrheic women: a systematic review and meta-analysis

Variations in strength-related status across the menstrual cycle in eumenorrheic women: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

9. Impact of the menstrual cycle on vascular function in premenopausal women: systematic review and meta-analysis.

Impact of the menstrual cycle on vascular function in premenopausal women: systematic review and meta-analysis. Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

10. Menstruation in Girls and Adolescents: Using the Menstrual Cycle as a Vital Sign

Menstruation in Girls and Adolescents: Using the Menstrual Cycle as a Vital Sign Menstruation in Girls and Adolescents: Using the Menstrual Cycle as a Vital Sign - ACOG Menu ▼ Menstruation in Girls and Adolescents: Using the Menstrual Cycle as a Vital Sign Page Navigation ▼ Number 651, December 2015 (Replaces Committee Opinion 349, November 2006, Reaffirmed 2017) Committee on Adolescent Health Care The American Academy of Pediatrics endorses this document. This document reflects emerging (...) concepts on patient safety and is subject to change. The information should not be construed as dictating an exclusive course of treatment or procedure to be followed. Menstruation in Girls and Adolescents: Using the Menstrual Cycle as a Vital Sign ABSTRACT: Despite variations worldwide and within the U.S. population, median age at menarche has remained relatively stable—between 12 years and 13 years—across well-nourished populations in developed countries. Environmental factors, including

2015 American College of Obstetricians and Gynecologists

11. Women born with very low birth weight have similar menstrual cycle pattern, pregnancy rates and hormone profiles compared with women born at term. (PubMed)

Women born with very low birth weight have similar menstrual cycle pattern, pregnancy rates and hormone profiles compared with women born at term. Individuals born very preterm or with very low birth weight (VLBW) have a reduced likelihood to reproduce according to population-based register studies. Extremely low-birth weight born adults had a lower reproduction rate for both men and women in a follow-up study.To investigate if being born with VLBW is associated with differences (...) in the reproductive health, i.e. age of menarche, menstrual cycle pattern, pregnancy rates and hormone profile compared with women born at term.A prospective long-term follow-up of a cohort of live-born VLBW children and their controls studied repeatedly since birth and now assessed at 26-28 years of age. Of the totally 80 girls enrolled from birth 49 women (24 VLBW women and 25 controls) participated in the current follow-up. The women's anthropometric data and serum hormone levels were analysed.The reproductive

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2019 BMC Women's Health

12. Cyclic Change of Fatty Acid Composition in Meibum During the Menstrual Cycle. (PubMed)

Cyclic Change of Fatty Acid Composition in Meibum During the Menstrual Cycle. To evaluate the fatty acid (FA) composition in the meibum of pre- and postmenopausal women and age-matched men.This prospective study involved 24 healthy subjects; six premenopausal women in their 30s with a regular menstrual cycle (young-female [yF] group), six postmenopausal women in their 60s (elderly-female [eF] group), and 12 age-matched men (i.e., young-male [yM] and elderly-male [eM] groups, respectively (...) ). The menstrual cycle was divided into six phases (phase I-VI). Meibum was obtained from the meibomian gland orifices via a Daviel spoon, and its FA composition was then analyzed via gas chromatography mass spectrometry (GC-MS). Principal component analysis (PCA) was performed on the GC-MS results.The mean FA composition of all subjects was 40% saturated FAs (SFA) and 60% unsaturated FAs (UFAs). The PCA results of all groups indicated two categories (PC1 [77.5%] and PC2 [12.4%]); one consisting of yF-group

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2019 Investigative Ophthalmology & Visual Science

13. Vitamin D metabolites across the menstrual cycle: a systematic review. (PubMed)

Vitamin D metabolites across the menstrual cycle: a systematic review. Accurate estimation of vitamin D status is important for health research and can impact prevention and treatment of deficiency in women of reproductive age. We aimed to assess if blood concentrations of 25-hydroxyvitamin D [25(OH)D] or 1,25-dihydroxyvitamin D [1,25(OH)2D] change across the menstrual cycle.We conducted a systematic search in PubMed, Web of Science, CAB and BIOSIS of literature published until December 2018 (...) in 1,25(OH)2D within the follicular phase, including a 128% increase from day 1 to 15 and a 56% increase from day 0 to 12. Two studies found rises in 1,25(OH)2D concentrations from the follicular to luteal phase of 13 and 26%. Five studies did not find any changes in concentrations of 1,25(OH)2D.No conclusion can be drawn on the pattern of 1,25(OH)2D concentrations across the normal menstrual cycle due to inconsistencies in study findings. Evidence is currently insufficient to assess 25(OH)D

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2019 BMC Women's Health

14. Altered amygdalar volume and functional connectivity in primary dysmenorrhea during the menstrual cycle. (PubMed)

Altered amygdalar volume and functional connectivity in primary dysmenorrhea during the menstrual cycle. Primary dysmenorrhoea (PDM), characterized as menstrual pain without pelvic pathology, is associated with pain-related negative mood and hormone fluctuations. Previous studies strongly supported the link between pain and negative mood in affected individuals; however, it remains largely unknown in patients with PDM.We focused on the effects how spontaneous pain, negative mood and hormone (...) levels played on the central nervous system in 34 PDM women and 33 matched healthy controls across their cycles (periovulatory phase and menstruation phase) by using T1-weighted and functional imaging. Voxel-based morphometry and functional connectivity (FC) analyses were performed to evaluate brain structural and functional changes. Hormone concentrations (oestradiol, progesterone and cortisol) were also obtained.Abnormal state-related GM volume in the amygdala was found between periovulatory

2019 European Journal of Pain

15. Menstrual cycle phase predicts women's hormonal responses to sexual stimuli. (PubMed)

Menstrual cycle phase predicts women's hormonal responses to sexual stimuli. A robust body of research has demonstrated shifts in women's sexual desire and arousal across the menstrual cycle, with heightened desire and arousal coincident with heightened probability of conception (POC), and it is likely that ovarian hormones modulate these shifts. However, studies in which women are exposed to audiovisual sexual stimuli (AVSS) at high POC (mid-follicular) and low POC (luteal) phases have failed (...) to detect significant differences in genital or subjective arousal patterns based on menstrual cycle phase. Here, we tested whether hormonal responsivity to AVSS differs as a function of cycle phase at testing, and whether phase during which participants were first exposed to AVSS influences hormonal responsivity in subsequent test sessions. Twenty-two naturally cycling heterosexual women were exposed to AVSS during the follicular and luteal phases, with phase at first test session counterbalanced

2019 Hormones and behavior Controlled trial quality: uncertain

16. [Acupuncture artificial menstrual cycle method for abnormal uterine bleeding-ovulatory dysfunction (spleen deficiency syndrome)]. (PubMed)

[Acupuncture artificial menstrual cycle method for abnormal uterine bleeding-ovulatory dysfunction (spleen deficiency syndrome)]. To compare the clinical efficacy between acupuncture artificial menstrual cycle method and medication artificial menstrual cycle method for abnormal uterine bleeding-ovulatory (AUB-O) dysfunction (spleen deficiency syndrome).Sixty patients were randomly assigned into an observation group and a control group, 30 cases in each one. 3 cases dropped out (...) in the observation group and 27 cases were included into analysis; 2 cases dropped out in the control group and 28 cases were included into analysis. The patients in the observation group were treated with acupuncture artificial menstrual cycle method. The acupoints were selected according to different stages of menstrual cycle. The acupuncture was given for 30 min per treatment, once every other day; no treatment was given during menstrual period. Xuehai (SP 10), Sanyinjiao (SP 6), Taixi (KI 3), Guanyuan (CV 4

2019 Zhongguo zhen jiu = Chinese acupuncture & moxibustion Controlled trial quality: uncertain

17. Effects of sex and menstrual cycle phase on cardiac response and alpha- amylase levels in psychosocial stress. (PubMed)

Effects of sex and menstrual cycle phase on cardiac response and alpha- amylase levels in psychosocial stress. The impact of sex and the menstrual cycle phase on the autonomic response to psychosocial stress remains controversial. This study explored autonomic nervous system activity through salivary alpha-amylase, heart rate, and heart rate variability responses to the Trier Social Stress Test (TSST) in healthy young people. The sample was composed of 25 men, 26 women in the luteal phase (...) , and 25 women in the follicular phase, from 18 to 25 years of age. Participants were exposed to the TSST or a control condition. The results indicate that women in their follicular phase showed a blunted alpha-amylase response to stress compared to men and women in the luteal phase. In addition, men showed higher sympatho-vagal activity in the stress condition compared to the two groups of women. These results confirm that sex and the menstrual cycle phase are potential modulators of autonomic nervous

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2019 Biological psychology Controlled trial quality: uncertain

18. Effect of Calcium and Vitamin D Supplements as an Adjuvant Therapy to Metformin on Menstrual Cycle Abnormalities, Hormonal Profile, and IGF-1 System in Polycystic Ovary Syndrome Patients: A Randomized, Placebo-Controlled Clinical Trial. (PubMed)

Effect of Calcium and Vitamin D Supplements as an Adjuvant Therapy to Metformin on Menstrual Cycle Abnormalities, Hormonal Profile, and IGF-1 System in Polycystic Ovary Syndrome Patients: A Randomized, Placebo-Controlled Clinical Trial. This study aims to investigate the effect of combining calcium and vitamin D supplements with metformin on menstrual cycle abnormalities, gonadotropins, and IGF-1 system in vitamin D-deficient/insufficient PCOS women.This is a randomized, placebo-controlled (...) -1), and insulin-like growth factor binding protein-1 (IGFBP-1) were detected at the baseline during the early follicular phase of a spontaneous or induced menstrual cycle and after 8 weeks of intervention (except for the final gonadotropins levels which were assayed from samples obtained during the early follicular phase of a spontaneous menstrual cycle).Thirty-four patients (85%) completed the study. After 8 weeks of intervention, calcium and vitamin D co-supplementation led to a significant

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2019 Advances in pharmacological sciences Controlled trial quality: uncertain

19. [The influence of the menstrual cycle on acute and persistent pain after laparoscopic cholecystectomy]. (PubMed)

[The influence of the menstrual cycle on acute and persistent pain after laparoscopic cholecystectomy]. Fluctuations of female sex hormones during menstrual cycle influence pain perception. Endogenous pain inhibition is impaired in follicular phase of menstrual cycle. We tested the primary hypothesis that the women having surgery during their follicular phase have more acute pain and require higher opioids than those in the luteal phase, and secondarily we tested that women who have surgery (...) during their follicular phase have more incisional pain at 3 month postoperatively.127 adult females having laparoscopic cholecystectomy were randomized to have surgery during the luteal or follicular phase of their menstrual cycle. Standardized anesthesia and pain management regimen was given to all patients. Pain and analgesic consumption were evaluated in post-anesthesia care unit and every 4h in the first 24h. Adverse effects were questioned every 4h. Time to oral intake and ambulation were

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2019 Revista brasileira de anestesiologia Controlled trial quality: uncertain

20. Association between irregular menstrual cycles and occupational characteristics among female workers in Korea. (PubMed)

Association between irregular menstrual cycles and occupational characteristics among female workers in Korea. To examine the association between irregular menstrual cycles and occupational characteristics among Korean female workers.We analyzed data on paid female workers from the Korea National Health and Nutrition Examination Survey (KNHANES) V (2010-2012).We evaluated the possible associations between irregular menstrual cycles and work variables (occupational classification, working hours (...) , and shift work) using univariate and multivariate logistic regression analyses. Weighted prevalence was calculated according to each work variable to approximate the Korean population.Irregular menstrual cycles were the most common in women in the 'pink collar' group (16.61%). The frequency of irregular menstrual cycles was 2-fold higher in women working >60 h per week (25.64%) than in those working 20-60 h per week (11.09%). Irregular menstrual cycles were more prevalent in shift workers (15.85%) than

2019 Maturitas

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