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Melasma

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161. Cadherin 11 Involved in Basement Membrane Damage and Dermal Changes in Melasma. Full Text available with Trip Pro

Cadherin 11 Involved in Basement Membrane Damage and Dermal Changes in Melasma. Basement membrane (BM) disruption and dermal changes (elastosis, collagenolysis, vascular ectasia) have been reported in melasma. Although ultraviolet (UV) irradiation can induce these changes, UV is not always necessary for melasma development. Cadherin 11 (CDH11), which is upregulated in some melasma patients, has previously been shown to stimulate melanogenesis. Because CDH11 action requires cell-cell adhesion (...) between fibroblasts and melanocytes, BM disruption in vivo should facilitate this. The aim of this study was to examine whether CDH11 overexpression leads to BM disruption and dermal changes, independent of UV irradiation. Immunohistochemistry/immunofluorescence, real-time PCR, Western blotting, and zymography suggested that BM disruption/dermal changes and related factors were present in the hyperpigmented skin of CDH11-upregulated melasma patients and in CDH11-overexpressing fibroblasts

2015 Acta Dermato-Venereologica

162. Oral Tranexamic Acid with Fluocinolone-Based Triple Combination Cream Versus Fluocinolone-Based Triple Combination Cream Alone in Melasma: An Open Labeled Randomized Comparative Trial. Full Text available with Trip Pro

Oral Tranexamic Acid with Fluocinolone-Based Triple Combination Cream Versus Fluocinolone-Based Triple Combination Cream Alone in Melasma: An Open Labeled Randomized Comparative Trial. Melasma is a common acquired cause of facial hyperpigmentation with no definitive therapy. Tranexamic acid, a plasmin inhibitor, has demonstrated depigmenting properties and combining this oral drug with other modalities of treatment has shown promising results.To compare the efficacy of a combination of oral (...) tranexamic acid and fluocinolone-based triple combination cream with that of fluocinolone-based triple combination cream alone in melasma among Indian patients.40 patients of melasma of either sex attending to dermatology OPD were enrolled in this study. Participants were randomly divided into two groups with 20 patients in each group. Group A patients were asked to apply the cream only and Group B patients received oral tranexamic acid 250 mg twice daily and applied a triple combination cream containing

2015 Indian journal of dermatology Controlled trial quality: uncertain

163. Topical Tranexamic Acid as an Adjuvant Treatment in Melasma: Side-by-Side Comparison Clinical Study. (Abstract)

Topical Tranexamic Acid as an Adjuvant Treatment in Melasma: Side-by-Side Comparison Clinical Study. Tranexamic acid (TNA) is a novel therapeutic agent for hyperpigmented skin disorders. The efficacy and safety of topical TNA in patients with melasma has not been heretofore studied. The main objective of this study is to evaluate the efficacy and safety of topical TNA combined with intense pulsed light (IPL) treatment in Asians with melasma.A randomized, split-face (internally controlled) study (...) was conducted in 15 women who received four monthly sessions of IPL to both sides of the face. Topical TNA or vehicle was applied to a randomly assigned side during and after IPL treatment. Patients were followed up for 12 weeks after completing the IPL treatments. Baseline and follow-up melanin index (MI; measured by Mexameter®, Courage and Khazaka, Cologne, Germany) and modified melasma area and severity index (mMASI) scores were determined.Thirteen subjects completed the study without serious adverse

2015 Journal of Dermatological Treatment Controlled trial quality: uncertain

164. Prevention of melasma relapses with sunscreen combining protection against UV and short wavelengths of visible light: a prospective randomized comparative trial. (Abstract)

Prevention of melasma relapses with sunscreen combining protection against UV and short wavelengths of visible light: a prospective randomized comparative trial. 25443629 2015 02 18 2014 12 16 1097-6787 72 1 2015 Jan Journal of the American Academy of Dermatology J. Am. Acad. Dermatol. Prevention of melasma relapses with sunscreen combining protection against UV and short wavelengths of visible light: a prospective randomized comparative trial. 189-90.e1 10.1016/j.jaad.2014.08.023 S0190-9622(14

2015 Journal of the American Academy of Dermatology Controlled trial quality: uncertain

165. Melasma in a Male Patient due to Estrogen Therapy for Prostate Cancer Full Text available with Trip Pro

Melasma in a Male Patient due to Estrogen Therapy for Prostate Cancer 26719650 2015 12 31 2018 11 13 1013-9087 27 6 2015 Dec Annals of dermatology Ann Dermatol Melasma in a Male Patient due to Estrogen Therapy for Prostate Cancer. 763-4 10.5021/ad.2015.27.6.763 Ogita Azusa A Department of Dermatology, Nippon Medical School Hospital, Tokyo, Japan. Funasaka Yoko Y Department of Dermatology, Nippon Medical School Hospital, Tokyo, Japan. Ansai Shin-Ichi S Department of Dermatology, Nippon Medical

2015 Annals of dermatology

166. The first clinical experience on efficacy of topical flutamide on melasma compared with topical hydroquinone: a randomized clinical trial. Full Text available with Trip Pro

The first clinical experience on efficacy of topical flutamide on melasma compared with topical hydroquinone: a randomized clinical trial. Treatment of melasma is unsatisfactory most of the times. Hormonal role is shown to exist in pathogenesis of the melasma, and sex-hormone related drugs may have an effect on melasma.To investigate efficacy of 1% flutamide cream versus 4% hydroquinone cream on melasma.In a parallel randomized clinical trial, 74 women with melasma were allocated to receive (...) a sunscreen along with 4% hydroquinone cream or 1% flutamide cream. Melasma Area and Severity Index (MASI), mexameter melanin assay, and patient satisfaction were investigated.Mean age of the participants was 33.8 years. Mean length of time suffering from Melasma was 96.3 months. The subjects reported in average 1.1 hours per day of exposure to sunlight. Mean standardized total patient satisfaction score was 28.8 (standard deviation [SD] 17.2) in flutamide group patients versus 18 (SD 15.5) in control

2015 Drug design, development and therapy Controlled trial quality: uncertain

167. Glycolic Acid Peels/Azelaic Acid 20% Cream Combination and Low Potency Triple Combination Lead to Similar Reduction in Melasma Severity in Ethnic Skin: Results of a Randomized Controlled Study Full Text available with Trip Pro

Glycolic Acid Peels/Azelaic Acid 20% Cream Combination and Low Potency Triple Combination Lead to Similar Reduction in Melasma Severity in Ethnic Skin: Results of a Randomized Controlled Study Numerous therapeutic options have been tried in the management of melasma.This prospective randomized study was planned to assess the efficacy of low potency triple combination (TC) cream (TC-hydroquinone 2%/tretinoin 0.05%/fluocinolone 0.01%) versus glycolic acid (GA) peels/azelaic acid (AA) 20% cream (...) (GA/AA) combination in melasma.Forty patients with melasma were recruited into this study and randomized into two groups. Group A consisting 20 patients received TC cream once a day for night time application for 3 months. Group B comprising of 20 patients received GA/AA 20% cream combination for 3 months. The disease severity was monitored with digital photography, melasma area and severity index (MASI) score, which was calculated at baseline, 6 weeks and 12 weeks, and visual analog scale (VAS

2015 Indian journal of dermatology Controlled trial quality: uncertain

168. A Prospective Multi-Center Study Using Laser for the Treatment of Melasma and Lentigines in Asian Skin

A Prospective Multi-Center Study Using Laser for the Treatment of Melasma and Lentigines in Asian Skin A Prospective Multi-Center Study Using Laser for the Treatment of Melasma and Lentigines in Asian Skin - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. A Prospective Multi-Center Study Using Laser for the Treatment of Melasma and Lentigines in Asian Skin The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02385994 Recruitment Status : Completed First Posted : March 11, 2015 Last Update Posted : January 31

2015 Clinical Trials

169. Skin cancers detected as casual findings with Reflectance Confocal Microscopy (RCM) in the assessment of melasma treatment. (Abstract)

Skin cancers detected as casual findings with Reflectance Confocal Microscopy (RCM) in the assessment of melasma treatment. 26264775 2016 09 26 2015 12 28 1365-2133 173 6 2015 Dec The British journal of dermatology Br. J. Dermatol. Skin cancers detected as casual findings with reflectance confocal microscopy in the assessment of melasma treatment. 1553-5 10.1111/bjd.14066 Chavez-Bourgeois M M http://orcid.org/0000-0002-6081-6736 Melanoma Unit, Department of Dermatology, Hospital Clinic

2015 British Journal of Dermatology

170. Copper Bromide Laser vs Triple-Combination Cream for the Treatment of Melasma: A Randomized Clinical Trial. Full Text available with Trip Pro

Copper Bromide Laser vs Triple-Combination Cream for the Treatment of Melasma: A Randomized Clinical Trial. 25715311 2015 09 21 2016 11 25 2168-6084 151 7 2015 Jul JAMA dermatology JAMA Dermatol Copper Bromide Laser vs Triple-Combination Cream for the Treatment of Melasma: A Randomized Clinical Trial. 791-2 10.1001/jamadermatol.2014.5580 Hammami Ghorbel Houda H Department of Dermatology, University Hospital of Nice, Nice, France. Boukari Fériel F Department of Dermatology, University Hospital

2015 JAMA dermatology Controlled trial quality: uncertain

171. Treatment of Melasma With Glycolic Acid-Salicylic Acid Peel Versus Glycolic Acid Peel

Treatment of Melasma With Glycolic Acid-Salicylic Acid Peel Versus Glycolic Acid Peel Treatment of Melasma With Glycolic Acid-Salicylic Acid Peel Versus Glycolic Acid Peel - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Treatment of Melasma With Glycolic Acid-Salicylic Acid Peel Versus Glycolic Acid Peel The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02812719 Recruitment Status : Withdrawn (Study did not receive funding and will not be implemented.) First Posted : June 24, 2016 Last Update Posted : June

2015 Clinical Trials

172. A split face study to document the safety and efficacy of clearance of melasma with a 5 ns q switched Nd YAG laser versus a 50 ns q switched Nd YAG laser. (Abstract)

A split face study to document the safety and efficacy of clearance of melasma with a 5 ns q switched Nd YAG laser versus a 50 ns q switched Nd YAG laser. To determine the safety and efficacy of a 50 ns Q switched Nd YAG laser vs. a 5 ns Q switched Nd YAG laser for clearance of melasma. To compare subject satisfaction, efficacy, and comfort level between the two lasers.This is a prospective, randomized split face clinical study. The study was approved by the Scripps IRB. Ten healthy female (...) subjects with moderate to severe melasma were enrolled. Each subject had three laser treatments one month apart. Patients were followed up approximately 1 month, 3 months, and 6 months after the final laser treatment. A treatment session consisted of a microdermabrasion, 1064 nm QS laser, and topicals. Subjects were asked to rate treatment pain based on a numerical scale range 0-10 (0 = no pain and 10 = worst pain). A melasma area and severity index (MASI) grading system was applied. Also, melanin

2015 Lasers in surgery and medicine Controlled trial quality: uncertain

173. Characteristics of keratinocytes in facial solar lentigo with flattened rete ridges: comparison with melasma. (Abstract)

Characteristics of keratinocytes in facial solar lentigo with flattened rete ridges: comparison with melasma. Flattened rete ridges occurring on the face are not uncommon in solar lentigo (SL).To investigate the morphological changes of keratinocytes in facial SL with flattened rete ridges and melasma.In total, 25 patients with facial SL showing flattened rete ridges and 20 patients with melasma, in which rete ridge flattening is also a common feature, were included in the study. Skin biopsies (...) of keratinocytes in the thickened epidermis. By contrast, melasma samples showed no significant difference in epidermal thickness or keratinocyte morphology in terms of number or size compared with normal skin.These findings suggest that senescent changes in keratinocytes are important in the development of SL, even in the absence of rete ridge elongation, and the removal of keratinocytes harbouring melanin could be a possible strategy for SL treatment.© 2015 British Association of Dermatologists.

2015 Clinical & Experimental Dermatology

174. Treatment of Melasma in Men With Low-Fluence Q-Switched Neodymium-Doped Yttrium-Aluminum-Garnet Laser Versus Combined Laser and Glycolic Acid Peeling. (Abstract)

Treatment of Melasma in Men With Low-Fluence Q-Switched Neodymium-Doped Yttrium-Aluminum-Garnet Laser Versus Combined Laser and Glycolic Acid Peeling. Low-fluence Q-switched neodymium-doped yttrium-aluminum-garnet 1,064-nm laser (LFQS) and glycolic acid (GA) peeling have been reported as a treatment option for melasma. However, there are limited data on their efficacy in men.To compare the efficacy and safety of LFQS monotherapy with combined LFQS and 30% GA peeling in male patients (...) with melasma.Fifteen males with mixed type melasma were randomized to receive 5 weekly sessions of LFQS on one side of the face and LFQS plus 30% GA peeling on the contralateral side and were followed for 12 weeks. Twelve patients completed the protocol.Mean relative lightness index (RL*I) of the combined treatment side was lowered throughout the study period, with the maximal improvement of 52.3% reduction at the fourth week follow-up (p = .023). Patient self-assessment was favorable in the combined treatment

2015 Dermatologic Surgery Controlled trial quality: uncertain

175. Melasma: clinical diagnosis and management options. (Abstract)

Melasma: clinical diagnosis and management options. Melasma is a common acquired disorder of pigmentation most commonly seen in those with skin of colour. It has long been a condition that is frustrating for both the dermatologist and patient to treat. This article provides a review of the literature on melasma and examines, in detail, various treatment options currently available to treat it. © 2015 The Australasian College of Dermatologists.

2015 Australasian Journal of Dermatology

176. Pilot Study of an Automated Method to determine Melasma Area and Severity Index. (Abstract)

Pilot Study of an Automated Method to determine Melasma Area and Severity Index. Objective outcome measures for melasma severity are essential for the evaluation of severity as well as results of treatment. The modified Melasma Area and Severity Index (mMASI) score is a validated tool for assessing melasma severity but is often subject to inter-observer variability.To develop and validate a novel image analysis software designed to automatically calculate the area and degree (...) of hyperpigmentation in melasma from computer image analysis of whole-face digital photographs, thereby deriving an automated mMASI score (aMASI).The algorithm was developed in collaboration between dermatologists and image analysis experts. Firstly, using an adaptive threshold method, the algorithm identifies, segments and calculates the areas involved. It then calculates the darkness. Finally, the derived area and darkness are then used to calculate mMASI. The scores derived from the algorithm are validated

2015 British Journal of Dermatology

177. Changes in nuclear morphology and chromatin texture of basal keratinocytes in melasma. (Abstract)

Changes in nuclear morphology and chromatin texture of basal keratinocytes in melasma. The pathogenesis of melasma and the role of keratinocytes in disease development and maintenance are not completely understood. Dermal abnormalities, the expression of inflammatory mediators, growth factors, epithelial expression of melanocortin and sexual hormones receptors suggest that not only melanocytes, but entire epidermal melanin unit is involved in melasma physiopathology.To compare nuclear (...) morphological features and chromatin texture between basal keratinocytes in facial melasma and adjacent normal skin.We took facial skin biopsies (2 mm melasma and adjacent normal skin) from women processed for haematoxylin and eosin. Thirty non-overlapping basal keratinocyte nuclei were segmented and descriptors of area, highest diameter, perimeter, circularity, pixel intensity, profilometric index (Ra) and fractal dimension were extracted using ImageJ software.Basal keratinocyte nuclei from facial melasma

2015 Journal of the European Academy of Dermatology and Venereology

178. A prospective, split-face, randomized study of the efficacy and safety of a novel fractionated intense pulsed light treatment for melasma in Asians. (Abstract)

A prospective, split-face, randomized study of the efficacy and safety of a novel fractionated intense pulsed light treatment for melasma in Asians. Intense pulsed light (IPL) has been reported to effectively treat melasma in previous studies, but an aggravation of pigmentation was noted. Fractionated IPL is a novel technique in which microsecond-domain fractionated pulses are delivered to the target area.To compare the safety and efficacy of low-fluency, frequently scheduled fractionated IPL (...) and conventional IPL for melasma treatment.This was a 14-week, split-face study in which 30 Asian women were treated with weekly fractionated IPL on one side of the face and biweekly conventional IPL on the other side.The non-inferiority of a weekly fractionated IPL regimen to a biweekly conventional IPL regimen was verified by a lower margin of the 95% confidence interval for the difference in the Melasma Area and Severity Index (MASI) change from baseline of 2.61 for each side. This value was greater than

2015 Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology Controlled trial quality: uncertain

179. Effectiveness of low-fluence and short-pulse intense pulsed light in the treatment of melasma: A randomized study. (Abstract)

Effectiveness of low-fluence and short-pulse intense pulsed light in the treatment of melasma: A randomized study. Various treatment protocols for melasma have been suggested in the literature, but the efficacy and safety of treatment varies according to the report.To investigate the selective photothermolytic effect of fluence-dependent intense pulsed light (IPL) in the treatment of melasma.Twenty Korean adults with melasma were enrolled, randomly assigned to two groups and treated at fluences (...) of 10 or 13 J/cm(2) of IPL weekly over 6 weeks. Subjects were evaluated at baseline and weekly during the 6 weeks of treatment and at 3 weeks following the final treatment. Melanin and erythema indices were scored using a spectrophotometer.The modified Melasma Area Severity Index (MASI) score of 20 patients at inclusion was 11.6 (± 0.9). Both 10J and 13J IPL treatment groups had decreased modified MASI scores from 2 weeks onward at statistically significant levels. Both 10J and 13J IPL treatment

2015 Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology Controlled trial quality: uncertain

180. Pupal melanization is associated with higher fitness in Spodoptera exigua Full Text available with Trip Pro

Pupal melanization is associated with higher fitness in Spodoptera exigua Melanism has long been thought to be a habitat adaptation with a fitness cost. Here we reported a homozygous melanic strain (SEM) of Spodoptera exigua (Hübner) (Insecta: Lepidoptera: Noctuidae) established with black pupae spontaneously occurring within a typical laboratory population (SEW). The melanization is expressed globally, and only in the pupal stage. After pupation, the melanic SEM pupae gradually accumulate (...) melanin to become completely black within 6 hours, whereas the wild-type SEW pupae gradually turn yellow-brown. The melanic SEM strain exhibits faster development in all life stages, heavier pupa weight, more mating time, higher fecundity, and accordingly, higher net reproductive rate and population trend index. While no reproductive isolation was observed between the SEM and SEW strains, the mating times per female of the reciprocal crosses and the SEM intracrosses were significantly higher than

2015 Scientific reports

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