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121. Serum iron level, ferritin and total iron binding capacity level among nonpregnant women with and without melasma (Full text)

Serum iron level, ferritin and total iron binding capacity level among nonpregnant women with and without melasma Melasma is a common acquired disorder characterized by symmetric, hyperpigmented patches with an irregular outline, occurring most commonly on the face. It is most prevalent among young to middle-aged women. Although iron overload affects skin pigmentation, effect of iron deficiency on skin is not clear. So, we evaluated serum iron level, ferritin and total iron binding capacity (...) (TIBC) level among nonpregnant women with and without melasma.A cross-sectional case study was conducted in 2012 at university dermatologic department on 33 nonpregnant women with melasma (case) and 33 nonpregnant women without melasma (control). Serum iron level, TIBC and ferritin in the two groups was measured and compared.Serum iron level was lower in the case group (85 ± 11) in comparison with control group (102 ± 9), but the difference was not significant (P: 0.9). Mean TIBC and Ferritin were

2015 Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences PubMed

122. Changes in Melanin and Melanocytes in Mottled Hypopigmentation after Low-Fluence 1,064-nm Q-Switched Nd:YAG Laser Treatment for Melasma (Full text)

Changes in Melanin and Melanocytes in Mottled Hypopigmentation after Low-Fluence 1,064-nm Q-Switched Nd:YAG Laser Treatment for Melasma 26082600 2015 06 17 2018 11 13 1013-9087 27 3 2015 Jun Annals of dermatology Ann Dermatol Changes in Melanin and Melanocytes in Mottled Hypopigmentation after Low-Fluence 1,064-nm Q-Switched Nd:YAG Laser Treatment for Melasma. 340-2 10.5021/ad.2015.27.3.340 Jang Yong Hyun YH Department of Dermatology, Kyungpook National University School of Medicine, Daegu

2015 Annals of dermatology PubMed

123. Pilot Study of an Automated Method to determine Melasma Area and Severity Index. (PubMed)

Pilot Study of an Automated Method to determine Melasma Area and Severity Index. Objective outcome measures for melasma severity are essential for the evaluation of severity as well as results of treatment. The modified Melasma Area and Severity Index (mMASI) score is a validated tool for assessing melasma severity but is often subject to inter-observer variability.To develop and validate a novel image analysis software designed to automatically calculate the area and degree (...) of hyperpigmentation in melasma from computer image analysis of whole-face digital photographs, thereby deriving an automated mMASI score (aMASI).The algorithm was developed in collaboration between dermatologists and image analysis experts. Firstly, using an adaptive threshold method, the algorithm identifies, segments and calculates the areas involved. It then calculates the darkness. Finally, the derived area and darkness are then used to calculate mMASI. The scores derived from the algorithm are validated

2015 British Journal of Dermatology

124. Characteristics of keratinocytes in facial solar lentigo with flattened rete ridges: comparison with melasma. (PubMed)

Characteristics of keratinocytes in facial solar lentigo with flattened rete ridges: comparison with melasma. Flattened rete ridges occurring on the face are not uncommon in solar lentigo (SL).To investigate the morphological changes of keratinocytes in facial SL with flattened rete ridges and melasma.In total, 25 patients with facial SL showing flattened rete ridges and 20 patients with melasma, in which rete ridge flattening is also a common feature, were included in the study. Skin biopsies (...) of keratinocytes in the thickened epidermis. By contrast, melasma samples showed no significant difference in epidermal thickness or keratinocyte morphology in terms of number or size compared with normal skin.These findings suggest that senescent changes in keratinocytes are important in the development of SL, even in the absence of rete ridge elongation, and the removal of keratinocytes harbouring melanin could be a possible strategy for SL treatment.© 2015 British Association of Dermatologists.

2015 Clinical & Experimental Dermatology

125. Treatment of Melasma in Men With Low-Fluence Q-Switched Neodymium-Doped Yttrium-Aluminum-Garnet Laser Versus Combined Laser and Glycolic Acid Peeling. (Full text)

Treatment of Melasma in Men With Low-Fluence Q-Switched Neodymium-Doped Yttrium-Aluminum-Garnet Laser Versus Combined Laser and Glycolic Acid Peeling. Low-fluence Q-switched neodymium-doped yttrium-aluminum-garnet 1,064-nm laser (LFQS) and glycolic acid (GA) peeling have been reported as a treatment option for melasma. However, there are limited data on their efficacy in men.To compare the efficacy and safety of LFQS monotherapy with combined LFQS and 30% GA peeling in male patients (...) with melasma.Fifteen males with mixed type melasma were randomized to receive 5 weekly sessions of LFQS on one side of the face and LFQS plus 30% GA peeling on the contralateral side and were followed for 12 weeks. Twelve patients completed the protocol.Mean relative lightness index (RL*I) of the combined treatment side was lowered throughout the study period, with the maximal improvement of 52.3% reduction at the fourth week follow-up (p = .023). Patient self-assessment was favorable in the combined treatment

2015 Dermatologic Surgery PubMed

126. Melasma: clinical diagnosis and management options. (PubMed)

Melasma: clinical diagnosis and management options. Melasma is a common acquired disorder of pigmentation most commonly seen in those with skin of colour. It has long been a condition that is frustrating for both the dermatologist and patient to treat. This article provides a review of the literature on melasma and examines, in detail, various treatment options currently available to treat it. © 2015 The Australasian College of Dermatologists.

2015 Australasian Journal of Dermatology

127. A Prospective Multi-Center Study Using Laser for the Treatment of Melasma and Lentigines in Asian Skin

A Prospective Multi-Center Study Using Laser for the Treatment of Melasma and Lentigines in Asian Skin A Prospective Multi-Center Study Using Laser for the Treatment of Melasma and Lentigines in Asian Skin - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. A Prospective Multi-Center Study Using Laser for the Treatment of Melasma and Lentigines in Asian Skin The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02385994 Recruitment Status : Completed First Posted : March 11, 2015 Last Update Posted : January 31

2015 Clinical Trials

128. Changes in nuclear morphology and chromatin texture of basal keratinocytes in melasma. (PubMed)

Changes in nuclear morphology and chromatin texture of basal keratinocytes in melasma. The pathogenesis of melasma and the role of keratinocytes in disease development and maintenance are not completely understood. Dermal abnormalities, the expression of inflammatory mediators, growth factors, epithelial expression of melanocortin and sexual hormones receptors suggest that not only melanocytes, but entire epidermal melanin unit is involved in melasma physiopathology.To compare nuclear (...) morphological features and chromatin texture between basal keratinocytes in facial melasma and adjacent normal skin.We took facial skin biopsies (2 mm melasma and adjacent normal skin) from women processed for haematoxylin and eosin. Thirty non-overlapping basal keratinocyte nuclei were segmented and descriptors of area, highest diameter, perimeter, circularity, pixel intensity, profilometric index (Ra) and fractal dimension were extracted using ImageJ software.Basal keratinocyte nuclei from facial melasma

2015 Journal of the European Academy of Dermatology and Venereology

129. A prospective, split-face, randomized study of the efficacy and safety of a novel fractionated intense pulsed light treatment for melasma in Asians. (PubMed)

A prospective, split-face, randomized study of the efficacy and safety of a novel fractionated intense pulsed light treatment for melasma in Asians. Intense pulsed light (IPL) has been reported to effectively treat melasma in previous studies, but an aggravation of pigmentation was noted. Fractionated IPL is a novel technique in which microsecond-domain fractionated pulses are delivered to the target area.To compare the safety and efficacy of low-fluency, frequently scheduled fractionated IPL (...) and conventional IPL for melasma treatment.This was a 14-week, split-face study in which 30 Asian women were treated with weekly fractionated IPL on one side of the face and biweekly conventional IPL on the other side.The non-inferiority of a weekly fractionated IPL regimen to a biweekly conventional IPL regimen was verified by a lower margin of the 95% confidence interval for the difference in the Melasma Area and Severity Index (MASI) change from baseline of 2.61 for each side. This value was greater than

2015 Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology

130. Effectiveness of low-fluence and short-pulse intense pulsed light in the treatment of melasma: A randomized study. (PubMed)

Effectiveness of low-fluence and short-pulse intense pulsed light in the treatment of melasma: A randomized study. Various treatment protocols for melasma have been suggested in the literature, but the efficacy and safety of treatment varies according to the report.To investigate the selective photothermolytic effect of fluence-dependent intense pulsed light (IPL) in the treatment of melasma.Twenty Korean adults with melasma were enrolled, randomly assigned to two groups and treated at fluences (...) of 10 or 13 J/cm(2) of IPL weekly over 6 weeks. Subjects were evaluated at baseline and weekly during the 6 weeks of treatment and at 3 weeks following the final treatment. Melanin and erythema indices were scored using a spectrophotometer.The modified Melasma Area Severity Index (MASI) score of 20 patients at inclusion was 11.6 (± 0.9). Both 10J and 13J IPL treatment groups had decreased modified MASI scores from 2 weeks onward at statistically significant levels. Both 10J and 13J IPL treatment

2015 Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology

131. Glycolic Acid Peels/Azelaic Acid 20% Cream Combination and Low Potency Triple Combination Lead to Similar Reduction in Melasma Severity in Ethnic Skin: Results of a Randomized Controlled Study (Full text)

Glycolic Acid Peels/Azelaic Acid 20% Cream Combination and Low Potency Triple Combination Lead to Similar Reduction in Melasma Severity in Ethnic Skin: Results of a Randomized Controlled Study Numerous therapeutic options have been tried in the management of melasma.This prospective randomized study was planned to assess the efficacy of low potency triple combination (TC) cream (TC-hydroquinone 2%/tretinoin 0.05%/fluocinolone 0.01%) versus glycolic acid (GA) peels/azelaic acid (AA) 20% cream (...) (GA/AA) combination in melasma.Forty patients with melasma were recruited into this study and randomized into two groups. Group A consisting 20 patients received TC cream once a day for night time application for 3 months. Group B comprising of 20 patients received GA/AA 20% cream combination for 3 months. The disease severity was monitored with digital photography, melasma area and severity index (MASI) score, which was calculated at baseline, 6 weeks and 12 weeks, and visual analog scale (VAS

2015 Indian journal of dermatology PubMed

132. Acupuncture for melasma in women: a systematic review of randomised controlled trials. (Full text)

Acupuncture for melasma in women: a systematic review of randomised controlled trials. Melasma is a common facial skin disorder seen in women. Manual acupuncture (MA) is widely used alone or in combination with conventional treatments for melasma in China.To assess the effectiveness and safety of MA for melasma, and explore the range of treatments applied.Six databases were searched systematically for randomised controlled trials (RCTs) on acupuncture for melasma in women up to November 2014 (...) and safe for women with melasma, but insufficient evidence was found to reach conclusions. The encircling needling method, the quick needling method, intensive needle manipulations and individualised points' selection were widely used. Well-designed trials are required.PROSPERO Systematic review registration: CRD42013006396.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

2015 Acupuncture in medicine : journal of the British Medical Acupuncture Society PubMed

133. Efficacy and Safety of Fluocinolone Acetonide, Hydroquinone, and Tretinoin Cream in Chinese Patients with Melasma: A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Parallel-Group Study. (PubMed)

Efficacy and Safety of Fluocinolone Acetonide, Hydroquinone, and Tretinoin Cream in Chinese Patients with Melasma: A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Parallel-Group Study. This study aimed to determine the efficacy and safety of fluocinolone acetonide, hydroquinone, and tretinoin (FAHT) cream for the treatment of moderate and severe facial melasma. The primary objective was assessment of clinical efficacy, instrumental measured efficacy, and integral therapeutic (...) efficacy at the end of weeks 4 and 8.A total of 233 subjects were randomly allocated (1:1 ratio) to receive topically administered FAHT cream (n = 117) or placebo (n = 116) once nightly for 8 weeks. Observed side effects were documented throughout.In the per protocol set (PPS; those subjects who met all requirements of the protocol), the integral therapeutic efficacy rate of FAHT cream on moderate and severe melasma was 68.57% (vs. placebo, 0.94%), the clinical effective rate of FAHT cream was 74.29

2015 Clinical drug investigation

134. The histopathological characteristics of male melasma: Comparison with female melasma and lentigo. (PubMed)

The histopathological characteristics of male melasma: Comparison with female melasma and lentigo. Knowledge of the histopathology of melasma is a prerequisite for understanding its pathogenesis. However, the histopathological characteristics of male melasma are not well characterized.We sought to investigate the histopathological characteristics of melasma in men compared with those of women with melasma and solar lentigo.Biopsy specimens were obtained from both the lesional skin (...) and the adjacent nonlesional skin in 8 men with melasma, 10 women with melasma, and 5 men and women each with solar lentigo. The samples were stained using Fontana-Masson and Verhoeff-van Gieson. Immunohistochemistry for melanocytes, the estrogen receptor, progesterone receptor, factor VIIIa-related antigen, stem cell factor, and c-kit was performed.Increased vascularity was found in the lesion of male melasma. The lesion to nonlesion ratio of the vessel area was increased in male melasma compared with lentigo

2012 Journal of American Academy of Dermatology

135. The efficacy in melasma treatment using a 1410 nm fractional photothermolysis laser. (PubMed)

The efficacy in melasma treatment using a 1410 nm fractional photothermolysis laser. Melasma treatment modalities including topical and procedural therapy have been employed with variable results and high recurrence rate.To quantitatively assess improvement in melasma and side effects after 1410 nm fractional photothermolysis laser treatments and to determine efficacy at 1-, 2- and 3-month follow-up after treatment.Thirty volunteers with melasma were treated with 1410 nm fractional (...) photothermolysis for four passes on full face and additional four passes on melasma area. They were randomly treated on one side of their face with 20 mJ at 5% coverage and the other side of their face with 20 mJ at 20% coverage. All subjects were treated monthly for five times. Melanin index, Visual analogue scale and Melasma Area and Severity Index score were measured at baseline and 1-, 2- and 3-month follow-up after complete treatment protocol.There was statistically significant improvement of Melanin

2014 Journal of the European Academy of Dermatology and Venereology

136. A comparative study of low-fluence 1064-nm Q-switched Nd:YAG laser with or without chemical peeling using Jessner's solution in melasma patients. (PubMed)

A comparative study of low-fluence 1064-nm Q-switched Nd:YAG laser with or without chemical peeling using Jessner's solution in melasma patients. Although low-fluence 1064-nm Q-switched Nd:YAG laser (QSNYL) is widely used for the treatment of melasma, multiple treatments are necessary for clinical improvement. Superficial chemical peeling using Jessner's solution has been used for treatment of melasma conventionally.To evaluate the additional therapeutic effect and adverse effects of Jessner's (...) peel when combined with 1064-nm QSNYL for melasma patients in a double-blind, placebo-controlled design.Total of 52 patients were included. Patients who received 10 sessions of 1064-nm QSNYL plus chemical peeling with placebo (group A) in a two-week interval and those who received 10 sessions of 1064-nm QSNYL plus chemical peeling with Jessner's solution (group B) in a two-week interval were analyzed. Responses were evaluated using the Melasma Area and Severity Index (MASI) score, physician's

2014 Journal of Dermatological Treatment

137. Systematic review of randomized controlled trials on interventions for melasma: an abridged Cochrane review. (PubMed)

Systematic review of randomized controlled trials on interventions for melasma: an abridged Cochrane review. Multiple treatments exist for melasma; they are often substandard and associated with side effects.We sought to assess the effectiveness of interventions used in the management of all types of melasma.We undertook a systematic review using the methodology of the Cochrane Collaboration.We included 20 studies with a total of 2125 participants covering 23 different treatments. A meta (...) -analysis was not possible because of the heterogeneity of treatments. Triple-combination cream (hydroquinone, tretinoin, and fluocinolone acetonide) was more effective at lightening melasma than hydroquinone alone (relative risk 1.58, 95% confidence interval 1.26-1.97) or any of the agents in a dual-combination cream. Azelaic acid (20%) was significantly more effective than 2% hydroquinone (relative risk 1.25, 95% confidence interval 1.06-1.48) at lightening melasma. In 2 studies where tretinoin

2014 Journal of American Academy of Dermatology

138. Topical tranexamic acid as a promising treatment for melasma. (PubMed)

Topical tranexamic acid as a promising treatment for melasma. In recent times, tranexamic acid (TA) is claimed to have whitening effects especially for ultraviolet-induced hyperpigmentation including melasma. The aim of our study was to evaluate the efficacy and safety of topical solution of TA and compare it with combined solution of hydroquinone and dexamethasone as the gold standard treatment of melasma in Iranian women.This was a double-blind split-face trial of 12 weeks which was conducted (...) in Isfahan, Iran. Fifty Iranian melasma patients applied topical solution of 3% TA on one side of the face, and topical solution of 3% hydroquinone + 0.01% dexamethasone on the other side two times a day. The Melasma Area and Severity Index (MASI) and the side effects were evaluated at baseline and every 4 weeks before and after photographs to be compared by a dermatologist were taken. The patient satisfaction was documented at week 12.A repeated measurement analysis was used to evaluate the changes

2014 Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

139. Effect of 82% Lactic Acid in Treatment of Melasma (Full text)

Effect of 82% Lactic Acid in Treatment of Melasma Melasma is an acquired, chronic, and symmetrical hypermelanosis, characterized by brown patches of variable darkness on sun exposed areas of body. There are numerous modalities of treatment currently in use for this disease, of which the chemical peeling is very commonly used. Therefore, the present work was done to see the effect of 82% lactic acid peel in the treatment of melasma. A total number of 20 patients of either sex attending the OPD (...) of dermatology department with clinically evident melasma were included in the study. 82% Lactic acid peel was applied on the face for 12 weeks in each patient. Patients were evaluated clinically and photographically at various intervals and in follow-up till 24 weeks. Assessment of patient satisfaction and side effects were also noted. All the subjects completed the study. Application of this peel for 12 weeks significantly decreased the melasma area severity index score and also melasma severity scale

2014 International scholarly research notices PubMed

140. Risk factors for facial melasma in women: a case-control study. (PubMed)

Risk factors for facial melasma in women: a case-control study. Melasma is a localized chronic acquired hypermelanosis, common in adult women and which has an important impact on their life quality. Its pathology is unknown, despite some recognized triggering factors.To evaluate risk factors for developing facial melasma in women.This was a case-control study involving adult women with or without facial melasma, paired by age. Variables were grouped into hierarchical levels: personal (...) ), antidepressant/anxiolytic use (OR 4·96), menstrual irregularity (OR 3·83), pregnancy history (OR 3·59), years of oral contraceptive use (OR 1·23) and anxiety scores (OR 1·08). A family history of melasma was reported in 61% of cases and 13% of controls (OR 10·40).Facial melasma is independently associated with elements linked to pigmentation capacity, family ancestry, chronic sun exposure, sexual hormone stimuli, psychotropics and anxiety traits.© 2014 British Association of Dermatologists.

2014 British Journal of Dermatology

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