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101. The Effect of Melasma on the Quality of Life in a Sample of Women Living in Singapore (PubMed)

The Effect of Melasma on the Quality of Life in a Sample of Women Living in Singapore Melasma is a common disorder of acquired hyperpigmentation characterized by irregular brown macules and patches that occur primarily on sun-exposed areas.This was a prospective cross-sectional study that recruited 49 women clinically diagnosed with melasma from a tertiary dermatology referral center in Singapore. Trained investigators assessed the melasma severity objectively using the chromameter (...) and mexameter and subjectively using the Melasma Area and Severity Index. The effect of melasma on the quality of life on the patients was assessed using the melasma quality of life scale and dermatology life quality index questionnaires.The mean ± SD Melasma Area and Severity Index score was 12.1±6.5 (median 10.8). The mean ± SD melasma quality of life scale score was 25.6±15.3 (median 24.0). Melasma quality of life scale scores are significantly correlated (Spearman's coefficient = 0.597, p-value <0.001

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2016 The Journal of clinical and aesthetic dermatology

102. Assessment of efficacy, safety, and tolerability of 4-n-butylresorcinol 0.3% cream: an Indian multicentric study on melasma (PubMed)

Assessment of efficacy, safety, and tolerability of 4-n-butylresorcinol 0.3% cream: an Indian multicentric study on melasma Melasma is one of the commonly reported pigmentory disorders in the Indian population. Numerous therapeutic modalities are available. However, very few have produced complete satisfactory response. 4-n-Butylresorcinol 0.3% cream has recently been introduced in India as a new hypopigmenting agent. It is a resorcinol derivative and acts by inhibiting both tyrosinase (...) and tyrosinase-related protein-1.The available published literatures are with 4-n-butylresorcinol 0.1% cream, and there is paucity of clinical studies with 4-n-butylresorcinol 0.3% cream. Furthermore, considering the fact that Indian skin is more prone to irritation with hypopigmenting agents, our study explores the efficacy, safety, and tolerability of 4-n-butylresorcinol 0.3% cream in Indian subjects with melasma.Fifty-two subjects with melasma participated in this open-label, single arm, observational

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2016 Clinical, cosmetic and investigational dermatology

103. Confetti-like Sparing: A Diagnostic Clinical Feature of Melasma (PubMed)

Confetti-like Sparing: A Diagnostic Clinical Feature of Melasma Diagnostic uncertainty when a patient presents with melasma-like Undings can lead to suboptimal treatment and inaccurate prognostic expectations. In this study, the authors present a unique clinical feature of melasma that they term the "Fitzpatrick macule" and test its Utility in establishing diagnostic certainty. The "Fitzpatrick macule" is a confetti-like macule of regularly pigmented skin located within a larger patch (...) of melasma hyperpigmentation. To test its diagnostic Utility, the authors compared clinical photography of known cases of melasma with common mimickers, such as poikiloderma of Civatte and solar lentiginosis, and determined the positivity rate of the Fitzpatrick macule in each scenario. Their results show that 89.1 percent of clinical photographs of melasma were positive for the presence of Fitzpatrick macules compared to 1.1 percent that were negative. In contrast, 37.5 and 56.3 percent of clinical

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2016 The Journal of clinical and aesthetic dermatology

104. Treatment of Melasma with the Photoacoustic Twin Pulse Mode of Low-Fluence 1,064 nm Q-Switched Nd:YAG Laser (PubMed)

Treatment of Melasma with the Photoacoustic Twin Pulse Mode of Low-Fluence 1,064 nm Q-Switched Nd:YAG Laser Low-fluence 1,064 nm Q-switched Nd:YAG laser has been widely used for the treatment of melasma. Although new Q-switched Nd:YAG lasers with photoacoustic twin pulse (PTP) mode have been recently developed for high-efficiency, there is limited information available for the new technique.This study was designed to investigate the efficacy and adverse effects after few sessions of repeated (...) low fluence 1,064 nm Q-switched Nd:YAG laser treatment with PTP mode in Asian women with melasma.Twenty-two Korean women were treated with a total of five sessions of low-fluence PTP mode Nd:YAG laser treatment (Pastelle®) at 2 weeks interval. Responses to treatments were evaluated by using Melasma Area and Severity Index (MASI) scoring, colorimeter measurement, and the investigators' and patients' overall assessments. Adverse events were recorded at each visit.Investigators' and patients' overall

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2016 Annals of dermatology

105. Heterogeneous Pathology of Melasma and Its Clinical Implications (PubMed)

Heterogeneous Pathology of Melasma and Its Clinical Implications Melasma is a commonly acquired hypermelanosis that affects sun-exposed areas of the skin, with frequent facial involvement. Its histologic manifestations are evident in the epidermis, extracellular matrix, and dermis. In addition to epidermal pigmentation, pathologic findings of melasma include extracellular matrix abnormality, especially solar elastosis. The disrupted basement membrane has been described in melasma with variable (...) incidences. In the dermis, an increase in vascularity and an increase in the number of mast cells were observed, indicating that dermal factors have critical roles in the pathogenesis of melasma, despite the fact that melasma is characterized by epidermal hyperpigmentation. This review discusses such histologic characteristics of melasma, with consideration to their implications for melasma treatment.

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2016 International journal of molecular sciences

106. Interventions for melasma. (PubMed)

Interventions for melasma. Melasma is an acquired symmetrical pigmentary disorder where confluent grey-brown patches typically appear on the face. Available treatments for melasma are unsatisfactory.To assess interventions used in the management of all types of melasma: epidermal, dermal, and mixed.In May 2010 we searched the Cochrane Skin Group Specialised Register, the Cochrane Central Register of Controlled Trials (Clinical Trials) in The Cochrane Library, MEDLINE, EMBASE, PsycINFO (...) a different set of interventions. They can be grouped into those including a bleaching agent such as hydroquinone, triple-combination creams (hydroquinone, tretinoin, and fluocinolone acetonide), and combination therapies (hydroquinone cream and glycolic acid peels), as well as less conventional therapies including rucinol, vitamin C iontophoresis, and skin-lightening complexes like Thiospot and Gigawhite.Triple-combination cream was significantly more effective at lightening melasma than hydroquinone

2010 Cochrane

107. Treatment of Melasma With Glycolic Acid-Salicylic Acid Peel Versus Glycolic Acid Peel

Treatment of Melasma With Glycolic Acid-Salicylic Acid Peel Versus Glycolic Acid Peel Treatment of Melasma With Glycolic Acid-Salicylic Acid Peel Versus Glycolic Acid Peel - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Treatment of Melasma With Glycolic Acid-Salicylic Acid Peel Versus Glycolic Acid Peel The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02812719 Recruitment Status : Withdrawn (Study did not receive funding and will not be implemented.) First Posted : June 24, 2016 Last Update Posted : June

2015 Clinical Trials

108. Tranexamic acid for adults with melasma: a systematic review and meta-analysis

Tranexamic acid for adults with melasma: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing and effect

2018 PROSPERO

109. Evaluation of the efficacy of cysteamine 5% cream in the treatment of epidermal melasma: a randomized double-blind placebo-controlled trial. (PubMed)

Evaluation of the efficacy of cysteamine 5% cream in the treatment of epidermal melasma: a randomized double-blind placebo-controlled trial. Melasma is a difficult-to-treat hyperpigmentary disorder. While cysteamine is a known potent depigmenting agent, its efficacy in treating melasma has not been tested.To study the efficacy of cysteamine 5% cream in the treatment of patients with epidermal melasma.In this double-blind randomized study, participating patients (n = 50) received either placebo (...) (n = 25) or cysteamine cream (n = 25). Cysteamine cream or placebo were applied on the lesions once a day at bedtime over 4 months. The efficacy of treatments was determined through Mexameter skin colorimetry, Melasma Area Severity Index (MASI) score, Investigator's Global Assessment (IGA) and patients' questionnaires, all performed at baseline and after 2 and 4 months of treatment.At baseline, the mean differences between pigmented and normal skin (calculated by Mexameter) were 75.2 ± 37

2015 British Journal of Dermatology

110. A split face study to document the safety and efficacy of clearance of melasma with a 5 ns q switched Nd YAG laser versus a 50 ns q switched Nd YAG laser. (PubMed)

A split face study to document the safety and efficacy of clearance of melasma with a 5 ns q switched Nd YAG laser versus a 50 ns q switched Nd YAG laser. To determine the safety and efficacy of a 50 ns Q switched Nd YAG laser vs. a 5 ns Q switched Nd YAG laser for clearance of melasma. To compare subject satisfaction, efficacy, and comfort level between the two lasers.This is a prospective, randomized split face clinical study. The study was approved by the Scripps IRB. Ten healthy female (...) subjects with moderate to severe melasma were enrolled. Each subject had three laser treatments one month apart. Patients were followed up approximately 1 month, 3 months, and 6 months after the final laser treatment. A treatment session consisted of a microdermabrasion, 1064 nm QS laser, and topicals. Subjects were asked to rate treatment pain based on a numerical scale range 0-10 (0 = no pain and 10 = worst pain). A melasma area and severity index (MASI) grading system was applied. Also, melanin

2015 Lasers in surgery and medicine

111. Comparison of thyroid disorder between patients with melasma and control group: a systematic review and meta-analysis

Comparison of thyroid disorder between patients with melasma and control group: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence

2018 PROSPERO

112. Cadherin 11 Involved in Basement Membrane Damage and Dermal Changes in Melasma. (PubMed)

Cadherin 11 Involved in Basement Membrane Damage and Dermal Changes in Melasma. Basement membrane (BM) disruption and dermal changes (elastosis, collagenolysis, vascular ectasia) have been reported in melasma. Although ultraviolet (UV) irradiation can induce these changes, UV is not always necessary for melasma development. Cadherin 11 (CDH11), which is upregulated in some melasma patients, has previously been shown to stimulate melanogenesis. Because CDH11 action requires cell-cell adhesion (...) between fibroblasts and melanocytes, BM disruption in vivo should facilitate this. The aim of this study was to examine whether CDH11 overexpression leads to BM disruption and dermal changes, independent of UV irradiation. Immunohistochemistry/immunofluorescence, real-time PCR, Western blotting, and zymography suggested that BM disruption/dermal changes and related factors were present in the hyperpigmented skin of CDH11-upregulated melasma patients and in CDH11-overexpressing fibroblasts

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2015 Acta Dermato-Venereologica

113. The first clinical experience on efficacy of topical flutamide on melasma compared with topical hydroquinone: a randomized clinical trial. (PubMed)

The first clinical experience on efficacy of topical flutamide on melasma compared with topical hydroquinone: a randomized clinical trial. Treatment of melasma is unsatisfactory most of the times. Hormonal role is shown to exist in pathogenesis of the melasma, and sex-hormone related drugs may have an effect on melasma.To investigate efficacy of 1% flutamide cream versus 4% hydroquinone cream on melasma.In a parallel randomized clinical trial, 74 women with melasma were allocated to receive (...) a sunscreen along with 4% hydroquinone cream or 1% flutamide cream. Melasma Area and Severity Index (MASI), mexameter melanin assay, and patient satisfaction were investigated.Mean age of the participants was 33.8 years. Mean length of time suffering from Melasma was 96.3 months. The subjects reported in average 1.1 hours per day of exposure to sunlight. Mean standardized total patient satisfaction score was 28.8 (standard deviation [SD] 17.2) in flutamide group patients versus 18 (SD 15.5) in control

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2015 Drug design, development and therapy

114. Skin cancers detected as casual findings with Reflectance Confocal Microscopy (RCM) in the assessment of melasma treatment. (PubMed)

Skin cancers detected as casual findings with Reflectance Confocal Microscopy (RCM) in the assessment of melasma treatment. 26264775 2016 09 26 2015 12 28 1365-2133 173 6 2015 Dec The British journal of dermatology Br. J. Dermatol. Skin cancers detected as casual findings with reflectance confocal microscopy in the assessment of melasma treatment. 1553-5 10.1111/bjd.14066 Chavez-Bourgeois M M http://orcid.org/0000-0002-6081-6736 Melanoma Unit, Department of Dermatology, Hospital Clinic

2015 British Journal of Dermatology

115. Topical Tranexamic Acid as an Adjuvant Treatment in Melasma: Side-by-Side Comparison Clinical Study. (PubMed)

Topical Tranexamic Acid as an Adjuvant Treatment in Melasma: Side-by-Side Comparison Clinical Study. Tranexamic acid (TNA) is a novel therapeutic agent for hyperpigmented skin disorders. The efficacy and safety of topical TNA in patients with melasma has not been heretofore studied. The main objective of this study is to evaluate the efficacy and safety of topical TNA combined with intense pulsed light (IPL) treatment in Asians with melasma.A randomized, split-face (internally controlled) study (...) was conducted in 15 women who received four monthly sessions of IPL to both sides of the face. Topical TNA or vehicle was applied to a randomly assigned side during and after IPL treatment. Patients were followed up for 12 weeks after completing the IPL treatments. Baseline and follow-up melanin index (MI; measured by Mexameter®, Courage and Khazaka, Cologne, Germany) and modified melasma area and severity index (mMASI) scores were determined.Thirteen subjects completed the study without serious adverse

2015 Journal of Dermatological Treatment

116. Copper Bromide Laser vs Triple-Combination Cream for the Treatment of Melasma: A Randomized Clinical Trial. (PubMed)

Copper Bromide Laser vs Triple-Combination Cream for the Treatment of Melasma: A Randomized Clinical Trial. 25715311 2015 09 21 2016 11 25 2168-6084 151 7 2015 Jul JAMA dermatology JAMA Dermatol Copper Bromide Laser vs Triple-Combination Cream for the Treatment of Melasma: A Randomized Clinical Trial. 791-2 10.1001/jamadermatol.2014.5580 Hammami Ghorbel Houda H Department of Dermatology, University Hospital of Nice, Nice, France. Boukari Fériel F Department of Dermatology, University Hospital

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2015 JAMA dermatology

117. Prevention of melasma relapses with sunscreen combining protection against UV and short wavelengths of visible light: a prospective randomized comparative trial. (PubMed)

Prevention of melasma relapses with sunscreen combining protection against UV and short wavelengths of visible light: a prospective randomized comparative trial. 25443629 2015 02 18 2014 12 16 1097-6787 72 1 2015 Jan Journal of the American Academy of Dermatology J. Am. Acad. Dermatol. Prevention of melasma relapses with sunscreen combining protection against UV and short wavelengths of visible light: a prospective randomized comparative trial. 189-90.e1 10.1016/j.jaad.2014.08.023 S0190-9622(14

2015 Journal of the American Academy of Dermatology

118. Melasma in a Male Patient due to Estrogen Therapy for Prostate Cancer (PubMed)

Melasma in a Male Patient due to Estrogen Therapy for Prostate Cancer 26719650 2015 12 31 2018 11 13 1013-9087 27 6 2015 Dec Annals of dermatology Ann Dermatol Melasma in a Male Patient due to Estrogen Therapy for Prostate Cancer. 763-4 10.5021/ad.2015.27.6.763 Ogita Azusa A Department of Dermatology, Nippon Medical School Hospital, Tokyo, Japan. Funasaka Yoko Y Department of Dermatology, Nippon Medical School Hospital, Tokyo, Japan. Ansai Shin-Ichi S Department of Dermatology, Nippon Medical

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2015 Annals of dermatology

119. Randomized, Double-Blind, Split-Face Study Evaluating Fractional Ablative Erbium:YAG Laser-Mediated Trans-Epidermal Delivery of Cosmetic Actives and a Novel Acoustic Pressure Wave Ultrasound Technology for the Treatment of Skin Aging, Melasma, and Acne Sc (PubMed)

Randomized, Double-Blind, Split-Face Study Evaluating Fractional Ablative Erbium:YAG Laser-Mediated Trans-Epidermal Delivery of Cosmetic Actives and a Novel Acoustic Pressure Wave Ultrasound Technology for the Treatment of Skin Aging, Melasma, and Acne Sc Fractional laser resurfacing enhances trans-epidermal delivery (TED), however laser penetration depths >250- μm fail to substantively increase drug delivery.Evaluate the safety and efficacy of a novel acoustic pressure wave ultrasound device (...) following fractional ablative Er:YAG 2940-nm laser (FELR) and topical agents for rhytids, melasma, and acne scars.Randomized, blinded, parallel group split-face side-by-side, controlled study evaluating FELR and topical anti-aging and anti-pigment agents to entire face succeeded by ultrasound to randomized side. Fifteen subjects were enrolled to three treatment arms:rhytids, melasma, and acne scars. Two monthly treatments were administered with 1, 3, and 6 month follow-up. Efficacy was assessed

2015 Journal of drugs in dermatology : JDD

120. Oral Tranexamic Acid with Fluocinolone-Based Triple Combination Cream Versus Fluocinolone-Based Triple Combination Cream Alone in Melasma: An Open Labeled Randomized Comparative Trial. (PubMed)

Oral Tranexamic Acid with Fluocinolone-Based Triple Combination Cream Versus Fluocinolone-Based Triple Combination Cream Alone in Melasma: An Open Labeled Randomized Comparative Trial. Melasma is a common acquired cause of facial hyperpigmentation with no definitive therapy. Tranexamic acid, a plasmin inhibitor, has demonstrated depigmenting properties and combining this oral drug with other modalities of treatment has shown promising results.To compare the efficacy of a combination of oral (...) tranexamic acid and fluocinolone-based triple combination cream with that of fluocinolone-based triple combination cream alone in melasma among Indian patients.40 patients of melasma of either sex attending to dermatology OPD were enrolled in this study. Participants were randomly divided into two groups with 20 patients in each group. Group A patients were asked to apply the cream only and Group B patients received oral tranexamic acid 250 mg twice daily and applied a triple combination cream containing

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2015 Indian journal of dermatology

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