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61. Efficacy and Safety of PiQo4 Device for Treatment of Melasma

Efficacy and Safety of PiQo4 Device for Treatment of Melasma Efficacy and Safety of PiQo4 Device for Treatment of Melasma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Efficacy and Safety of PiQo4 Device (...) for Treatment of Melasma The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03565341 Recruitment Status : Recruiting First Posted : June 21, 2018 Last Update Posted : February 26, 2019 See Sponsor: Focus Medical, LLC Information

2018 Clinical Trials

62. Oral and Topical Tranexamic Acid for the Treatment of Melasma

outcome will be the percentage of reduction at 12-week period of mMASI and melanin index. The incidence of adverse effects will be reported at weeks 4, 8 and 12. Condition or disease Intervention/treatment Phase Melasma Chloasma Melanosis Drug: Oral Tranexamic Acid Drug: 5% topical tranexamic acid Drug: 4% hydroquinone Phase 3 Detailed Description: Tranexamic acid has been used for treating melasma due to its effect on decreasing the activity of tyrosinase and melanogenesis. This 3-arm clinical trial (...) . FDA-regulated Drug Product: Yes Studies a U.S. FDA-regulated Device Product: No Product Manufactured in and Exported from the U.S.: Yes Keywords provided by Centro Dermatológico Dr. Ladislao de la Pascua: Melasma Chloasma Melanosis Tranexamic acid Hydroquinone Therapeutics Additional relevant MeSH terms: Layout table for MeSH terms Melanosis Hyperpigmentation Pigmentation Disorders Skin Diseases Tranexamic Acid Hydroquinone Antifibrinolytic Agents Fibrin Modulating Agents Molecular Mechanisms

2018 Clinical Trials

63. Identification of Biomarkers and Characterization of Melasma

Cosmetique Information provided by (Responsible Party): Pierre Fabre Dermo Cosmetique Study Details Study Description Go to Brief Summary: Melasma (also called chloasma and pregnancy mask) is characterized by pigmented lesions darker than their usual complexion on the faces of affected subjects. The physiopathology of melasma is still poorly understood. To date, the factors that favor the onset of melasma appear to be: genetic predisposing factors, changes in sex hormone levels, and sun exposure (...) , and therefore effective, for the subjects. Condition or disease Intervention/treatment Phase Chloasma Procedure: Biopsy Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 24 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Basic Science Official Title: Identification of Biological Markers and Biometrological Characterization of Melasma Estimated Study Start Date

2018 Clinical Trials

64. Melasma in Men: A Review of Clinical, Etiological, and Management Issues Full Text available with Trip Pro

Melasma in Men: A Review of Clinical, Etiological, and Management Issues Melasma is a common skin condition that affects both men and women. However, it is more commonly seen in women and dark-skinned individuals, such as in Hispanics, Asians, and African Americans who live in areas with intense ultraviolet radiation. Melasma is less common in men, but it negatively affects the quality of life in men as much as it does in women. While melasma has been studied in detail in women, however (...) , there is a paucity of studies on the clinico- etiopathology and therapeutics of melasma in men. This article reviews and discusses important clinical, etiological, and treatment aspects of melasma in men. The authors recommend that clinicians educate their patients on the causes, prevention and treatment methods, and recurrence rates of melasma. The authors also recommend that clinicians take into careful consideration each patient's preferences and expectations when creating treatment regimens, as these might

2018 The Journal of clinical and aesthetic dermatology

65. Seasonal variations in body melanism and size of the wolf spider Pardosa astrigera (Araneae: Lycosidae) Full Text available with Trip Pro

Seasonal variations in body melanism and size of the wolf spider Pardosa astrigera (Araneae: Lycosidae) Variations in species morphology and life-history traits strongly correlate with geographic and climatic characteristics. Most studies on morphological variations in animals focus on ectotherms distributed on a large geographic scale across latitudinal and/or altitudinal gradient. However, the morphological variations of spiders living in the same habitats across different seasons have (...) not been reported. In this study, we used the wolf spider, Pardosa astrigera, as a model to determine seasonal differences in adult body size, melanism, fecundity, and egg diameter both in the overwintering and the first generation for 2010 and 2016. The results showed that in 2010, both females and males of the overwintering generation were significantly darker than the first generation. Moreover, the overwintering females were markedly larger and produced more and bigger eggs than the first

2018 Ecology and evolution

66. Melanization of Dirofilaria immitis Larvae in Different Culicid Species Full Text available with Trip Pro

Melanization of Dirofilaria immitis Larvae in Different Culicid Species Dirofilaria immitis is an important filarioid transmitted by culicids. The vector role of these arthropods may be influenced by biological events as melanization against D. immitis larvae. This study aimed to detect the occurrence of melanization in Culex quinquefasciatus, Aedes (Stegomyia) aegypti and Aedes (Stegomyia) albopictus experimentally infected with D. immitis.Five populations (Cx. quinquefasciatus RECIFE (P1), Ae (...) . albopictus RECIFE (P2), Ae. aegypti RECIFE (P3), Ae. aegypti CAMPINAS (P4) and Ae. aegypti ROCKEFELLER (P5)) were artificially fed with infected blood containing D. immitis microfilariae. Ten mosquitoes per day from each population were dissected for 14 days.Melanized larvae of D. immitis were observed in all population except in P3. The period in which melanized larvae were found varied from the third to the 14th day post-infection. Difference in the number of these larvae was observed between P5 and P2

2018 Journal of Arthropod-Borne Diseases

67. DNA Methylation in Malar Melasma and Its Change by Sunscreen, Retinoic Acid and Niacinamide.

DNA Methylation in Malar Melasma and Its Change by Sunscreen, Retinoic Acid and Niacinamide. DNA Methylation in Malar Melasma and Its Change by Sunscreen, Retinoic Acid and Niacinamide. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. DNA Methylation in Malar Melasma and Its Change by Sunscreen, Retinoic Acid and Niacinamide. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03392623 Recruitment Status : Completed First Posted : January 8, 2018 Last Update Posted : January 9, 2018 Sponsor: Universidad

2018 Clinical Trials

68. Efficacy and safety of a novel picosecond laser using combination of 1 064 and 595 nm on patients with melasma: A prospective, randomized, multicenter, split-face, 2% hydroquinone cream-controlled clinical trial. (Abstract)

Efficacy and safety of a novel picosecond laser using combination of 1 064 and 595 nm on patients with melasma: A prospective, randomized, multicenter, split-face, 2% hydroquinone cream-controlled clinical trial. Melasma is a common acquired, chronic hypermelanosis and still remains a therapeutic challenge. The low-fluence 1 064 nm Q-switched Nd:YAG laser is the most widely used for the treatment of moderate to severe melasma in Asia. Recently, the picosecond laser has been introduced (...) for various pigmentary disorders such as melasma. We evaluated the efficacy and safety of a picosecond laser with dual-wavelengths (1 064 and 595 nm) and topical 2% hydroquinone (HQ) combination therapy on patients with melasma, and compared results with those obtained with 2% HQ alone.This was a prospective, randomized, split-face, controlled trial comparing two treatments with combined 7 week 2% HQ (daily) and 5 week picosecond laser (weekly) versus 7 week 2% HQ. The primary efficacy variable

2018 Lasers in surgery and medicine Controlled trial quality: uncertain

69. Senescent fibroblasts in melasma pathophysiology. (Abstract)

Senescent fibroblasts in melasma pathophysiology. It has been proposed that melasma is a photoageing skin disorder. The photoaged fibroblasts have been suggested as an important source of melanogenic factors which are involved in the regulation of pigmentation. To investigate whether melasma includes senescent cells, lesional and perilesional normal skin from 38 melasma patients was assessed using a cell senescence marker, p16INK4A . The results showed that lesional dermal skin had more (...) p16INK4A -positive senescent cells than perilesional skin. The impact of senescent fibroblasts was further investigated in a pilot study using radiofrequency (RF) intervention for melasma. It showed that the RF therapy decreased the number of senescent cells with increased expression of procollagen-1, which were associated with reduced epidermal pigmentation. This leads us to the speculation that senescent fibroblasts may contribute to drive melasma and might be considered as a potential therapeutic

2018 Experimental Dermatology

70. Oral Tranexamic Acid and Topical Hydroquinone in the Treatment of Melasma

Oral Tranexamic Acid and Topical Hydroquinone in the Treatment of Melasma Oral Tranexamic Acid and Topical Hydroquinone in the Treatment of Melasma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Oral (...) Tranexamic Acid and Topical Hydroquinone in the Treatment of Melasma The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03751163 Recruitment Status : Completed First Posted : November 22, 2018 Last Update Posted : November 26, 2018 Sponsor: Fakultas Kedokteran Universitas Indonesia Information provided

2018 Clinical Trials

71. Mapping black panthers: Macroecological modeling of melanism in leopards (Panthera pardus). Full Text available with Trip Pro

Mapping black panthers: Macroecological modeling of melanism in leopards (Panthera pardus). The geographic distribution and habitat association of most mammalian polymorphic phenotypes are still poorly known, hampering assessments of their adaptive significance. Even in the case of the black panther, an iconic melanistic variant of the leopard (Panthera pardus), no map exists describing its distribution. We constructed a large database of verified records sampled across the species' range (...) , and used it to map the geographic occurrence of melanism. We then estimated the potential distribution of melanistic and non-melanistic leopards using niche-modeling algorithms. The overall frequency of melanism was ca. 11%, with a significantly non-random spatial distribution. Distinct habitat types presented significantly different frequencies of melanism, which increased in Asian moist forests and approached zero across most open/dry biomes. Niche modeling indicated that the potential distributions

2017 PLoS ONE

72. Interventions for melasma: a systematic review and meta-analysis of the efficacy and safety of interventions assessed in randomized controlled trials

Interventions for melasma: a systematic review and meta-analysis of the efficacy and safety of interventions assessed in randomized controlled trials Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2020 PROSPERO

73. Effects of gua sha therapy on Chloasma.: a systematic review and meta analysis

Effects of gua sha therapy on Chloasma.: a systematic review and meta analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2020 PROSPERO

74. African ancestry is associated with facial melasma in women: a cross-sectional study. Full Text available with Trip Pro

African ancestry is associated with facial melasma in women: a cross-sectional study. Melasma is a chronic acquired focal hypermelanosis affecting photoexposed areas, especially for women during fertile age. Several factors contribute to its development: sun exposure, sex steroids, medicines, and family history. Melanic pigmentation pathway discloses several SNPs in different populations. Here, we evaluated the association between genetic ancestry and facial melasma.A cross-sectional study (...) involving women with melasma and an age-matched control group from outpatients at FMB-Unesp, Botucatu-SP, Brazil was performed. DNA was extracted from oral mucosa swabs and ancestry determined by studying 61 INDELs. The genetic ancestry components were adjusted by other known risk factors by multiple logistic regression.We evaluated 119 women with facial melasma and 119 controls. Mean age was 39 ± 9 years. Mean age at beginning of disease was 27 ± 8 years. Pregnancy (40%), sun exposure (37

2017 BMC Medical Genetics

75. Melanization in response to wounding is ancestral in arthropods and conserved in albino cave species Full Text available with Trip Pro

Melanization in response to wounding is ancestral in arthropods and conserved in albino cave species Many species adapted to aphotic subterranean habitats have lost all body pigmentation. Yet, melanization is an important component of wound healing in arthropods. We amputated appendages in a variety of cave-adapted and surface-dwelling arthropods. A dark clot formed at the site of injury in most species tested, including even albino cave-adapted species. The dark coloration of the clots was due (...) to melanin deposition. The speed of wound melanization was uncorrelated with a difference in metabolic rate between surface and cave populations of an amphipod. The chelicerate Limulus polyphemus, all isopod crustaceans tested, and the cave shrimp Troglocaris anophthalmus did not melanize wounds. The loss of wound melanization in T. anophthalmus was an apomorphy associated with adaptation to subterranean habitats, but in isopods it appeared to be a symplesiomorphy unrelated to colonization

2017 Scientific reports

76. Treatment of Melasma with Pulsed-Dye Laser and 1,064-nm Q-Switched Nd:YAG Laser: A Split-Face Study Full Text available with Trip Pro

Treatment of Melasma with Pulsed-Dye Laser and 1,064-nm Q-Switched Nd:YAG Laser: A Split-Face Study Melasma is an acquired pigmentary disorder that is often therapeutically challenging. Recent evidence suggests that vascular abnormalities are involved in melasma pathogenesis. Pulsed-dye laser (PDL) is considered as standard therapy for vascular lesions.To assess the efficacy of PDL combined with low-fluence Q-switched Nd:YAG laser (QSNY) in the treatment of melasma.Seventeen melasma patients (...) were enrolled in this study. All subjects were treated with a total of nine QSNY treatment sessions at one-week intervals. Three sessions of PDL were additionally performed immediately after QSNY treatment on the half of the face at baseline, week 4, and week 8. The melasma area and the severity index (MASI) score was calculated at the baseline, one week after the last treatment (week 9), as well as at the follow-up 8 weeks after the last treatment (week 16). Dermoscopic images at the baseline were

2017 Annals of dermatology

77. Assessment of the effects of skin microneedling as adjuvant therapy for facial melasma: a pilot study. Full Text available with Trip Pro

Assessment of the effects of skin microneedling as adjuvant therapy for facial melasma: a pilot study. Melasma is a common chronic and relapsing acquired dyschromia. Skin microneedling was reported resulting sustained long-term improvement of recalcitrant melasma, however, the exact mechanism that promotes this skin lightening is not known. This study aimed to investigate clinical and histologic alterations promoted by skin microneedling in facial melasma.Open pilot trial including six women (...) with facial refractory melasma submitted to two sessions of microneedling (1.5 mm) each 30 days followed by daily triple combination and broad-spectrum sunscreen. Comparison of pretreatment (T0) and 15 days after last microneedling procedure (T45) was made by standardized pictures, skin colorimetry, MASI, MELASQoL and histological parameters (haematoxylin-eosin, picrosirius-red, periodic acid Schiff and Fontana-Masson staining).The age of the subjects varied from 34 to 46 years-old, the phototypes were

2017 BMC Dermatology

78. The clinicoaetiological, hormonal and histopathological characteristics of melasma in men. Full Text available with Trip Pro

The clinicoaetiological, hormonal and histopathological characteristics of melasma in men. Melasma is relatively uncommon in males, and there is a paucity of data on male melasma, including its clinical pattern, triggering factors, endocrine profile and histopathological findings.To characterize the clinical findings and aetiological factors, including hormonal and histopathological features, of male melasma.Male patients with melasma and age- and sex-matched healthy controls (HCs) were (...) recruited. Demographic profile, risk factors, clinical pattern and Wood lamp findings of patients were recorded. Sera were obtained from patients and HCs to determine hormone levels. Biopsy specimens were obtained from lesional and adjacent nonlesional skin.In total, 50 male patients with melasma and 20 HCs were recruited into the study. Mean age of patients was 27.58 ± 4.51 years. The most common clinical pattern of melasma was malar, which occurred in 52% of cases. Positive family history was present

2017 Clinical & Experimental Dermatology

79. <i>In Vitro</i> Activity of Luliconazole, Lanoconazole, and Efinaconazole Compared with Five Antifungal Drugs Against Melanized Fungi and Relatives. Full Text available with Trip Pro

In Vitro Activity of Luliconazole, Lanoconazole, and Efinaconazole Compared with Five Antifungal Drugs Against Melanized Fungi and Relatives. The in vitro activities of novel azoles compared to those of five antifungal drugs against clinical (n = 28) and environmental (n = 102) isolates of black mold and melanized yeast were determined. Luliconazole and lanoconazole had the lowest geometric mean MICs, followed by efinaconazole, against tested isolates compared to the other drugs (...) . Therefore, it appears that these new imidazole and triazole drugs are promising candidates for the treatment of infections due to melanized fungi and their relatives.Copyright © 2017 American Society for Microbiology.

2017 Antimicrobial Agents and Chemotherapy

80. Comparing the efficacy of topical hydroquinone 2% vs. intradermal tranexamic acid microinjections in treating melasma: a split-face controlled trial. (Abstract)

Comparing the efficacy of topical hydroquinone 2% vs. intradermal tranexamic acid microinjections in treating melasma: a split-face controlled trial. Melasma is a benign, acquired and chronic hypermelanosis. Topical hydroquinone (HQ) is a conventional choice to treat melasma. Tranexamic acid (TA) is a relatively new brightening agent that interferes with keratinocyte-melanocyte interactions. The aim of the present study was to compare the efficacy and safety of TA intradermal injections with HQ (...) the melanin value during the first four weeks (p value =.013); but after 20 weeks, the overall changes was not different between the two groups (p value =.17).Monthly TA intradermal injections can be an effective treatment for melasma. Further studies are required to support our results.

2017 Journal of Dermatological Treatment Controlled trial quality: uncertain

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