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Melasma

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581. Development and validation of a health-related quality of life instrument for women with melasma. (PubMed)

Development and validation of a health-related quality of life instrument for women with melasma. Melasma can have significant emotional and psychological effects on those affected with the condition. In the past, the impact of melasma on health-related quality of life (HRQoL) has been assessed using general measures of skin disease that equally weigh both the physical and psychosocial distress arising from the presence of a dermatological condition.Our purpose was to develop and validate (...) a disease-specific HRQoL instrument to identify the areas of the patient's life most impaired by melasma as well as the effects of the condition on their level of functioning in correlation with disease severity: the Melasma Quality of Life scale (MELASQOL).A random sample of 102 women identified by an investigator as having melasma were evaluated by the investigator using the Melasma Area and Severity Index (MASI). The patients were then anonymously surveyed with the SKINDEX-16, the Fear of Negative

2003 British Journal of Dermatology

582. Prevalence and awareness of melasma during pregnancy. (PubMed)

Prevalence and awareness of melasma during pregnancy. Melasma is an acquired hypermelanosis of the face. There is little information on its prevalence during pregnancy in Iran. Objective To determine the prevalence and awareness of melasma during pregnancy at the Shahed University Hospitals of Tehran, Iran.A cross-sectional study was carried out by clinical examination and questionnaire on 400 pregnant women.The prevalence of melasma was 15.8%[95% confidence interval (CI) 12.3-19.4]. Malar (...) pattern was seen in 65.9% of cases, whereas 33.8% of the patients had a centrofacial pattern. No case with a mandibular pattern was found. Positive family history of melasma was present in 54.7% of the cases. There was a statistically significant relation between melasma and ethnicity, phototype and grade of parity. However, no significant relation was observed between melasma and use of sunscreens, history of thyroid or liver disorders, trimester of pregnancy or phenotype (eye and hair color). 11.3

2006 International Journal of Dermatology

583. Adapalene in the treatment of melasma: a preliminary report. (PubMed)

Adapalene in the treatment of melasma: a preliminary report. 12227492 2002 10 01 2015 11 19 0385-2407 29 8 2002 Aug The Journal of dermatology J. Dermatol. Adapalene in the treatment of melasma: a preliminary report. 539-40 Dogra Sunil S Kanwar Amrinder J AJ Parsad Devinder D eng Clinical Trial Letter Randomized Controlled Trial England J Dermatol 7600545 0385-2407 0 Dermatologic Agents 0 Keratolytic Agents 0 Naphthalenes 1L4806J2QF Adapalene 5688UTC01R Tretinoin IM Adapalene Adult Dermatologic

2002 The Journal of dermatology

584. Glycolic acid peels in the treatment of melasma among Asian women. (PubMed)

Glycolic acid peels in the treatment of melasma among Asian women. Melasma is a common disorder of facial hyperpigmentation among Asian women. Many modalities of treatment are available but none is satisfactory.This study was undertaken to see if glycolic acid peels are effective and safe in the treatment of melasma and fine facial wrinkling.Ten Asian women with moderate to severe melasma were recruited into the study. The women had twice daily applications of a cream containing 10% glycolic (...) was by an independent dermatologist, the patients themselves, and the use of the Munsell color chart and photographs. The nonparametric Wilcoxon Rank-Sum test was used for statistical analysis.The melasma and fine facial wrinkling improved on both sides of the face. The side that received glycolic acid peels did better but the results were not statistically significant (P > 0.059).A cream containing 10% glycolic acid and 2% hydroquinone (Neostrata AHA Age Spot and Skin Lightening Gel) improved melasma and fine

1997 Dermatologic Surgery

585. The treatment of melasma. 20% azelaic acid versus 4% hydroquinone cream. (PubMed)

The treatment of melasma. 20% azelaic acid versus 4% hydroquinone cream. The efficacy of 20% azelaic acid cream and 4% hydroquinone cream, both used in conjunction with a broad-spectrum sunscreen, against melasma was investigated in a 24-week, double-blind study with 329 women. Over the treatment period the azelaic acid cream yielded 65% good or excellent results; no significant treatment differences were observed with regard to overall rating, reduction in lesion size, and pigmentary intensity

1991 International journal of dermatology

586. Topical retinoic acid (tretinoin) for melasma in black patients. A vehicle-controlled clinical trial. (PubMed)

Topical retinoic acid (tretinoin) for melasma in black patients. A vehicle-controlled clinical trial. Melasma is an acquired, masklike, facial hyperpigmentation. The pathogenesis and treatment of melasma in black (African-American) patients is poorly understood. We investigated the efficacy of topical 0.1% all-trans-retinoic acid (tretinoin) in the treatment of melasma in black patients. Twenty-eight of 30 black patients with melasma completed a 10-month, randomized, vehicle-controlled clinical (...) trial in which they applied either 0.1% tretinoin or vehicle cream daily to the entire face. They were evaluated clinically (using our Melasma Area and Severity Index), colorimetrically, and histologically.After 40 weeks, there was a 32% improvement in the Melasma Area and Severity Index score in the tretinoin treatment group compared with a 10% improvement in the vehicle group. Colorimetric measurements showed lightening of melasma after 40 weeks of tretinoin treatment vs vehicle. Lightening

1994 Archives of Dermatology

587. Topical tretinoin (retinoic acid) improves melasma. A vehicle-controlled, clinical trial. (PubMed)

Topical tretinoin (retinoic acid) improves melasma. A vehicle-controlled, clinical trial. Melasma is a common disorder of cutaneous hyperpigmentation predominantly affecting the faces of women. Little is known about the aetiology of melasma, and treatment is frequently disappointing. Topical tretinoin is of benefit in treating other forms of hyperpigmentation, for example liver spots, and we therefore investigated its effectiveness in melasma. Thirty-eight women completed a randomized, vehicle (...) -controlled study, in which they applied 0.1% tretinoin (n = 19) or vehicle cream (n = 19) once daily to the face for 40 weeks. At the end of treatment 13 (68%) of 19 tretinoin-treated patients were clinically rated as improved or much improved, compared with 1 (5%) of 19 in the vehicle group (P = 0.0006). Significant improvement first occurred after 24 weeks of tretinoin treatment. Colorimetry (an objective measure of skin colour) demonstrated a 0.9 unit lightening of tretinoin-treated melasma and a 0.3

1993 The British journal of dermatology

588. Combination treatment of melasma with pulsed CO2 laser followed by Q-switched alexandrite laser: a pilot study. (PubMed)

Combination treatment of melasma with pulsed CO2 laser followed by Q-switched alexandrite laser: a pilot study. Melasma is very difficult to treat and often refractory to treatment with topical creams and pigmented-lesion lasers.Pulsed CO2 laser alone is compared with the combination of pulsed CO2 laser followed by Q-switched alexandrite laser in the treatment of dermal-type melasma. This combination is proposed to be effective by first destroying the abnormal melanocytes with the pulsed CO2

1999 Dermatologic Surgery

589. Topical isotretinoin for melasma in Thai patients: a vehicle-controlled clinical trial. (PubMed)

Topical isotretinoin for melasma in Thai patients: a vehicle-controlled clinical trial. Melasma is an acquired hyperpigmentary disorder commonly seen in Orientals. Recently it has been demonstrated that tretinoin (all-trans-retinoic acid) can produce significant clinical improvement of melasma. However, moderate cutaneous side effects (retinoid dermatitis) occurred in a number of patients.To investigate the efficacy of topical 0.05 per cent isotretinoin gel (Isotrex) in the treatment of melasma (...) in Thai patients.Thirty patients with moderate to severe melasma entered a 40-week, randomized, vehicle-controlled clinical trial in which they applied either 0.05 per cent isotretinoin gel, or its vehicle base together with a broad spectrum sunscreen (SPF 28) daily to the entire face. They were evaluated clinically (using Melasma Area and Severity Index), and colorimetrically (using our Melasma Area and Melanin Index).After 40 weeks, the average MASI and MAMI scores of the isotretinoin-treated group

1999 Journal of the Medical Association of Thailand = Chotmaihet thangphaet

590. Treatment of melasma using kojic acid in a gel containing hydroquinone and glycolic acid. (PubMed)

Treatment of melasma using kojic acid in a gel containing hydroquinone and glycolic acid. Melasma is difficult to clear. Many agents have been used, such as hydroquinone, and glycolic acid and glycolic acid peels, kojic acid, a tyrosinase inhibitor in the fungus Aspergilline oryzae.To see if the addition of 2% kojic acid in a gel containing 10% glycolic acid and 2% hydroquinone will improve melasma further.Forty Chinese women with epidermal melasma were treated with 2% kojic acid in a gel (...) containing 10% glycolic acid and 2% hydroquinone on one half of the face. The other half was treated with the same application but without kojic acid. The side receiving the kojic acid was randomized. Determination of efficacy was based on clinical evaluation, photographs and self-assessment questionnaires at 4 weekly intervals until the end of the study at 12 weeks. The non-parametric Wilcoxon's rank sum test was used for statistical analysis.All patients showed improvement in melasma on both sides

1999 Dermatologic Surgery

591. [Melasma in pregnancy: reduction of its appearance with the use of a broad-spectrum photoprotective agent]. (PubMed)

[Melasma in pregnancy: reduction of its appearance with the use of a broad-spectrum photoprotective agent]. 65 pregnant women distributed in two groups, by a double-blind method received a placebo or a sunscreen cream (Pabafil SPF 10, with absorption range from 290 to 360 nm) for daily use on face during the second quarter of their pregnancy in summer time. In 30 patients "with optimum fulfillment" in the products application (16 with placebo and 14 with sunscreen cream) the melasma appearances (...) were significantly lower in those with sunscreen application. In subgroups of the total number of pregnant women, with similar proportion of patients with placebo and sunscreen, the melasma appearances were significantly lower in skin types I-II, and in those that used cosmetics (versus those that did not). No differences were observed in subgroups by age, parity, and with or without history of previous melasma.

1987 Medicina cutánea ibero-latino-americana

592. Therapeutic effect of topical application of linoleic acid and lincomycin in combination with betamethasone valerate in melasma patients. (PubMed)

Therapeutic effect of topical application of linoleic acid and lincomycin in combination with betamethasone valerate in melasma patients. Melasma is an acquired symmetric hypermelanosis characterized by irregular light-to gray-brown macules and patches on sun-exposed areas. Many therapeutic agents are available but are unsatisfactory. Recently, it has been demonstrated that lincomycin (LM) and linoleic acid (LA) can inhibit melanogenesis in vitro. Our purpose was to investigate the clinical (...) efficacy of topical application of LM and LA in combination with betamethasone valerate (BV) in melasma patients. Forty-seven Korean female adults with clinically diagnosed melasma were enrolled in a 6-week, double-blind, randomized clinical trial. Patients were treated with one application of the vehicle (group A), 2% LM mixed with 0.05% BV (group B), or 2% LM mixed with 0.05% BV and 2% LA (group C) on the face every night. Determination of efficacy was based on the Melasma Area and Severity Index

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2002 Journal of Korean medical science

593. The efficacy of a broad-spectrum sunscreen in the treatment of melasma. (PubMed)

The efficacy of a broad-spectrum sunscreen in the treatment of melasma. A double-blind study comparing a broad-spectrum sunscreen agent with its vehicle in the treatment of melasma was performed in fifty-three patients who were concomitantly using a depigmentating solution. In this study, 96.2 percent of those who used the sunscreen agent showed improvement as compared with 80.7 percent of those who used placebo. These results confirm the positive role of sun protection in the treatment (...) of melasma and also establish hydroquinone as a major therapeutic agent in pigmentary disorders.

1983 Cutis; cutaneous medicine for the practitioner

594. Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma. (PubMed)

Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma. Melasma is a macular hypermelanosis of the sun-exposed areas of the face and neck. The clinical efficacy of azelaic acid (20%) and hydroquinone creams (2%) in the treatment of this benign pigmentary disorder was compared in a randomized, double-blind study with 155 patients of Indo-Malay-Hispanic origin. The creams were applied twice daily. A broad spectrum sunscreen was used concomitantly. Over a period of 24 (...) weeks, 73% of the azelaic acid patients, compared with 19% of the hydroquinone patients, had good to excellent overall results, as measured by the reduction of melasma pigmentary intensity and lesion size. Transient mild to moderate irritant reactions were initially seen with both test drugs.

1989 Acta dermato-venereologica. Supplementum

595. Efficacy of glycolic acid peels in the treatment of melasma. (PubMed)

Efficacy of glycolic acid peels in the treatment of melasma. Melasma is an acquired hypermelanosis that is often recalcitrant to treatment with hypopigmenting agents.To assess the efficacy of 4% hydroquinone cream vs 4% hydroquinone cream combined with glycolic acid peels as treatment for melasma.Twenty-one Hispanic women with bilateral epidermal and mixed melasma were enrolled in a split-faced prospective trial lasting 8 weeks. Patients underwent 20% to 30% glycolic acid peels every 2 weeks (...) to one side of the face only in addition to twice-daily full-face application of 4% hydroquinone cream and sun protective factor 25 UV-B sunscreen each morning. Pigmentation was measured objectively using a mexameter and the Melasma Area and Severity Index and subjectively using a linear analog scale and physician and patient global evaluation.Hydroquinone treatment alone and treatment with the combination of hydroquinone and glycolic acid had a significant effect in reducing skin pigmentation

2002 Archives of Dermatology

596. Validation of a melasma quality of life questionnaire for Brazilian Portuguese language: the MelasQoL-BP study and improvement of QoL of melasma patients after triple combination therapy. (PubMed)

Validation of a melasma quality of life questionnaire for Brazilian Portuguese language: the MelasQoL-BP study and improvement of QoL of melasma patients after triple combination therapy. Pigmentation disorders, such as melasma, greatly influence the quality of life (QoL) of affected individuals who usually consider the disorder to be more severe than the objective clinical scores. Several instruments have been successfully developed to evaluate QoL. However, they must be adapted to the target (...) population in terms of language and cultural diversity. The first, specific QoL questionnaire for melasma (MelasQoL) was developed for English speaking patients.To validate the Brazilian Portuguese version of the MelasQoL evaluation questionnaire for patients with melasma (MelasQoL-BP) and to assess the impact of treatment with a triple combination cream (hydroquinone, fluocinolone acetonide and tretinoin) on the QoL of patients with moderate-to-severe melasma.Three hundred individuals from the five

2006 British Journal of Dermatology

597. [Double-blind clinical study of the treatment of melasma with azelaic acid versus hydroquinone]. (PubMed)

[Double-blind clinical study of the treatment of melasma with azelaic acid versus hydroquinone]. A comparative double-blind study was carried out on sixty patients received oral contraceptives. Patients were treated with 20% azelaic acid or 4% hydroquinone. They were observed for 24 weeks and the results compared and checked for side effects. The results showed that the azelaic acid was not better than the hydroquinone in the treatment of melasma but it could be used as alternative drug.

1989 Medicina cutánea ibero-latino-americana

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