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41. Evaluation of Therapeutic Efficacy and Safety of Tranexamic Acid Local Infiltration in Combination with Topical 4% Hydroquinone Cream Compared to Topical 4% Hydroquinone Cream Alone in Patients with Melasma: A Split-Face Study Full Text available with Trip Pro

Evaluation of Therapeutic Efficacy and Safety of Tranexamic Acid Local Infiltration in Combination with Topical 4% Hydroquinone Cream Compared to Topical 4% Hydroquinone Cream Alone in Patients with Melasma: A Split-Face Study Melasma is an acquired pigmentary disorder characterized by hyperpigmented macules and/or patches affecting sun-exposed skin. Tranexamic acid (TA) can reduce melanin content of epidermis. Thus, we conducted this study to evaluate the efficacy and safety of tranexamic acid (...) local infiltration in combination with topical 4% hydroquinone cream compared to topical 4% hydroquinone cream alone in patients with melasma.This study was a prospective assessor- and analyst-blind, randomized split-face clinical trial which was performed on patients with bilateral malar epidermal melasma. A total of 55 patients were enrolled, and each side of their face was randomly allocated to either TA+HQ or HQ alone treatment. The MASI score was applied as an objective measurement to compare

2018 Dermatology research and practice Controlled trial quality: uncertain

42. Roof-Inhabiting Cousins of Rock-Inhabiting Fungi: Novel Melanized Microcolonial Fungal Species from Photocatalytically Reactive Subaerial Surfaces Full Text available with Trip Pro

Roof-Inhabiting Cousins of Rock-Inhabiting Fungi: Novel Melanized Microcolonial Fungal Species from Photocatalytically Reactive Subaerial Surfaces Subaerial biofilms (SAB) are an important factor in weathering, biofouling, and biodeterioration of bare rocks, building materials, and solar panel surfaces. The realm of SAB is continually widened by modern materials, and the settlers on these exposed solid surfaces always include melanized, stress-tolerant microcolonial ascomycetes. After (...) their first discovery on desert rock surfaces, these melanized chaetothyrialean and dothidealean ascomycetes have been found on Mediterranean monuments after biocidal treatments, Antarctic rocks and solar panels. New man-made modifications of surfaces (e.g., treatment with biocides or photocatalytically active layers) accommodate the exceptional stress-tolerance of microcolonial fungi and thus further select for this well-protected ecological group. Melanized fungal strains were isolated from a microbial

2018 Life

43. Estrogen associated with UVB irradiation recapitulates the specific melanosome distribution observed in Caucasoid Melasma. (Abstract)

Estrogen associated with UVB irradiation recapitulates the specific melanosome distribution observed in Caucasoid Melasma. 30478899 2019 01 01 1365-2133 2018 Nov 26 The British journal of dermatology Br. J. Dermatol. Oestrogen associated with ultraviolet B irradiation recapitulates the specific melanosome distribution observed in caucasoid melasma. 10.1111/bjd.17453 Gauthier Y Y Pigmentary Disorders Outpatient Clinic, National Reference Center for Rare Skin Disorders, Saint André, Hospital

2018 British Journal of Dermatology

44. Indoor wet cells as a habitat for melanized fungi, opportunistic pathogens on humans and other vertebrates Full Text available with Trip Pro

Indoor wet cells as a habitat for melanized fungi, opportunistic pathogens on humans and other vertebrates Indoor wet cells serve as an environmental reservoir for a wide diversity of melanized fungi. A total of 313 melanized fungi were isolated at five locations in Guangzhou, China. Internal transcribed spacer (rDNA ITS) sequencing showed a preponderance of 27 species belonging to 10 genera; 64.22% (n = 201) were known as human opportunists in the orders Chaetothyriales and Venturiales

2018 Scientific reports

45. Evaluation Instruments for Quality of Life Related to Melasma: An Integrative Review Full Text available with Trip Pro

Evaluation Instruments for Quality of Life Related to Melasma: An Integrative Review The aim of this study was to analyze scientific production concerning the validation and cultural adaptation of quality of life evaluation instruments for patients with melasma and to offer a critical reflection on these methods. A literature review was performed based on a search of the Web of Science, Bireme, PubMed, Elsevier Scopus, and Google Scholar databases. All published articles from indexed (...) periodicals in these electronic databases up to December 2015 were included. Eight articles were identified, of which only one (12.5%) referred to the development and validation of a specific instrument for evaluation of the quality of life of melasma patients. An additional six articles (75%) referred to transcultural adjustment and validation of the same instrument in other languages, and another (12.5%) article reported the development of a generic instrument for evaluation of quality of life

2018 Clinics

46. Double-blind, Placebo-controlled Trial to Evaluate the Effectiveness of Polypodium Leucotomos Extract in the Treatment of Melasma in Asian Skin: A Pilot Study Full Text available with Trip Pro

Double-blind, Placebo-controlled Trial to Evaluate the Effectiveness of Polypodium Leucotomos Extract in the Treatment of Melasma in Asian Skin: A Pilot Study Introduction: Melasma is a common pigmentary disorder with a multifactorial etiology that can hinder its management. The aqueous extract of the fern Polypodium leucotomos (PLE), Fernblock® (IFC, Madrid, Spain), has demonstrated antioxidant and photoprotective activities and has been used for the treatment of several pigmentary disorders (...) . The aim of this study was to evaluate the efficacy and safety of oral PLE in the treatment of melasma in Asian patients. Methods: Forty healthy adult patients with clinical diagnoses of melasma who were receiving treatment with topical 4% hydroquinone cream and sunscreen with a sun protection factor (SPF) of 50+ were recruited for inclusion in this study from the National Skin Centre in Singapore. They were randomized to receive either oral PLE supplementation or placebo for 12 weeks. Patients were

2018 The Journal of clinical and aesthetic dermatology Controlled trial quality: predicted high

47. Fractional erbium-doped yttrium aluminum garnet laser-assisted drug delivery of hydroquinone in the treatment of melasma Full Text available with Trip Pro

Fractional erbium-doped yttrium aluminum garnet laser-assisted drug delivery of hydroquinone in the treatment of melasma Melasma is a difficult-to-treat hyperpigmentary disorder. Ablative fractional laser (AFL)-assisted delivery of topically applied drugs to varied targets in the skin has been an area of ongoing study and research.The objective of this study was to evaluate the efficacy and safety of fractional erbium-doped yttrium aluminum garnet (Er:YAG) laser as an assisted drug delivery (...) for enhancing topical hydroquinone (HQ) permeation into the skin of melasma patients.Thirty female patients with bilateral melasma were randomly treated in a split-face controlled manner with a fractional Er:YAG laser followed by 4% HQ cream on one side and 4% HQ cream alone on the other side. All patients received six laser sessions with a 2-week interval. The efficacy of treatments was determined through photographs, dermoscopic photomicrographs and Melasma Area Severity Index (MASI) score, all performed

2018 Clinical, cosmetic and investigational dermatology Controlled trial quality: uncertain

48. Dual Effect of Photobiomodulation on Melasma: Downregulation of Hyperpigmentation and Enhanced Solar Resistance—A Pilot Study Full Text available with Trip Pro

Dual Effect of Photobiomodulation on Melasma: Downregulation of Hyperpigmentation and Enhanced Solar Resistance—A Pilot Study Overview. Melasma is a resistant, sun-induced facial hyperpigmentation capable of remaining present for decades with ensuing psychological distress. Treatment is difficult and focuses on an array of measures to reduce skin hyperpigmentation resulting from triggered hyperactive melanocytes. The pathogenesis of melanoma is not clearly understood but it has been reported (...) that some growth factors and specific cell-signaling pathways are involved. Objective. The objective of the current study was to evaluate the use of pulsed photobiomodulation to modulate melasma via the regulation of gene expression pertaining to skin pigmentation. Methods. We evaluated a two-step approach via a spilt-face pilot study involving seven patients with bilateral dermal melasma who had formerly undergone unsuccessful treatments. During treatment, the initial mobilization phase

2018 The Journal of clinical and aesthetic dermatology

49. Melanic variation underlies aposematic color variation in two hymenopteran mimicry systems. Full Text available with Trip Pro

Melanic variation underlies aposematic color variation in two hymenopteran mimicry systems. The stinging hymenopteran velvet ants (Mutillidae) and bumble bees (Apidae: Bombus spp.) have both undergone extensive diversification in aposematic color patterns, including yellow-red hues and contrasting dark-light body coloration, as a result of Müllerian mimicry. Understanding the genetic and developmental mechanisms underlying shifts in these mimetic colors requires characterization

2017 PLoS ONE

50. The Effects of Acupuncture Combined with Auricular Acupressure in the Treatment of Chloasma. Full Text available with Trip Pro

The Effects of Acupuncture Combined with Auricular Acupressure in the Treatment of Chloasma. To investigate the effectiveness of acupuncture combined with auricular acupressure in chloasma treatment.A prospective, randomized controlled assessor-blind clinical trial was performed and 135 patients were assigned into acupuncture combined with auricular acupressure (A), acupuncture (B), and control (C) groups, each with 45 patients. For groups A and B, body and facial acupuncture were applied for 2 (...) were significantly increased compared to pretreatment (P < 0.01 and P < 0.05, resp.). The differences were significant compared to group C (P < 0.01 and P < 0.05, resp.). No adverse events occurred.Acupuncture combined with auricular acupressure could significantly increase the therapeutic effect of chloasma treatment and could be better than vitamins C and E.

2018 Evidence-based Complementary and Alternative Medicine (eCAM) Controlled trial quality: uncertain

51. Pulsed Dye Laser versus Intense Pulsed Light in Melasma: A Split- Face Comparative Study. (Abstract)

Pulsed Dye Laser versus Intense Pulsed Light in Melasma: A Split- Face Comparative Study. Recent reports suggest that melasma may have a vascular component. Vascular targeting lasers and light treatment can be a therapeutic option that will provide benefits to the patients.To compare the efficacy and tolerability of pulsed dye laser (PDL) and intense pulsed light in treatment of melasma.Twenty-eight Egyptian female patients with melasma were treated with PDL on the right hemiface (Group (...) A) and with the intense pulsed light on the left hemiface (Group B). Clinical assessment was performed according to the hemifacial modified Melasma Area and Severity Index score (mMASI). Tissue biopsies were taken from patients for immunohistochemical staining with vascular endothelial growth factor (VEGF) antibody.The hemifacial mMASI score was significantly reduced after treatment in studied groups with no statistically significant difference. Intense pulsed light (IPL) group showed higher efficacy of treatment

2018 Journal of Dermatological Treatment

52. Oral Tranexamic Acid for the Treatment of Melasma: A Review. (Abstract)

Oral Tranexamic Acid for the Treatment of Melasma: A Review. Melasma is a common acquired disorder of hyperpigmentation that commonly affects those with skin of color. Tranexamic acid (TXA) is a novel treatment for melasma that has a multimodal mechanism of action.To provide a comprehensive review of the literature regarding the evidence on the mode of action, safety profile, and efficacy of TXA in the treatment of melasma.The literature was searched for publications on TXA in the treatment (...) of melasma using MEDLINE, Scopus, and Google Scholar.Oral TXA has clearly demonstrated the efficacy for melasma in Asian skin, even in low doses (e.g., 500 mg daily) over short periods (8-12 weeks). It is also a safe therapeutic option, which is easy to administer with few and mild side effects. Studies have shown that TXA does not increase the thromboembolic risk, although patients should be screened carefully for contraindications and risk factors prior to commencement of the therapy.Oral TXA is a safe

2018 Dermatologic Surgery

53. The Safety and Efficacy of Treatment With a 1,927-nm Diode Laser With and Without Topical Hydroquinone for Facial Hyperpigmentation and Melasma in Darker Skin Types. (Abstract)

The Safety and Efficacy of Treatment With a 1,927-nm Diode Laser With and Without Topical Hydroquinone for Facial Hyperpigmentation and Melasma in Darker Skin Types. The nonablative, fractional, 1,927-nm diode laser is theoretically a safe and effective treatment for hyperpigmentation and melasma in darker skin and may potentiate topical cosmeceutical delivery.To evaluate the use of a nonablative, fractional, 1,927-nm diode laser with and without topical 2% hydroquinone (HQ) cream for moderate

2018 Dermatologic Surgery Controlled trial quality: uncertain

54. Efficacy of Platelet-rich Plasma in for Melasma Treatment

Efficacy of Platelet-rich Plasma in for Melasma Treatment Efficacy of Platelet-rich Plasma in Treatment of Melasma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Efficacy of Platelet-rich Plasma (...) in Treatment of Melasma The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03674203 Recruitment Status : Completed First Posted : September 17, 2018 Last Update Posted : January 28, 2019 Sponsor: Instituto Mexicano del Seguro Social Information provided by (Responsible Party): CLOTILDE FUENTES OROZCO

2018 Clinical Trials

55. Melasma: Updates and Perspectives. Full Text available with Trip Pro

Melasma: Updates and Perspectives. Management of melasma is highly challenging due to inconsistent treatment results and frequent relapses. However, recent studies revealed that melasma may not only be a disease of melanocytes, but also a photoaging skin disorder. Herein, we attempt to validate that melasma is indeed a photoaging disorder by presenting the histopathologic findings of melasma: solar elastosis, altered basement membrane, increased vascularization and increased mast cell count. We

2018 Experimental Dermatology

56. Combination of amphotericin B and terbinafine against melanized fungi associated with chromoblastomycosis. Full Text available with Trip Pro

Combination of amphotericin B and terbinafine against melanized fungi associated with chromoblastomycosis. Our in vitro studies showed that a combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with chromoblastomycosis (CBM) and similar infections, including those with Cladophialophora carrionii, Cladophialophora arxii, Exophialadermatitidis, Exophialaspinifera, Fonsecaea monophora, Fonsecaea nubica, Fonsecaea pedrosoi

2018 Antimicrobial Agents and Chemotherapy

57. Melasma: update on management. (Abstract)

Melasma: update on management. Melasma is a common, acquired, chronic cutaneous pigment disorder that is often difficult to treat and has a high recurrence rate. The goal of a melasma treatment regimen is to decrease pigment production and increase elimination. Topical tyrosinase inhibitors block melanin synthesis and thereby reduce pigment production. Peels and laserand light-based devices increase melanin elimination. A multimodality treatment approach targeting both pigment production

2018 Seminars in Cutaneous Medicine and Surgery

58. LaseMD System for the Treatment of Melasma

LaseMD System for the Treatment of Melasma LaseMD System for the Treatment of Melasma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. LaseMD System for the Treatment of Melasma The safety and scientific (...) will evaluate the clinical outcomes associated with use of the LaseMD Laser System for the treatment of melasma. Condition or disease Intervention/treatment Phase Melasma Device: LaseMD System Not Applicable Detailed Description: This clinical trial is a designed as a prospective, multi-site, non-randomized study of 20 subjects. Subjects will receive up to 5 study treatments completed 21 days apart. Phone follow-up will occur at Day 3 following each treatment for the assessment of adverse events

2018 Clinical Trials

59. Efficacy and Safety of PiQo4 Device for Treatment of Melasma

Efficacy and Safety of PiQo4 Device for Treatment of Melasma Efficacy and Safety of PiQo4 Device for Treatment of Melasma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Efficacy and Safety of PiQo4 Device (...) for Treatment of Melasma The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03565341 Recruitment Status : Recruiting First Posted : June 21, 2018 Last Update Posted : February 26, 2019 See Sponsor: Focus Medical, LLC Information

2018 Clinical Trials

60. Oral and Topical Tranexamic Acid for the Treatment of Melasma

outcome will be the percentage of reduction at 12-week period of mMASI and melanin index. The incidence of adverse effects will be reported at weeks 4, 8 and 12. Condition or disease Intervention/treatment Phase Melasma Chloasma Melanosis Drug: Oral Tranexamic Acid Drug: 5% topical tranexamic acid Drug: 4% hydroquinone Phase 3 Detailed Description: Tranexamic acid has been used for treating melasma due to its effect on decreasing the activity of tyrosinase and melanogenesis. This 3-arm clinical trial (...) . FDA-regulated Drug Product: Yes Studies a U.S. FDA-regulated Device Product: No Product Manufactured in and Exported from the U.S.: Yes Keywords provided by Centro Dermatológico Dr. Ladislao de la Pascua: Melasma Chloasma Melanosis Tranexamic acid Hydroquinone Therapeutics Additional relevant MeSH terms: Layout table for MeSH terms Melanosis Hyperpigmentation Pigmentation Disorders Skin Diseases Tranexamic Acid Hydroquinone Antifibrinolytic Agents Fibrin Modulating Agents Molecular Mechanisms

2018 Clinical Trials

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