How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

597 results for

Melasma

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

1. Melasma

Melasma Melasma - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Melasma Last reviewed: February 2019 Last updated: February 2018 Summary A harmless pigmentary disorder, seen primarily on the malar region of women with darker skin. Aetiological factors include hormonal and UV light exposure. Treatment is with topical retinoids, bleaching agents, chemical peels, and laser or light therapy. Sun protection is important (...) for maintaining the effects of treatment. Definition Melasma is an acquired pigmentary disorder of sun-exposed areas. Ball Arefiev KL, Hantash BM. Advances in the treatment of melasma: a review of the recent literature. Dermatol Surg. 2012 Jul;38(7 Pt 1):971-84. http://www.ncbi.nlm.nih.gov/pubmed/22583339?tool=bestpractice.com Characteristically, patients have muddy brown macules on the skin, predominantly in the malar and central facial areas; however, it can also affect areas such as the forearms and neck

2018 BMJ Best Practice

2. Role of oxidative stress in melasma: a prospective study on serum and blood markers of oxidative stress in melasma patients. (PubMed)

Role of oxidative stress in melasma: a prospective study on serum and blood markers of oxidative stress in melasma patients. Melasma is a common pigmentary disorder presenting in the dermatological clinic. Many factors have been implicated in the pathogenesis, however, the cause still remains elusive. Recently the effect of oxidative damage has been proposed in the etiopathogenesis of melasma. This study was undertaken to evaluate the role of oxidative stress in patients with melasma.Fifty (...) patients with melasma, age 18 years of age and older, and an equal number of age and sex-matched controls were included in the study. Baseline severity assessment using the modified Melasma Area and Severity Index (modified MASI score) was done in all patients. Serum malondialdehyde, blood superoxide dismutase, and blood glutathione peroxidase levels were measured in cases and controls group and results were compared.The serum levels of malondialdehyde, superoxide dismutase, and blood glutathione were

2017 International Journal of Dermatology

3. Azelaic Acid is an Effective and Safer Alternative to Hydroquinone in Treating Mild to Moderate Melasma in Women

Azelaic Acid is an Effective and Safer Alternative to Hydroquinone in Treating Mild to Moderate Melasma in Women "Azelaic Acid is an Effective and Safer Alternative to Hydroquinone in " by Elizabeth Schmidt < > > > > > Title Author Date of Graduation Summer 8-13-2016 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor Elizabeth Crawford, PA-C Rights . Abstract Background: Hydroquinone has been the gold standard in treating melasma, but it does (...) not come without possible adverse events, which include leukoderma and ochronosis, both of which may be irreversible. Furthermore, hydroquinone has been banned in Europe and Asia due to adverse events and toxicity. Azelaic acid may be an alternative to hydroquinone and boasts not only skin lightening properties but bacteriostatic, keratinolytic, and antioxidant capacities as well. Can azelaic acid be a safer option with comparable efficacy in the treatment of melasma? Methods: An exhaustive search

2016 Pacific University EBM Capstone Project

4. The effect of melasma on self-esteem: A pilot study (PubMed)

The effect of melasma on self-esteem: A pilot study Melasma is a common disorder of hyperpigmentation characterized by tan or brown macules and patches affecting sun-exposed areas, particularly the face. Melasma has been shown to have a significant impact on the quality of life and self-esteem of those affected. We interviewed six patients who were diagnosed with moderate-to-severe melasma with regard to the effect of their disorder on their self-esteem. All patients reported a significant (...) negative effect on their quality of life and self-esteem. With successful therapy using a triple combination of cream and oral tranexamic acid to treat their melasma, all reported a marked improvement in self-esteem. Physicians who treat patients with melasma should be aware of its profound psychosocial effects and the improvement that successful melasma treatment can have on self-esteem.

Full Text available with Trip Pro

2017 International journal of women's dermatology

5. A review of laser and light therapy in melasma (PubMed)

A review of laser and light therapy in melasma Melasma is a dysregulation of the homeostatic mechanisms that control skin pigmentation and excess pigment is produced. Traditional treatment approaches with topical medications and chemical peels are commonly used but due to the refractory and recurrent nature of melasma, patients often seek alternative treatment strategies such as laser and light therapy. Several types of laser and light therapy have been studied in the treatment of melasma (...) a benefit. Vascular-specific lasers do not appear to be effective for the treatment of melasma. Ablative fractionated lasers should be used with caution because they have a very high risk for postinflammatory hypo- and hyperpigmentation. The use of nonablative fractionated laser treatments compared with other laser and light options may result in slightly longer remission intervals. Picosecond lasers, fractional radiofrequency, and laser-assisted drug delivery are promising future approaches to treat

Full Text available with Trip Pro

2017 International journal of women's dermatology

6. Oral and topical tranexamic acid in the treatment of melasma: systematic review

Oral and topical tranexamic acid in the treatment of melasma: systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2019 PROSPERO

7. Laser and Laser Compound Therapy for Melasma: A Meta-Analysis. (PubMed)

Laser and Laser Compound Therapy for Melasma: A Meta-Analysis. Treatment of melasma is challenging because its pathogenesis is unclear and it is prone to recurrence. We performed a meta-analysis to evaluate the efficacy and safety of laser and laser compound therapy for melasma.We searched the Cochrane, Embase, and Medline databases for all relevant studies published from inception to July 2018. All randomized controlled trials of melasma describing treatment with lasers or laser compound (...) -analysis provide evidence that laser and laser compound therapy can improve the area and severity of melasma. Further high-quality clinical studies should be carried out in the future to confirm this conclusion.

2019 Journal of Dermatological Treatment

8. The Management of Melasma on Skin Types V and VI Using Light Emitting Diode Treatment. (PubMed)

The Management of Melasma on Skin Types V and VI Using Light Emitting Diode Treatment. This study investigated light emitting diode (LED) treatment for patients with melasma on darker skin types.Melasma is a common disfiguring skin condition in women which is difficult to treat and is refractory. The cause of melasma remains unclear.In this study, 60 female participants aged between 25 and 60 years, who presented with melasma, were enrolled (n = 39.85). They were purposely assigned to two (...) groups according to their skin types. Both groups received a total of 36 LED light treatments over a period of 9 months.Both subjective and objective results indicated a significant improvement of melasma. Statistical analyses revealed significant improvements in both groups.The results of this study suggest that LED is effective in managing melasma. These results will provide a basis for future therapeutic use of phototherapy to improve melasma.

2019 Photomedicine and laser surgery

9. Topical silymarin versus hydroquinone in the treatment of melasma: A comparative study. (PubMed)

Topical silymarin versus hydroquinone in the treatment of melasma: A comparative study. Melasma is a highly prevalent hyperpigmentation disorder with a high relapsing rate and a negative impact on the psychological state of the affected patients. The exact pathogenesis of melasma is not completely elucidated; however, ultraviolet induced oxidative stress has an important role in its pathogenesis. Silymarin, antioxidant drug, reduces the harmful effects of solar ultraviolet radiation (...) such as inflammation, immune responses, DNA damage, and pigmentation.To assess the efficacy and safety of topical silymarin with different concentrations (0.7% and 1.4%) versus hydroquinone 4% in the treatment of melasma.Forty-two adult female patients with melasma were assigned to three equal groups each containing 14 patients; group1 was treated by silymarin 0.7% cream, group 2 was treated by silymarin 1.4% cream and group 3 was treated by hydroquinone 4% cream. The duration of treatment was 3 months.MASI score

Full Text available with Trip Pro

2019 Journal of cosmetic dermatology

10. Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma. (PubMed)

Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma. Melasma is a pigmentary disorder characterized by hyperpigmented patchy skin in sun-exposed areas, especially the face. Treatment of melasma can be challenging since long-term therapy is required, reoccurrence is common and existing therapies are insufficient and unsatisfactory. To investigate new treatment options, we performed an exploratory double-blinded, randomized split-face study (...) to assess the efficacy of the tyrosinase inhibitor Thiamidol compared to hydroquinone in women with mild to moderate melasma. After 12 weeks, modified melasma area and severity index (mMASI) scores significantly improved on both the Thiamidol-treated and the hydroquinone-treated sides of the face. Additionally, Thiamidol treatment improved mMASI scores significantly better than hydroquinone, and more subjects improved following treatment with Thiamidol (79%) compared with hydroquinone (61%). During

2019 Journal of Investigative Dermatology

11. Clinical and epidemiologic features of melasma: a multicentric cross-sectional study from India. (PubMed)

Clinical and epidemiologic features of melasma: a multicentric cross-sectional study from India. Though melasma is a common skin condition in India, epidemiological studies are few and geographically confined. The present study was designed to gain insights into factors involved in causation and aggravation of melasma, demographic distribution, clinical presentations, and treatment patterns.A cross-sectional multicentric study was conducted in 10 centers distributed across the four regions (...) of India. Data including demographics, personal and family medical history, triggering and aggravating factors, clinical patterns, and details of past treatment regimens were recorded, and severity was estimated using the modified Melasma Area and Severity Index (MASI) score. Data collected by site dermatologists were collated and analyzed.The study evaluated 1,001 patients with melasma from 10 centers. Mean age was 38.02 years. Females dominated (85%). Proportion of males was highest in the east (22.2

2019 International Journal of Dermatology

12. Melasma and thyroid disorders: a systematic review and meta-analysis. (PubMed)

Melasma and thyroid disorders: a systematic review and meta-analysis. Thyroid hormones may play a key role in melasma; however, melasma link with thyroid disorders remains controversial.To compare the serum levels of thyroid-stimulating hormone (TSH), T4, T3, anti-thyroid peroxidase (anti-TPO), and antithyroglobulin between patients with melasma and control group using meta-analysis.We screened 10 databanks and search engines, searched mesh and nonmesh terms. The identified evidences were (...) reviewed and quality assessed using the Newcastle-Ottawa Scale (NOS). The heterogeneity between the primary results was investigated using Cochrane and I-square indices. Random effect model was applied to combine the standardized mean differences of thyroid function indicators between patients with and without melasma. P values meta-analysis was used to investigate the association between anti-TPO and melasma.We included seven studies, 473 cases, and 379 controls that had been investigated. The total

2019 International Journal of Dermatology

13. Prospective Randomised Controlled Trial Comparing Treatment Efficacy and Tolerance of Picosecond Alexandrite Laser with a Diffractive Lens Array and Triple Combination Cream in Female Asian Patients with Melasma. (PubMed)

Prospective Randomised Controlled Trial Comparing Treatment Efficacy and Tolerance of Picosecond Alexandrite Laser with a Diffractive Lens Array and Triple Combination Cream in Female Asian Patients with Melasma. Recent evidence suggests melasma to be a photoaging disorder. Triple combination creams (TCC; fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%) remain the gold standard treatment. Picosecond alexandrite laser treatment using a diffractive lens array (DLA) has been (...) identified to be effective for improving photoaging conditions.We aimed to compare the efficacy and tolerance of the picosecond alexandrite laser with those of DLA and TCC in female Asian patients with melasma.Twenty-nine patients were randomly assigned to group A1 (3 laser sessions at 4-week intervals), A2 (5 laser sessions at 4-week intervals), or B (TCC daily for at least 8 weeks and then tapered until the final evaluation). The Melasma Area, Severity Index (MASI) score and VISIA were assessed

2019 Journal of the European Academy of Dermatology and Venereology

14. Comparative Efficacy of 35% Glycolic Acid Peel Alone or in Combination With 10% and 20% Trichloroacetic Acid Spot Peel for Melasma: A Randomized Control Trial. (PubMed)

Comparative Efficacy of 35% Glycolic Acid Peel Alone or in Combination With 10% and 20% Trichloroacetic Acid Spot Peel for Melasma: A Randomized Control Trial. To study and compare the therapeutic efficacy and side effects of 35% glycolic acid (GA) full face peel alone or in combination with 10% or 20% trichloroacetic acid (TCA) spot peel for facial melasma.Thirty patients with facial melasma were randomly divided into 3 equal Groups A, B, and C. Group A was treated with 35% GA full-face peel (...) , Group B and C with 35% GA full-face peel followed by 10% and 20% TCA spot peel respectively once every 15 days. Four peels were performed once every 15 days. The response to the treatment was evaluated by the percentage reduction in melasma area severity index (MASI) scoring.All 3 groups had significant reduction of MASI, but there was no significant difference between the groups. Group A had minimum side effects.Chemical peels with GA alone or in combination with TCA do result in a significant

2019 Dermatologic Surgery

15. Efficacy of Intense Pulse Light Therapy and Tripple Combination Cream Versus Intense Pulse Light Therapy and Tripple Combination Cream Alone in Epidermal Melasma Treatment. (PubMed)

Efficacy of Intense Pulse Light Therapy and Tripple Combination Cream Versus Intense Pulse Light Therapy and Tripple Combination Cream Alone in Epidermal Melasma Treatment. To compare the efficacy of intense pulse light therapy (IPL) and triple combination cream (TCC) versus intense pulse light therapy and triple combination cream alone in epidermal melasma treatment, downgrading MASI score to more than 10.Randomized controlled trial.Dermatology Department, Lady Reading Hospital, Peshawar, from (...) August 2014 to January 2015.Patients of 18-45 years were included in the study with Fitzpatrick skin type II-V. Sample of 96 patients was divided in to three groups of 32 each, through consecutive (non-probability) sampling method. Detailed history was taken, Woods Lamp Examination done, and melasma area and severity index (MASI) score was calculated. TCC had to be applied daily at night for two months by group A patients while group B was consigned for IPL therapy fortnightly, and those in group C

2018 Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

16. Efficacy and safety of a novel picosecond laser using combination of 1 064 and 595 nm on patients with melasma: A prospective, randomized, multicenter, split-face, 2% hydroquinone cream-controlled clinical trial. (PubMed)

Efficacy and safety of a novel picosecond laser using combination of 1 064 and 595 nm on patients with melasma: A prospective, randomized, multicenter, split-face, 2% hydroquinone cream-controlled clinical trial. Melasma is a common acquired, chronic hypermelanosis and still remains a therapeutic challenge. The low-fluence 1 064 nm Q-switched Nd:YAG laser is the most widely used for the treatment of moderate to severe melasma in Asia. Recently, the picosecond laser has been introduced (...) for various pigmentary disorders such as melasma. We evaluated the efficacy and safety of a picosecond laser with dual-wavelengths (1 064 and 595 nm) and topical 2% hydroquinone (HQ) combination therapy on patients with melasma, and compared results with those obtained with 2% HQ alone.This was a prospective, randomized, split-face, controlled trial comparing two treatments with combined 7 week 2% HQ (daily) and 5 week picosecond laser (weekly) versus 7 week 2% HQ. The primary efficacy variable

2018 Lasers in surgery and medicine

17. A split-face, investigator-blinded comparative study on the efficacy and safety of Q-switched Nd:YAG laser plus microneedling with vitamin C versus Q-switched Nd:YAG laser for the treatment of recalcitrant melasma. (PubMed)

A split-face, investigator-blinded comparative study on the efficacy and safety of Q-switched Nd:YAG laser plus microneedling with vitamin C versus Q-switched Nd:YAG laser for the treatment of recalcitrant melasma. High recurrence has previously been reported in the treatment of melasma with low-fluence 1,064-nm Q-switched neodymium-doped yttrium aluminium garnet (QS-Nd:YAG) laser. On the other hand, the efficacy and safety of the QS-Nd:YAG laser plus microneedling with vitamin C have not been (...) evaluated in patients with mixed-type melasma.Sixteen patients with recalcitrant dermal- or mixed-type melasma were included in the study. One side of patients' face was treated with QS-Nd:YAG laser plus microneedling with vitamin C (Group A) and the other side with QS-Nd:YAG laser alone (Group B) for four sessions at four-week intervals. Melasma Area Severity Index (MASI) scores and clinician's evaluation of clinical response were assessed monthly.Group A had a significantly lower mean MASI score

2018 Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology

18. Effects of a fractional picosecond 1,064 nm laser for the treatment of dermal and mixed type melasma. (PubMed)

Effects of a fractional picosecond 1,064 nm laser for the treatment of dermal and mixed type melasma. Picosecond laser is a novel modality for pigmented skin disorders with extremely short pulse duration. Little is known about the effects of the picosecond laser in melasma.This study aimed to investigate the efficacy of fractional picosecond 1,064 nm laser in melasma treatment.A prospective, randomized, assessor-blinded, intra-individual split face comparative study.Female subjects (...) with melasma were enrolled and received fractional picosecond 1,064 nm laser plus 4% hydroquinone cream on one randomly assigned side of the face; the results were compared to the use of hydroquinone cream only on the contralateral side. The modified melasma area severity index (mMASI) score, melanin index by Mexameter MX18®, participant satisfaction score by quartile rating scale, and the quality of life by the dermatology life quality index (DLQI) were evaluated over 12 weeks.Thirty female subjects

2018 Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology

19. A Randomized, Double-Blind, Placebo-Controlled, Split-Face Study of the Efficacy of Topical Epidermal Growth Factor for the Treatment of Melasma. (PubMed)

A Randomized, Double-Blind, Placebo-Controlled, Split-Face Study of the Efficacy of Topical Epidermal Growth Factor for the Treatment of Melasma. Melasma is a condition in which patients develop symmetric, reticulated, hyperpigmented macules and patches on the face which is thought to be the result of ultraviolet (UV) exposure and hormonal influences, although the pathogenesis is not completely understood. The topical application of epidermal growth factor has been used as a whitening agent (...) , moisturizer, and an aid for wound healing. In this study, we explore the efficacy of topical EGF in the treatment of melasma.This was a randomized, double-blind, placebo-controlled, split-face study to determine the efficacy of a topical EGF serum in the treatment of melasma. Fifteen women with a mean age of 44 were randomized to treatment side of the face and applied a topical EGF serum and a placebo twice daily to each designated side of the face for eight weeks. Patient satisfaction was assessed by use

2018 Journal of drugs in dermatology : JDD

20. Comparison of therapeutic effects of conventional and liposomal form of 4% topical hydroquinone in patients with melasma. (PubMed)

Comparison of therapeutic effects of conventional and liposomal form of 4% topical hydroquinone in patients with melasma. Melasma is a common acquired hyperpigmentation disorder observed mainly in young women. Hydroquinone is the basic treatment that its effect alone and in combination with other medications has been proven. Liposomes are microscopic vesicles in which water and lipid-soluble medications can be introduced to enhance their efficacy and specificity. The aim of this study (...) was to compare therapeutic effects of topical liposomal hydroquinone with its conventional form on melasma.This double-blind randomized clinical trial study was conducted on 20 women. Participants were asked to apply a certain amount of topical liposomal hydroquinone on one side of the face and conventional hydroquinone on the other side for three months. Skin pigmentation severity was measured using Melasma Area and Severity Index (MASI) at each visit, separately for each side of the face every month until

2018 Journal of cosmetic dermatology

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>