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Medications Predisposing to Heat Illness

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1. Medications Predisposing to Heat Illness

Medications Predisposing to Heat Illness Medications Predisposing to Heat Illness Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 (...) Medications Predisposing to Heat Illness Medications Predisposing to Heat Illness Aka: Medications Predisposing to Heat Illness , Drugs Predisposing to Heat Illness II. Causes: Sympathomimetics (alpha adrenergic agonists) s -containing supplements s III. Causes: Anticholinergics Scopolamine Benztropine mesylate s IV. Causes: Neurologic and psychiatric agents Antiparkinsonism Medications Butyrophenones ( ) ( ) Protriptyline s Miscellaneous psychiatric agents s ( ) V. Causes: Cardiovascular s s s ( ) ( ) VI

2018 FP Notebook

2. CRACKCast E141 – Heat Illness

, chronic disease, obesity, medications Pump or circulation problem: Beta blockers, CCBs Dehydration Diuretics Inhibition of sweating Anticholinergics, stimulant drugs Exertional heat illness: Lack of acclimatization Inadequate hydration (cool, flavored liquids) – goal body weight within 1% of previous day’s weight Weight class / category athletes Wet bulb globe temperature > 25 [1a] Include a discussion of heat illness pathophysiology Car analogy . Coolant (blood) is circulated by a pump (heart) from (...) and manifestations. CHS occurs during periods of sustained high ambient temperatures and humidity, such as during summer heat waves. Victims are often older adults and poor and live in underventilated dwellings without air conditioning. Debilitated patients who have limited access to oral fluids may develop water depletion heat exhaustion, which progresses to heatstroke if untreated. Victims of CHS commonly suffer from chronic diseases, alcoholism, or schizophrenia, which predisposes to heat illness

2018 CandiEM

3. Heat Stroke: A Medical Emergency Appearing in New Regions Full Text available with Trip Pro

. Both patients were morbidly obese and had several predisposing illnesses. However since heat stroke is a rare condition in areas with temperate climate, they were not diagnosed until several days after admittance; hence treatment with cooling was delayed. Both patients were admitted to the intensive care unit, where they were treated with an external cooling device and received treatment for complications. Both cases ended fatally. As global warming continues, more heat waves will occur (...) Heat Stroke: A Medical Emergency Appearing in New Regions Heat stroke is an acute, life-threatening emergency characterized clinically by elevated body temperature and central nervous system dysfunction. Early recognition and treatment including aggressive cooling and management of life-threatening systemic complications are essential to reduce morbidity and mortality. This case report describes two Danish patients diagnosed with heat stroke syndrome during a heat wave in the summer of 2014

2017 Case reports in critical care

4. Medications Predisposing to Heat Illness

Medications Predisposing to Heat Illness Medications Predisposing to Heat Illness Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 (...) Medications Predisposing to Heat Illness Medications Predisposing to Heat Illness Aka: Medications Predisposing to Heat Illness , Drugs Predisposing to Heat Illness II. Causes: Sympathomimetics (alpha adrenergic agonists) s -containing supplements s III. Causes: Anticholinergics Scopolamine Benztropine mesylate s IV. Causes: Neurologic and psychiatric agents Antiparkinsonism Medications Butyrophenones ( ) ( ) Protriptyline s Miscellaneous psychiatric agents s ( ) V. Causes: Cardiovascular s s s ( ) ( ) VI

2015 FP Notebook

5. High-Flow Heated and Humidified Oxygen Therapy and Gastric Distension

being pumped into it is a concern for anesthesiologists as it increases the risk of nausea and vomiting during surgery (aspiration). The objective of this study is use an ultrasound machine to measure the volume of fluid in the stomach before and after HFNO is used in a standard clinical manner. Condition or disease Intervention/treatment Phase Gastric Distention Device: High-Flow Heated and Humidified Oxygen Therapy (HFHHNO) Not Applicable Detailed Description: High Flow Heated and Humidified Nasal (...) Sponsor: University Health Network, Toronto Collaborator: Kaiser Permanente Information provided by (Responsible Party): University Health Network, Toronto Study Details Study Description Go to Brief Summary: High Flow Heated and Humidified Nasal Oxygen therapy (HFHHNO) has been increasingly used in emergency medicine to assist patients with short term respiratory failure and to provide adequate oxygen to the body prior to intubation. Gastric distension which is the bloating of the stomach due to air

2017 Clinical Trials

6. Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient

Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient Guidelines for the Provision and Assessment of Nutrition Sup... : Critical Care Medicine You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. Login No user account? Lippincott Journals Subscribers , use your username or email along with your password to log in. Remember me on this computer Register for a free account (...) patient care by advancing the science and practice of clinical nutrition and metabolism. The mission of SCCM is to secure the highest quality care for all critically ill and injured patients. Guideline Limitations : These A.S.P.E.N.−SCCM Clinical Guidelines are based on general conclusions of health professionals who, in developing such guidelines, have balanced potential benefits to be derived from a particular mode of medical therapy against certain risks inherent with such therapy. However

2016 Society of Critical Care Medicine

7. Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient

and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Volume 40 Issue 8 Journal of Parenteral and Enteral Nutrition pages: 1200-1200 First Published online: September 15, 2016 Corresponding Author E-mail address: Department of Medicine, University of Louisville, Louisville, Kentucky Beth Taylor and Steven McClave are co–first authors of this article. Stephen A. McClave, MD (...) , in which the feeding is thought to help attenuate the metabolic response to stress, prevent oxidative cellular injury, and favorably modulate immune responses. Improvement in the clinical course of critical illness may be achieved by early EN, appropriate macro‐ and micronutrient delivery, and meticulous glycemic control. Delivering early nutrition support therapy, primarily by the enteral route, is seen as a proactive therapeutic strategy that may reduce disease severity, diminish complications

2016 American Society for Parenteral and Enteral Nutrition

8. Pharmacologic and Nonpharmacologic Therapies in Adult Patients With Exacerbation of COPD

2019 ii Key Messages Purpose of Review To evaluate the effectiveness and harms of pharmacologic and nonpharmacologic treatments for exacerbations of chronic obstructive pulmonary disease. Key Messages • Antibiotic therapy increases the clinical cure rate and reduces the clinical failure rate. • Oral and intravenous corticosteroids improve dyspnea and reduce the clinical failure rate. • Antibiotics and corticosteroids are not associated with increase in serious adverse events. • The evidence (...) the quality of healthcare in the United States. These reviews provide comprehensive, science-based information on common, costly medical conditions, and new healthcare technologies and strategies. Systematic reviews are the building blocks underlying evidence-based practice; they focus attention on the strength and limits of evidence from research studies about the effectiveness and safety of a clinical intervention. In the context of developing recommendations for practice, systematic reviews can help

2019 Effective Health Care Program (AHRQ)

9. Heat stroke

Heat stroke Heat stroke - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Heat stroke Last reviewed: February 2019 Last updated: November 2017 Summary Generally associated with core temperatures >40°C (>104°F), though heat stroke can occur at lower core temperatures. Diagnosis rests on the observation of hyperthermia in the presence of profound CNS dysfunction. Medicines may predispose patients to heat stroke (e.g (...) ]) but to a smaller extent than in heat stroke. History and exam presence of risk factors hyperthermia profound CNS disturbance headache nausea and vomiting anxiety dizziness tachycardia jaundice muscle tenderness hypotension gastrointestinal bleeding bruising and skin bleeding older age impaired cognition patients unable to care for themselves medicines people unacclimatised to hot environments young, active people exercising intensely under hot, humid conditions Diagnostic investigations serum electrolytes FBC

2017 BMJ Best Practice

10. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection

immunodeficiency syndrome AIM AIDS Impact Model AIS AIDS Indicator Survey ALT alanine transaminase ART antiretroviral therapy ARV antiretroviral (drug) ATV atazanavir AUC area under the curve AZT azidothymidine (also known as zidovudine) BMI body mass index CDC United States Centers for Disease Control and Prevention CI confidence interval COPD chronic obstructive pulmonary disease CNS central nervous system CrAg cryptococcal antigen CVD cardiovascular disease CTX co-trimoxazole CVD cardiovascular disease d4T (...) and breastfeeding women 382 Annex 10: WHO clinical staging of HIV disease in adults, adolescents and children 386 Annex 11: Doses of recommended antiretroviral drugs 388 Annex 12: Viral load testing strategy 396 Annex 13: Key drug interactions for antiretrovirals 397 Annex 14: Algorithm for the management of people with HIV and suspected of having TB 412 Annex 15: Algorithm for the management of people with HIV and suspected of having TB (seriously ill patients) 413 Annex 16: Checklist for periodic evaluation

2016 World Health Organisation HIV Guidelines

11. Biologic therapy for psoriasis

relate to other factors (for example, other co-therapies or the underlying disease) that the risk of fetal abnormalities in women with psoriasis who conceive on biologic therapy has not been adequately studied and therefore cannot be áá British Association of Dermatologists guidelines for biologic therapy for psoriasis 2017 20 X For example http://www.medicinesinpregnancy.org/Medicine--pregnancy XI There are no known interactions between biologic therapies and contraceptive methods (see drug-specific (...) are trained and competent in the use of biologic therapies áá Reviewing biologic therapy R9 Assess initial response to biologic therapy in people with psoriasis at time points appropriate for the drug in question, and then on a regular basis during therapy (for example, every 6 months) áá R10 Review response to biologic therapy by taking into account: · psoriasis disease severity compared with baseline (for example, Psoriasis Area and Severity Index [PASI] baseline to endpoint score VI ) · the agreed

2017 British Association of Dermatologists

12. Systematic review of needs for medical devices for ageing populations

Region. Five main health conditions, with 19 associated sub-topics, were identified: • cardiovascular diseases; • malignant neoplasms; • respiratory diseases; • sense organ diseases; • neuropsychiatric conditions. This report provides a literature-based review of medical devices needed by older people. The results have been used to create lists of devices categorized in terms of whether they are preventive, diagnostic or therapeutic. Broad clinical safety and effectiveness information has also been (...) • neuropsychiatric conditions: – Alzheimer’s disease and other dementias. Therefore, there were 19 groups of populations associated with the above topics, broadly grouped within five major health conditions. 2.2 MEDICAL DEVICES Medical devices are required in all aspects of clinical practice, and many are the focus of a substantial commitment in terms of research and development worldwide. Effective medical devices are needed in the management of many chronic health conditions and, if selected, purchased

2015 ASERNIP-S

13. March 2014 supplement to the 2013 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection

of HIV/AIDS, WHO; Shirin Heidari, International AIDS Society; David Jamieson, PFSCM, United States of America; Janice Lee, Drugs for Neglected Diseases Initiative, Switzerland; Atieno Ojo, UNICEF.10 Community-based delivery of antiretroviral therapy We thank the meeting participants for their contribution: Marielle Bemelmans (Médecins Sans Frontières), Cephas Chikanda (Anova Health Institute), Tom Decroo (Institute for Tropical Medicine, Belgium), Bernard Michael Etukoit (The AIDS Support (...) therapy 3. Pharmaceutical equivalence and clinical interchangeability between lamivudine and emtricitabine 4. Use of efavirenz during pregnancy as part of first-line antiretroviral therapy: a public health perspective 5. Optimizing antiretroviral drugs for children: medium- and long-term priorities 6. Changing role of CD4 cell counts in HIV care and treatment 7. Scaling up viral load testing in resource-limited settings Supplementary sections to Chapter 9 – Guidance on operations and service delivery

2014 World Health Organisation HIV Guidelines

14. Guidelines for the Clinical and Operational Management of Drug-Resistant Tuberculosis

medicines 230 Importation of drug-resistant tuberculosis medicines 231 Storage and distribution in-country 231 Rational use 231 References 232 Appendices 233 CONTENTS viiAbbreviations 2LI second-line injectable drug AFB acid-fast bacillus Am amikacin Amx/Clv amoxicillin/clavulanate ART antiretroviral therapy ARV antiretroviral (drug) ATS American Thoracic Society AUC24 area under the concentration-time curve from 0 to 24 h BTS British Thoracic Society CD4 cells CD4+T lymphocytes Cf clofazimine Cfx cipro (...) in? ammatory syndrome TBTEAM TB TEchnical Assistance Mechanism TDR-TB totally drug-resistant TB Tdf tenofovir Th thiacetazone The Union International Union Against Tuberculosis and Lung Disease TLA thin layer agar UVGI ultraviolet germicidal irradiation Vi viomycin VWS ventilated workstation WHO World Health Organization XDR-TB extensively drug-resistant tuberculosis; multidrug-resistant tuberculosis plus resistance to ? uoroquinolones plus one second-line injectable drug Z pyrazinamide x ABBREVIATIONS

2013 International Union Against TB and Lung Disease

15. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection

preventive therapy 156 8.1.2 Tuberculosis 158 8.1.3 Cryptococcal infection 165 8.1.4 Hepatitis B and C 166 8.1.5 Malaria 167 8.1.6 Sexually transmitted infections and cervical cancer 168 8.1.7 Vaccines for people living with HIV 169 8.2 Preventing and managing other comorbidities and chronic care for people living with HIV 170 8.2.1 Screening for and care of noncommunicable diseases 170 8.2.2 Mental health 171 8.2.3 Drug use and drug use disorders 171 8.2.4 Nutritional care and support 172 8.2.5 (...) lamivudine ABC abacavir AIDS acquired immunodeficiency syndrome Ar T antiretroviral therapy Ar V antiretroviral (drug) ATV atazanavir ATV/r atazanavir/ritonavir AZT zidovudine (also known as ZDV) BMI body mass index CD4 T–lymphocyte cell bearing CD4 receptor CDC United States Centers for Disease Control and Prevention CNS central nervous system d4T stavudine DALYs death- and disability-adjusted life-years DBS dried blood spot ddI didanosine DNA deoxyribonucleic acid DrV darunavir DrV/r darunavir

2013 World Health Organisation HIV Guidelines

16. Heat Illness Risk Factors

Illness Risk Factors Aka: Heat Illness Risk Factors From Related Chapters II. Pathophysiology Predisposing conditions alter heat balance See III. Causes: Increased endogenous heat load Vigorous or overexertion drugs (see below) IV. Causes: Increased Exogenous Heat load Increased V. Causes: Decreased Heat Dissipation Exogenous cause Humidity Evaporation of sweat stops at 75% humidity (and sweating has no cooling effect at 95% humidity) Occlusive or excessive clothing Endogenous cause Dehydration Lack (...) of acclimatization Poor physical conditioning Healed burns Dermatitis Dysfunction See VI. Causes: Other predisposing factors for abnormal heat balance Prior Concurrent infection Age over 65 years Myocardial dysfunction Vascular disease Decreased muscle mass Decreased skin blood supply Chronic illness Decreased mobility Children (especially tightly bundled infants) See rate greater metabolic heat during activity and at rest (higher basal metabolic rate) Slower acclimitization Decreased sweat response and capacity

2018 FP Notebook

17. The Effects of Soft Tissue Therapy and Exercise on Hamstring Tightness

. The hypotheses of this study are that neurodynamic sliding will have an effect on all variables and myofascial decompression will only have an effect on range of motion. Condition or disease Intervention/treatment Phase Hamstring Tightness Myofascial Pain Musculoskeletal Pain Other: Neurodynamic Sliding Other: Myofascial Decompression Other: Diathermy Not Applicable Detailed Description: Predisposing factors to hamstring injury include neural tension and muscle flexibility restrictions due to fascial (...) be in the Sprints, Jumps, or Multi (heptathlon, pentathlon, or decathlon) groups complain of hamstring tightness and/or injury in the last calendar year have less than 80⁰ for Active Knee Extension test. Exclusion Criteria: Past history or current neurological disorders or orthopedic diseases Surgery of the lower extremity that involves an autograft on the tested leg Past history of hamstring surgery Receiving current treatment for a hamstring injury Received any form of myofascial therapy or neurodynamic

2018 Clinical Trials

18. High-Flow Nasal Cannula Versus Conventional Oxygen Therapy After Extubation in Liver Transplantation

complications for patients undergoing liver transplantation after extubation. Condition or disease Intervention/treatment Gas Exchange Device: HFNC group Detailed Description: Humidified oxygen therapy via high-flow nasal cannula (HFNC) is a recently available technique delivering heated and humidified high flow oxygen through simple nasal prongs. HFNC provides flows up to 60 L/min of heated air and oxygen at a constant fraction of inspired oxygen (FiO 2 ) up to 1.0. Several studies (1-3) have demonstrated (...) , 2019 Sponsor: Policlinico Universitario Agostino Gemelli Information provided by (Responsible Party): Dr. Giuliano Ferrone, Policlinico Universitario Agostino Gemelli Study Details Study Description Go to Brief Summary: Humidified oxygen therapy via high-flow nasal cannula (HFNC) is a recently available technique delivering heated and humidified high flow oxygen through simple nasal prongs. In immunocompetent patients HFNC can help generating low levels of Continuous Positive Airway Pressure (CPAP

2018 Clinical Trials

19. Evaluation of Occupational Exposure Limits for Heat Stress in Outdoor Workers — United States, 2011–2016 Full Text available with Trip Pro

Evaluation of Occupational Exposure Limits for Heat Stress in Outdoor Workers — United States, 2011–2016 Heat stress, an environmental and occupational hazard, is associated with a spectrum of heat-related illnesses, including heat stroke, which can lead to death. CDC's National Institute for Occupational Safety and Health (NIOSH) publishes recommended occupational exposure limits for heat stress (1). These limits, which are consistent with those of the American Conference of Governmental (...) Industrial Hygienists (ACGIH) (2), specify the maximum combination of environmental heat (measured as wet bulb globe temperature [WBGT]) and metabolic heat (i.e., workload) to which workers should be exposed. Exposure limits are lower for workers who are unacclimatized to heat, who wear work clothing that inhibits heat dissipation, and who have predisposing personal risk factors (1,2). These limits have been validated in experimental settings but not at outdoor worksites. To determine whether the NIOSH

2018 Morbidity and Mortality Weekly Report

20. Guidelines on Chronic Coronary Syndromes Full Text available with Trip Pro

and antithrombotic therapy 31 3.3.2.6 Non-cardiac surgery and antithrombotic therapy 32 3.3.3 Statins and other lipid-lowering drugs 34 3.3.4 Renin−angiotensin−aldosterone system blockers 34 3.3.5 Hormone replacement therapy 35 3.4 Revascularization 35 4. Patients with new onset of heart failure or reduced left ventricular function 36 5. Patients with a long-standing diagnosis of chronic coronary syndromes 38 5.1 Patients with stabilized symptoms <1 year after an acute coronary syndrome or patients with recent (...) in asymptomatic apparently healthy subjects (primary prevention) and patients with established chronic coronary syndromes (secondary prevention) 21 Figure 7 The five As of smoking cessation 24 Figure 8 Suggested stepwise strategy for long-term anti-ischaemic drug therapy in patients with chronic coronary syndromes and specific baseline characteristics 28 Figure 9 Decision tree for patients undergoing invasive coronary angiography 36 Figure 10 Proposed algorithm according to patient types commonly observed

2019 European Society of Cardiology

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