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Medications Affecting Thyroid Function

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1. Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention: A Systematic Review

, Los Angeles Los Angeles, CA Nancy Lane, M.D. Director and Distinguished Professor Center for Musculoskeletal Health and Department of Internal Medicine University of California at Davis, School of Medicine Sacramento, California Jasvinder Singh, M.D., M.P.H. Division of Rheumatology University of Alabama Birmingham, AL vii Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention: A Systematic Review Structured Abstract Objective. To summarize the effects of long-term (...) of Patient, Bone, or Osteoporosis Drug Characteristics 28 Denosumab 29 Key Points 29 Eligible Studies 29 Outcomes 30 Variation in Long-Term Treatment Efficacy as a Function of Patient, Bone, or Osteoporosis Drug Characteristics 31 Raloxifene 32 Key Points 32 Eligible Studies 32 Outcomes 33 Variation in Long-Term Treatment Efficacy as a Function of Patient, Bone, or Osteoporosis Drug Characteristics 34 Hormone Therapy 35 x Key Points 35 Eligible Studies 35 Outcomes 37 Variation in Long-Term Treatment

2019 Effective Health Care Program (AHRQ)

2. Newer Drugs for Type 2 Diabetes: An Emerging Adjunctive Therapy to Insulin for Type 1 Diabetes?

Diabetes Canada, have acknowledged that there may be a role for adjunctive therapy in some T1D patients. 10,23,40 In the US, pramlintide acetate injection (Symlin) is the only noninsulin drug approved for adjunctive treatment of T1D. 13,29 Metformin, a T2D medication, is mentioned by Diabetes Canada and the American Diabetes Association for off-label use to reduce insulin requirements and total cholesterol/low-density lipoprotein ratios, 10,17,23 with the caveat that it does not improve hemoglobin A1C (...) Newer Drugs for Type 2 Diabetes: An Emerging Adjunctive Therapy to Insulin for Type 1 Diabetes? Newer Drugs for Type 2 Diabetes: An Emerging Adjunctive Therapy to Insulin for Type 1 Diabetes? | CADTH.ca CADTH Document Viewer Newer Drugs for Type 2 Diabetes: An Emerging Adjunctive Therapy to Insulin for Type 1 Diabetes? Table of Contents Search this document Newer Drugs for Type 2 Diabetes: An Emerging Adjunctive Therapy to Insulin for Type 1 Diabetes? January 2018 Summary There are two major

2018 CADTH - Issues in Emerging Health Technologies

3. A Study to Evaluate the Food Effect on Drug Availability, Pharmacokinetic (PK) Properties, Safety and Tolerability of Two Different Dose Combination Therapy of Saxagliptin/Dapagliflozin/Metformin Extended-release (XR) Against Individual Component Co-admin

A Study to Evaluate the Food Effect on Drug Availability, Pharmacokinetic (PK) Properties, Safety and Tolerability of Two Different Dose Combination Therapy of Saxagliptin/Dapagliflozin/Metformin Extended-release (XR) Against Individual Component Co-admin A Study to Evaluate the Food Effect on Drug Availability, Pharmacokinetic (PK) Properties, Safety and Tolerability of Two Different Dose Combination Therapy of Saxagliptin/Dapagliflozin/Metformin Extended-release (XR) Against Individual (...) and 32 kg/m2 inclusive and weigh at least 50 kg and no more than 100 kg inclusive. Exclusion Criteria: History of any clinically significant disease or disorder which, in the opinion of the principal investigator (PI), may either put the volunteer at risk because of participation in the study, or influence the results or the volunteer's ability to participate in the study. Current or recent (within 3 months of first IMP dosing) gastrointestinal (GI) disease that may impact drug absorption and affect

2017 Clinical Trials

4. Medications Affecting Thyroid Function

Medications Affecting Thyroid Function Medications Affecting Thyroid Function Aka: Medications Affecting Thyroid Function , Drug-Induced Thyroiditis From Related Chapters II. Causes: Medications associated with Hypothyroidism Inorganic Iodide Cyanates Interleukin-2 inhibitors III. Causes: Medications associated with Hyperthyroidism Excess hormone intake Excess exposure Dietary (contains ) (contains 37% ) IV. Causes: Medications causing Thyroiditis Type 1 -induced Increased hormone synthesis (pre-existing (...) links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Medications Affecting Thyroid Function." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Drug-induced thyroiditis (C0342179) Concepts Pathologic Function ( T046 ) ICD10 SnomedCT 237539004 German Arzneimittelinduzierte Thyreoiditis Korean 약물 유발성 갑상샘염 English thyroiditis drug-induced , thyroiditis drug-induced

2018 FP Notebook

5. Effects of Inorganic Iodine Therapy Administered to Lactating Mothers With Graves Disease on Infant Thyroid Function Full Text available with Trip Pro

Effects of Inorganic Iodine Therapy Administered to Lactating Mothers With Graves Disease on Infant Thyroid Function The effects of maternal inorganic iodine therapy on infant thyroid function are not well known.This study investigated the effects on infant thyroid function of maternal inorganic iodine therapy when administered to lactating mothers with Graves disease.This study was a prospective case series performed at the Tajiri Thyroid Clinic, Kumamoto, Japan.Subjects were 26 infants (...) of inorganic iodine to lactating mothers with Graves disease did not affect thyroid function in most infants despite high levels of exposure to iodine via breast milk.

2017 Journal of the Endocrine Society

6. Improving Adherence to Therapy and Clinical Outcomes While Containing Costs: Opportunities From the Greater Use of Generic Medications: Best Practice Advice From the Clinical Guidelines Committee of the American College of Physicians Full Text available with Trip Pro

. Diabetes Care 2009 32 647 9 Briesacher BA , Andrade SE , Fouayzi H , Chan KA . Medication adherence and use of generic drug therapies. Am J Manag Care 2009 15 450 6 Shrank WH , Hoang T , Ettner SL , Glassman PA , Nair K , DeLapp D . et al The implications of choice: prescribing generic or preferred pharmaceuticals improves medication adherence for chronic conditions. Arch Intern Med 2006 166 332 7 Taira DA , Wong KS , Frech-Tamas F , Chung RS . Copayment level and compliance with antihypertensive (...) Improving Adherence to Therapy and Clinical Outcomes While Containing Costs: Opportunities From the Greater Use of Generic Medications: Best Practice Advice From the Clinical Guidelines Committee of the American College of Physicians Opportunities From the Greater Use of Generic Medications | Annals of Internal Medicine | American College of Physicians '); } '); })(); Sign in below to access your subscription for full content INDIVIDUAL SIGN IN | You will be directed to acponline.org

2015 American College of Physicians

7. AACE/ACE/AME Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules

antithyroid drugs 4 to 7 days before treatment and consider resumption 1 week after radioiodine ther- apy [BEL 2, GRADE B]. 7.2.6.2. Contraindications • Radioiodine is contraindicated in preg- nant and breastfeeding subjects [BEL 2, GRADE A].12 Thyroid Nodule Management, Endocr Pract. 2016;22(Suppl 1) • In females of childbearing potential, per- form a pregnancy test before administra- tion of radioiodine [BEL 2, GRADE A]. 7.2.6.3. Follow-up after radioiodine therapy • Regular thyroid function monitoring (...) encourage medical professionals to use this information in conjunction with their best clinical judgment. Any decision by practitioners to apply these guidelines must be made in light of local resources and individual patient circumstances and preference. Copyright © 2016 AACE.2 Thyroid Nodule Management, Endocr Pract. 2016;22(Suppl 1) Abbreviations: AACE = American Association of Clinical Endocrinologists; ACE = American College of Endocrinology; AFTN = autonomously function- ing thyroid nodule; AME

2016 American Association of Clinical Endocrinologists

8. Therapeutic challenges in the application of serum thyroid stimulating hormone testing in the management of patients with hypothyroidism on replacement thyroid hormone therapy: a review. (Abstract)

Therapeutic challenges in the application of serum thyroid stimulating hormone testing in the management of patients with hypothyroidism on replacement thyroid hormone therapy: a review. Normalizing serum thyroid stimulating hormone (TSH) levels by lifelong treatment with levothyroxine (LT4) remains the primary goal of therapy for patients with hypothyroidism. The reference ranges for TSH are derived from populations with (supposedly) normal thyroid function. But, TSH results are affected (...) by a number of factors including alterations in TSH levels with age, concurrent illnesses, circadian rhythm, inter- and intra-assay differences, and some commonly used medications that interfere with thyroid function or the TSH test. Furthermore, some patients are complex to manage and bringing serum TSH to within its reference range does not always resolve their symptoms of hypothyroidism. Furthermore, changes in TSH within the reference range may provoke symptoms in some sensitive patients, and others

2019 Current medical research and opinion

9. Drug-Induced Liver Injury

andpathologicalphenotypesandthecurrentabsenceofspeci?c biomarkers. This makes the diagnosis of drug-induced liver injury an uncertain process, requiring a high degree of aware- ness of the condition and the careful exclusion of alternative aetiologies of liver disease. Idiosyncratic hepatotoxicity can be severe, leading to a particularly serious variety of acute liver failure for which no effective therapy has yet been developed. These Clinical Practice Guidelines summarize the available evi- dence on risk factors, diagnosis, management and risk (...) . Clinical trials produce reliable information about the devel- opment of abnormal liver biochemistries and DILI if the inci- dence is high. However, such trials usually include a limited number of patients and are therefore underpowered to detect rare adverse effects such as idiosyncratic hepatotoxicity. Conse- quently,themajorityofdataareprovidedbyretrospectivestud- ies of databases from pharmacovigilance centres and/or pharmaceutical companies, aimed to determine the most fre- quently associated drugs

2019 European Association for the Study of the Liver

10. Serum levels of fetuin-A are negatively associated with log transformation levels of thyroid-stimulating hormone in patients with hyperthyroidism or euthyroidism: An observational study at a medical center in Taiwan. Full Text available with Trip Pro

Serum levels of fetuin-A are negatively associated with log transformation levels of thyroid-stimulating hormone in patients with hyperthyroidism or euthyroidism: An observational study at a medical center in Taiwan. Fetuin-A is a protein with various biological functions. It plays a role in insulin resistance and arterial calcium deposition. Thyroid dysfunction may affect energy expenditure, glucose metabolism, and the risk of cardiovascular diseases. In the present study, we compared (...) the serum fetuin-A concentrations in hyperthyroid patients with those in euthyroid patients.We recruited 30 newly-diagnosed hyperthyroid patients (the HY group) and treated them with anti-thyroid regimens as clinically indicated. We recruited 30 euthyroid individuals (the EU group) as controls. We compared laboratory parameters at the baseline and at 6 months. We then determined the associations between the levels of fetuin-A and free thyroxine (fT4), thyroid-stimulating hormone (TSH), or log

2018 Medicine

11. Clinical Appropriateness Guidelines: Radiation Oncology Brachytherapy, intensity modulated radiation therapy (IMRT), stereotactic body radiation therapy (SBRT) and stereotactic radiosurgery (SRS) treatment guidelines

Health. All Rights Reserved. 3 AIM’s Clinical Appropriateness Guidelines (hereinafter “AIM’s Clinical Appropriateness Guidelines” or the “Guidelines”) are designed to assist providers in making the most appropriate treatment decision for a specific clinical condition for an individual. As used by AIM, the Guidelines establish objective and evidence-based, where possible, criteria for medical necessity determinations. In the process, multiple functions are accomplished: ? To establish criteria (...) for medical necessity review , due to billing practices or claims that are not consistent with other providers in terms of frequency or some other manner. CPT ® (Current Procedural Terminology) is a registered trademark of the American Medical Association (AMA). CPT ® five digit codes, nomenclature and other data are copyright by the American Medical Association. All Rights Reserved. AMA does not directly or indirectly practice medicine or dispense medical services. AMA assumes no liability for the data

2018 AIM Specialty Health

12. Use of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes in Preclinical Cancer Drug Cardiotoxicity Testing: A Scientific Statement From the American Heart Association Full Text available with Trip Pro

). The clinical effects of an oncological drug (and any active metabolites that are likely not generated in vitro) will depend on the cellular uptake of drug, differences in types and levels of kinase expression across cell types, and potential cross talk between adversely affected cardiomyocytes and other cardiac cell types and those within the vasculature. Other marketed targeted therapies include proteasome inhibitors (cellular complexes that break down proteins, including cardiac sarcomeric proteins (...) , MD, PhD, FAHA , MD, PhD, FAHA, Vice Chair Gary Gintant , Paul Burridge , Lior Gepstein , Sian Harding , Todd Herron , Charles Hong , José Jalife , Joseph C. Wu , Originally published 19 Sep 2019 Circulation Research. 2019;125:e75–e92 Abstract It is now well recognized that many lifesaving oncology drugs may adversely affect the heart and cardiovascular system, including causing irreversible cardiac injury that can result in reduced quality of life. These effects, which may manifest in the short

2019 American Heart Association

13. The Preventive Effect of Parotid Gland Massage on Salivary Gland Dysfunction During High-Dose Radioactive Iodine Therapy for Differentiated Thyroid Cancer: A Randomized Clinical Trial. (Abstract)

The Preventive Effect of Parotid Gland Massage on Salivary Gland Dysfunction During High-Dose Radioactive Iodine Therapy for Differentiated Thyroid Cancer: A Randomized Clinical Trial. To evaluate the preventive effect of parotid gland (PG) massage for PG damage during the I therapy, we prospectively investigated the serum amylase value and salivary gland scintigraphy (SGS) after I therapy.One hundred patients with thyroidectomized differentiated thyroid cancer who underwent high-dose I therapy (...) were enrolled in the clinical trial and randomized into 2 groups (PG massage group and nonmassage group). The serum amylase value was obtained before and 24 hours after I therapy, and the SGSs were also taken just before and at 8 months after the I therapy. Change in serum amylase value and SGS was compared between PG massage and nonmassage groups.The difference value of serum amylase was significantly lower in PG massage group than in nonmassage group (P = 0.0052). Worsening of PG function on SGS

2019 Clinical nuclear medicine Controlled trial quality: uncertain

14. Interventional Spine and Pain Procedures in Patients on Antiplatelet and Anticoagulant Medications

NSAIDs. | Summary Recommendations for Non-ASA NSAIDs Non-ASA NSAIDs are used for pain control and, unlike ASA, are not required for cardiac and cerebral protection. Therefore, these drugs may be discontinued without negatively affecting cardiac and cerebral function. For interventional pain procedures where the bleeding risks and the consequences of hematoma development may be higher (eg, high-risk procedures; ) consideration should be given to discontinue these medications. Besides ibuprofen (...) Interventional Spine and Pain Procedures in Patients on Antiplatelet and Anticoagulant Medications Interventional Spine and Pain Procedures in Patients on Anti... : Regional Anesthesia and Pain Medicine You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. Login No user account? Lippincott Journals Subscribers , use your username or email along with your password to log in. Remember me on this computer Register for a free account

2018 American Society of Regional Anesthesia and Pain Medicine

15. The effect of long-term thyroid-stimulating hormone suppressive therapy on the gonadal steroid hormones of patients with thyroid carcinoma after surgery Full Text available with Trip Pro

The effect of long-term thyroid-stimulating hormone suppressive therapy on the gonadal steroid hormones of patients with thyroid carcinoma after surgery To analyze the effect of long-term thyroid-stimulating hormone (TSH) suppressive therapy on the gonadal hormones and related symptoms in patients after surgery.From 2008 to 2011, totally 238 patients were recruited, who underwent thyroid surgery and subsequent TSH suppression treatment in Department of thyroid Surgery, China-Japan Union (...) . 442.5 pmol/L in 6-8 years group, P=0.018; (IV) the level of follicle-stimulating hormone (FSH) did not show any change in terms of the dose and the duration of TSH treatment; (V) the menstrual volume, dysmenorrhea condition, menstrual cycle and menopause related indicators did not show any difference in terms of doses and duration of TSH treatment (P=0.701, 0.412 and 0.507 respectively).The long term of TSH repressive therapy after surgery did not affect T and E2 level in male patients

2017 Gland surgery

16. Administration of medicinal products by non - medical personnel as part of Clinical Nuclear Medicine Procedures

adverse reaction • Communication with patients; o eliciting relevant information on potential contraindications, allergies and concurrent drug therapy o obtaining consent to administer the medicine o advice to patient about potential delayed affects and actions required • Intravenous injection and infusion • Intermediate Life Support • Relevant documentation MEDICINES USED IN NUCLEAR MEDICINE AS PART OF THE CLINICAL PROCEDURE (2013) [ * Medicines for which this draft contains sample templates] Page 6 (...) and assessment’ 4 More detailed information on each licensed drug is available in the manufacturers Summary of Product Characteristics (SPC) and the British National Formulary (BNF) This guidance is not intended to cover medicines used for clinical treatment of adverse events occurring during nuclear medicine procedures (eg. Reaction to any pharmaceutical administered including the relevant radiopharmaceutical, worsening of a pre-existing condition such as asthma) or non-pharmaceutical adjuncts used

2013 British Nuclear Medicine Society

17. Metformin affects thyroid function in male rats Full Text available with Trip Pro

Metformin affects thyroid function in male rats An intriguing area of research in type 2 diabetes recently discovered association of metformin therapy with thyroid functional and morphological changes. We aimed to evaluate the external symptoms and biochemical indicators concerning thyroid function in rats treated with metformin. Male wistar rats were randomly divided into four groups: Group (D-/M-), Group (D-/M+), Group (D+/M-), and Group (D+/M+), according to whether they were induced (...) to diabetic model or placed on metformin. Characteristics of food intake, body weight, and other external symptoms were recorded. Thyroid function, concluding serum thyrotropin (TSH), free triiodothyronine (FT3), free thyroxine (FT4), were measured. We found a significantly higher TSH and lower FT4 in rats in Group (D+/M-), compared with rats in Group (D-/M-), but no significant change in FT3 level. Rats on metformin treatment exhibited relatively lower body weight and symptoms like irritability

2017 Oncotarget

18. Outcomes of Radiofrequency Ablation Therapy for Large Benign Thyroid Nodules: A Mayo Clinic Case Series. (Abstract)

of predominantly solid TNs, improves compressive symptoms and cosmetic concerns, and does not affect normal thyroid function. Radiofrequency ablation has an acceptable safety profile and should be considered as a low-risk alternative to conventional treatment of symptomatic benign TNs.Copyright © 2017 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved. (...) did not affect thyroid function. In 1 patient with subclinical hyperthyroidism due to toxic adenoma, thyroid function normalized 4 months after ablation of the toxic nodule. Compressive symptoms resolved in 8 of 12 patients (67%) and improved in the other 4 (33%). Cosmetic concerns improved in all 8 patients. The procedure had no sustained complications.In this population, RFA of benign large TNs performed similarly to the reports from Europe and Asia. It induces a substantial volume reduction

2018 Mayo Clinic Proceedings

19. Longitudinal characterization of autoantibodies to the thyrotropin receptor (TRAb) during alemtuzumab therapy; evidence that TRAb may precede thyroid dysfunction by many years. Full Text available with Trip Pro

of TRAb prior to clinical presentation. TRAb can stimulate (TSAb), block (TBAb), or not affect ("neutral") the TSHR function, causing hyperthyroidism, hypothyroidism, or euthyroidism, respectively.A longitudinal retrospective analysis was conducted of TRAb bioactivity over a period of nine years in 45 multiple sclerosis patients receiving ALTZ using available stored serum. Of these 45 patients, 31 developed thyroid dysfunction (TD) and 14 remained euthyroid despite being followed for a minimum of five (...) Longitudinal characterization of autoantibodies to the thyrotropin receptor (TRAb) during alemtuzumab therapy; evidence that TRAb may precede thyroid dysfunction by many years. Thyroid autoimmunity, especially Graves' disease or hypothyroidism with positive autoantibodies (TRAb) to the thyrotropin receptor (TSHR), occurs in 30-40% of patients with relapsing multiple sclerosis following treatment with alemtuzumab (ALTZ). ALTZ therapy therefore provides a unique opportunity to study the evolution

2018 Thyroid

20. Adaptive Tyrosine Kinase Inhibitor (TKI) Therapy In Patients With Thyroid Cancer

Completion Date : December 2022 Estimated Study Completion Date : December 2023 Resource links provided by the National Library of Medicine related topics: available for: resources: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Standard of Care: DTC Standard of Care (SOC) TKI Therapy for Differentiated Thyroid Cancer (DTC): Lenvatinib + Sorafenib. Drug: Lenvatinib Standard of Care: Lenvatinib 24 mg daily. All participants will start receiving standard of care treatment (...) in the protocol guidelines. Voluntary agreement to provide written informed consent and the willingness and ability to comply with all aspects of the protocol Exclusion Criteria: Participants who have received any anticancer treatment (including Chinese herbal medicine specified for the treatment of tumor) within 21 days or any investigational agent within 30 days prior to the first dose of study drug. This does not apply to the use of TSH-suppressive thyroid hormone therapy. Major surgery within 21 days

2018 Clinical Trials

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