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Medications Affecting Thyroid Function

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1. Medications Affecting Thyroid Function

Medications Affecting Thyroid Function Medications Affecting Thyroid Function Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 (...) Medications Affecting Thyroid Function Medications Affecting Thyroid Function Aka: Medications Affecting Thyroid Function , Drug-Induced Thyroiditis From Related Chapters II. Causes: Medications associated with Hypothyroidism Inorganic Iodide Cyanates Interleukin-2 inhibitors III. Causes: Medications associated with Hyperthyroidism Excess hormone intake Excess exposure Dietary (contains ) (contains 37% ) IV. Causes: Medications causing Thyroiditis Type 1 -induced Increased hormone synthesis (pre-existing

2018 FP Notebook

2. Thyroid function variations within the reference range do not affect quality of life, mood, or cognitive function in community-dwelling older men. (PubMed)

Thyroid function variations within the reference range do not affect quality of life, mood, or cognitive function in community-dwelling older men. Variations in thyroid function within the laboratory reference range have been associated with a number of clinical outcomes. However, quality of life, mood, and cognitive function have not been extensively studied, and it is not clear whether mild variations in thyroid function have major effects on these neurocognitive outcomes.Data were analyzed (...) from the Osteoporotic Fractures in Men (MrOS) Study, a cohort of community-dwelling men aged 65 years and older in the United States. A total of 539 participants who were not taking thyroid medications and had age-adjusted TSH levels within the reference range underwent detailed testing of quality of life, mood, and cognitive function at baseline. The same quality of life, mood, and cognitive outcomes were measured again in 193 of the men after a mean follow-up of 6 years. Outcomes were analyzed

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2016 Thyroid

3. AACE/ACE/AME Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules

encourage medical professionals to use this information in conjunction with their best clinical judgment. Any decision by practitioners to apply these guidelines must be made in light of local resources and individual patient circumstances and preference. Copyright © 2016 AACE.2 Thyroid Nodule Management, Endocr Pract. 2016;22(Suppl 1) Abbreviations: AACE = American Association of Clinical Endocrinologists; ACE = American College of Endocrinology; AFTN = autonomously function- ing thyroid nodule; AME (...) AACE/ACE/AME Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules ENDOCRINE PRACTICE Vol 22 (Suppl 1) May 2016 1 AACE/ACE/AME Guidelines AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ASSOCIAZIONE MEDICI ENDOCRINOLOGI MEDICAL GUIDELINES FOR CLINICAL PRACTICE FOR THE DIAGNOSIS AND MANAGEMENT OF THYROID NODULES – 2016 UPDATE APPENDIX Hossein Gharib, MD, MACP , MACE 1 , Co-Chair; Enrico Papini, MD, FACE 2 , Co-Chair

2016 American Association of Clinical Endocrinologists

4. Thyroid disease: assessment and management

with thyroid disease, their families and carers 6 1.2 Investigating suspected thyroid dysfunction or thyroid enlargement 8 1.3 Managing primary hypothyroidism 10 1.4 Follow-up and monitoring of primary hypothyroidism 11 1.5 Managing and monitoring subclinical hypothyroidism 13 1.6 Managing thyrotoxicosis 15 1.7 Follow-up and monitoring of hyperthyroidism 20 1.8 Managing and monitoring subclinical hyperthyroidism 22 1.9 Diagnosing, managing and monitoring thyroid enlargement with normal thyroid function 23 (...) with Graves' disease or toxic nodular goitre 42 Antithyroid drugs for people with hyperthyroidism 43 Follow-up and monitoring of hyperthyroidism 45 Managing and monitoring subclinical hyperthyroidism 46 Investigating non-malignant thyroid enlargement with normal thyroid function 47 Managing non-malignant thyroid enlargement 49 Context 51 Key facts and figures 51 Current practice 52 Finding more information and resources 53 Thyroid disease: assessment and management (NG145) © NICE 2019. All rights reserved

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

5. Thyroid hormones treatment for subclinical hypothyroidism

) After 1.5 years No important difference Cognitive function High More 27.1 28.1 Risk of Bias No serious concerns Imprecision No serious concerns Indirectness No serious concerns Inconsistency No serious concerns Publication bias No serious concerns Thyroid hormone has little or no effect on cognitive function High GRADE score, because of: GRADE certainty ratings The authors have a lot of confidence that the true effect is similar to the estimated effect The authors believe that the true effect (...) close to the estimated effect High The true effect might be markedly different from the estimated effect The true effect is probably markedly different from the estimated effect Moderate Low Very low Mean score: 0-infinity (High better) After 1.5 years No important difference Cognitive function Low More 27.1 29.7 Risk of Bias No serious concerns Imprecision Serious Indirectness Serious Inconsistency No serious concerns Publication bias No serious concerns Thyroid hormone may have little or no effect

2019 Publication 4890971

6. Maternal Thyroid Function in Early Pregnancy and Child Attention-Deficit Hyperactivity Disorder: An Individual-Participant Meta-Analysis. (PubMed)

, fertility treatment, usage of medication affecting the thyroid, and pre-existing thyroid disease. We used logistic regression models to study the association of maternal thyroid function with the primary outcome, ADHD, assessed via the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) criteria by parents and/or teachers at a median child age of 4.5 to 7.6 years, and with the secondary outcome, an ADHD symptom score above the 90th percentile. Effect modification (...) Maternal Thyroid Function in Early Pregnancy and Child Attention-Deficit Hyperactivity Disorder: An Individual-Participant Meta-Analysis. Background: Thyroid hormone is essential for optimal fetal brain development. Evidence suggests that both low and high maternal thyroid hormone availability may have adverse effects on child neurodevelopmental outcomes, but the effect on behavioral problems remains unclear. We studied the association of maternal thyrotropin (TSH) and free thyroxine (fT4

2019 Thyroid

7. Lenvatinib (thyroid carcinoma) - Benefit assessment according to §35a Social Code Book V

Internal Commission No.: A19-19 Address of publisher: Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen Im Mediapark 8 50670 Köln Germany Phone: +49 221 35685-0 Fax: +49 221 35685-1 E-mail: berichte@iqwig.de Internet: www.iqwig.de Extract of dossier assessment A19-19 Version 1.0 Lenvatinib (thyroid carcinoma) 13 May 2019 Institute for Quality and Efficiency in Health Care (IQWiG) - ii - Medical and scientific advice: ? Ingo Schmidt-Wolf, Bonn, Germany IQWiG thanks the medical (...) , cancer treatment = 21 days or treatment with an investigational agent = 30 days before the first study medication (exception: treatment with TSH-suppressive thyroid hormones) ? anticoagulants (e.g. warfarin), except treatment with low molecular weight heparin Permitted concomitant treatment: ? all drugs that were required for the patients’ health and did not interact with the study intervention ? treatment of complications and AEs as well as treatment for the alleviation of symptoms (e.g. blood

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

8. Serum levels of fetuin-A are negatively associated with log transformation levels of thyroid-stimulating hormone in patients with hyperthyroidism or euthyroidism: An observational study at a medical center in Taiwan. (PubMed)

Serum levels of fetuin-A are negatively associated with log transformation levels of thyroid-stimulating hormone in patients with hyperthyroidism or euthyroidism: An observational study at a medical center in Taiwan. Fetuin-A is a protein with various biological functions. It plays a role in insulin resistance and arterial calcium deposition. Thyroid dysfunction may affect energy expenditure, glucose metabolism, and the risk of cardiovascular diseases. In the present study, we compared (...) the serum fetuin-A concentrations in hyperthyroid patients with those in euthyroid patients.We recruited 30 newly-diagnosed hyperthyroid patients (the HY group) and treated them with anti-thyroid regimens as clinically indicated. We recruited 30 euthyroid individuals (the EU group) as controls. We compared laboratory parameters at the baseline and at 6 months. We then determined the associations between the levels of fetuin-A and free thyroxine (fT4), thyroid-stimulating hormone (TSH), or log

2018 Medicine

9. Overview of thyroid dysfunction

any part of this process is affected, and is usually characterised by the presence of high or low levels of thyroid-stimulating hormone (TSH, secreted by the pituitary gland) and free thyroid hormones. Causes of thyroid disorders include autoimmunity (e.g., Graves' disease), infections (e.g., post-viral inflammation), other systemic medical conditions, medications (e.g., lithium, amiodarone), nutritional excesses or deficiencies (e.g., of iodine), tumours (thyroid, or rarely pituitary), trauma (...) is diagnostic of Graves' disease. Ross DS, Burch HB, Cooper DS, et al. 2016 American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. Thyroid. 2016 Oct;26(10):1343-1421. https://www.liebertpub.com/doi/full/10.1089/thy.2016.0229 http://www.ncbi.nlm.nih.gov/pubmed/27521067?tool=bestpractice.com In questionable cases, measurement of TRAb is used as a diagnostic test. A toxic multinodular goitre (MNG) contains multiple autonomously functioning

2018 BMJ Best Practice

10. Overview of thyroid dysfunction

any part of this process is affected, and is usually characterised by the presence of high or low levels of thyroid-stimulating hormone (TSH, secreted by the pituitary gland) and free thyroid hormones. Causes of thyroid disorders include autoimmunity (e.g., Graves' disease), infections (e.g., post-viral inflammation), other systemic medical conditions, medications (e.g., lithium, amiodarone), nutritional excesses or deficiencies (e.g., of iodine), tumours (thyroid, or rarely pituitary), trauma (...) is diagnostic of Graves' disease. Ross DS, Burch HB, Cooper DS, et al. 2016 American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. Thyroid. 2016 Oct;26(10):1343-1421. https://www.liebertpub.com/doi/full/10.1089/thy.2016.0229 http://www.ncbi.nlm.nih.gov/pubmed/27521067?tool=bestpractice.com In questionable cases, measurement of TRAb is used as a diagnostic test. A toxic multinodular goitre (MNG) contains multiple autonomously functioning

2018 BMJ Best Practice

11. Subacute granulomatous thyroiditis

follicular damage and release of preformed hormone and is characterised by low thyroid uptake on nuclear scan and elevated ESR or CRP. Thyroid pain and tenderness, which may be migratory and affect different areas of the gland at different times, is typical of the thyrotoxic phase. Thyroid is often enlarged, firm, and tender to palpation. Ultrasound of the thyroid shows areas of hypoechoic echotexture with decreased or normal vascular flow by Doppler. The condition is self-limited, and no specific (...) to many months, characterised by transient thyrotoxicosis, hypothyroidism, and then a return to normal thyroid function in >90% of patients. Nishihara E, Ohye H, Amino N, et al. Clinical characteristics of 852 patients with subacute thyroiditis before treatment. Intern Med. 2008;47(8):725-9. http://www.ncbi.nlm.nih.gov/pubmed/18421188?tool=bestpractice.com Fatourechi V, Aniszewski JP, Fatourechi GZ, et al. Clinical features and outcome of subacute thyroiditis in an incidence cohort: Olmsted county

2018 BMJ Best Practice

12. Recommendation on screening adults for asymptomatic thyroid dysfunction in primary care

or thyroid surgery; exposure to medications known to affect thyroid function; exposure to thyroid radioiodine therapy, or radiotherapy to the head or neck area; or pituitary or hypothalamic diseases. Methods The task force is an independent panel of clinicians and methodologists that makes recommendations on primary and secondary prevention in primary care ( ). This recommendation was developed by a working group of 4 task force members (R.B., J.D., D.R. and B.T.) with scientific support from Public (...) dysfunction: Individuals who have had a previously diagnosed thyroid disease or surgery; Individuals receiving thyroid medications or medications that may affect thyroid function (i.e., lithium, amiodarone); Individuals with previous or ongoing exposure to thyroid radioiodine therapy or head and neck radiotherapy; or Individuals with pituitary or hypothalamic diseases. * Screening refers to measuring levels of thyroid-stimulating hormone (TSH) in patients with no apparent signs or symptoms of thyroid

2019 Canadian Task Force on Preventive Health Care

13. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer

regarding the initial management of thyroid cancer include those relating to screening for thyroid cancer, staging and risk assessment, surgical management, radioiodine remnant ablation and therapy, and thyrotropin suppression therapy using levothyroxine. Recommendations related to long-term management 1 University of Colorado School of Medicine, Aurora, Colorado. 2 Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts. 3 The Mayo Clinic, Rochester, Minnesota. 4 Boston Medical (...) of the scienti?c or medical content of the manuscript was dictated by the ATA. THYROID Volume 26, Number 1, 2016 ª American Thyroid Association ª Mary Ann Liebert, Inc. DOI: 10.1089/thy.2015.0020 1 of differentiated thyroid cancer include those related to surveillance for recurrent disease using imaging and serum thyroglobulin, thyroid hormone therapy, management of recurrent and metastatic disease, consideration for clinical trials and targeted therapy, as well as directions for future research. Conclusions

2015 Pediatric Endocrine Society

14. Liver, Pancreas and Thyroid Function in Burn Patients

Information provided by (Responsible Party): The University of Texas Medical Branch, Galveston Study Details Study Description Go to Brief Summary: The purpose of this study is to determine the extent to which severe burn injuries affect the morphology and function of liver, pancreas and thyroid. The evaluation of the liver will be performed non-invasively with liver fibrosis scores based on standard blood parameters and the measurement of liver stiffness (correlated with liver fibrosis) and controlled (...) affect the morphology and function of liver, pancreas and thyroid. The evaluation of the liver will be performed non-invasively with liver fibrosis scores based on standard blood parameters, the ultrasound-guided measurement of the liver size and the measurement of liver stiffness (correlated with liver fibrosis) and controlled attenuation parameter (CAP, correlated with hepatic steatosis) via transient elastography (FibroScan©, Echosens SA, Paris, France). The thyroid will be assessed by ultrasound

2018 Clinical Trials

15. Coexistence of medullary thyroid carcinoma and recurrent non-functional pituitary adenoma: a case report (PubMed)

be explained by being affected by simultaneous primary neoplasms or tumor-to-tumor metastasis phenomenon.We present the case of a 60-year-old Persian man who presented to the clinic with a chief complaint of headache for the last 2 months. His past medical history was significant for non-functional pituitary macroadenoma and medullary thyroid carcinoma and he had received a total thyroidectomy and a transsphenoidal surgery several years ago. Diagnostic evaluations revealed that the pituitary adenoma has (...) recurred. He was well and symptom-free after the second transsphenoidal surgery for resection of the adenoma. Noticeably, investigations were negative for any form of multiple endocrine neoplasia syndromes; however, we could not rule them out definitively.To the best of our knowledge, it is the first case reported in the literature of a patient who has been affected by recurrent non-functional pituitary adenoma and medullary thyroid carcinoma, concomitantly. Although this association can be accidental

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2018 Journal of medical case reports

16. Thyroid Disease

There are a wide variety of diseases that affect the thyroid gland and range from hyperplastic to neoplastic, autoimmune, or inflammatory. They can present with functional abnormality or a palpable structural change. Imaging has a key role in diagnosing and characterizing the thyroid finding for management. Imaging is also essential in the management of thyroid cancer. Thyroid nodules are the most common finding in the thyroid gland. The majority of thyroid nodules are benign [1,2]. Initiating workup is costly (...) gland. It typically occurs over many years and is more common in women in their fifth and sixth decades of life. Enlargement of the gland can occur with or without nodules and can involve the whole gland symmetrically or predominantly affect one lobe. Thyrotoxicosis is a condition of elevated thyroid hormone production. The most common causes are intrinsic to the thyroid and include Graves disease, toxic adenoma, toxic multinodular goiter, and subacute thyroiditis. Pituitary causes of thyrotoxicosis

2019 American College of Radiology

17. Therapeutic challenges in the application of serum thyroid stimulating hormone testing in the management of patients with hypothyroidism on replacement thyroid hormone therapy: a review. (PubMed)

Therapeutic challenges in the application of serum thyroid stimulating hormone testing in the management of patients with hypothyroidism on replacement thyroid hormone therapy: a review. Normalizing serum thyroid stimulating hormone (TSH) levels by lifelong treatment with levothyroxine (LT4) remains the primary goal of therapy for patients with hypothyroidism. The reference ranges for TSH are derived from populations with (supposedly) normal thyroid function. But, TSH results are affected (...) by a number of factors including alterations in TSH levels with age, concurrent illnesses, circadian rhythm, inter- and intra-assay differences, and some commonly used medications that interfere with thyroid function or the TSH test. Furthermore, some patients are complex to manage and bringing serum TSH to within its reference range does not always resolve their symptoms of hypothyroidism. Furthermore, changes in TSH within the reference range may provoke symptoms in some sensitive patients, and others

2019 Current medical research and opinion

18. Triclosan and triclocarban exposure and thyroid function during pregnancy – a randomized intervention (PubMed)

from 20 weeks' gestation. Urinary triclosan, TSH, T4 and T3 were assessed at enrollment, 36weeks' gestation and/or post-delivery; anthropometric measures at birth were ascertained from medical records. 78 and 76 mothers were assigned to the TC-containing and no-TC-containing product arms, respectively. No differences were observed in any thyroid function measure at any time point or in any anthropometric measurement at birth between either exposure arms or lowest and highest urinary triclosan (...) quartile groups. TCs from wash products, primarily liquid and bar soaps, did not affect thyroid function measures during pregnancy or babies' anthropometric measures at delivery.Copyright © 2017 Elsevier Inc. All rights reserved.

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2017 Reproductive toxicology (Elmsford, N.Y.) Controlled trial quality: uncertain

19. Seasonal affective disorder

Seasonal affective disorder Seasonal affective disorder - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Seasonal affective disorder Last reviewed: February 2019 Last updated: June 2018 Summary Not considered to be a unique diagnostic entity in itself, but rather a sub-type specifier used to describe temporal variations in recurrent major depressive or bipolar disorders over at least a 2-year period. Most commonly (...) clinical management and monitoring are typically required. Light therapy and/or bupropion (extended release) may be used as prophylactic therapy. Definition All patients must meet the diagnostic criteria for recurrent major depression or bipolar mood disorder. Seasonal affective disorder (SAD) is then a sub-type specifier used to describe temporal variations of these disorders. As such, SAD is not considered a stand-alone diagnosis or comorbid condition to recurrent major depression or bipolar disorder

2018 BMJ Best Practice

20. Thyroid Cancer

Thyroid Cancer Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up † S. Filetti 1 , C. Durante 1 , D. Hartl 2 , S. Leboulleux 3 , L.D. Locati 4 , K. Newbold 5 , M.G. Papotti 6 , A. Berruti 7 , on behalf of the ESMO Guidelines Committee* 1 Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy; 2 Department of Head and Neck Oncology, Gustave Roussy and Université Paris Saclay, Villejuif; 3 Department of Nuclear (...) The Author(s) 2019. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com. Downloaded from https://academic.oup.com/annonc/advance-article-abstract/doi/10.1093/annonc/mdz400/5573120 by guest on 14 October 20192 This ESMO Clinical Practice Guidelines provide updated state-of-the-art recommendations on management of thyroid cancer (diagnosis, treatment and follow-up), compiled

2019 European Society for Medical Oncology

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