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Medication Causes of Dyspepsia

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101. Clinical Improvement and in Quality of Life-Functional Dyspepsia-

Galdakao-Usansolo Study Details Study Description Go to Brief Summary: Functional dyspepsia (FD)is defined as the presence of symptoms thought to originate in the gastroduodenal region with no evidence of structural disease that is likely to explain the symptoms. The cause of this condition is unclear, not being a recognized treatment for it. The conventional treatments for those patients are symptom based. Unfortunately, these medications are not very effective. Patients with FD report poorer health (...) -behavioural therapy; and c) proressive-muscle relaxation according to Jacobson Behavioral: Psychological support Active Comparator: No psychological support Patients of this group only received the conventional medical treatment, not receiving any psychological support Other: No intervention Outcome Measures Go to Primary Outcome Measures : Change from baseline in DYSPEPSIA RELATED HEALTH SCALE (DRHS) [ Time Frame: Participants will be followed at the recruit momento (t0) after treatment (t1) and six

2013 Clinical Trials

102. A randomized controlled trial of brief psychoanalytic psychotherapy in patients with functional dyspepsia. (Abstract)

A randomized controlled trial of brief psychoanalytic psychotherapy in patients with functional dyspepsia. Functional dyspepsia (FD) is a common cause of upper gastrointestinal symptoms and discomfort. The present study aimed to assess the effectiveness of brief core conflictual relationship theme (CCRT) psychoanalytic psychotherapy on changing gastrointestinal symptoms, alexithymia, and defense mechanisms in patients with FD. In a randomized controlled trial study, 49 patients with FD were (...) randomly assigned to medical treatment with brief psychodynamic therapy (24 subjects) or medical treatment alone (25 subjects). Gastrointestinal symptoms, defense mechanisms, and alexithymia were assessed before the trial, after treatment, and at 1- and 12-month follow-ups. The results showed that brief psychodynamic therapy improved all of the gastrointestinal symptoms, including heartburn, nausea, fullness, bloating, upper abdominal pain, and lower abdominal pain, after treatment and at two follow

2013 Asian journal of psychiatry Controlled trial quality: uncertain

103. Comparison of half-dose and full-dose triple therapy regimens for Helicobacter pylori eradication in patients with end-stage renal disease Full Text available with Trip Pro

Comparison of half-dose and full-dose triple therapy regimens for Helicobacter pylori eradication in patients with end-stage renal disease The aim of this study was to compare the half-dose and full-dose triple therapy regimens for Helicobacter pylori (Hp) eradication in patients with end-stage renal disease.H. Pylori is one the most important causes of dyspepsia in patients with end-stage renal disease (ESRD).Sixty-six patients with ESRD were enrolled in the study with Hp infection and peptic (...) , the rate of eradication and complications were compared between two groups.The successful Hp eradication was achieved in 26 patients (74%) in group A and in 22 patients (74%) in group B. The difference between 2 groups was not statistically significant (p=0.973) (per protocol analysis).Half-dose triple-therapy with clarithromycin, amoxicillin and omeprazole is as effective as full-dose triple-therapy to eradicate the Hp in patients with ESRD. According to lower toxicity level, complications and cost

2014 Gastroenterology and hepatology from bed to bench Controlled trial quality: uncertain

104. Cognitive Behavior Therapy (CBT) for Children With Functional Gastrointestinal Disorders

will be treated individually (face-to-face). The treatment consists of 10 weekly sessions of exposure-based CBT. The study uses a pre- post-design with no control group. Condition or disease Intervention/treatment Phase Functional Gastrointestinal Disorders (FGID) FGID According to the Rome III Criteria Irritable Bowel Syndrome (IBS) Functional Abdominal Pain Functional Dyspepsia Other: Cognitive behavior therapy Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (...) by a treating physician Exclusion Criteria: Concurrent serious medical condition or gastrointestinal symptoms likely caused by an organic disorder. Psychiatric disorder more urgent to treat than the abdominal pain. On-going psychological treatment. Absence from school more than 40 %. Ongoing maltreatment, violence or severe parental psychiatric illness. Pronounced language or learning difficulties that hinder the child to benefit from the treatment. Contacts and Locations Go to Information from the National

2014 Clinical Trials

105. Endofaster Test for Helicobacter Pylori Detection in Patients on Proton Pump Inhibitor Therapy

Endofaster Test for Helicobacter Pylori Detection in Patients on Proton Pump Inhibitor Therapy Endofaster Test for Helicobacter Pylori Detection in Patients on Proton Pump Inhibitor Therapy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Endofaster Test for Helicobacter Pylori Detection in Patients on Proton Pump Inhibitor Therapy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02126722 Recruitment Status : Unknown Verified April 2014 by Niso Biomed S.R.L.. Recruitment status was: Not yet recruiting

2014 Clinical Trials

106. Amoxicillin/Metronidazole Based Quadruple Therapy for Helicobacter Pylori Eradication

Intervention/treatment Phase Dyspepsia Peptic Ulcer Drug: Lansoprazole Drug: Bismuth Potassium Citrate Drug: Amoxicillin Drug: Metronidazole Drug: Clarithromycin Phase 4 Detailed Description: Helicobacter pylori is the most successful human pathogen infecting an estimated 50% of the global population. It is a common and potentially curable cause of dyspepsia and peptic ulcer disease. Eradication in patients with peptic ulcer or even functional or non-investigated dyspepsia is a cost effective approach (...) Date : July 2014 Actual Primary Completion Date : January 2015 Actual Study Completion Date : January 2015 Resource links provided by the National Library of Medicine available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Amoxicillin/metronidazole Amoxicillin/metronidazole-based quadruple therapy for 14 days: Lansoprazole 30mg bid, Bismuth Potassium Citrate 220mg bid, amoxicillin 1000mg bid, Metronidazole 400mg qid Drug: Lansoprazole antisecretory drug of each

2014 Clinical Trials

107. Randomised clinical trial comparing sequential and concomitant therapies for Helicobacter pylori eradication in routine clinical practice. (Abstract)

-investigated/functional dyspepsia or peptic ulcer disease were included. Randomised (1:1) to sequential (omeprazole (20 mg/12 h) and amoxicillin (1 g/12 h) for 5 days, followed by 5 days of omeprazole (20 mg/12 h), clarithromycin (500 mg/12 h) and metronidazole (500 mg/12 h)), or concomitant treatment (same drugs taken concomitantly for 10 days). Eradication was confirmed with (13)C-urea breath test or histology 4 weeks after treatment. Adverse events (AEs) and compliance were evaluated with questionnaires (...) and residual medication count.338 consecutive patients were randomised. Mean age was 47 years, 60% were women, 22% smokers and 20% had peptic ulcer. Concomitant and sequential eradication rates were, respectively, 87% vs 81% by intention-to-treat (p=0.15) and 91% vs 86% (p=0.131) per protocol. Respective compliances were 83% vs 82%. Treatment-emergent AEs were reported in 59% of patients (no differences found between treatments). AEs were mostly mild (60%), and average length was 6.1 days, causing

2014 Gut Controlled trial quality: uncertain

108. Dyspepsia

to higher doses Adjunctive medication options Metoclopramide (prokinetic agent) May offer benefit in Nonulcer Dyspepsia Risk of tardive diskinesia Ineffective Medications (avoid) Sucralfate offers no benefit in Nonulcer Dyspepsia Misoprostel offers no benefit in Nonulcer Dyspepsia XII. Approach: Step 4 - Consider Helicobacter Pylori testing Indications Lack of relief with empiric antisecretory therapy Undifferentiated Dyspepsia treatment does not benefit without ulcer However ulcer status unknown (...) (MEDLINEPLUS) Nearly everyone has had indigestion at one time. It's a feeling of discomfort or a burning feeling in your upper abdomen. You may have or belch and feel bloated. You may also feel nauseated, or even throw up. You might get indigestion from eating too much or too fast, eating high-fat foods, or eating when you're stressed. Smoking, drinking too much alcohol, using some medicines, being tired, and having ongoing stress can also cause indigestion or make it worse. Sometimes the cause

2015 FP Notebook

109. Ghrelin and Gastric Emptying in Children With Functional Dyspepsia

condition in children and adolescents. One of the most often diagnosed types of abdominal pain is functional dyspepsia (FD). FD is abdominal pain or discomfort (e.g., nausea, bloating) in the upper abdomen that does not get better by having a bowel movement. One possible explanation for having FD is a delay in the emptying of food from the stomach, or delayed gastric (stomach) emptying. Failing to empty the stomach quickly enough may result in the feeling of being full and cause symptoms of bloating (...) , nausea, vomiting and pain. Further, hormonal changes occur before, during, or after eating food that appear to impact stomach emptying. One of the hormones that changes with meals is called ghrelin. The relationship between ghrelin and stomach emptying needs to be explored more in children with FD. Better understanding of what causes FD symptoms may help us to improve treatment for this condition. Condition or disease Functional Dyspepsia Study Design Go to Layout table for study information Study

2012 Clinical Trials

110. Phase 2a Study of IW-9179 to Treat Functional Dyspepsia

Dyspepsia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01712412 Recruitment Status : Terminated (Slow enrollment) First Posted : October 23, 2012 Last Update Posted : March 19, 2014 Sponsor: Ironwood Pharmaceuticals, Inc. Information provided by (Responsible Party): Ironwood Pharmaceuticals, Inc (...) . Study Details Study Description Go to Brief Summary: The objectives of this study are to determine the safety and efficacy of IW-9179 administered to patients with functional dyspepsia (FD). Condition or disease Intervention/treatment Phase Dyspepsia Functional Gastrointestinal Disorders Drug: IW-9179 Drug: Placebo Phase 2 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 10 participants Allocation: Randomized Intervention Model

2012 Clinical Trials

111. INDIGESTION AND ABDOMINAL PAIN WITH NEGATIVE FINDINGS Full Text available with Trip Pro

INDIGESTION AND ABDOMINAL PAIN WITH NEGATIVE FINDINGS 20268526 2010 03 18 2018 12 01 0008-4409 57 5 1947 Nov Canadian Medical Association journal Can Med Assoc J Common causes of indigestion and abdominal pain in patients with negative findings. 425-32 ALVAREZ W C WC eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 OM Abdominal Pain etiology Dyspepsia etiology Humans 4713:1410f1 ABDOMINAL PAIN/Causes INDIGESTION/causes 2010 3 19 6 0 1947 11 1 0 0 2012 7 28 6 0 ppublish 20268526

1947 Canadian Medical Association Journal

112. Quadruple and Phytomedicine-based Therapies in H. Pylori Infection

. Condition or disease Intervention/treatment Phase Helicobacter Pylori [H. Pylori] as the Cause of Diseases Drug: Quadruple Allopathic therapy Drug: Pylorex plus Phase 2 Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 176 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Phytomedicine-based and Quadruple Therapies in Helicobacter (...) Pylori Infection. A Comparative Randomized Trial Study Start Date : January 2010 Actual Primary Completion Date : September 2012 Actual Study Completion Date : January 2013 Resource links provided by the National Library of Medicine available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Pylorex plus Pylorex plus consisting of medicinal plants. Drug: Quadruple Allopathic therapy Other Names: Omeprazol Amoxicillin Metronodazole TRITEC (ranitidine bismuth citrate) Drug

2013 Clinical Trials

113. Capsule Endoscopy Versus Conservative Therapy for Obscure Gastrointestinal Bleeding

adding more. Capsule Endoscopy Versus Conservative Therapy for Obscure Gastrointestinal Bleeding The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01837030 Recruitment Status : Withdrawn (not feasible due to funding) First Posted : April 22, 2013 Last Update Posted : June 14, 2018 Sponsor: Medical (...) University of South Carolina Information provided by (Responsible Party): Medical University of South Carolina Study Details Study Description Go to Brief Summary: This study is a single center prospective randomized control trial comparing the utility of performing capsule endoscopy compared to conservative management with oral iron therapy as the initial course of action in patients with non-severe obscure occult or obscure overt gastrointestinal (GI) bleeding. The investigators hypothesize

2013 Clinical Trials

114. Prospective Study : Helicobacter Pylori Eradication Therapy in Accordance With Past Antibiotics Use

of Medicine. Recruitment status was: Recruiting First Posted : September 10, 2013 Last Update Posted : January 1, 2014 Sponsor: Ajou University School of Medicine Information provided by (Responsible Party): Sun Gyo Lim, Ajou University School of Medicine Study Details Study Description Go to Brief Summary: Prospective study : Helicobacter pylori eradication therapy in accordance with past antibiotics use. Condition or disease Intervention/treatment Phase Helicobacter Eradication Drug: Helicobacter pylori (...) eradication Phase 4 Detailed Description: Antibiotics resistant is serious problem in helicobacter pylori eradication. Clarithromycin is very important antibiotics in eradication. But clarithromycin resistance is increased. Major cause of clarithromycin resistance is past consumption of macrolide. Thus the investigators propose eradication of macrolide used group bismuth contained four drugs therapy. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial

2013 Clinical Trials

115. Psychosomatic Therapy, Feasibility and Cost Analysis

Description Go to Brief Summary: Medically unexplained symptoms (MUS) are a common and important problem in primary care. Patients repeatedly presenting MUS to their general practitioner (GP) suffer from their symptoms, are functionally impaired, and are at risk of unnecessary and possibly harmful tests, referrals and treatment. Evidence indicate that specific interventions for patients with MUS, such as reattribution therapy and cognitive behavioural therapy are of limited help. According to experts (...) for one year. Participants are patients consulting their GP more than once with MUS and in which the GP presumes that psychosocial distress is an underlying cause. The intervention is the psychosomatic therapy delivered by a psychosomatic therapist, consists of a combination of information and education, relaxation therapy and mindfulness, cognitive approaches and activating therapy. This multi-component approach is captured into a protocol in which therapists are able to modify the treatment in order

2013 Clinical Trials

116. Internet-delivered Cognitive Behavior Therapy for Adolescents With Functional Gastrointestinal Disorders: a Pilot Study

experience and good Swedish language skills. Exclusion Criteria: concurrent serious medical conditions or gastrointestinal symptoms likely caused by an organic disorder. psychiatric diagnosis more urgent to treat than the abdominal pain. on-going psychological treatment. absence from school more than 20%. on-going maltreatment, violence or severe parental psychiatric illness in the family. pronounced language and learning difficulties depending on whether the youth was expected to benefit from (...) Internet-delivered Cognitive Behavior Therapy for Adolescents With Functional Gastrointestinal Disorders: a Pilot Study Internet-delivered Cognitive Behavior Therapy for Adolescents With Functional Gastrointestinal Disorders: a Pilot Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2013 Clinical Trials

117. Additive Effect of Endonase on Eradication Rate of First Line Therapy for Helicobacter Pylori

Sacred Heart Hospital Information provided by (Responsible Party): Yeonsoo Kim, Chuncheon Sacred Heart Hospital Study Details Study Description Go to Brief Summary: Endonase, a kind of protease, is known to cause both extensive degradation of mucins and a reduction in mucus viscosity. As part of the search for more effective forms of therapy against H. pylori when it colonizes not only the surface of the surface mucosal cells but also the surface mucous gel layer covering the mucosal surface (...) of the stomach. The investigators decided to investigate whether or not endonase might have additive effect of pronase on the efficacy of eradication therapy against Helicobacter pylori. Condition or disease Intervention/treatment Phase Gastric Ulcer Associated With Helicobacter Pylori Drug: Endonase Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 112 participants Allocation: Randomized Intervention Model: Parallel

2012 Clinical Trials

118. Empirical Rescue Therapies of Helicobacter Pylori Infection

Jiao Tong University School of Medicine Study Details Study Description Go to Brief Summary: The increase of antibiotic resistance to H. pylori causes failure of treatment. Furazolidone, amoxicillin and tetracycline are good candidates for rescue therapy since resistance to these three antimicrobials was rare. It is necessary to assess the efficacy and safety of these four bismuth-containing quadruple regimens with above antibiotics as empirical rescue therapies for H. pylori eradication. Condition (...) or disease Intervention/treatment Phase Functional Dyspepsia Scarred Peptic Ulcer Drug: Proton Pump Inhibitor Drug: Bismuth Drug: Metronidazole Drug: Tetracycline Drug: Furazolidone Drug: Amoxicillin Phase 4 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 424 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Helicobacter Pylori Treatment

2012 Clinical Trials

119. Clopidogrel and proton pump inhibitors: is there a significant drug-drug interaction? (Abstract)

Clopidogrel and proton pump inhibitors: is there a significant drug-drug interaction? Dual antiplatelet therapy with aspirin and clopidogrel is among the most efficacious treatment for patients after acute coronary syndromes and for those who have had a percutaneous coronary intervention and coronary stent implantation. Patients who are treated with dual antiplatelet therapy are usually also ordered medications that reduce the secretion of gastric acid (such as H2 receptor blockers or proton (...) pump inhibitors [PPIs]) in order to decrease the risk of gastrointestinal bleeding and dyspepsia. Numerous observational studies reported that omeprazole (a PPI) attenuates the antiplatelet activity and clinical effectiveness of clopidogrel and causes adverse cardiovascular events. Based on these findings, several medical agencies in the world have issued communications regarding the negative interaction between clopidogrel and PPIs, urging clinicians to evaluate the need for starting treatment

2011 Canadian journal of cardiovascular nursing = Journal canadien en soins infirmiers cardio-vasculaires

120. Richard Smith: What causes cholera? A Victorian debate

cholera), and willing to challenge conventional thinking. McNab’s rival in the debate is Dr Dunstaple, an old fashioned doctor who enjoys the status of being a doctor and is more interested in pig sticking than medicine. Dunstaple is an emotional man and is driven close to madness in his hatred of and distain for his rival, causing much distress to his daughter and wife. It’s alarming for the lice ridden, near skeletons left in Krishnapur that the two doctors have theories and treatments (...) Richard Smith: What causes cholera? A Victorian debate Richard Smith: What causes cholera? A Victorian debate - The BMJ ---> Yesterday I was in The Cholera Hospital in Dhaka, Bangladesh; today I’m reading about a highly emotional debate about the causes and treatment of cholera that took place in India in the 1857, during the Indian Mutiny. Both experiences have taught me something, and you might learn something as well. Cholera today Cholera is endemic in Bangladesh, as it is in some 50

2015 The BMJ Blog

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