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Medication Causes of Neutropenia

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1. Medication Causes of Neutropenia

Medication Causes of Neutropenia Medication Causes of Neutropenia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Medication Causes (...) of Neutropenia Medication Causes of Neutropenia Aka: Medication Causes of Neutropenia , Neutropenia due to Medication , Drug-Induced Neutropenia , Drug-Induced Agranulocytosis From Related Chapters II. Pathophysiology Drugs are second most common cause of Induce hypoproliferation via marrow injury III. Causes: Most common Chemotherapeutics (standard effect, see below) inhibitors ( s) Trimethoprim-Sulfamethoxazole ( , ) Clomipramine Dipyrone Concurrent use is predisposing factor IV. Causes: Chemotherapeutics

2018 FP Notebook

2. Febrile neutropenia

of cancer therapy and is an oncological emergency. Empirical antibiotic therapy upon presentation has dramatically improved outcomes and decreased mortality from febrile neutropenia. A causative organism is only identified one third of the time, and therefore antibiotics are aimed at treating a broad spectrum of pathogens. Due to an inability to mount an inflammatory response, many patients with febrile neutropenia do not demonstrate localising signs or symptoms other than fever. Prophylactic (...) Febrile neutropenia Febrile neutropenia - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Febrile neutropenia Last reviewed: February 2019 Last updated: October 2018 Summary Defined as a fever >38°C (>101°F) for 1 hour, with an absolute neutrophil count (ANC) of ≤500 cells/microlitre, or an ANC ≤1000 cells/microlitre with a projected nadir of ≤500 cells/microlitre. It is the most common life-threatening complication

2018 BMJ Best Practice

3. Febrile neutropenia

of cancer therapy and is an oncological emergency. Empirical antibiotic therapy upon presentation has dramatically improved outcomes and decreased mortality from febrile neutropenia. A causative organism is only identified one third of the time, and therefore antibiotics are aimed at treating a broad spectrum of pathogens. Due to an inability to mount an inflammatory response, many patients with febrile neutropenia do not demonstrate localising signs or symptoms other than fever. Prophylactic (...) Febrile neutropenia Febrile neutropenia - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Febrile neutropenia Last reviewed: February 2019 Last updated: October 2018 Summary Defined as a fever >38°C (>101°F) for 1 hour, with an absolute neutrophil count (ANC) of ≤500 cells/microlitre, or an ANC ≤1000 cells/microlitre with a projected nadir of ≤500 cells/microlitre. It is the most common life-threatening complication

2018 BMJ Best Practice

4. Assessment of neutropenia

to non-self antigens from members of the same species) neutropenia is also a relatively common cause of neutropenia in infants. Infections and medications remain common causes in children. Congenital causes are rarer than acquired causes, and epidemiological data are limited. The most common and important diseases affecting neutrophil production are severe congenital neutropenia and cyclic neutropenia. Common variable immunodeficiency is the most common immunodeficiency encountered. Differentials (...) from decreased production, accelerated utilisation, increased destruction, or a shift in compartments. A combination of these mechanisms may be present. Causes can be congenital or acquired. The most serious complication of neutropenia is infection, which can be fatal. The source is usually endogenous flora of the gut and mucosa (commonly Staphylococcus and gram-negative organisms). Fungal infections occur with increased frequency, but there is no increased risk of viral or parasitic infection

2018 BMJ Best Practice

5. Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy

, infectious disease specialists, emergency medicine physicians, nurses, and advanced practice providers who may treat patients with neutropenia resulting from cancer treatment. Methods: An Expert Panel was convened to develop update clinical practice guideline recommendations based on a systematic review of the medical literature. Key Recommendations for outpatient management of fever and neutropenia are outlined in . Additional details regarding the quality of evidence and strength of recommendations (...) identification of candidate patients for outpatient treatment. (¶)See Recommendation 3.1 regarding evaluation of patients for hospital admission. CISNE, Clinical Index of Stable Febrile Neutropenia; MASCC, Multinational Association for Supportive Care in Cancer. Guideline Questions What is the recommended initial diagnostic approach for patients with fever who are seeking emergency medical care within 6 weeks of receiving chemotherapy? Which patients with FN are at low risk of medical complications

2018 American Society of Clinical Oncology Guidelines

6. Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy

, infectious disease specialists, emergency medicine physicians, nurses, and advanced practice providers who may treat patients with neutropenia resulting from cancer treatment. Methods: An Expert Panel was convened to develop update clinical practice guideline recommendations based on a systematic review of the medical literature. Key Recommendations for outpatient management of fever and neutropenia are outlined in . Additional details regarding the quality of evidence and strength of recommendations (...) identification of candidate patients for outpatient treatment. (¶)See Recommendation 3.1 regarding evaluation of patients for hospital admission. CISNE, Clinical Index of Stable Febrile Neutropenia; MASCC, Multinational Association for Supportive Care in Cancer. Guideline Questions What is the recommended initial diagnostic approach for patients with fever who are seeking emergency medical care within 6 weeks of receiving chemotherapy? Which patients with FN are at low risk of medical complications

2018 Infectious Diseases Society of America

7. Guideline for the management of fever and neutropenia in children with cancer and hematopoietic stem-cell transplantation recipients: 2017 update.

Guideline for the management of fever and neutropenia in children with cancer and hematopoietic stem-cell transplantation recipients: 2017 update. Guideline for the management of fever and neutropenia in children with cancer and hematopoietic stem-cell transplantation recipients: 2017 update. | National Guideline Clearinghouse success fail JUN 10 2017 2018 2019 14 Apr 2018 - 12 Jul 2018 COLLECTED BY Organization: Formed in 2009, the Archive Team (not to be confused with the archive.org Archive (...) NGC:011254 2017 Jun 20 NEATS Assessment Guideline for the management of fever and neutropenia in children with cancer and hematopoietic stem-cell transplantation recipients: 2017 update. Lehrnbecher T, Robinson P, Fisher B, Alexander S, Ammann RA, Beauchemin M, Carlesse F, Groll AH, Haeusler GM, Santolaya M, Steinbach WJ, Castagnola E, Davis BL, Dupuis LL, Gaur AH, Tissing WJE, Zaoutis T, Phillips R, Sung L. Guideline for the management of fever and neutropenia in children with cancer

2017 National Guideline Clearinghouse (partial archive)

8. Neutropenia Causes

: Neutropenia Causes , Agranulocytosis Causes From Related Chapters II. Causes: Decreased Neutrophil Production Marrow Infiltration (tumor invasion) Granulomatous infiltration (e.g. ) Marrow Injury Radiation Medications See Infection See III. Causes: Increased Neutrophil Destruction Severe (increased consumption) Antineutrophil Hypersplenism (Splenic trapping) Chediak-Higashi Syndrome (rare ) Medications Phenylbutazone Phenothiazine IV. Causes: Lower Clinical Significance (based on automated count (...) Neutropenia Causes Neutropenia Causes Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Neutropenia Causes Neutropenia Causes Aka

2018 FP Notebook

9. Infectious Causes of Neutropenia

Infectious Causes of Neutropenia Infectious Causes of Neutropenia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Infectious Causes (...) of Neutropenia Infectious Causes of Neutropenia Aka: Infectious Causes of Neutropenia , Neutropenia due to Infection II. Pathophysiology Infection is most common cause of acquired Infectious is often via marrow injury Granulomatous infections infiltrate marrow III. Causes: Severe Neutropenia l (especially ) (HIV) IV. Causes: Viral Infections (HIV) Varicella V. Causes: Bacterial Infections VI. Causes: Fungal Infections Images: Related links to external sites (from Bing) These images are a random sampling from

2018 FP Notebook

10. Neutropenia with Multiple Antipsychotics Including Dose Dependent Neutropenia with Lurasidone (PubMed)

Neutropenia with Multiple Antipsychotics Including Dose Dependent Neutropenia with Lurasidone Antipsychotic-induced agranulocytosis is a significant side effect that is known to occur with most of the antipsychotic medications. It usually resolves once the medications are stopped and patients are able to be switched over to another antipsychotic medication. Lurasidone has not been reported to cause leukopenia and neutropenia. This case report is of a patient with a past history of risperidone (...) induced-aganulocytosis developing dose related leukopenia and neutropenia with lurasidone.

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2017 Clinical Psychopharmacology and Neuroscience

11. Severe congenital neutropenia caused by the ELANE gene mutation in a Vietnamese boy with misdiagnosis of tuberculosis and autoimmune neutropenia: a case report. (PubMed)

Severe congenital neutropenia caused by the ELANE gene mutation in a Vietnamese boy with misdiagnosis of tuberculosis and autoimmune neutropenia: a case report. Severe congenital neutropenia (SCN) is an immunodeficiency disease characterized low blood neutrophil counts, early bacterial infections, and risk of leukaemia development. Heterozygous mutations in the ELANE gene coding neutrophil elastase are associated with SCN. Patients with SCN suffer from recurrent bacterial infections and often (...) succumb them. To our knowledge, this is the first report of SCN from Vietnam.A 6-year-old boy was admitted due to severe bacterial infection and severe neutropenia. He had recurrent infections from 8 months of age, and was misdiagnosed with tuberculosis and and autoimmune neutropenia in infancy at 21 and 41 months of age, respectively. His medical report has showed severe neutropenia for many times. In direct DNA sequencing analysis, we found an ELANE gene mutation (R81P), which had been confirmed

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2015 BMC Hematology

12. Costs associated with febrile neutropenia in Japanese patients with primary breast cancer: post-hoc analysis of a randomized clinical trial. (PubMed)

Costs associated with febrile neutropenia in Japanese patients with primary breast cancer: post-hoc analysis of a randomized clinical trial. Febrile neutropenia (FN), a decrease in blood neutrophils accompanied by fever, is a major adverse event (AE) associated with cancer chemotherapy. We aimed to estimate the direct medical costs associated with FN management in breast cancer patients within a clinical trial with pegfilgrastim, a pegylated form of recombinant granulocyte colony-stimulating (...) developed FN in the placebo group.For the pegfilgrastim and placebo groups, the total cost during the first cycle of chemotherapy was ¥189 135 and ¥98 106. This difference is associated with prophylactic use of pegfilgrastim. Our analysis clarified in the placebo group that FN incidents of 119/173 (68.6%), the mean drug cost related to all AEs and hospitalization caused by the first cycle of chemotherapy were ¥14 411and ¥11 180, respectively. The cost of each for FN treatment was ¥16 429 for the placebo

2018 Japanese journal of clinical oncology

13. The Infectious and Non-Infectious Etiology, Clinical Picture and Outcome of Neutropenia in Immunocompetent Hospitalized Children. (PubMed)

The Infectious and Non-Infectious Etiology, Clinical Picture and Outcome of Neutropenia in Immunocompetent Hospitalized Children. Acquired neutropenia in immunocompetent children is common, and its differential diagnosis ranges from benign causes to life-threatening diseases. We described the etiology, clinical picture and outcome of new-onset neutropenia in immunocompetent children assessed in the emergency department and hospitalized at our medical center.Previously healthy children admitted (...) with neutropenia (absolute neutrophil count <1.5 × 10(9)/L) were included. Serious bacterial infections were defined as culture-positive blood, urine, cerebrospinal fluid, articular fluid or stool infections, pneumonia, Brucellosis and Rickettsiosis.A total of 601 patients (5 days-202 months old) were enrolled; 3 (0.5%), 48 (8%), 165 (27.5%) and 385 (64%) had absolute neutrophil counts <0.2, 0.2-0.5, 0.5-1.0 and 1.0-1.5 × 10(9)/L, respectively. Associated leukopenia and thrombocytopenia were diagnosed in 186

2018 Pediatric Infectious Dsease Journal

14. Neutropenia in the age of genetic testing: Advances and challenges. (PubMed)

Neutropenia in the age of genetic testing: Advances and challenges. Identification of genetic causes of neutropenia informs precision medicine approaches to medical management and treatment. Accurate diagnosis of genetic neutropenia disorders informs treatment options, enables risk stratification, cancer surveillance, and attention to associated medical complications. The rapidly expanding genetic testing options for the evaluation of neutropenia have led to exciting advances but also new (...) challenges. This review provides a practical guide to germline genetic testing for neutropenia.© 2018 Wiley Periodicals, Inc.

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2018 American journal of hematology

15. International Guideline for the Management of Fever and Neutropenia in Children with Cancer and/or Undergoing Hematopoietic Stem Cell Transplantation

associated with invasive bacterial infection in children with cancer, neutropenia, and fever. J Clin Oncol 19:3415-21, 2001 29. Tezcan G, Kupesiz A, Ozturk F, et al: Episodes of fever and neutropenia in children with cancer in a tertiary care medical center in Turkey. Pediatr Hematol Oncol 23:217- 29, 2006 30. West DC, Marcin JP, Mawis R, et al: Children with cancer, fever, and treatment- induced neutropenia: risk factors associated with illness requiring the administration of critical care therapies (...) International Guideline for the Management of Fever and Neutropenia in Children with Cancer and/or Undergoing Hematopoietic Stem Cell Transplantation 1 TITLE: Guideline for the Management of Fever and Neutropenia in Children with Cancer and/or Undergoing Hematopoietic Stem Cell Transplantation (Long Version) RUNNING HEAD: Pediatric fever and neutropenia guideline AUTHORS: Thomas Lehrnbecher * 1 , Robert Phillips* 2 , Sarah Alexander 3 , Frank Alvaro 6 , Fabianne Carlesse 7 , Brian Fisher 8

2012 SickKids Supportive Care Guidelines

16. Extensive gingival necrosis and sequestration of the alveolar bone caused by methimazole-induced neutropenia and three-year follow-up (PubMed)

Extensive gingival necrosis and sequestration of the alveolar bone caused by methimazole-induced neutropenia and three-year follow-up Methimazole is an anti-thyroid drug that can cause life-threatening neutropenia in rare situations. The aim of this case report is to describe a set of oral complications associated with methimazole-induced neutropenia and the healing of the gingiva after proper treatment.A 31-year-old female patient hospitalized for systemic symptoms of sore throat and fever (...) and showing extensive gingival necrosis with pain was referred to the Department of Periodontics from the Department of Endocrinology. Methimazole-induced neutropenia was diagnosed based on blood test results and her medical history. Methimazole was discontinued and a range of treatments was administered, including the injection of granulocyte colony stimulating factor.After systemic treatment, the gingiva began to heal as the neutrophil count increased. Approximately one year later, the gingiva had

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2015 Journal of periodontal & implant science

17. INVASIVE FUNGAL INFECTION AMONG FEBRILE PATIENTS WITH CHEMOTHERAPY-INDUCED NEUTROPENIA IN THAILAND. (PubMed)

INVASIVE FUNGAL INFECTION AMONG FEBRILE PATIENTS WITH CHEMOTHERAPY-INDUCED NEUTROPENIA IN THAILAND. Invasive fungal infections (IFI) can cause serious morbidity and mortality among febrile patients with chemotherapy-induced neutropenia (CIN). In order to evaluate the incidence, treatment outcome and factors associated with IFI in this patient population in Thailand, we retrospectively reviewed the medical record of patients admitted to Siriraj Hospital from January 2008 to June 2010. Criteria (...) used to diagnosed IFI were those of the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases/Mycoses Study Group (EORTC/MSG) consensus 2008 criteria. Three hundred ten episodes of chemotherapy-induced neutropenia occurred in 233 patients. IFI were found in 37 episodes (12%) and occurred only in patients who received chemotherapy for hematological malignancies. The incidence of IFI among

2017 Southeast Asian Journal of Tropical Medicine and Public Health

18. How I manage children with neutropenia. (PubMed)

How I manage children with neutropenia. Neutropenia, usually defined as a blood neutrophil count <1·5 × 109 /l, is a common medical problem for children and adults. There are many causes for neutropenia, and at each stage in life the clinical pattern of causes and consequences differs significantly. I recommend utilizing the age of the child and clinical observations for the preliminary diagnosis and primary management. In premature infants, neutropenia is quite common and contributes (...) to the risk of sepsis with necrotizing enterocolitis. At birth and for the first few months of life, neutropenia is often attributable to isoimmune or alloimmune mechanisms and predisposes to the risk of severe bacterial infections. Thereafter when a child is discovered to have neutropenia, often associated with relatively minor symptoms, it is usually attributed to autoimmune disorder or viral infection. The congenital neutropenia syndromes are usually recognized when there are recurrent infections

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2017 British journal of haematology

19. Comparison of antipseudomonal beta-lactams for febrile neutropenia empiric therapy: systematic review and network meta-analysis. (PubMed)

Comparison of antipseudomonal beta-lactams for febrile neutropenia empiric therapy: systematic review and network meta-analysis. To compare the effectiveness and safety of antipseudomonal β-lactam empiric monotherapy for febrile neutropenia by network meta-analysis.Searches using Pubmed, Cochrane CENTRAL, EMBASE and Web of Science Core Collection were carried out in June 2016. English articles, non-English articles, full-length articles, short articles and conference abstracts were allowed (...) . Eligible trial design was a parallel-group individual randomization. We included febrile neutropenia adult and paediatric patients undergoing chemotherapy for either solid tumours or haematological malignancies and treated with intravenous antipseudomonal β-lactams for initial empiric therapy. Protocol was registered with PROSPERO ID 42016043377.Of 1275 articles detected by the search, 50 studies with 10 872 patients were finally included. Among the guideline-recommended cefepime, meropenem, imipenem

2017 Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

20. Anakinra: Safety and Efficacy in the Management of Fever During Neutropenia and Mucositis in ASCT

Status : Recruiting First Posted : July 31, 2017 Last Update Posted : December 6, 2018 See Sponsor: Radboud University Information provided by (Responsible Party): Radboud University Study Details Study Description Go to Brief Summary: Oral and intestinal mucositis are major risk factors for the occurrence of fever during neutropenia and bloodstream infections after intensive chemo- and radiotherapy. These complications often require dose reductions or cause delay of treatment, and thereby interfere (...) Anakinra: Safety and Efficacy in the Management of Fever During Neutropenia and Mucositis in ASCT Anakinra: Safety and Efficacy in the Management of Fever During Neutropenia and Mucositis in ASCT - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove

2017 Clinical Trials

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