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Medication Causes of Neuropathy

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1. Medication Causes of Neuropathy

Medication Causes of Neuropathy Medication Causes of Neuropathy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Medication Causes (...) of Neuropathy Medication Causes of Neuropathy Aka: Medication Causes of Neuropathy , Drug-Induced Polyneuropathy , Peripheral Neuropathy Due to Medications II. Causes (Axonal and sensory effects unless otherwise noted) (sensorimotor) s (demyelinating) (sensorimotor) Misoprostel (motor) (sensorimotor) Paclitaxel (demyelinating) s (e.g. ) Vincristine (sensorimotor) III. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Medication

2018 FP Notebook

2. Lack of historical evidence to support folic acid exacerbation of the neuropathy caused by vitamin B12 deficiency. (PubMed)

Lack of historical evidence to support folic acid exacerbation of the neuropathy caused by vitamin B12 deficiency. In 1998 a Tolerable Upper Intake Level (UL) for folic acid was established based on case reports from the 1940s suggesting that high-dosage folic acid intake, used to treat patients with pernicious anemia, had the potential to precipitate or speed-up the development of neurological problems. This UL has been employed in the decision-making process used by more than 80 countries (...) . The likely cause of the neurological problems encountered is the development of vitamin B12 neuropathy when pernicious anemia was treated with high-dosage folic acid before vitamin B12 was widely available in the early 1950s. Thus, the historical record does not provide compelling evidence that folic acid can potentially cause neurologic complications among those with low vitamin B12 status and lends support for reconsidering the basis for the UL of folic acid.Published by Oxford University Press

2019 American Journal of Clinical Nutrition

3. Peripheral neuropathy: sometimes medication-related

. Other contributory causes include drug combinations, diabetes and chronic high-volume alcohol consumption. Their progression is variable, and is generally reversible once the medication is stopped, but their regression is often slow. ©Prescrire 1 September 2013 Download the full review. For more information: Go to the "Search" page and type in "neuropathy" then choose the keyword "neuropathy (drug-induced)" | | | Prescrire Your change of address has been received and will be processed promptly (...) Peripheral neuropathy: sometimes medication-related Prescrire IN ENGLISH - Spotlight ''Peripheral neuropathy: sometimes medication-related'', 1 September 2013 {1} {1} {1} | | > > > Peripheral neuropathy: sometimes medication-related Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight Peripheral neuropathy: sometimes medication-related Numerous

2014 Prescrire

4. TCMS for the Treatment of Foot Pain Caused By Diabetic Neuropathy

of DN. No significant adverse reactions or side effects have been reported from the use of magnetic stimulation for the headache treatment. Some patients who have migraine headaches have excellent pain relief with the magnetic treatment even if they did not get pain relief using medications. The investigators do not know whether this magnetic treatment will relieve the foot pain caused by diabetic neuropathy, so they will test this by applying 50 strong magnet pulses to the painful area of each foot (...) TCMS for the Treatment of Foot Pain Caused By Diabetic Neuropathy TCMS for the Treatment of Foot Pain Caused By Diabetic Neuropathy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. TCMS for the Treatment

2018 Clinical Trials

5. Giant Axonal Neuropathy with Unusual Neuroimagings Caused by Compound Heterozygous Mutations in GAN Gene (PubMed)

Giant Axonal Neuropathy with Unusual Neuroimagings Caused by Compound Heterozygous Mutations in GAN Gene 30246730 2019 03 20 2542-5641 131 19 2018 10 05 Chinese medical journal Chin. Med. J. Giant Axonal Neuropathy with Unusual Neuroimagings Caused by Compound Heterozygous Mutations in GAN Gene. 2371-2372 10.4103/0366-6999.241804 Cai Shuang S Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China. Lin Jie J Department of Neurology, Huashan Hospital, Fudan University

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2018 Chinese medical journal

6. Mutations in XRCC1 cause cerebellar ataxia and peripheral neuropathy (PubMed)

Mutations in XRCC1 cause cerebellar ataxia and peripheral neuropathy 29472272 2019 02 16 1468-330X 89 11 2018 Nov Journal of neurology, neurosurgery, and psychiatry J. Neurol. Neurosurg. Psychiatry Mutations in XRCC1 cause cerebellar ataxia and peripheral neuropathy. 1230-1232 10.1136/jnnp-2017-317581 O'Connor Emer E Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK. Vandrovcova Jana J Department of Molecular Neuroscience, Institute of Neurology (...) College London, London, UK. Marino Silvia S Department of Neuropathology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Manzur Adnan Y AY Department of Neurology, Great Ormond Street Hospital for Children, London, UK. Roberts Mark M Department of Neurology, Salford Royal NHS Foundation Trust, Manchester, UK. Hanna Michael G MG Medical Research Council Center for Neuromuscular Diseases, University College London and National Hospital for Neurology

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2018 Journal of neurology, neurosurgery, and psychiatry

7. Sciatic neuropathy caused by a pressure ulcer: A case report. (PubMed)

Sciatic neuropathy caused by a pressure ulcer: A case report. Sciatic neuropathy has various causes; however, cases in which a pressure ulcer led to sciatic neuropathy have not been reported to date.A 33-year-old woman with no pre-existing mobility problems visited our department with the chief complaint of an extensive pressure ulcer and necrosis in her right buttock. She had a medical history of being bedridden for 2 days while in a coma due to a drug overdose 2 months previously. Physical (...) to some extent with granulation tissue. However, gait disorders, accompanied by symptoms of sciatic neuropathy, continued. The patient was transferred to the department of gastroenterology for the treatment of toxic hepatitis, which occurred during her inpatient treatment.Physicians should be aware that sciatic neuropathy may occur during the treatment of patients with a pressure ulcer who exhibit no symptoms of paraplegia or quadriplegia. To prevent neuropathy, aggressive treatment of the pressure

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2018 Medicine

8. Optic neuropathy causing vertical unilateral hemianopsia after pars plana vitrectomy for a macular hole: A case report. (PubMed)

Optic neuropathy causing vertical unilateral hemianopsia after pars plana vitrectomy for a macular hole: A case report. Recent progress in medical technology has resulted in improved surgical outcomes of pars plana vitrectomy (PPV); with microincision systems, the incidence of procedure-related complications during surgery has been reduced. However, unpredictable visual field defects after PPV remain an unresolved issue. A few reports have shown that damage to the retinal neurofibers owing (...) to dry-up during air/fluid exchange or retinal neurotoxicity of the dye used to visualize the internal limiting membrane (ILM), as well as unintentional removal of retinal neurofibers during ILM peeling, are responsible for such visual field disorders. In this report, we present a case of extensive visual field defect due to optic neuropathy exhibiting vertical hemianopsia after PPV.A 50-year-old woman underwent PPV and cataract surgery for a macular hole and mild cataract under retrobulbar

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2018 Medicine

9. Diabetic neuropathy

of symptoms and deficits, involving sensory, motor, and autonomic nerve fibres, and multiple organ systems. Diabetic peripheral neuropathy is the most common chronic complication of diabetes, characterised by the presence of peripheral nerve dysfunction, diagnosed after the exclusion of other causes. Pain is the outstanding complaint in most patients, but many patients are completely asymptomatic. Treatment has traditionally focused on control of hyperglycaemia as a means of slowing progression (...) ), and tapentadol (an agonist of the mu-opioid receptor and noradrenaline reuptake inhibitor) are the only prescription drugs currently approved for treating painful diabetic neuropathy in some countries. Definition Diabetic neuropathy (DN) is a highly prevalent complication of diabetes (type 1 or type 2) and is characterised by the presence of symptoms, and/or signs of peripheral nerve dysfunction, and/or autonomic nerve dysfunction. It is diagnosed after the exclusion of other causes. Frequently, however

2018 BMJ Best Practice

10. Compound Heterozygote Mutation of C12orf65 Causes Distal Motor Neuropathy and Optic Atrophy (PubMed)

Compound Heterozygote Mutation of C12orf65 Causes Distal Motor Neuropathy and Optic Atrophy 28091420 2017 03 13 2018 11 13 2542-5641 130 2 2017 01 20 Chinese medical journal Chin. Med. J. Compound Heterozygote Mutation of C12orf65 Causes Distal Motor Neuropathy and Optic Atrophy. 242-244 10.4103/0366-6999.198019 Fang Xiao-Jing XJ Department of Neurology, Peking University First Hospital, Beijing 100034, China. Zhang Wei W Department of Neurology, Peking University First Hospital, Beijing 100034 (...) Proteins 0 Peptide Termination Factors IM Child Female Hereditary Sensory and Motor Neuropathy genetics Heterozygote Humans Mitochondrial Proteins genetics Mutation genetics Optic Atrophy genetics Peptide Termination Factors genetics There are no conflicts of interest. 2017 1 17 6 0 2017 1 17 6 0 2017 3 14 6 0 ppublish 28091420 ChinMedJ_2017_130_2_242_198019 10.4103/0366-6999.198019 PMC5282685 Proteins. 2012 Nov;80(11):2629-42 22821833 J Neurol Neurosurg Psychiatry. 2014 May;85(5):486-92 24198383 Am J

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2017 Chinese medical journal

11. Homozygous mutation in HSPB1 causing distal vacuolar myopathy and motor neuropathy (PubMed)

Homozygous mutation in HSPB1 causing distal vacuolar myopathy and motor neuropathy 28702508 2018 11 13 2376-7839 3 4 2017 Aug Neurology. Genetics Neurol Genet Homozygous mutation in HSPB1 causing distal vacuolar myopathy and motor neuropathy. e168 10.1212/NXG.0000000000000168 Bugiardini Enrico E MRC Centre for Neuromuscular Diseases (E.B., A.M.R., J.C.B., M.G.H., J.L.H., M.M.R., E.M.), UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery; Department of Molecular (...) Neuroscience (D.S.L., A.M.P., M.G.H., H.H., J.L.H.), and Division of Neuropathology (J.L.H.), UCL Institute of Neurology, London; Department of Neurology (M.S.), The Royal London Hospital; and Department of Clinical Neurophysiology (J.C.B.), Norfolk and Norwich University Hospital, UK. eng MR/K000608/1 Medical Research Council United Kingdom G1001253 Medical Research Council United Kingdom G108/638 Medical Research Council United Kingdom MR/J004758/1 Medical Research Council United Kingdom G0802760 Medical

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2017 Neurology: Genetics

12. Parosteal lipoma as a rare cause of peripheral neuropathy and local irritation: A report of 12 cases (PubMed)

Parosteal lipoma as a rare cause of peripheral neuropathy and local irritation: A report of 12 cases The aim of this study was to evaluate the clinical features and functional results of patients with parosteal lipomas.A total of 12 patients (8 females and 4 males; mean age: 45 (10-62) years) with parosteal lipomas who were treated between April 1986 and April 2014, were included into the study. The medical records of the patients were reviewed to analyze the clinical features and functional (...) was observed after a mean follow-up of 16 months.Parosteal lipomas are uncommon tumors that can be diagnosed with their characteristic radiological features. Parosteal lipomas occurring in the proximal radius may easily cause paralysis of the posterior interosseous nerve or muscle weakness.Level IV, Therapeutic study.Copyright © 2017 Turkish Association of Orthopaedics and Traumatology. Production and hosting by Elsevier B.V. All rights reserved.

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2017 Acta orthopaedica et traumatologica turcica

13. Tiny Tips: “TREADMILLS” Peripheral Neuropathy mnemonic

, glucose, urea, creatinine), and thyroid stimulating hormone (TSH) 2 . There are many causes for peripheral neuropathy, so when considering the etiology, think “TREADMILLS.” T oxins Ethanol, Heavy metals, Tetanus, Organophosphates, Diphtheria R enal Failure E ndocrine Diabetes, Hypothyroidism A cquired Immunodeficiency Syndrome (AIDS) D rugs/ D eficiency Amiodarone, Procainamide, Digoxin, Hydralazine, Statins, Isoniazid, Chloroquine, Misoprostol, Metronidazole, Nitrofurantoin Vitamin B6 deficiency (...) Tiny Tips: “TREADMILLS” Peripheral Neuropathy mnemonic Tiny Tips: “TREADMILLS” Peripheral Neuropathy mnemonic - CanadiEM Tiny Tips: “TREADMILLS” Peripheral Neuropathy mnemonic In , by Sean Patrick February 20, 2018 Peripheral neuropathy is prevalent in up to 2.4% of the general population 1 . It is often characterized by an asymmetric distribution with sensory symptoms following a dermatomal pattern. Initial investigations include a complete blood count (CBC), metabolic panel (electrolytes

2018 CandiEM

14. Practice Advisory for the Prevention of Perioperative Peripheral Neuropathies

. They are not supported by scientific literature to the same degree as standards or guidelines because of the lack of sufficient numbers of adequately controlled studies. Practice advisories are subject to periodic revision as warranted by the evolution of medical knowledge, technology, and practice. This document updates the “Practice Advisory for the Prevention of Perioperative Peripheral Neuropathies: An Updated Report by the American Society of Anesthesiologists Task Force on Prevention of Perioperative (...) with specific preexisting conditions such as diabetes, vascular disease, alcoholism, sex, and extremes of body weight ( Category B3 evidence ). Case reports indicate that both upper and lower neuropathies occur with diabetes, preexisting paresthesias, heavy alcohol use, and smoking history ( Category B4 evidence ). Such conditions often are noted in a patient’s medical history or found during a physical assessment. Survey Findings. Ninety-three percent of the consultants who responded agree that a focused

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2018 American Society of Anesthesiologists

15. Idebenone (Raxone) - for the treatment of visual impairment in adolescent and adult patients with Leber?s Hereditary Optic Neuropathy (LHON).

and adult patients with Leber’s Hereditary Optic Neuropathy (LHON). LHON is a rare mitochondrial disease of the eye, caused by one of three main mutations in mitochondrial DNA. The disease predominantly affects males, with onset usually occurring in early adulthood and it results in a sudden deterioration in vision. Final data submitted by the applicant was received on 22 nd June 2018. Santhera (UK) Limited are seeking reimbursement for idebenone on the High Tech Drug Scheme (HTDS). Idebenone is a short (...) Idebenone (Raxone) - for the treatment of visual impairment in adolescent and adult patients with Leber?s Hereditary Optic Neuropathy (LHON). 1 Cost-effectiveness of idebenone (Raxone®) for the treatment of visual impairment in adolescent and adult patients with Leber’s Hereditary Optic Neuropathy (LHON) The NCPE has issued a recommendation regarding the cost-effectiveness of idebenone (Raxone®). Following assessment of the applicant’s submission, the NCPE recommends that idebenone (Raxone®

2018 Pediatric Endocrine Society

16. [Genetic sequencing panel for motor-sensory hereditary neuropathy diagnosis]

would have additional benefits in identifying phenotype-guided mutations in the diagnosis of motor-sensory hereditary neuropathy. It is important to consider that in general the tests report non-conclusive or uncertain results, thus causing potential adverse consequences to the patients and their families. In general, the clinical practice guidelines assessed do not recommend genetic sequencing panels, although they do recommend detecting PMP22 gene duplication if type 1 motor sensory hereditary (...) neuropathy is suspected, and MFN2 gene if type 2 motor sensory hereditary neuropathy is suspected, since both types are the most prevalent. The coverage policies assessed do not consider genetic sequencing test coverage; however, regarding the detection of motor-sensory hereditary neuropathy associated genes, there is no consensus on coverage since some consider them diagnostic tests at investigational stage and medically unnecessary. Final publication URL www.iecs.org.ar Indexing Status Subject indexing

2017 Health Technology Assessment (HTA) Database.

17. Could Topical Minoxidil Cause Non-Arteritic Anterior Ischemic Optic Neuropathy? (PubMed)

Could Topical Minoxidil Cause Non-Arteritic Anterior Ischemic Optic Neuropathy? Minoxidil hair formulation is commonly used for the treatment of male or female androgenic alopecia. Minoxidil is a Health Canada and US FDA-approved medication for hair loss in men and women. The drug is marketed as 2% and 5% topical solutions. This over-the-counter product is considered safe, but should be used with caution. Furthermore, minoxidil is an orally active vasodilator for treatment of severe (...) hypertension. Typical side effects of minoxidil are faster heart rate, augmented heart function and stroke volume (which can be associated with reduced vascular resistance upon baroflex stimulus), retained sodium and water and abnormal hair growth. The most common adverse reactions of the topical formulation are limited to irritant and allergic contact dermatitis on the scalp. Herein, we report a non-arteritic anterior ischemic optic neuropathy caused by topical 5% minoxidil treatment that was resolved

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2016 Journal of clinical and diagnostic research : JCDR

18. A novel missense mutation in the C2C domain of otoferlin causes profound hearing impairment in an Omani family with auditory neuropathy (PubMed)

A novel missense mutation in the C2C domain of otoferlin causes profound hearing impairment in an Omani family with auditory neuropathy To identify genetic defects in an Omani family diagnosed with deafness. A cross-sectional association study was conducted at the Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, Al-Khoud, Oman and the Centre of Medical Genetics, University of Antwerp, Antwerp, Belgium between August 2010 and September 2014 (...) . Microsatellites markers for nine non-syndromic genes were used to genotype the defective locus using the extracted DNA from family members. Sanger sequencing method was used to identify the disease causative mutation. Eazy linkage 5.05 was used to calculate the logarithm of odds score. Lasergene suite was used to detect the mutation position, and Phyre2, SMART, Rasmol, and GOR IV were used to predict the effects of the defect on protein structure and function. The disease was linked to markers located

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2016 Saudi medical journal

19. Small fibre neuropathy in Fibromyalgia: cause or consequence?

Small fibre neuropathy in Fibromyalgia: cause or consequence? Small fiber neuropathy in fibromyalgia Research into the role of the brain and mind in chronic pain Small fibre neuropathy in Fibromyalgia: cause or consequence? March 8, 2016 by Dan Clauw recently wrote an insightful editorial for Pain[1], in which he highlighted an important finding about the idea that people with fibromyalgia show signs of ‘small fibre neuropathy’. Changes in intra-epidermal nerve fibres (‘small fibres’) have been (...) small fibre neuropathy, which the authors interpreted as suggesting that the mechanisms driving the changes probably differ, too. Clauw uses this as a springboard to point out that naming these differences in intra-epidermal nerve density as ‘small fibre neuropathy’ in those that don’t have the classic set of signs and symptoms of small fibre neuropathy is likely to cause confusion, because (a) it implies a causative link and (b) it ignores the subtle, but relevant, heterogeneity in morphology

2016 Body in Mind blog

20. An update on the causes, assessment and management of third division sensory trigeminal neuropathies. (PubMed)

and various medical conditions.Objective To review the aetiology, evaluation and management of V3 neuropathy in a retrospective case-series of patients referred to a specialist nerve injury clinic over an eight-year period, particularly focusing on the non-iatrogenic causes of this presentation.Methods A retrospective analysis of the case notes of 372 patients referred to the specialist nerve injury clinic between 2006 and 2014 was carried out to establish the cause of the neuropathy and subsequent (...) An update on the causes, assessment and management of third division sensory trigeminal neuropathies. Introduction Sensory neuropathies of the mandibular division of the trigeminal (V3) nerve can be debilitating, causing difficulty with daily function. It has a variety of causes, including iatrogenic injury, usually caused by third molar removal, local anaesthetic administration, implant placement or endodontic treatment. Non-iatrogenic causes include infection, primary or secondary neoplasia

2016 British Dental Journal

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