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Meconium Drug Screen

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1. Meconium Drug Screen

Meconium Drug Screen Meconium Drug Screen Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Meconium Drug Screen Meconium Drug Screen (...) Aka: Meconium Drug Screen , Toxicology Screening of Meconium II. Indication Suspected III. Mechanism Meconium accumulates drug exposure throughout pregnancy In utero exposure of drugs implied by positive test Exposure may have been months prior to delivery IV. General Lab testing methadology is critical to efficacy s are non-specific Confirmatory testing is highly specific Gas chromatography mass spectrometry (GC/MS) Liquid Chromatography mass spectrometry (LC/MS) V. Efficacy False positives

2018 FP Notebook

2. Screening Pregnant Women and Their Neonates for Illicit Drug Use: Consideration of the Integrated Technical, Medical, Ethical, Legal, and Social Issues (PubMed)

Screening Pregnant Women and Their Neonates for Illicit Drug Use: Consideration of the Integrated Technical, Medical, Ethical, Legal, and Social Issues North America is currently suffering from one of the worst epidemics of illicit drug use in recent history: the opioid crisis. Pregnant women are not immune to the ravages of substance misuse which affects themselves, their pregnancies, and the wider community. The prevalence of drug misuse in pregnancy is not well quantified due to the lack (...) of good validated tests, cooperation between clinicians and scientists developing tests, and consensus as to who should be tested and how results should be used. A wide range of tissues can be tested for drug use, including maternal blood, urine, and hair; neonatal meconium, urine, and hair; and placenta and umbilical cord tissues. Testing methods range from simple spectrophotometry and clinical chemistry to sophisticated analytical HPLC or mass spectrometry techniques. The drive for ever greater

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2018 Frontiers in pharmacology

3. Meconium Drug Screen

Meconium Drug Screen Meconium Drug Screen Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Meconium Drug Screen Meconium Drug Screen (...) Aka: Meconium Drug Screen , Toxicology Screening of Meconium II. Indication Suspected III. Mechanism Meconium accumulates drug exposure throughout pregnancy In utero exposure of drugs implied by positive test Exposure may have been months prior to delivery IV. General Lab testing methadology is critical to efficacy s are non-specific Confirmatory testing is highly specific Gas chromatography mass spectrometry (GC/MS) Liquid Chromatography mass spectrometry (LC/MS) V. Efficacy False positives

2015 FP Notebook

4. Interest of Concentrations in Meconium of Buprenorphine and Methadone as a Prognostic Factor of NAS Outcome

of methadone [ Time Frame: variation over time at baseline and 24hrs to 48hrs after birth ] Secondary Outcome Measures : urine concentration of buprenorphine or methadone [ Time Frame: baseline and 24hrs to 48hrs after birth ] by the score of Lipsitz, [ Time Frame: 4 times a day when the newborn is awake from baseline to 48hrs ] Clinical evaluation of the newborn screening of other drugs in mother's urine and meconium [ Time Frame: baseline and 24hrs to 48hrs after birth ] Biospecimen Retention: Samples (...) Last Update Posted : November 7, 2017 Sponsor: University Hospital, Caen Information provided by (Responsible Party): University Hospital, Caen Study Details Study Description Go to Brief Summary: The aim of this study is to characterize the interest of concentrations in meconium of drugs used for treatment of pregnant opioid-dependent woman as a prognostic factor of time, severity and duration of neonatal abstinence syndrome (NAS). 43 women treated with buprenorphine, 49 with methadone

2016 Clinical Trials

5. Using Clinical Laboratory Tests to Monitor Drug Therapy in Pain Management Patients

the laboratory tests (screening or definitive) that were com- pared with other clinician tools (e.g., physician interview, medical record review, prescription monitoring programs, screener and opioid assessment for patients with pain). In general, screening tests have adequate clinical sensitivity but may not be highly spe- Using Clinical Laboratory Tests to Monitor Drug Therapy in Pain Management Patients JANNETTO PJ, BRATANOW N, CLARK WA, HAMILL-RUTH RJ, HAMMETT-STABLER CA, HUESTIS MA, KASSED CA, MCMILLIN (...) . It should be noted that this table is not meant to be a comprehensive list of all drugs that need to be tested for in every pain management patient, but instead should be used as a guideline. Tier I represents the scope of testing that should be done as part of routine monitoring and covers the common class- es of drugs of abuse, as well as the drugs commonly prescribed to pain management patients. Tier ll testing should also be added to screen for drug use/abuse in patients identified as high risk

2018 Publication 4890876

6. The effectiveness of positive ventilation versus endotracheal intubation in the prevention of morbidity after resuscitation in newborns with meconium aspiration syndrome

The effectiveness of positive ventilation versus endotracheal intubation in the prevention of morbidity after resuscitation in newborns with meconium aspiration syndrome Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (...) (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing and effect measures Timing and effect measures Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Context and rationale Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Example: Screening will be performed in two phases, namely

2018 PROSPERO

7. Fatty Acid Ethyl Esters in Meconium of Infants of Diabetic Mothers: a Pilot Trial

gestational diabetes mellitus). This lab draw would be added to the mother's routine lab studies and would not require an additional venipuncture. A second urine drug screen will be performed on the mother upon her admission to the University of Oklahoma Health Sciences Center for the delivery of her baby. If both screens are negative and the baby does not meet any of the exclusion criteria, the baby will be enrolled in the study. The initial meconium from each baby of the recruited mothers (...) will be gathered. Approximately 1 g of meconium will be collected, frozen, and evaluated for fatty acid ethyl ester analysis at the United States Drug Testing Laboratories, Inc. We will also be sending a dried blood spot from the baby which will be collected at the time of the baby's scheduled newborn screen. This dried blood spot will be evaluated for phosphatidylethanol, an ethanol by-product. Study Design Go to Layout table for study information Study Type : Observational [Patient Registry] Estimated

2014 Clinical Trials

8. Surgical Aspects of Cystic Fibrosis and Meconium Ileus (Diagnosis)

, and ultimately, fibrosis. Beginning in utero, this progressive process occurs variably over time. Approximately two thirds of infants later diagnosed with CF by neonatal screening have pancreatic insufficiency at birth. Approximately 10% of patients with CF remain pancreatic sufficient and tend to have a milder course. Indications Surgical exploration is indicated for patients with progressive distention, signs of peritonitis, or clinical deterioration. Surgery is always indicated for complicated meconium (...) in CF. An epidemiologic study of 27,703 patients, which used the age of CF diagnosis and the initial disease presentation to build survival models and to demonstrate disease severity in isolated patients with CF, revealed that in comparison with the SCREEN group diagnosed by a newborn screening program, patients diagnosed by meconium ileus had statistically significant higher risks of a shorter lifespan, acquisition of Pseudomonas aeruginosa infection, and a trend toward FEV 1 below 70

2014 eMedicine Pediatrics

9. Surgical Aspects of Cystic Fibrosis and Meconium Ileus (Follow-up)

, and ultimately, fibrosis. Beginning in utero, this progressive process occurs variably over time. Approximately two thirds of infants later diagnosed with CF by neonatal screening have pancreatic insufficiency at birth. Approximately 10% of patients with CF remain pancreatic sufficient and tend to have a milder course. Indications Surgical exploration is indicated for patients with progressive distention, signs of peritonitis, or clinical deterioration. Surgery is always indicated for complicated meconium (...) in CF. An epidemiologic study of 27,703 patients, which used the age of CF diagnosis and the initial disease presentation to build survival models and to demonstrate disease severity in isolated patients with CF, revealed that in comparison with the SCREEN group diagnosed by a newborn screening program, patients diagnosed by meconium ileus had statistically significant higher risks of a shorter lifespan, acquisition of Pseudomonas aeruginosa infection, and a trend toward FEV 1 below 70

2014 eMedicine Pediatrics

10. Surgical Aspects of Cystic Fibrosis and Meconium Ileus (Treatment)

, and ultimately, fibrosis. Beginning in utero, this progressive process occurs variably over time. Approximately two thirds of infants later diagnosed with CF by neonatal screening have pancreatic insufficiency at birth. Approximately 10% of patients with CF remain pancreatic sufficient and tend to have a milder course. Indications Surgical exploration is indicated for patients with progressive distention, signs of peritonitis, or clinical deterioration. Surgery is always indicated for complicated meconium (...) in CF. An epidemiologic study of 27,703 patients, which used the age of CF diagnosis and the initial disease presentation to build survival models and to demonstrate disease severity in isolated patients with CF, revealed that in comparison with the SCREEN group diagnosed by a newborn screening program, patients diagnosed by meconium ileus had statistically significant higher risks of a shorter lifespan, acquisition of Pseudomonas aeruginosa infection, and a trend toward FEV 1 below 70

2014 eMedicine Pediatrics

11. Surgical Aspects of Cystic Fibrosis and Meconium Ileus (Overview)

, and ultimately, fibrosis. Beginning in utero, this progressive process occurs variably over time. Approximately two thirds of infants later diagnosed with CF by neonatal screening have pancreatic insufficiency at birth. Approximately 10% of patients with CF remain pancreatic sufficient and tend to have a milder course. Indications Surgical exploration is indicated for patients with progressive distention, signs of peritonitis, or clinical deterioration. Surgery is always indicated for complicated meconium (...) in CF. An epidemiologic study of 27,703 patients, which used the age of CF diagnosis and the initial disease presentation to build survival models and to demonstrate disease severity in isolated patients with CF, revealed that in comparison with the SCREEN group diagnosed by a newborn screening program, patients diagnosed by meconium ileus had statistically significant higher risks of a shorter lifespan, acquisition of Pseudomonas aeruginosa infection, and a trend toward FEV 1 below 70

2014 eMedicine Pediatrics

12. Tracheal suction at birth in non-vigorous neonates born through meconium-stained amniotic fluid [Cochrane protocol]

Tracheal suction at birth in non-vigorous neonates born through meconium-stained amniotic fluid [Cochrane protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence (...) : Organisation web address: Timing and effect measures Timing and effect measures Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Context and rationale Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Example: Screening will be performed in two phases, namely initial screening based on title and abstract, followed

2017 PROSPERO

13. Gastrografin for treatment of meconium obstruction in term and preterm infants [Cochrane protocol]

Gastrografin for treatment of meconium obstruction in term and preterm infants [Cochrane protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web (...) address: Timing and effect measures Timing and effect measures Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Context and rationale Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Inclusion criteria: Exclusion criteria: Example: Screening will be performed in two phases, namely initial screening based on title and abstract, followed by full-text

2017 PROSPERO

14. User Testing of the Evivo Screening Test

User Testing of the Evivo Screening Test User Testing of the Evivo Screening Test - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. User Testing of the Evivo Screening Test The safety and scientific validity (...) , Inc. Study Details Study Description Go to Brief Summary: The study is an evaluation of the Evivo Screening Test's ability to differentiate between high and low levels of Bifidobacterium in infant stool specimens. Condition or disease Intervention/treatment Phase Gut Microbiome Device: Evivo Infant Gut Bifidobacterium Screening Test Not Applicable Detailed Description: This is a prospective, multi-center clinical study of the Evivo Infant Gut Bifidobacterium Screening Test ("Evivo Screening Test

2018 Clinical Trials

15. Newborn Screening for Cystic Fibrosis: A Review of the Clinical and Cost-Effectiveness

is to initiate early treatment and follow-up, the benefits of available therapeutic options may also be considered when deciding on whether to add CF screening to newborn screening panels. PREPARED BY: Canadian Agency for Drugs and Technologies in Health Tel: 1-866-898-8439 www.cadth.ca Newborn Screening for Cystic Fibrosis 9 REFERENCES 1. Screening newborns for cystic fibrosis [Internet]. Edmonton: Institute of Health Economics; 2007 [cited 2012 Apr 9]. Available from: http://www.ihe.ca/documents (...) : IRT/IRT: 99.9% IRT/DNA (single mutation)*: 99.9% IRT/DNA (12 mutations): 99.9% “Most babies with CF without meconium ileus, a family history or antenatal diagnosis are detected by newborn screening. Despite improved sensitivity with the 12- mutation analysis, most infants detected would have been diagnosed using the IRT/p.F508del protocol” Vernooij-van Langen, 2012 13 IRT cut-off level =60µg/l PAP cut-off level = 1.6µg/l (for IRT value =100µg/l) PAP cut-off level =30µg/l (for IRT value 60-100µg/l

2012 Canadian Agency for Drugs and Technologies in Health - Rapid Review

16. Comparison Of Surfactant Lung Lavage With Standard Care In The Treatment Of Meconium Aspiration Syndrome

. Surfactant Lung lavage has been shown to be alternative to bolus therapy in treating neonates with meconium aspiration as shown by many pilot studies. So the investigators have decided to study the role surfactant lung lavage in the treatment of meconium aspiration syndrome. Condition or disease Intervention/treatment Phase Meconium Aspiration Syndrome Drug: Bovine surfactant Not Applicable Detailed Description: Meconium is an odourless, thick, blackish green material first demonstrable in the foetal (...) Comparison Of Surfactant Lung Lavage With Standard Care In The Treatment Of Meconium Aspiration Syndrome Comparison Of Surfactant Lung Lavage With Standard Care In The Treatment Of Meconium Aspiration Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2011 Clinical Trials

17. Role of Antibiotics in Preventing Infection in Babies Born Through Meconium Stained Liquor

or refute the same. Most clinicians have a low threshold for using antibiotics in such babies. In view of the uncertainty regarding antibiotic usage in these babies, the investigators decided to investigate the role of prophylactic antibiotics in prevention of neonatal sepsis in babies born through meconium stained amniotic fluid. Condition or disease Intervention/treatment Phase Neonatal Sepsis Drug: Piperacillin-Tazobactam and Amikacin Not Applicable Detailed Description: Meconium passage in newborn (...) . These neonates will also be monitored by performing sepsis screens and blood culture for development of sepsis. Drug: Piperacillin-Tazobactam and Amikacin Inj Piperacillin-Tazobactam 50 mg/Kg/dose 12 hourly IV X 3 days (6 doses) Inj Amikacin 15 mg/kg/dose 24 hourly IV X 3 days (3 doses) No Intervention: No Antibiotic Group Neonates randomized to 'No antibiotic group' will receive supportive treatment as per standard unit protocol. These neonates will be monitored by performing sepsis screens and blood

2011 Clinical Trials

18. Perinatal Drug Abuse and Neonatal Drug Withdrawal (Treatment)

=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTc4NDkyLXRyZWF0bWVudA== processing > Perinatal Drug Abuse and Neonatal Drug Withdrawal Treatment & Management Updated: Jan 29, 2014 Author: Marvin Wang, MD; Chief Editor: Ted Rosenkrantz, MD Share Email Print Feedback Close Sections Sections Perinatal Drug Abuse and Neonatal Drug Withdrawal Treatment Medical Care Perhaps the most important aspect of medical care for the potentially withdrawing infant should be that all nurseries caring for such infants develop a care protocol addressing screening and treatment (...) screen in a newborn of a mother without a prescription for the suspected drug warrants an investigation by the state child protection agency. The hospital social services staff can coordinate and supervise the interactions of staff, parents, and state services. Occupational and physical therapy: Use of a team of therapists decreases the overall treatment time. Issues surrounding environmental stressors and patient contact can be addressed. Previous Next: Diet The following may be indicated

2014 eMedicine Pediatrics

19. Retrospective analysis of the diagnostic yield of newborn drug testing. (PubMed)

Retrospective analysis of the diagnostic yield of newborn drug testing. The objective of this study was to identify high-yield screening risk factors for detecting maternal non-medical drug use during pregnancy.A four year retrospective analysis was conducted at an academic medical center. Detailed chart review of both the newborn and mother's medical record was performed on all cases for which one or more drug(s) or metabolite(s) were identified and confirmed in meconium or urine.229 (9.2 (...) %) of 2,497 meconium samples out of 7,749 live births confirmed positive for one or more non-medical drugs. History of maternal non-medical drug and/or tobacco use in pregnancy was present in 90.8% of non-medical drug use cases. Addition of social risk factors and inadequate prenatal care increased the yield to 96.9%.Use of focused screening criteria based on specific maternal and social risk factors may detect many prenatal non-medical drug exposures.

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2014 BMC Pregnancy and Childbirth

20. Universal or targeted screening for fetal alcohol exposure: a cost-effectiveness analysis

. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study examined the cost-effectiveness of testing meconium to detect foetal alcohol spectrum disorder in newborns. The authors concluded that, from a societal perspective, screening and treatment was economically attractive if it was implemented universally and was a dominant strategy (...) The universal and the targeted screening strategies were compared with no screening. The laboratory test identified alcohol consumption during the second or third trimester of the mother’s pregnancy, but was unable to detect consumption only during the first trimester. The test was performed on the newborn's first stool (meconium). Location/setting Canada/hospital. Methods Analytical approach: The analysis was based on a decision-analytic model for the short-term and a Markov model with a lifetime horizon

2008 NHS Economic Evaluation Database.

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