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1,219 results for

Mean Corpuscular Volume

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141. Vitamin B12 Pregnancy Supplementation

with increased requirements for iron and increased blood volume of up to 40%. Because expansion in plasma volume is higher than the increase in the mass of red blood cells, there is a fall in hemoglobin concentration, which leads to physiological anemia, characterized with lower hemoglobin (Hb), hematocrit and red blood cells, but without changes in mean corpuscular volume (MCV). Anemia in pregnancy is defined with Hb values under 110 g/L in the first trimester and under 105 g/L in the second and third (...) points: on the 8th-10th and 22nd-24th weeks of pregnancy ] RBC count measured in SI (Systeme International) units (Nx10*12/L) Change of Hemoglobin (Hgb) concentration in first and second trimester [ Time Frame: at two time points: on the 8th-10th and 22nd-24th weeks of pregnancy ] Hgb concentration in SI units (g/L) Change of Hematocrit in first and second trimester [ Time Frame: at two time points: on the 8th-10th and 22nd-24th weeks of pregnancy ] volume percentage (%) Change of Mean corpuscular

2018 Clinical Trials

142. First Time in Human (FTIH) Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Single and Repeat Doses of GSK3439171A in Healthy Subjects and to Assess Food Effect

. Part A: Number of subjects with abnormal Hematology Values [ Time Frame: Up to 6 weeks ] Number of subjects with abnormal Hematology values including: Platelet Count, red blood cells, white blood cells, Reticulocyte, Hemoglobin, Hematocrit, Neutrophils, Lymphocytes, Monocytes, Eosinophils, Basophils, mean corpuscular volume, Mean Corpuscular Hemoglobin, Mean Corpuscular Hemoglobin Concentration, Prothrombin time and Prothrombin time for Part A will be reported. Part B: Number of subjects (...) with abnormal Hematology Values [ Time Frame: Up to 5 weeks ] Number of subjects with abnormal Hematology values including: Platelet Count, red blood cells, white blood cells, Reticulocyte, Hemoglobin, Hematocrit, Neutrophils, Lymphocytes, Monocytes, Eosinophils, Basophils, mean corpuscular volume, Mean Corpuscular Hemoglobin, Mean Corpuscular Hemoglobin Concentration, Prothrombin time and Prothrombin time for Part B will be reported. Part C: Number of subjects with abnormal Hematology Values [ Time Frame

2018 Clinical Trials

143. A Study of Acute Myocardial Infarction Using FDY-5301

, Total Protein 2.4 (U/L): Gamma Glutamyl Transferase, ALP, ALT, AST, Lactate Dehydrogenase Thyroid Function Analysis 3.1 Thyroid Stimulating Hormone (mlU/L), Triiodothyronine (ng/dL), Thyroxine (mg/dL) Hematology Analysis 4.1 Activated Clotting Time (seconds), Hemoglobin (g/dL), Red Blood Cell Count (10^6/mcL), Packed Cell Volume (%), Mean Corpuscular Volume (fL), Mean Corpuscular Hemoglobin (fmol/cell), Mean Corpuscular Hemoglobin Concentration (g/dL), Platelet Count (10^9/L), Total and Differential (...) -5301 The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03470441 Recruitment Status : Not yet recruiting First Posted : March 20, 2018 Last Update Posted : March 20, 2018 See Sponsor: Faraday Pharmaceuticals, Inc

2018 Clinical Trials

144. The Swedish Spinal Cord Injury Study on Cardiopulmonary and Autonomic Impairment

for trombocytes level Erythrocytes Mean Corpuscular Hemoglobin (Erc-MCH) [ Time Frame: Day 1 ] Analysis of venous blood sample for Erc-MCH level Erythrocytes Mean Corpuscular Volume (Erc-MCV) [ Time Frame: Day 1 ] Analysis of venous blood sample for Erc-MCV level Neutrophils [ Time Frame: Day 1 ] Analysis of venous blood sample for neutrophils level Eosinophils [ Time Frame: Day 1 ] Analysis of venous blood sample for Eosinophils level Basophils [ Time Frame: Day 1 ] Analysis of venous blood sample (...) more. The Swedish Spinal Cord Injury Study on Cardiopulmonary and Autonomic Impairment (SPICA) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03515122 Recruitment Status : Enrolling by invitation First Posted : May 3, 2018 Last Update Posted : May 7, 2018 Sponsor: Lund University Collaborator

2018 Clinical Trials

145. Daprodustat Bioequivalence and Food Effect Study

occurrence that at any dose may result in death, is life-threatening, may require hospitalization or prolongation of existing hospitalization, result in persistent disability/incapacity, or may led to any congenital anomaly or birth defect. Number of subjects with abnormal hematology parameters: Part 1 [ Time Frame: Up to Day 16 ] Laboratory assessment for hematology parameters will include Platelet count, haemoglobin (Hgb), Red blood cell (RBC) count, hematocrit, RBC indices like mean corpuscular volume (...) (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and percentage reticulocytes. White blood cell (WBC) count with differential will include neutrophils, lymphocytes, monocytes, eosinophils and basophils. Number of subjects with abnormal hematology parameters: Part 2 [ Time Frame: Up to Day 16 ] Laboratory assessment for hematology parameters will include Platelet count, Hgb, RBC count, hematocrit, RBC indices like MCV, MCH, MCHC, and percentage

2018 Clinical Trials

146. A Safety, Tolerability, Pharmacokinetics (PK) and Target Engagement Study in Healthy Volunteers and Subjects With Osteoarthritis (OA)

of existing hospitalization, results in disability/incapacity, or is a congenital anomaly/birth defect or is medically significant. Part A: Number of subjects with abnormal hematology parameters [ Time Frame: Up to 140 days ] Hematology parameters will be assessed including platelet count, red blood cell (RBC) count, hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), percent reticulocytes; white blood cell (WBC) count, neutrophils, lymphocytes, monocytes, eosinophils (...) have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Safety, Tolerability, Pharmacokinetics (PK) and Target Engagement Study in Healthy Volunteers and Subjects With Osteoarthritis (OA) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before

2018 Clinical Trials

147. Effects of GSK2798745 on Alveolar Barrier Disruption in a Segmental Lipopolysaccharide (LPS) Challenge Model

with hematology parameters of potential clinical concern [ Time Frame: Up to Day 9 ] Blood samples will be collected to measure platelet count, red blood cell (RBC) count, hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), percent reticulocytes, neutrophils, lymphocytes, monocytes, eosinophils and basophils. Number of subjects with clinical chemistry parameters of potential clinical concern [ Time Frame: Up to Day 9 ] Blood samples will be collected to measure blood urea (...) signs will be measured in a semi-supine position after 5 minutes rest and will include temperature, systolic and diastolic blood pressure and heart rate. Mean forced expiratory volume in 1 second (FEV1) [ Time Frame: Up to Day 9 ] FEV1 is the volume of air that can be forced out in one second after taking a deep breath. FEV1 was measured by spirometry. Mean forced vital capacity (FVC) [ Time Frame: Up to Day 9 ] FVC is the amount of air which can be forcibly exhaled from the lungs after taking

2018 Clinical Trials

148. Phase 1 Study of AlphaMedixâ„¢ in Adult Subjects With SSTR (+) NET

/90Y/111In- DOTATATE/DOTATOC or TAT Known hypersensitivity to 68Gallium, Octreotate, or any of the excipients of 68Ga-DOTATATE, AA infusion or AlphaMedix™. Therapeutic use of any somatostatin analogue, including Sandostatin® LAR (within 28 days) and Sandostatin® (within 1 day) prior to administration of investigational drug. Subjects with unusual hematological parameters, including an increased mean corpuscular volume (MCV) (>100,000), and especially in those who had previous chemotherapy (...) of AlphaMedix™ in Adult Subjects With SSTR (+) NET The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03466216 Recruitment Status : Recruiting First Posted : March 15, 2018 Last Update Posted : March 15, 2018 See Sponsor: Radiomedix

2018 Clinical Trials

149. The Application of Microcurrent in Athletes

-intervention will be body composition via DEXA, endurance performance (1 RM bench press and Squat) endurance (vo2max) and blood markers: haemoglobin; red blood cell; erythrocyte; haematocrit; mean corpuscular volume, transferrin; neutrophils; lymphocyte; monocytes, IL6, IL1, Myoglobin, salivary cortisol and testosterone. Elbow flexors, vastus medialis and vbastus lateralis muscle thickness Device: Microcurrent Microcurrent based treatments have been proposed more than 30 years. The manufacturer initially (...) with 3 h of sham comparator after training. Measurements pre and post-intervention will be body composition via DEXA, endurance performance (1 RM bench press and Squat) endurance (vo2max) and blood markers: haemoglobin; red blood cell; erythrocyte; haematocrit; mean corpuscular volume, transferrin; neutrophils; lymphocyte; monocytes, IL6, IL1, Myoglobin, salivary cortisol and testosterone. Elbow flexors, vastus medialis and vbastus lateralis muscle thickness Device: Microcurrent Microcurrent based

2018 Clinical Trials

150. A Research Study Looking at a New Study Medicine (NNC0194-0499) for Weight Control in People With Overweight or Obesity

(total), Creatinine, High sensitivity C-reactive protein (hsCRP) and Total protein in SI units Change in haematology [ Time Frame: Baseline (Day -1), Follow-up (Day 112) ] Parameters: Erythrocytes, Reticulocytes, Thrombocytes, Leucocytes (total), Neutrophils, Lymphocytes, Monocytes, Eosinophils, Basophils, Haemoglobin, Haematocrit, Mean corpuscular volume (MCV) and Mean corpuscular haemoglobin concentration (MCHC) in SI units Change in fibrinogen [ Time Frame: Baseline (Day -1), Follow-up (Day 112 (...) number of saved studies (100). Please remove one or more studies before adding more. A Research Study Looking at a New Study Medicine (NNC0194-0499) for Weight Control in People With Overweight or Obesity The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2018 Clinical Trials

151. Anemia Studies in Chronic Kidney Disease (CKD): Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat-Three-times Weekly Dosing in Dialysis (ASCEND-TD)

designed to assess subjects impression of disease severity of their anemia of CKD. Absolute values over time for composite of hematology parameters as a measure of safety [ Time Frame: Up to Week 52 ] The following hematology parameters will be measured: Hemoglobin, Hematocrit, RBC count, Mean corpuscular volume (MCV), Mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), Red cell distribution width (RDW), Reticulocyte count, Platelet count, white blood cell (WBC) count (...) , Total neutrophils, Eosinophils, Monocytes, Basophils, and Lymphocytes Changes from baseline over time in composite of hematology parameters as a measure of safety [ Time Frame: Up to Week 52 ] The following hematology parameters will be measured: Hemoglobin, Hematocrit, RBC count, Mean corpuscular volume (MCV), Mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), Red cell distribution width (RDW), Reticulocyte count, Platelet count, white blood cell (WBC) count, Total

2018 Clinical Trials

152. A Study to Evaluate the Effect of Itraconazole on the Pharmacokinetics (PK) of Nemiralisib

laboratory parameters [ Time Frame: Up to 41 days ] Hematology parameters will be analyzed as a measure of safety including platelet count, red blood cell (RBC) count, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, percent reticulocytes, neutrophils, lymphocytes, monocytes, eosinophils and basophils. Number of subjects with abnormal values for urinalysis [ Time Frame: Up to 30 days ] Urinalysis parameters will be analyzed including specific gravity. The dipstick method (...) studies before adding more. A Study to Evaluate the Effect of Itraconazole on the Pharmacokinetics (PK) of Nemiralisib The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03398421 Recruitment Status : Completed First Posted : January 12, 2018 Last Update Posted : January 15, 2019 Sponsor: GlaxoSmithKline

2018 Clinical Trials

153. Repeat Dose Study of GSK3772847 in Participants With Moderate to Severe Asthma With Allergic Fungal Airway Disease (AFAD)

in persistent disability/incapacity, congenital anomaly/birth defect or any other situation according to medical or scientific judgment. Number of participants with abnormal hematology parameters [ Time Frame: Up to Day 172 ] Laboratory assessment for hematology parameters will include Platelet count, hemoglobin, Red blood cell (RBC) count, hematocrit, Red blood cell distribution width (RDW), RBC indices like mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin (...) number of saved studies (100). Please remove one or more studies before adding more. Repeat Dose Study of GSK3772847 in Participants With Moderate to Severe Asthma With Allergic Fungal Airway Disease (AFAD) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2018 Clinical Trials

154. Pharmacokinetic Study of Oral Gepotidacin (GSK2140944) in Subjects With Uncomplicated Urinary Tract Infection (Acute Cystitis)

hemoglobin (MCH) [ Time Frame: Baseline and up to Day 13 ] Blood samples will be collected to assess change from Baseline in MCH. Change from Baseline in mean corpuscular volume (MCV) [ Time Frame: Baseline and up to Day 13 ] Blood samples will be collected to assess change from Baseline in MCV. Change from Baseline in hematocrit level [ Time Frame: Baseline and up to Day 13 ] Blood samples will be collected to assess change from Baseline in hematocrit level. Change from Baseline in red blood cell (RBC (...) machine. Change from Baseline in neutrophil, lymphocyte, monocyte, eosinophil, basophil and platelet count [ Time Frame: Baseline and up to Day 13 ] Blood samples will be collected to assess change from Baseline in neutrophil, lymphocyte, monocyte, eosinophil, basophil and platelet count. Change from Baseline in hemoglobin level [ Time Frame: Baseline and up to Day 13 ] Blood samples will be collected to assess change from Baseline in hemoglobin level. Change from Baseline in mean corpuscular

2018 Clinical Trials

155. Effects of Exercise on Physical Fitness Among Hemodialysis Patients With Chronic Kidney Disease

and the states closest to death. Change from baseline in Mental and health status (level of anxiety) at 6 month [ Time Frame: Baseline and 6 month ] the State-Trait Anxiety Inventory (STAI), The score range ranges from 0 to 60 points, so that high scores reflect greater anxiety. The scores obtained are transformed into decatypes (10 decatypes). Hemogram and Biochemical values , (hemoglobin, hematocrit and mean corpuscular volume ) [ Time Frame: Baseline ] Red blood cells, hemoglobin, hematocrit and mean (...) corpuscular volume were determined from whole blood anticoagulated with EDTA in a Sysmex XI-1000i hematological analyzer. with normal values for hemoglobin 14± 2 (g/dL) for women and of 16± 2 (g/dL) for men, for hematocrit 42± 5 % for women and of 47± 6 % for men and for corpuscular volumen 90 ± 7 (fL) for women and for men. Hemogram and Biochemical values (Iron, albumin, calcium and phosporus) [ Time Frame: Baseline ] Iron, albumin, calcium and phosphorus were made by spectrophotometry from serum

2018 Clinical Trials

156. A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD8233 in Healthy Male Subjects With Increased Elevated LDL-C Levels.

as a variable of safety and tolerability of AZD8233 following SC administration of single ascending doses. Laboratory assessments: Haematology - Haematocrit (HCT) [ Time Frame: From screening to 4 month follow-up. ] To assess HCT (volume percentage of RBC in blod) as a variable of safety and tolerability of AZD8233 following SC administration of single ascending doses. Laboratory assessments: Haematology - Mean corpuscular volume (MCV) [ Time Frame: From screening to 4 month follow-up. ] To assess MCV (...) as a variable of safety and tolerability of AZD8233 following SC administration of single ascending doses. Laboratory assessments: Haematology - Mean corpuscular hemoglobin (MCH) [ Time Frame: From screening to 4 month follow-up. ] To assess MCH as a variable of safety and tolerability following SC administration of single ascending doses. Laboratory assessments: Haematology - Mean corpuscular hemoglobin concentration (MCHC) [ Time Frame: From screening to 4 month follow-up. ] To assess MCHC as a variable

2018 Clinical Trials

157. A Study to Investigate the Efficacy and Safety of Two Doses of GSK2857916 in Subjects With Multiple Myeloma Who Have Failed Prior Treatment With an Anti-CD38 Antibody

[ Time Frame: Every 3 weeks up to 2 years ] Overall survival is defined as the time from first dose until death due to any cause. Number of subjects with abnormal hematology parameters [ Time Frame: Every 3 weeks up to 2 years ] Laboratory assessment for hematology parameters will include Platelet count, hemoglobin (Hgb), Red blood cell (RBC) count, hematocrit, reticulocyte count, RBC indices like mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin (...) x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study to Investigate the Efficacy and Safety of Two Doses of GSK2857916 in Subjects With Multiple Myeloma Who Have Failed Prior Treatment With an Anti-CD38 Antibody The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been

2018 Clinical Trials

158. Bioequivalence Study Between Levocetirizine Oral Disintegrating Tablet (ODT) and Levocetirizine Immediate Release Tablet (IRT)

: Up to Day 18 ] Laboratory assessment for hematology parameters will include Platelet count, hemoglobin, Red blood cell (RBC) count, hematocrit, RBC indices like mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and percentage reticulocytes. White blood cell (WBC) count with differential will include neutrophils, lymphocytes, monocytes, eosinophils and basophils. Number of subjects with abnormal hematology parameters: Part 2 [ Time Frame: Up to Day 18 ] Laboratory assessment (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. Bioequivalence Study Between Levocetirizine Oral Disintegrating Tablet (ODT) and Levocetirizine Immediate Release Tablet (IRT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03555890 Recruitment Status

2018 Clinical Trials

159. Phase I Study of GSK2982772 in Japanese Healthy Male Participants

Frame: Up to Day 39 ] The following hematology parameters will be analyzed: platelet count, red blood cell (RBC) count, hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), percent reticulocytes, neutrophils, lymphocytes, monocytes, eosinophils and basophils. Number of subjects with abnormal clinical chemistry parameters [ Time Frame: Up to Day 39 ] The following clinical chemistry parameters will be analyzed: blood urea nitrogen (BUN), creatinine, uric acid (...) of GSK2982772 in Japanese Healthy Male Participants The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03590613 Recruitment Status : Completed First Posted : July 18, 2018 Last Update Posted : January 29, 2019 Sponsor: GlaxoSmithKline Information provided by (Responsible Party): GlaxoSmithKline Study Details

2018 Clinical Trials

160. To Assess the Impact of Ferric Carboxymaltose Compared With Iron Sucrose in Chinese Subjects on Correcting Iron Deficiency Anaemia

) at the screening visit Transferrin Saturation (TSAT) <16% (any subject) at the screening visit Microcytic, hypochromic anaemia defined as: a) Mean corpuscular Hb concentration (MCHC) <32%; b) Mean corpuscular volume (MCV) < 80 fL; c)Mean corpuscular Hb (MCH) <27 pg Subjects with the ability to understand the requirements of the study and abide by the study restrictions, and who agree to return for the required assessments Before any study-specific procedure is conducted, the appropriate written informed (...) reached the maximum number of saved studies (100). Please remove one or more studies before adding more. To Assess the Impact of Ferric Carboxymaltose Compared With Iron Sucrose in Chinese Subjects on Correcting Iron Deficiency Anaemia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before

2018 Clinical Trials

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