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considered were: haemoglobin, haematocrit, meancorpuscularvolume, meancorpuscular haemoglobin, meancorpuscular haemoglobin concentration, hypochromic red blood cells (RBC), hyperchromic RBC, microcytic RBC, macrocytic RBC, reticulocytes, iron, ferritin, transferrin, transferrin saturation, C-reactive protein (CRP), urea, creatinine, calcium, phosphorus, albumin, total protein and glucose. We also analysed Kt/V, age and time on HD treatment. Patients were divided into 3 groups according (...) to the frequency or intensity of their pruritus, and we analysed and compared the variables between the 3 groups.Half (50%) of the patients reported never having pruritus, 32.4% occasionally and 17.6% every day. Pruritus was moderate in 41.2% of them and severe in 8.8%. None of the parameters considered revealed any statistically relevant differences between the three pruritus frequency groups, except for mean serum transferrin level (mg/dl) ('never'=268+/-64 vs 'occasionally'=244+/-40 vs 'every day'=217+/-56
of the International RLS Study Group (IRLSSG), and severity was assessed by the IRLSSG severity scale.Of 161 patients without any history of RLS, 8.7% developed first-onset RLS after spinal anesthesia. Symptoms were transient, with a mean duration of 33 +/- 30 days. Low meancorpuscularvolume and meancorpuscular hemoglobin were associated with the occurrence of new-onset RLS after spinal anesthesia.Transient RLS can be induced by spinal anesthesia. The mechanisms by which spinal anesthesia can trigger RLS
corpuscularvolume was higher in athletes, whilst the corpuscular hemoglobin content was only marginally higher in athletes than in non-athletes. Consequently corpuscular hemoglobin concentration mean was lower in athletes than in non-athletes. There was no difference of erythropoietin and soluble transferrin receptor, whilst in ferritin we found a difference between the groups. Endurance training does not change the values of hemoglobin and hematocrit. Increased meancorpuscularvolume and decreased (...) corpuscular hemoglobin concentration mean could be a result of changed properties of red blood cell-membrane caused by acidosis and higher osmolality during the training. In junior athletes we did not find an iron overload as described in some adult athletes.
Red cell and core temperature in spelunking. Alpine spelunking is practiced in darkness, isolation, cold and high humidity. In this paper we study the acute haematological effects of prolonged strenuous activity in five spelunkers who spent about 20 hours in a 700-meter deep cave without resting much or sleeping. On four occasions, we measured their red cell counts, haemoglobin, meancorpuscularvolume and percentage changes of plasma volume. We also measured their rectal temperature (...) to estimate, in the limits of this parameter, thermoregulatory response. After the spelunkers descended 5 hours to the bottom of the cave, we detected, in all of them, a significant increase in red cell counts and haemoglobin and a drop in meancorpuscularvolume and plasma volume. The day after recovery, we found a significant drop in all red cell parameters and a rise in plasma volumes. Rectal temperatures peaked at the exit. These findings suggest that alpine spelunking induces an initial
) age and weight of 14.58 (0.09) years and 57.75 (0.67) kg. The group of athletes was divided into seven subgroups according to the sport practiced: athletics (105), swimming (107), rowing (230), wrestling (225), weight lifting (47), various team sports (92), and other sports (67). Venous blood samples were drawn from the cubital vein, and the red blood cell count, packed cell volume, haemoglobin concentration, and meancorpuscularvolume were measured. Statistical indices were computed for each (...) subgroup (4.32 (0.04) x 10(12)/l, 0.314 (0.003) l/l, and 124.27 (0.93) g/l) and the swimming subgroup (4.40 (0.05) x 10(12)/l, 0.375 (0.005) l/l, and 125.90 (1.30) g/l). No differences were found in the meancorpuscular volume.Continuous (more than one year) high intensity sports training (twice a day/five days a week) results in a decrease in the basic red blood cell variables in pubescent boys and girls, this being most pronounced in the submaximal sports.
cotransport activity was undiminished in Kcc1(-/-) mice, decreased in Kcc3(-/-) mice, and almost completely abolished in mice lacking both isoforms, we conclude that K-Cl cotransport activity of mouse rbc is mediated largely by KCC3. Whereas rbc of either Kcc1(-/-) or Kcc3(-/-) mice were of normal density, rbc of Kcc1(-/-)Kcc3(-/-) mice exhibited defective volume regulation, including increased meancorpuscularvolume, decreased density, and increased susceptibility to osmotic lysis. K-Cl cotransport (...) activity was increased in rbc of SAD mice, which are transgenic for a hypersickling human hemoglobin S variant. Kcc1(-/-)Kcc3(-/-) SAD rbc lacked nearly all K-Cl cotransport activity and exhibited normalized values of meancorpuscularvolume, corpuscular hemoglobin concentration mean, and K(+) content. Although disruption of K-Cl cotransport rescued the dehydration phenotype of most SAD rbc, the proportion of the densest red blood cell population remained unaffected.
volumes were measured. At the same time points, meancorpuscularvolume and hematocrit were measured. Systolic and diastolic blood pressure, heart rate, and hemoglobin were measured every 5 min throughout the study. Volume kinetic analysis was performed for the volunteers receiving hydroxyethyl starch.Plasma volume did not change per se after thoracic epidural anesthesia despite a decrease in blood pressure. Plasma volume increased with fluid administration but remained unchanged with vasopressors (...) Epidural anesthesia, hypotension, and changes in intravascular volume. The most common side effect of epidural or spinal anesthesia is hypotension with functional hypovolemia prompting fluid infusions or administration of vasopressors. Short-term studies (20 min) in patients undergoing lumbar epidural anesthesia suggest that plasma volume may increase when hypotension is present, which may have implications for the choice of treatment of hypotension. However, no long-term information
an inpatient treatment program. Healthy comparison men were similarly tested.On admission, RBC count, hemoglobin level, and hematocrit were significantly lower in alcoholic subjects than comparison subjects; meancorpuscularvolume, SGOT, SGPT, and gamma-glutamyl transpeptidase were significantly higher. By discharge, all measures had improved, although RBC count, meancorpuscularvolume, and gamma-glutamyl transpeptidase levels remained significantly different from those of comparison subjects. Upon (...) Brain volumes, RBC status, and hepatic function in alcoholics after 1 and 4 weeks of sobriety: predictors of outcome. The authors asked if hematological indices of RBC status and hepatic function in newly sober alcoholic men are related to abnormalities in brain morphology, change with normalization of brain function during short-term sobriety, and predict prolonged sobriety.Alcoholic men received brain magnetic resonance imaging and laboratory assessments on admission and before discharge from
kcal per session (mean +/- SE across training weeks = 298+/-0.34 and 297+/-0.37 kcal per session for HI and LO, respectively). Plasma volume (PV, T-1824 dilution); calculated total blood (TBV) and red cell volumes (RCV); calculated total hemoglobin (THb); erythropoietin concentration ([Epo]) and selected hematologic variables were measured at baseline and weeks 2, 4, 8 and 12 of training.The observed relative (percent) changes in PV, TBV, RCV and THb from pre-training baseline values were (...) not statistically significant. Decreases (p < 0.05) in hematocrit (Hct), hemoglobin ([Hb]) and RBC count were observed in both training groups. Meancorpuscular Hb (MCH) and Hb concentration (MCHC) increased (p < 0.05) during training. [Epo] was decreased at week 2 compared with baseline (p < 0.03), but was similar to baseline at weeks 4, 8 and 12.Within the limits of this study, endurance training did not increase PV, TBV, RCV and THb in previously sedentary females regardless of the intensity of training.
in pretaper low intensity continuous training (LICT) and high intensity interval training (HIIT). Blood samples were obtained and 800-m running performance was measured before and after taper.Performance was not significantly enhanced by either taper protocol (post- vs pre-taper times 124.9 +/- 4.5 vs 126.1 +/- 4.2 s with LVT, 126.2 +/- 8.0 vs 125.7 +/- 6.6 s with MVT). For the entire group of 8 subjects, red cell count, hemoglobin (Hb), meancorpuscularvolume and meancorpuscular Hb concentration (...) Physiological responses to a 6-d taper in middle-distance runners: influence of training intensity and volume. This study examined some physiological and performance responses to a 6-d taper, and the influence of training intensity and volume on these responses.After 15 wk of training, 8 well-trained male middle-distance runners were randomly assigned to either a moderate volume taper (MVT, N = 4) or a low volume taper (LVT, N = 4), consisting of either a 50% or a 75% progressive reduction
-PI group, the PI group had significantly higher serum total cholesterol (4.8 +/- 1.0 vs 3.8 +/- 0.7 mmol/L, P <.001) and LDL cholesterol (2.9 +/- 0.8 vs 2.1 +/- 0.7 mmol/L, P <.001) levels and red blood cell meancorpuscularvolume (92.2 +/- 9.3 vs 86.8 +/- 7.2 microm3, P =.048). The CAC scores in the PI group were also higher than those in the non-PI group (11.0 +/- 28.6 [n = 43] vs 1.7 +/- 5.8, P =.043). CAC scores were marginally associated with log-transformed duration of the PI therapy (P (...) =.055). Serum CRP levels remained unchanged (5.5 +/- 13.6 mg/L [n = 45] vs 3.9 +/- 5.5 mg/L, P =.467). Serum total cholesterol level, LDL cholesterol level, red blood cell meancorpuscularvolume, and CAC scores were indicated by means of regression analyses to be associated with log-transformed duration of the PI therapy.The use of PIs is associated with coronary artery calcification, atherogenic lipid changes, and increased erythrocyte volume in individuals infected with HIV-1.
Diagnostic value of the meancorpuscularvolume in the detection of vitamin B12 deficiency Diagnostic value of the meancorpuscularvolume in the detection of vitamin B12 deficiency Diagnostic value of the meancorpuscularvolume in the detection of vitamin B12 deficiency Oosterhuis W P, Niessen R W, Bossuyt P M, Sanders G T, Sturk A Authors' objectives To review the diagnostic value of meancorpuscularvolume (MCV) for vitamin B12 (hereafter referred to as just B12) in both anaemic and non (...) for further research. Bibliographic details Oosterhuis W P, Niessen R W, Bossuyt P M, Sanders G T, Sturk A. Diagnostic value of the meancorpuscularvolume in the detection of vitamin B12 deficiency. Scandinavian Journal of Clinical and Laboratory Investigation 2000; 60(1): 9-18 PubMedID Other publications of related interest NHS Centre for Reviews and Dissemination. Search strategies to identify reviews and meta-analyses in MEDLINE and CINAHL. Available from: [accessed July 2014]. Indexing Status Subject
Hematologic differences between African-Americans and whites: the roles of iron deficiency and Î±-thalassemia on hemoglobin levels and meancorpuscularvolume The average results of some laboratory measurements, including the hemoglobin, meancorpuscularvolume (MCV), serum transferrin saturation (TS), serum ferritin, and white blood cell count of African-Americans differ from those of whites. Anonymized samples and laboratory data from 1491 African-American and 31 005 white subjects
Erythrocyte meancorpuscularvolume as a surrogate marker for 6-thioguanine nucleotide concentration monitoring in patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine. Meancorpuscularvolume may correlate with erythrocyte 6-thioguanine nucleotide concentrations in patients treated with azathioprine and 6-mercaptourine. We conducted a study of 166 patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine to determine (...) the relationship between meancorpuscularvolume and erythrocyte 6-thioguanine nucleotide concentrations, disease activity as measured by the Inflammatory Bowel Disease Questionnaire (active disease <170, remission >170), and leukopenia. Blood was submitted for meancorpuscularvolume, whole blood 6-thioguanine nucleotide concentration, and leukocyte count. The mean +/- SD meancorpuscularvolume during treatment was 94.7 +/- 6.6 fL and the mean +/- SD change in meancorpuscularvolume was 7.5 +/- 6.3 fL
Utility of gamma-glutamyl transpeptidase and meancorpuscularvolume in alcoholic liver disease. The present study was designed to establish the role of Gamma-glutamyl transpeptidase (gamma-GT) and meancorpuscularvolume (MCV) in alcoholic liver disease (ALD). Serum gamma-GT, total and direct bilirubin, albumin, total protein, AST, ALT and ALP were assayed by standard methods in a clinical chemistry autoanalyser. MCV, Hb, PCV and RBC were measured by an automated cell counter. Activity
The red cell osmometer. A useful inaccuracy in measurement of meancorpuscularvolume in hyperosmolar states. The Coulter S Counter gives a value for meancorpuscularvolume which does not necessarily reflect red cell size in vivo. This phenomenon may be used in early diagnosis and hence prevention of the 'hyperosmolar syndrome'.
Raised Coulter meancorpuscularvolume in diabetic ketoacidosis, and its underlying association with marked plasma hyperosmolarity An abnormal and transient increase of the Coulter mean red cell volume (MCV) was observed in four of 10 patients with diabetic decompensation. A sequential study of haematological and biochemical measurements in these patients revealed that this phenomenon was associated with the hyperosmolar state. The proposed mechanism and the clinical implications of this change
Should we screen for globin gene mutations in blood samples with meancorpuscularvolume (MCV) greater than 80 fL in areas with a high prevalence of thalassaemia? To investigate whether it is worthwhile, in areas where thalassaemia is common, to screen for globin gene mutations in subjects with a meancorpuscularvolume (MCV) above 80 fL, especially in partners of known thalassaemia carriers.Blood samples from 95 subjects with MCV between 80 and 85 fL were screened for the presence of alpha
Study of erythrocyte meancorpuscularvolume during cytotoxic therapy as a predictive parameter of the risk of secondary leukemia in Hodgkin's disease. Erythrocyte meancorpuscularvolume (MCV) evolution was studied during cytotoxic therapy in 12 patients with Hodgkin's disease who developed secondary acute leukemia and in 83 patients with Hodgkin's disease without secondary leukemia as control group. Significant differences were observed in the maximum MCV and in the MCV maximum increase