How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

1,219 results for

Mean Corpuscular Volume

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

101. To Assess the Relative Bioavailability (BA) of TRIUMEQ® and Dolutegravir and Lamivudine (DTG/3TC) Pediatric Dispersible Tablet Formulations in Healthy Volunteers

Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. To Assess the Relative Bioavailability (BA) of TRIUMEQ® and Dolutegravir and Lamivudine (DTG/3TC) Pediatric Dispersible Tablet Formulations in Healthy Volunteers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S (...) will be collected for PK analysis. Part 1: CL/F for 3TC 30 mg- following pediatric TRIUMEQ dispersible tablets-direct to mouth [ Time Frame: Pre-dose, 0.25 hour, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 8, 12, 16, 24, 48 and 72 hours post-dose before discharge at the end of each TP ] Whole blood samples of approximately 2 mL will be collected for PK analysis. Part 1: Apparent volume of distribution (Vz/F) for DTG 50 mg- following adult TRIUMEQ conventional tablet - direct to mouth [ Time Frame: Pre-dose, 0.25 hour, 0.5

2018 Clinical Trials

102. A Phase 1 TP-271 Oral PK Multiple Ascending Dose Study

; HDL = high-density lipoprotein; LDH = lactate dehydrogenase; LDL = low-density lipoprotein; MCH = mean corpuscular hemoglobin; MCHC = mean corpuscular hemoglobin concentration; MCV = mean corpuscular volume; RBC = red blood cell. Known allergy to tetracycline antibiotics or any of the excipients in TP 271 Clinically significant abnormality on a 12-lead ECG, which includes the following: Rhythm other than sinus Corrected QT interval using Fridericia's formula (QTcF) >450 msec Evidence of second (...) Study The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03450187 Recruitment Status : Recruiting First Posted : March 1, 2018 Last Update Posted : April 27, 2018 See Sponsor: Tetraphase Pharmaceuticals, Inc. Collaborator

2018 Clinical Trials

103. A Single Oral Dose Study to Evaluate Four Different Formulations of AZD9977 and the Effect of Food in Healthy Male Subjects

, dosing sessions of Part A and Part B and follow-up (5 to 7 days after final dose) ] To assess HCT (RBC) and reticulocyte absolute count (immature RBCs) as a variable of safety and tolerability after administration of single oral dose of AZD9977 capsule, ER capsules (fast rate and Int. rate) and oral suspension (reference). Laboratory assessments: Hematology - Mean corpuscular volume (MCV) [ Time Frame: At screening, dosing sessions of Part A and Part B and follow-up (5 to 7 days after final dose (...) ) ] To assess MCV as a variable of safety and tolerability after administration of single oral dose of AZD9977 capsule, ER capsules (fast rate and Int. rate) and oral suspension (reference). Laboratory assessments: Hematology - Mean corpuscular hemoglobin (MCH) [ Time Frame: At screening, dosing sessions of Part A and Part B and follow-up (5 to 7 days after final dose) ] To assess MCH as a variable of safety and tolerability after administration of single oral dose of AZD9977 capsule, ER capsules (fast rate

2018 Clinical Trials

104. A Safety, Tolerability, Acceptability, and Pharmacokinetic (PK) Study of Cabotegravir (CAB) in Healthy Human Immunodeficiency Virus (HIV)-Uninfected Chinese Men

parameters: Injection phase [ Time Frame: Up to 623 days ] Hematology parameters will be analyzed including platelet count, red blood cell (RBC) count, hemoglobin, hematocrit, white blood cell (WBC) count, reticulocyte count, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), percent reticulocytes, mean corpuscular hemoglobin concentration (MCHC), neutrophils lymphocytes, monocytes, eosinophils and basophils. Number of subjects with abnormal values for urinalysis: Injection phase [ Time (...) Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Safety, Tolerability, Acceptability, and Pharmacokinetic (PK) Study of Cabotegravir (CAB) in Healthy Human Immunodeficiency Virus (HIV)-Uninfected Chinese Men The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S

2018 Clinical Trials

105. Full blood count values as a predictor of poor outcome of pneumonia among HIV-infected patients. (PubMed)

. We assessed the different values of the first blood count performed on the patient as follows; total white blood cells (WBC), neutrophils, lymphocytes (LYM), basophils, eosinophils (EOS), red blood cells (RBC), hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, red blood cell distribution width (RDW), platelets (PLT), mean platelet volume, and platelet distribution width (PDW). The primary outcome measure was 30-day mortality (...) and the secondary, admission to an intensive care unit (ICU). The predictive power of the variables was determined by statistical calculation.One hundred sixty HIV-infected patients with pneumonia were identified. The mean age was 42 (11) years, 99 (62%) were male, 79 (49%) had ART. The main route of HIV transmission was through parenteral administration of drugs. Streptococcus pneumonia was the most frequently identified etiologic agent of CAP The univariate analysis showed that the values of PLT (p < 0.009

Full Text available with Trip Pro

2018 BMC Infectious Diseases

106. Exploring Adherence Monitoring in Sickle Cell Disease

adherence to mean corpuscular volume (MCV) lab values [ Time Frame: Continuous over two months, baseline to off study ] For each subject, we will calculate the proportion of days of opening the AdhereTech device across the two month study period (days with missing information will not be counted). We will extract mean corpuscular volume (MCV; L) lab value from each subject's medical record. We will estimate the Spearman's rank-based correlation, with 95% confidence interval, of the AdhereTech device (...) adherence with the mean corpuscular volume (MCV) lab value . Estimate the association between AdhereTech device HU adherence to the Medication Possession Ratio (MPR) [ Time Frame: Continuous over two months, baseline to off study ] For each subject, we will calculate the proportion of days of opening the AdhereTech device across the two month study period (days with missing information will not be counted). Medication Possession Ratio (MPR) will be calculated as: [(number of days medication in family's

2018 Clinical Trials

107. Characterization of the Pharmacokinetics of a Vaginal Ring With 2.0 g Progesterone in Post-menopausal Women

corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, erythrocyte distribution width, platelets, neutrophils, lymphocytes, monocytes, eosinophils. Blood chemistry 27 elements: glucose, urea, blood urea nitrogen (BUN), creatinine, BUN/creatinine ratio, uric acid, cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, low-density lipoprotein cholesterol, non-HDL cholesterol, atherogenic index, total protein, albumin, globulins, albumin/globulin ratio (...) (100). Please remove one or more studies before adding more. Characterization of the Pharmacokinetics of a Vaginal Ring With 2.0 g Progesterone in Post-menopausal Women The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03737656 Recruitment Status : Active, not recruiting First Posted : November 9

2018 Clinical Trials

108. Effect of Probiotics Supplementation on the Side Effects of Radiation Therapy Among Colorectal Cancer Patients

baseline and end line of intervention The mean corpuscular volume (MCV) [ Time Frame: Through study completion, an average of 1 yea ] The MCV in fl at both baseline and end line of intervention The mean corpuscular hemoglobin (MCH) [ Time Frame: Through study completion, an average of 1 yea ] The MCH in pg at both baseline and end line of intervention The mean corpuscular hemoglobin concentration (MCHC) [ Time Frame: Through study completion, an average of 1 yea ] The MCH in g/dl at both baseline (...) and end line of intervention The Platelet count [ Time Frame: Through study completion, an average of 1 yea ] The Platelet count as cells/ ul at both baseline and end line of intervention The of Hemoglobin [ Time Frame: Through study completion, an average of 1 yea ] The Hemoglobin in g/dl at both baseline and end line of intervention The mean platelet volume (MPV) [ Time Frame: Through study completion, an average of 1 yea ] The MPV in fl at both baseline and end line of intervention The level

2018 Clinical Trials

109. Bioequivalence of Two Fixed-dose Combination Tablets Containing Estradiol and Nomegestrol Acetate

corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, erythrocyte distribution width, platelets, neutrophils, lymphocytes, monocytes, eosinophils, basophils. Blood chemistry 27 elements: glucose, urea, blood urea nitrogen (BUN), creatinine, BUN/creatinine ratio, uric acid, cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, low-density lipoprotein (LDL), cholesterol, non-HDL cholesterol, atherogenic index, total protein, albumin, globulins, albumin (...) one or more studies before adding more. Bioequivalence of Two Fixed-dose Combination Tablets Containing Estradiol and Nomegestrol Acetate The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03749733 Recruitment Status

2018 Clinical Trials

110. Phase II Platform Trial of Novel Regimens Versus Standard of Care (SoC) in Non-small Cell Lung Cancer (NSCLC)

such as mean corpuscular hemoglobin will be evaluated. Change from Baseline of hematology parameter: mean corpuscular volume [ Time Frame: Baseline and up to 106 Weeks ] Change from Baseline for parameter such as mean corpuscular volume will be evaluated. Change from Baseline in hematology parameter: Red blood cell (RBC) count [ Time Frame: Baseline and up to 106 Weeks ] Change from Baseline for parameter such as RBC count will be evaluated. Change from Baseline of Clinical chemistry parameters: glucose (...) from Baseline of hematology parameters: hematocrit [ Time Frame: Baseline and up to 106 Weeks ] Change from Baseline for parameter such as hematocrit will be evaluated. Change from Baseline of hematology parameter: hemoglobin [ Time Frame: Baseline and up to 106 Weeks ] Change from Baseline for parameter such as hemoglobin will be evaluated. Change from Baseline of hematology parameter: mean corpuscular hemoglobin [ Time Frame: Baseline and up to 106 Weeks ] Change from Baseline for parameter

2018 Clinical Trials

111. Iron Deficiency is Prevalent among HIV-Infected Kenyan Adults and is Better Measured by Soluble Transferrin Receptor than Ferritin. (PubMed)

corpuscular volume [MCV]) in newly diagnosed, antiretroviral therapy-naive, HIV-infected (N = 138) and uninfected (N = 52) Kenyan adults enrolled in a study of the immune response to malaria. We compared markers between infected and uninfected groups with t test and Wilcoxon Rank-Sum, used Spearman correlation to determine the association between iron and inflammatory markers, and applied logistic regression to determine which markers best predicted anemia. HIV-infected individuals had lower hemoglobin (P (...) Iron Deficiency is Prevalent among HIV-Infected Kenyan Adults and is Better Measured by Soluble Transferrin Receptor than Ferritin. Iron deficiency (ID) and human immunodeficiency virus (HIV) infection frequently coexist. Little data exist on ID in HIV-infected individuals, partly because the iron marker ferritin is altered by inflammation common in HIV infection. We measured iron biomarkers (ferritin, soluble transferrin receptor [sTfR], hepcidin) and red cell indices (hemoglobin, mean

2018 American Journal of Tropical Medicine & Hygiene

112. Anemia in Pediatric Inflammatory Bowel Disease. (PubMed)

Anemia in Pediatric Inflammatory Bowel Disease. Anemia is the most frequent extra-intestinal finding in inflammatory bowel disease (IBD). The aim of this study is to determine the prevalence and types of anemia in pediatric patients with IBD at diagnosis and at approximately 1 year follow-up.This is a retrospective chart review of patients diagnosed with IBD from 2005 to 2012, ages 1 to 18 years. Patients who had hemoglobin, hematocrit, mean corpuscular volume, and iron indices obtained

2018 Journal of Pediatric Gastroenterology and Nutrition

113. Application of the automated haematology analyzer XN-30 in an experimental rodent model of malaria. (PubMed)

infected with rodent malarial parasites, with three-dimensional analysis permitting the precise measurement of parasitaemia (referred herein as the 'XN-30 system'). The XN-30 analyzer allowed not only the detection of iRBCs but also the monitoring of RBC, white blood cell, and platelet counts, as well as haematocrit, mean corpuscular volume and mean platelet volume values in the mouse blood sample. For anti-malarial drug development, aside from demonstrating possible efficacy in mouse models, XN-30

Full Text available with Trip Pro

2018 Malaria journal

114. Alcohol Biomarkers in Clinical and Forensic Contexts. (PubMed)

in PubMed concerning the direct and indirect alcohol markers discussed here, as well as on the authors' experience in laboratory analysis and clinical medicine.Alongside the direct demonstration of ethanol, the available markers of alcohol consumption include the classic indirect markers carbohydrate-deficient transferrin (CDT), gamma-glutamyltransferase (GGT), and mean corpuscular volume (MCV) as well as direct alcohol markers such as ethyl glucuronide (EtG) and ethyl sulfate (EtS) in serum and urine

Full Text available with Trip Pro

2018 Deutsches Arzteblatt international

115. Transcranial Doppler velocity among Jamaican children with sickle cell anaemia: determining the significance of haematological values and nutrition. (PubMed)

(P = 0·007) and oxygen saturation (P = 0·005). There was no association of TAMV with height-age or body mass index (BMI) z-scores. Adjusting for gender, BMI z-score, age, previous stroke and oxygen saturation, mean corpuscular volume (P = 0·005) and reticulocyte count (P = 0·013) were positively associated with TAMV, while haemoglobin concentration (P = 0·009) was negatively associated. There was good agreement [99%; weighted Kappa 0·98 (95% confidence interval 0·89-1), P = 0·0001] in TCD (...) Transcranial Doppler velocity among Jamaican children with sickle cell anaemia: determining the significance of haematological values and nutrition. This study investigated the association of nutritional and haematological variables with maximum time-averaged mean velocity (TAMV) measured by transcranial Doppler (TCD) velocity and the agreement of classification between two protocols. TCD categories included: normal (<170 cm/s), conditional (170-199 cm/s) and abnormal (≥200 cm/s) based on TAMV

2018 British journal of haematology

116. Corneal endothelial alterations in alcohol dependence syndrome. (PubMed)

compared. The endothelial parameters were also compared before and after the abstinence of alcohol in the former group. The ADS group was further analysed to assess the influence of life time alcohol consumption, years/pattern of drinking, levels of Liver enzymes, levels of mean corpuscular volume, screening questionnaires and stages of fatty liver on corneal endothelium.On comparing the two groups using Mann-Whitney U test, a significant difference was found in central corneal thickness (CCT

2018 British Journal of Ophthalmology

117. A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects. (PubMed)

issues (2 subjects) whereas placebo treated subjects only reported stomatitis (1 subject). Although no other adverse events were reported, statistically significant decrements in several erythrocyte parameters including hemoglobin (HgB) and hematocrit (Hct) as well as in red blood cell count (RBC), red blood cell distribution width (RDW), mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) were observed in the RAPA-treatment group. None of these changes manifested clinically (...) significant effects during the short duration of this study. Similarly, no changes were noted in any other clinical laboratory, cognitive, physical performance, or self-perceived health status measure over the study period. Immune parameters were largely unchanged as well, possibly due to the advanced ages of the cohort (70-93 years; mean age 80.5). RAPA-associated increases in a myeloid cell subset and in TREGS were detected, but changes in most other PBMC cell subsets were not statistically significant

2018 Experimental Gerontology

118. Hematocrit Values Predict Carotid Intimal-Media Thickness in Obese Patients With Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study (PubMed)

cells, neutrophils, neutrophil/lymphocyte ratio, platelet count, hemoglobin, mean corpuscular volume, hematocrit values were associated with ear or subclinical atherosclerosis, in obese patients of various classes suffering from NAFLD.One hundred consecutive obese patients presenting NAFLD at ultrasound, with low prevalence of co-morbidities and no history or instrumental features of CV diseases, underwent carotid intima-media thickness (IMT) assessment by Doppler ultrasonography. All of them were

Full Text available with Trip Pro

2018 Frontiers in endocrinology

119. Storage stability of commonly used haematological parameters at 33 °C: Electronic supplementary material available online for this article. (PubMed)

to determine whether the percent differences were significantly lesser than the maximum acceptable bias.Haemoglobin, red blood cell count, white blood cell count, mean corpuscular haemoglobin and lymphocyte count showed acceptable bias after storage for at least 24 hours at 33 ºC. Haematocrit, mean corpuscular volume, mean corpuscular haemoglobin concentration, platelet count and mean platelet volume showed unacceptable shift in less than 4 hours when stored at 33 ºC.Since many haematological parameters

Full Text available with Trip Pro

2018 Biochemia medica

120. Local ancestry transitions modify snp-trait associations (PubMed)

that the minor allele of rs16890640 occuring on a European background with a downstream local ancestry transition to African ancestry results in significantly lower mean corpuscular hemoglobin and volume. This finding represents a new way of discovering genetic interactions, and is supported by molecular data that suggest changes to local ancestry may impact local chromatin looping.

Full Text available with Trip Pro

2018 Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>