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Mean Corpuscular Volume

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81. Factors influencing erythrocyte sedimentation rate in adults: New evidence for an old test. (PubMed)

individuals (44.5% males; age range, 18-91 years) randomly selected from the population of a Spanish municipality. The ESR was measured using a standardized method. We assessed habitual alcohol consumption in standard drinking units, along with tobacco smoking, regular physical exercise (by questionnaire), body mass index, and variables defining metabolic syndrome. Multivariate analyses were performed, including mean corpuscular volume and hemoglobin concentration in the models.The ESR was higher

2019 Medicine

82. Urinary Ethyl Glucuronide Can Be Used as a Biomarker of Habitual Alcohol Consumption in the General Population. (PubMed)

day). Plasma HDL cholesterol concentration, erythrocyte mean corpuscular volume (MCV), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyltransferase (GGT) were determined as indirect biomarkers of alcohol consumption. Sensitivity, specificity, positive and negative predictive value, and proportions of agreement between reported consumption and EtG were calculated. To test the agreement of EtG concentration and alcohol consumption in categories, linear regression

2019 Journal of Nutrition

83. Preoperative Hematocrit (HCT) is a Novel and Simple Predictive Marker for Gastric Cancer Patients Who Underwent Radical Gastrectomy. (PubMed)

models were used to identify the best anemic markers associated with prognosis. Time-dependent receiver operating characteristics analysis (t-ROC) and the estimated area under the curve (AUC) were used to compare the prognostic values.Of all patients, 1709 (75.1%) were male, and the median age was 61 years. Univariate analyses showed that preoperative hematocrit (HCT), hemoglobin, and mean corpuscular volume were associated with OS (all P < 0.05). However, in a separate analysis of individual stages

2019 Annals of Surgical Oncology

84. What are the recommended clinical assessment and screening tests during pregnancy?

of the 3 rd trimester may be indicated ahead of childbirth. Strong NA (CBR)* KCE 2004 amended ? There is no evidence that platelet and leukocyte counts are useful during pregnancy. However, in Belgium, this test is often routinely performed in the laboratory at the time of anaemia detection. NA NA * Level of evidence from Australian 2014 guideline: CBR= Consensus based recommendation because insufficient evidence to support recommendation (see Table 3 in chapter 5.3.). **MCV= Mean corpuscular volume (...) ; MCH= Mean corpuscular haemoglobin; MCHC= Mean corpuscular haemoglobin concentration KCE Report 248Cs Assessment and screening during pregnancy 15 4.4.2. Blood group, rhesus and atypical red cell antibodies – update KCE 2004 Recommendation Strength of Recommendation Level of Evidence ? Offer to determine in early pregnancy each pregnant woman’s blood group and rhesus (Rh) factor if they are unknown and to screen for atypical red cell antibodies. Strong B* * Level of evidence from NICE 2008

2015 Belgian Health Care Knowledge Centre

85. Alabel/Alaglio (aminolevulinic acid hydrochloride)

pigmentation was found in small bile ducts, hepatocytes, Kupffer cells and proximal tubule epithelial cells in males and females at =44 mg/kg/day. In both males and females at =183 mg/kg/day, brown urine, decreases in hemoglobin concentration, mean corpuscular hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin concentration, and platelet count, increases in reticulocyte count and monocyte proportion, increases in AST, ALT, LDH, total cholesterol and phospholipid, decreased urine pH, dark (...) [in terms of hydrochloride]) were given to male and female Wistar rats (n = 10/sex/group) for 13 weeks. In the =44 mg/kg/day groups, decreases in mean corpuscular hemoglobin and mean corpuscular volume, brown pigmentation in the liver and kidney, and bile duct hyperplasia were found in both males and females, and increases in reticulocyte count and total bilirubin, unicellular and focal hepatocellular necroses, and periductal lymphocytic infiltration were found in males. In the 183 mg/kg/day group, hair

2013 Pharmaceuticals and Medical Devices Agency, Japan

86. Laboratory diagnosis of non-immune hereditary red cell membrane disorders

indices, MCV is not discriminative for HS. MCHC has been found useful as indicator for HS with concurrent neonatal jaundice . In the case of HS with compensated hemolytic anemia, MCHC is often in the upper limit of the normal range or increased . Both the MCV and the mean sphered cell volume (MSCV) values for red cells are displayed by the Beckman Coulter cell analyzer. The MSCV value is expected to be greater than that of MCV as a result of cell volume increase after spherization in a hypo‐osmolar (...) of hemolytic conditions in which the ‘primary’ lesion is a ‘leak’ to the monovalent cations sodium (Na + ) and potassium (K + ) , , resulting in an altered hydration status shown by a significant change in mean cell volume (MCV) . Four subtypes have been identified: overhydrated HSt, dehydrated HSt, cryohydrocytosis (CHC), and familial pseudohyperkalemia (FP) (Table ). Only FP is an asymptomatic trait, whereas the other three conditions vary in both clinical severity and in qualitative features. All

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2015 British Committee for Standards in Haematology

87. Effects of acute and chronic exercise on the osmotic stability of erythrocyte membrane of competitive swimmers. (PubMed)

at the beginning of those weeks were considered due to chronic adaptations, while the effects observed at the end of the weeks were considered due to acute manifestations of the exercise load of that week. Acute changes resulting from the exercise comprised increases in creatine kinase activity (CK) and leukocyte count (Leu), and decrease in hematocrit (Ht) and mean corpuscular volume (MCV), at the end of the first week; increase in the activities of CK and lactate dehydrogenase (LDH), in the uric acid (UA (...) ) concentration and Leu count, at the end of the seventh week; increases in CK and LDH activities and in the mean corpuscular hemoglobin concentration (MCHC), at the end of the 13th week; and decrease in the value of the osmotic stability index 1/H50 and increases in the CK activity and platelets (Plt) count, at the end of the 18th week. Chronic changes due to training comprised increase in the values of 1/H50, CK, LDH, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C

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2017 PLoS ONE

88. Iron Deficiency Anemia: A Guide to Oral Iron Supplements

weeks in the ferrous group (2.84 vs Niferex 0.60, p <0.0001). Statistically significant increases in ferritin and mean corpuscular volume were also seen in patients taking ferrous sulfate rather than Niferex, .[14] Vitamin C Ascorbic acid has been theorized to improve absorption by reducing iron to a ferrous Fe+2 state to optimize its solubility. Increasing doses of vitamin C exhibited a dose-dependent response in iron absorption during concomitant administration in healthy volunteers, ranging from

2015 Clinical Correlations

89. Venetoclax (Venclyxto) - Chronic, B-Cell Lymphocytic Leukemia

validated in accordance with ICH guidelines. The stability indicating nature of the methods for assay and impurities was demonstrated by means of forced degradation studies. Satisfactory information regarding the reference standard used for assay and impurities testing has been presented. Batch analysis data are provided for twenty eight venetoclax batches manufactured by the commercial process at production scale and above. Eight of the batches were manufactured at the commercial manufacturing site

2017 European Medicines Agency - EPARs

90. Management of Multiple Sclerosis

is the best means to measure disease progression. 7, level III; 21, level III Refer to Figure 5 on EDSS. Figure 5. The Expanded Disability Status Scale Source: For Information on Multiple Sclerosis (Internet communication, 16 December 2014 at Death Normal neurological function No disability with only minimal signs Minimal disability Moderaties disability Relatively severe disability Disability affects full daily activities Assistance required to walk & work (...) search period) had suggested males progressed faster in their EDSS in relapsing MS. But in primary progressive MS, the rate of disability accumulation was equal in both sexes. • Age of onset 21, level III ? Mean age of onset for relapsing MS is younger than progressive MS (29.6 ± 9.5 years vs 39.3 ± 11.3 years; p 0.4% Currently, it is more of a research metric for efficacy in drug trials and the ability to achieve this as well as applicability in daily clinical practice still needs further

2015 Ministry of Health, Malaysia

91. Guidelines for identification and management of substance use and substance use disorders in pregnancy

alcohol spectrum disorders FIGO International Federation of Gynecology and Obstetrics GABA gamma-aminobutyric acid GDG guidelines development group GGT gamma-glutamyl transpeptidase DSM Diagnostic and Statistical Manual of Mental Disorders HCW health-care workers HIV human immunodeficiency virus ICD International Classification of Diseases IUGR intrauterine growth retardation ITT intention-to-treat IV intravenous MCV mean corpuscular volume M-H Mantel-Haenszel MD mean differences MI motivational (...) and feasibility, to set the strength of the recommendations (see decision tables and evidence profiles in annex). The strength of the recommendation was set as either: ‘strong’: meaning that the Guideline Development Group was confident that the quality of the evidence of effect, combined with certainty about the values, preferences, benefits and feasibility, made this a recommendation that should be done in most circumstances and settings; or ‘conditional’: meaning there was less certainty about the quality

2014 World Health Organisation Guidelines

92. Indicators of Male Gout Patients' Comorbidities with the Theory on Traditional Chinese Medicine. (PubMed)

is the only index reflecting that renal function showed significant difference between the two groups and the average levels were out of the normal range (1.09 ± 0.28 versus 1.17 ± 0.31, p=0.001). Further, we also observed significance difference on abnormality rates of cystatin C between the two groups. (χ2=5.543, p= 0.019). Besides, the comparison between the two subtypes also showed significant difference on hematocrit (43.12 ± 3.60 versus 42.26 ± 4.17%, p=0.007), mean corpuscular volume (89.52 ± 6.07 (...) versus 86.81 ± 7.11fL, p=0.001), and mean corpuscular hemoglobin concentration (338.00 ± 11.67 versus 334.86 ± 13.58g/L, p=0.004). In general, we put forward that male gout patients with ODHS should be more vigilant of damage of renal function, and those with IPSBS should pay more attention to prevent cardiac-cerebral vascular diseases and diabetes. Increased Cys C level might be correlated with risk of comorbidities, especially diabetes . Thus, it is of significance to diagnose the TCMS in acute

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2018 Evidence-based Complementary and Alternative Medicine (eCAM)

93. Lactoferrin plus health education versus total dose infusion (TDI) of low-molecular weight (LMW) iron dextran for treating iron deficiency anemia (IDA) in pregnancy: a randomized controlled trial. (PubMed)

age. Both groups showed a significant clinical improvement of anemia 4 weeks post-therapy. There was no statistically significant difference in mean Hb level improvement in both groups after 1 month of therapy. However, mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) improved significantly more in group B than A while iron indices (serum iron and serum ferritin) were significantly more in group A than group B.Pineapple flavored lactoferrin oral sachets plus health education can (...) daily with health education (group A) and TDI of LMW iron dextran (group B).The primary efficacy parameter was clinical improvement and the amount of increase in hemoglobin concentration by 4 weeks after therapy, secondary outcome measures included measurement of the rest of RBC, and iron indices, the adverse effects related to iron therapy and the patient compliance to the treatment.There was insignificant difference between both groups regarding sociodemographic data, parity and mean gestational

2018 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

94. Safety of standardized Macleaya cordata extract in an eighty-four-day dietary study in dairy cows. (PubMed)

84 of the study. There was no statistically significant difference (p > .10) among the three groups on body condition score, milk production or milk composition over the study period. There were no significant differences in body weight gain or feed consumption among the three groups. Animals in the SANG-10000 group had significantly higher mean corpuscular volume (MCV) than the C group (p < .1) and lower mean corpuscular haemoglobin concentration (MCHC) than the SANG-1000 group (p < .1

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2018 Journal of animal physiology and animal nutrition

95. Effects of flaxseed oil on blood hepcidin and hematologic factors in hemodialysis patients. (PubMed)

group received 6 g/d flaxseed oil for 8 wk, whereas the control group received 6 g/d medium chain triglycerides (MCT) oil. At baseline and the end of week 8, serum hepcidin, and blood hemoglobin, hematocrit, red blood cells (RBCs), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were measured after a 12- to 14-h fast.Flaxseed oil consumption significantly reduced serum hepcidin concentration up to 25% during 8 weeks (...) , and the reduction was significant in comparison with the MCT oil group. In addition, the number of RBCs, blood hemoglobin, hematocrit, MCH and MCHC increased significantly in the flaxseed oil group up to 6%, 10%, 6%, 5%, and 2%, respectively, and these elevations were significant in comparison with the MCT oil group. There was no significant difference between the two groups in mean changes of MCV.This study indicates that daily consumption of 6 g flaxseed oil reduces serum hepcidin and improves hematologic

2018 Hemodialysis international. International Symposium on Home Hemodialysis

96. Long-Term Nutritional Outcomes of Near-Total Gastrectomy in Gastric Cancer Treatment: a Comparison with Total Gastrectomy Using Propensity Score Matching Analysis (PubMed)

, and then recovered slightly over time (P<0.05); however, there was no difference in the levels between the groups. The prognostic nutritional index values and serum albumin levels decreased significantly until postoperative 6 months and then recovered (P<0.05); the levels decreased more in the nTG group than in the TG group (P<0.05). The mean corpuscular volumes and serum transferrin levels increased significantly until postoperative 1 year and then recovered slightly over time (P<0.05); however

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2018 Journal of gastric cancer

97. Prevalence of β-Thalassemia Mutations among Northeastern Iranian Population and their Impacts on Hematological Indices and Application of Prenatal Diagnosis, a Seven-Years Study (PubMed)

in mean corpuscular volume and hemoglobin A2 levels between the nine most commonly reported mutation types (p<0.001).This study makes a reliable guide for β-thalassemia diagnosis in the region. The possibility of a correlation between HBB mutations and hematological indices opens a gate of future investigations.

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2018 Mediterranean journal of hematology and infectious diseases

98. Evaluation of Iron Deficiency Anemia Frequency as a Risk Factor in Glaucoma (PubMed)

subjects (Group 1) and 131 glaucoma patients (Group 2) were included. The erythrocytes parameters, hemoglobin, red blood cell, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, and red blood cell distribution width, and iron status indicators, Fe (iron), total iron binding capacity, and ferritin of the cases, in normal subjects and glaucoma patients were compared.There was no statistically significant difference for the erythrocyte parameters

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2018 Anemia

99. Can routine peripheral blood counts like neutrophil-to-lymphocyte ratio be beneficial in prediagnosis of testicular cancer and its stages? (PubMed)

difference was found between the two groups in terms of neutrophil counts, NLR, PLR, and MPV. NLR and PLR were significantly higher and MPV was significantly lower in testicular cancer group compared to the control group. NLR was 3.1 ± 1.4 and 2.0 ± 1.5, PLR was 141.3 ± 53.2 and 115.7 ± 44.8, and MPV was 8.9 ± 1.0 and 9.3 ± 1.1 for testicular cancer and control groups, respectively (P < 0.05). Furthermore, differences were observed between only mean corpuscular volume, mean corpuscular hemoglobin (...) Can routine peripheral blood counts like neutrophil-to-lymphocyte ratio be beneficial in prediagnosis of testicular cancer and its stages? The purpose of this study was to assess the diagnostic role of preoperative hematological parameters, especially neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) in germ cell testicular malignancies and their prediagnostic role in staging of testicular cancer.In this cross-sectional retrospective study

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2018 Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

100. Effectiveness and safety of ferric carboxymaltose compared to iron sucrose in women with iron deficiency anemia: phase IV clinical trials. (PubMed)

 < 0.001) in patients treated with IS after four weeks of therapy. The rise in mean corpuscular volume was from 66.82 ± 5.24 to 86.76 ± 3.765 and 68.05 ± 5.56 to 93.80 ± 3.80 and rise in serum ferritin levels were from 8.32 ± 1.787 to 38.94 ± 6.095 μg/L and 8.16 ± 1.540 to 27 ± 8.175 μg/L in patients treated with FCM and IS respectively after four weeks of therapy. No serious adverse effects were reported.Parenteral therapy is effective in IDA, but FCM elevates hemoglobin level and restored iron stores (...) Medical College and Hospital, Jammu & Kashmir, India identified with IDA were enrolled for the study. Intravenous FCM and IS were both given as per the protocol. Change in the laboratory parameters such as hemoglobin (Hb), mean corpuscular value, and serum ferritin levels at two weeks and four weeks interval after the treatment was recorded.A significant increase in the mean Hb was observed from 7.76 ± 0.709 to 13.25 ± 0.606 in patients treated with FCM and 7.64 ± 0.710 to 11.59 ± 0.733 g/dL (P

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2018 BMC Women's Health

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