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Mean Corpuscular Volume

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81. Effects of acute and chronic exercise on the osmotic stability of erythrocyte membrane of competitive swimmers. (PubMed)

at the beginning of those weeks were considered due to chronic adaptations, while the effects observed at the end of the weeks were considered due to acute manifestations of the exercise load of that week. Acute changes resulting from the exercise comprised increases in creatine kinase activity (CK) and leukocyte count (Leu), and decrease in hematocrit (Ht) and mean corpuscular volume (MCV), at the end of the first week; increase in the activities of CK and lactate dehydrogenase (LDH), in the uric acid (UA (...) ) concentration and Leu count, at the end of the seventh week; increases in CK and LDH activities and in the mean corpuscular hemoglobin concentration (MCHC), at the end of the 13th week; and decrease in the value of the osmotic stability index 1/H50 and increases in the CK activity and platelets (Plt) count, at the end of the 18th week. Chronic changes due to training comprised increase in the values of 1/H50, CK, LDH, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C

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2017 PLoS ONE

82. Iron Deficiency Anemia: A Guide to Oral Iron Supplements

weeks in the ferrous group (2.84 vs Niferex 0.60, p <0.0001). Statistically significant increases in ferritin and mean corpuscular volume were also seen in patients taking ferrous sulfate rather than Niferex, .[14] Vitamin C Ascorbic acid has been theorized to improve absorption by reducing iron to a ferrous Fe+2 state to optimize its solubility. Increasing doses of vitamin C exhibited a dose-dependent response in iron absorption during concomitant administration in healthy volunteers, ranging from

2015 Clinical Correlations

83. Guidelines for identification and management of substance use and substance use disorders in pregnancy

alcohol spectrum disorders FIGO International Federation of Gynecology and Obstetrics GABA gamma-aminobutyric acid GDG guidelines development group GGT gamma-glutamyl transpeptidase DSM Diagnostic and Statistical Manual of Mental Disorders HCW health-care workers HIV human immunodeficiency virus ICD International Classification of Diseases IUGR intrauterine growth retardation ITT intention-to-treat IV intravenous MCV mean corpuscular volume M-H Mantel-Haenszel MD mean differences MI motivational (...) and feasibility, to set the strength of the recommendations (see decision tables and evidence profiles in annex). The strength of the recommendation was set as either: ‘strong’: meaning that the Guideline Development Group was confident that the quality of the evidence of effect, combined with certainty about the values, preferences, benefits and feasibility, made this a recommendation that should be done in most circumstances and settings; or ‘conditional’: meaning there was less certainty about the quality

2014 World Health Organisation Guidelines

84. Indicators of Male Gout Patients' Comorbidities with the Theory on Traditional Chinese Medicine. (PubMed)

is the only index reflecting that renal function showed significant difference between the two groups and the average levels were out of the normal range (1.09 ± 0.28 versus 1.17 ± 0.31, p=0.001). Further, we also observed significance difference on abnormality rates of cystatin C between the two groups. (χ2=5.543, p= 0.019). Besides, the comparison between the two subtypes also showed significant difference on hematocrit (43.12 ± 3.60 versus 42.26 ± 4.17%, p=0.007), mean corpuscular volume (89.52 ± 6.07 (...) versus 86.81 ± 7.11fL, p=0.001), and mean corpuscular hemoglobin concentration (338.00 ± 11.67 versus 334.86 ± 13.58g/L, p=0.004). In general, we put forward that male gout patients with ODHS should be more vigilant of damage of renal function, and those with IPSBS should pay more attention to prevent cardiac-cerebral vascular diseases and diabetes. Increased Cys C level might be correlated with risk of comorbidities, especially diabetes . Thus, it is of significance to diagnose the TCMS in acute

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2018 Evidence-based Complementary and Alternative Medicine (eCAM)

85. Lactoferrin plus health education versus total dose infusion (TDI) of low-molecular weight (LMW) iron dextran for treating iron deficiency anemia (IDA) in pregnancy: a randomized controlled trial. (PubMed)

age. Both groups showed a significant clinical improvement of anemia 4 weeks post-therapy. There was no statistically significant difference in mean Hb level improvement in both groups after 1 month of therapy. However, mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) improved significantly more in group B than A while iron indices (serum iron and serum ferritin) were significantly more in group A than group B.Pineapple flavored lactoferrin oral sachets plus health education can (...) daily with health education (group A) and TDI of LMW iron dextran (group B).The primary efficacy parameter was clinical improvement and the amount of increase in hemoglobin concentration by 4 weeks after therapy, secondary outcome measures included measurement of the rest of RBC, and iron indices, the adverse effects related to iron therapy and the patient compliance to the treatment.There was insignificant difference between both groups regarding sociodemographic data, parity and mean gestational

2018 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

86. Safety of standardized Macleaya cordata extract in an eighty-four-day dietary study in dairy cows. (PubMed)

84 of the study. There was no statistically significant difference (p > .10) among the three groups on body condition score, milk production or milk composition over the study period. There were no significant differences in body weight gain or feed consumption among the three groups. Animals in the SANG-10000 group had significantly higher mean corpuscular volume (MCV) than the C group (p < .1) and lower mean corpuscular haemoglobin concentration (MCHC) than the SANG-1000 group (p < .1

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2018 Journal of animal physiology and animal nutrition

87. Effects of flaxseed oil on blood hepcidin and hematologic factors in hemodialysis patients. (PubMed)

group received 6 g/d flaxseed oil for 8 wk, whereas the control group received 6 g/d medium chain triglycerides (MCT) oil. At baseline and the end of week 8, serum hepcidin, and blood hemoglobin, hematocrit, red blood cells (RBCs), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were measured after a 12- to 14-h fast.Flaxseed oil consumption significantly reduced serum hepcidin concentration up to 25% during 8 weeks (...) , and the reduction was significant in comparison with the MCT oil group. In addition, the number of RBCs, blood hemoglobin, hematocrit, MCH and MCHC increased significantly in the flaxseed oil group up to 6%, 10%, 6%, 5%, and 2%, respectively, and these elevations were significant in comparison with the MCT oil group. There was no significant difference between the two groups in mean changes of MCV.This study indicates that daily consumption of 6 g flaxseed oil reduces serum hepcidin and improves hematologic

2018 Hemodialysis international. International Symposium on Home Hemodialysis

88. Long-Term Nutritional Outcomes of Near-Total Gastrectomy in Gastric Cancer Treatment: a Comparison with Total Gastrectomy Using Propensity Score Matching Analysis (PubMed)

, and then recovered slightly over time (P<0.05); however, there was no difference in the levels between the groups. The prognostic nutritional index values and serum albumin levels decreased significantly until postoperative 6 months and then recovered (P<0.05); the levels decreased more in the nTG group than in the TG group (P<0.05). The mean corpuscular volumes and serum transferrin levels increased significantly until postoperative 1 year and then recovered slightly over time (P<0.05); however

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2018 Journal of gastric cancer

89. Prevalence of β-Thalassemia Mutations among Northeastern Iranian Population and their Impacts on Hematological Indices and Application of Prenatal Diagnosis, a Seven-Years Study (PubMed)

in mean corpuscular volume and hemoglobin A2 levels between the nine most commonly reported mutation types (p<0.001).This study makes a reliable guide for β-thalassemia diagnosis in the region. The possibility of a correlation between HBB mutations and hematological indices opens a gate of future investigations.

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2018 Mediterranean journal of hematology and infectious diseases

90. Evaluation of Iron Deficiency Anemia Frequency as a Risk Factor in Glaucoma (PubMed)

subjects (Group 1) and 131 glaucoma patients (Group 2) were included. The erythrocytes parameters, hemoglobin, red blood cell, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, and red blood cell distribution width, and iron status indicators, Fe (iron), total iron binding capacity, and ferritin of the cases, in normal subjects and glaucoma patients were compared.There was no statistically significant difference for the erythrocyte parameters

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2018 Anemia

91. Can routine peripheral blood counts like neutrophil-to-lymphocyte ratio be beneficial in prediagnosis of testicular cancer and its stages? (PubMed)

difference was found between the two groups in terms of neutrophil counts, NLR, PLR, and MPV. NLR and PLR were significantly higher and MPV was significantly lower in testicular cancer group compared to the control group. NLR was 3.1 ± 1.4 and 2.0 ± 1.5, PLR was 141.3 ± 53.2 and 115.7 ± 44.8, and MPV was 8.9 ± 1.0 and 9.3 ± 1.1 for testicular cancer and control groups, respectively (P < 0.05). Furthermore, differences were observed between only mean corpuscular volume, mean corpuscular hemoglobin (...) Can routine peripheral blood counts like neutrophil-to-lymphocyte ratio be beneficial in prediagnosis of testicular cancer and its stages? The purpose of this study was to assess the diagnostic role of preoperative hematological parameters, especially neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) in germ cell testicular malignancies and their prediagnostic role in staging of testicular cancer.In this cross-sectional retrospective study

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2018 Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

92. Effectiveness and safety of ferric carboxymaltose compared to iron sucrose in women with iron deficiency anemia: phase IV clinical trials. (PubMed)

 < 0.001) in patients treated with IS after four weeks of therapy. The rise in mean corpuscular volume was from 66.82 ± 5.24 to 86.76 ± 3.765 and 68.05 ± 5.56 to 93.80 ± 3.80 and rise in serum ferritin levels were from 8.32 ± 1.787 to 38.94 ± 6.095 μg/L and 8.16 ± 1.540 to 27 ± 8.175 μg/L in patients treated with FCM and IS respectively after four weeks of therapy. No serious adverse effects were reported.Parenteral therapy is effective in IDA, but FCM elevates hemoglobin level and restored iron stores (...) Medical College and Hospital, Jammu & Kashmir, India identified with IDA were enrolled for the study. Intravenous FCM and IS were both given as per the protocol. Change in the laboratory parameters such as hemoglobin (Hb), mean corpuscular value, and serum ferritin levels at two weeks and four weeks interval after the treatment was recorded.A significant increase in the mean Hb was observed from 7.76 ± 0.709 to 13.25 ± 0.606 in patients treated with FCM and 7.64 ± 0.710 to 11.59 ± 0.733 g/dL (P

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2018 BMC Women's Health

93. MKSAP: 55-year-old woman after bariatric surgery

ago, was normal. On physical examination, blood pressure is 140/79 mm Hg and pulse rate is 63/min. BMI is 25. The examination is otherwise unremarkable. Laboratory studies reveal a hemoglobin level of 10.5 g/dL (105 g/L) and a mean corpuscular volume of 95 fL. Which of the following deficiencies best explains this patient’s current findings? A. Copper B. Iron C. Vitamin A D. Vitamin B12 MKSAP Answer and Critique The correct answer is C. Vitamin A. Vitamin A deficiency is most likely to explain (...) (vitamin B6). Copper deficiency may cause muscle weakness due to myeloneuropathy, ataxia, and cognitive deficits that may be difficult to differentiate from B12 deficiency. Less common neurologic findings include bilateral visual loss. Hematologic findings in copper deficiency include microcytic anemia, which may mimic iron deficiency anemia, and leukopenia. Although iron deficiency does occur following RYGB, this patient is on iron replacement and has a normal mean corpuscular volume. Patients

2018 KevinMD blog

94. Oral Iron Absorption Study

of erythropoiesis. Change from Baseline in hematocrit at Days 14 and 28 [ Time Frame: Baseline (Day 1), Days 14 and 28 ] Blood samples will be collected to characterize the effect of daprodustat or rhEPO on indices of erythropoiesis. Change from Baseline in red blood cell number at Days 14 and 28 [ Time Frame: Baseline (Day 1), Days 14 and 28 ] Blood samples will be collected to characterize the effect of daprodustat or rhEPO on indices of erythropoiesis. Change from Baseline in mean corpuscular volume at Days (...) of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03457701 Recruitment Status : Not yet recruiting First Posted : March 7, 2018 Last Update Posted : March 18, 2019 See Sponsor: GlaxoSmithKline Information provided by (Responsible Party): GlaxoSmithKline Study Details Study Description Go to Brief

2018 Clinical Trials

95. GSK1325756 Relative Bioavailability Study in Healthy Elderly Subjects

assessment for clinical chemistry parameters will include blood urea nitrogen (BUN), creatinine, glucose, potassium, sodium, calcium, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase, total and direct bilirubin, total protein and albumin. Number of subjects with abnormal clinical hematology parameters [ Time Frame: Up to 58 days ] Laboratory assessment for clinical hematology will include platelet, red blood cell (RBC), hemoglobin, hematocrit, mean corpuscular volume (...) (MCV), mean corpuscular hemoglobin (MCH), percent reticulocytes, neutrophils, lymphocytes, monocytes, eosinophils and basophils Number of subjects with abnormal urinalysis parameters [ Time Frame: Up to 58 days ] Laboratory assessment for urinalysis will include specific gravity, potential of hydrogen (pH), glucose, protein, blood, ketones, bilirubin, urobilinogen, nitrite and leukocyte. AUC from time zero (pre-dose) to last time of quantifiable concentration (AUC[0-t]) of danirixin reference

2018 Clinical Trials

96. A Study to Assess the Bioavailability of Different Formulations of AZD5718 and the Food Effect on the Selected Formulation of AZD5718 in Healthy Volunteers

] ] Safety and tolerability of AZD5718 by assessment of urinalysis (glucose). Safety and tolerability of AZD5718 by assessment of clinical laboratory evaluations (hematology)- Mean corpuscular volume (MCV) [ Time Frame: [Part 1 - At screening (From Day -28 to Day-2); Treatment period 1 (Day-1), Treatment period 1 to 5 (Day 1 to 3)] and [Part 2- At Day-1, Day 1 to 3, 5 to 7 days post final dose] ] Safety and tolerability of AZD5718 by assessment of MCV. Safety and tolerability of AZD5718 by assessment (...) count [ Time Frame: [Part 1 - At screening (From Day -28 to Day-2); Treatment period 1 (Day-1), Treatment period 1 to 5 (Day 1 to 3)] and [Part 2- At Day-1, Day 1 to 3, 5 to 7 days post final dose] ] Safety and tolerability of AZD5718 by assessment of reticulocytes absolute count. Safety and tolerability of AZD5718 by assessment of clinical Laboratory evaluations (hematology)- mean corpuscular hemoglobin (MCH) [ Time Frame: [Part 1 - At screening (From Day -28 to Day-2); Treatment period 1 (Day-1

2018 Clinical Trials

97. Forearm Blood Flow in Chronic Kidney Disease Subjects With Anemia (FBF-CKD)

(Day1) to Day 59 ] Blood samples will be collected to measure MCH. Absolute values of the hematology parameter of mean corpuscular volume (MCV) [ Time Frame: Up to 59 days ] Blood samples will be collected to measure MCV. Change from Baseline in hematology parameter of MCV [ Time Frame: Baseline (Day1) to Day 59 ] Blood samples will be collected to measure MCV. Absolute values of clinical laboratory parameters of sodium, potassium, carbon-dioxide (total), chloride, glucose and urea [ Time Frame: Up (...) values of hematology parameter of red blood cell distribution width (RDW) [ Time Frame: Up to 59 days ] Blood samples will be collected to measure RDW. Change from Baseline in RDW [ Time Frame: Baseline (Day1) to Day 59 ] Blood samples will be collected to measure RDW. Absolute values of the hematology parameter of mean corpuscular hemoglobin (MCH) [ Time Frame: Up to 59 days ] Blood samples will be collected to measure MCH. Change from Baseline in hematology parameter of MCH [ Time Frame: Baseline

2018 Clinical Trials

98. Study of a Combination of GSK1795091 and Immunotherapies in Subjects With Advanced Solid Tumors

) count, hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), neutrophils, lymphocytes, monocytes, eosinophils and basophils. Number of subjects with abnormal clinical chemistry parameters [ Time Frame: Up to 2 years ] The following clinical chemistry parameters will be evaluated: blood urea nitrogen (BUN), creatinine, glucose, calculated creatinine clearance (CrCl), potassium, sodium, calcium, aspartate aminotransferase (AST), alanine aminotransferase (ALT (...) or more studies before adding more. Study of a Combination of GSK1795091 and Immunotherapies in Subjects With Advanced Solid Tumors The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03447314 Recruitment Status : Recruiting

2018 Clinical Trials

99. Vitamin D Supplementation in Children With Sickle Cell Disease

in neutrophil counts [ Time Frame: 3 months ] Group difference in the mean change of blood neutrophil counts from baseline to 3 months Mean change in mean corpuscular volume [ Time Frame: 3 months ] Group difference in the mean change of blood mean corpuscular volume from baseline to 3 months Mean change in serum creatinine [ Time Frame: 3 months ] Group difference in the mean change of serum creatinine from baseline to 3 months. Mean change in serum bilirubin [ Time Frame: 3 months ] Group difference (...) in Children With Sickle Cell Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03417947 Recruitment Status : Not yet recruiting First Posted : January 31, 2018 Last Update Posted : September 14, 2018 See Sponsor: St

2018 Clinical Trials

100. Biodistribution of 89Zirconium-labelled GSK2398852 Using PET Imaging

related reactions will be summarized. Number of subjects with abnormal hematology parameters [ Time Frame: Up to Day 28 ] The following hematology parameters will be assessed: platelet count, red blood cell (RBC) count, hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), percentage of reticulocytes, neutrophils, lymphocytes, monocytes, eosinophils and basophils. Number of subjects with abnormal clinical chemistry parameters [ Time Frame: Up to Day 28 (...) of 89Zirconium-labelled GSK2398852 Using PET Imaging The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03417830 Recruitment Status : Terminated (Change in benefit/risk profile.) First Posted : January 31, 2018 Last Update Posted : December 12, 2018 Sponsor: GlaxoSmithKline Information provided by (Responsible

2018 Clinical Trials

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