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Mean Corpuscular Volume

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1. Mean Corpuscular Volume to White Blood Cell Ratio for Thiopurine Monitoring in Pediatric Inflammatory Bowel Disease. (PubMed)

Mean Corpuscular Volume to White Blood Cell Ratio for Thiopurine Monitoring in Pediatric Inflammatory Bowel Disease. Thiopurines, commonly used to treat inflammatory bowel disease (IBD), cause lymphopenia and red blood cell macrocytosis, requiring therapeutic monitoring. Mean corpuscular volume/white blood cell (MCV/WBC) ratio has been proposed as a surrogate for therapeutic monitoring. Our aim was to investigate MCV/WBC ratio for assessing clinical response to thiopurines among pediatric IBD

2019 Journal of Pediatric Gastroenterology and Nutrition

2. High Mean Corpuscular Volume Predicts Poor Outcome for Patients With Gastroesophageal Adenocarcinoma. (PubMed)

High Mean Corpuscular Volume Predicts Poor Outcome for Patients With Gastroesophageal Adenocarcinoma. Elevated mean corpuscular volume (MCV) is associated with a diminished prognosis for various tumor entities. This study aimed to evaluate the association between preoperative serum MCV levels and both overall (OS) and disease-free survival (DFS) for patients with resectable adenocarcinomas of the esophagogastric junction (AEG).This study included consecutive patients undergoing surgical (...) ). In the subgroup analysis of neoadjuvantly treated and untreated patients, MCV remained an independent prognostic factor for OS (HR, 1.08; 95% CI, 1.04-1.12; P < 0.001) and DFS (HR, 1.07; 95% CI, 1.03-1.12; P < 0.001) in both groups. In the univariate analysis, tumor stage and differentiation, adjuvant chemotherapy, MCV, mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were significantly correlated with diminished OS and DFS.Preoperatively elevated MCV is an independent

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2019 Annals of Surgical Oncology

3. Prognostic Value of Preoperative Red Cell Distribution Width: Fine-Tuning by Mean Corpuscular Volume. (PubMed)

Prognostic Value of Preoperative Red Cell Distribution Width: Fine-Tuning by Mean Corpuscular Volume. Abnormal red cell distribution width (RDW), reflecting heterogeneity of red blood cell (RBC) size, is associated with cardiovascular disease outcomes. However, it is unclear whether RBC size itself, expressed as mean corpuscular volume (MCV), provides additional prognostic value. Therefore, we investigated the relationship between outcomes after cardiac surgery and both RDW and MCV

2019 Annals of Thoracic Surgery

4. Prevalence of preoperative anemia, abnormal mean corpuscular volume and red cell distribution width among surgical patients in Singapore, and their influence on one year mortality. (PubMed)

Prevalence of preoperative anemia, abnormal mean corpuscular volume and red cell distribution width among surgical patients in Singapore, and their influence on one year mortality. Preoperative anemia and high red cell distribution width (RDW) are associated with higher perioperative mortality. Conditions with high RDW levels can be categorized by mean corpuscular volume (MCV). The relationship between RDW, anemia and MCV may explain causality between high RDW levels and outcomes. We aim

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2017 PLoS ONE

5. Clinical Importance of Mean Corpuscular Volume as a Prognostic Marker After Esophagectomy for Esophageal Cancer: A Retrospective Study. (PubMed)

Clinical Importance of Mean Corpuscular Volume as a Prognostic Marker After Esophagectomy for Esophageal Cancer: A Retrospective Study. To elucidate the clinical value of mean corpuscular volume (MCV) for prognostic prediction in patients with esophageal cancer who underwent radical esophagectomy.High MCV is suggested to be relevant to the incidence and prognosis of several malignancies. However, few studies investigating the correlation between MCV and survival outcome of esophageal cancer

2018 Annals of Surgery

6. The prognostic value of interaction between mean corpuscular volume and red cell distribution width in mortality in chronic kidney disease (PubMed)

The prognostic value of interaction between mean corpuscular volume and red cell distribution width in mortality in chronic kidney disease Recently, both red cell distribution width (RDW) and mean corpuscular volume (MCV) have been associated with unfavorable outcomes in several medical conditions. Therefore, we conducted this retrospective study of 1075 patients with stage 3-5 chronic kidney disease to investigate whether interactions between RDW and MCV influence the risk of mortality

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2018 Scientific reports

7. Gradient Relationship between Increased Mean Corpuscular Volume and Mortality Associated with Cerebral Ischemic Stroke and Ischemic Heart Disease: A Longitudinal Study on 66,294 Taiwanese (PubMed)

Gradient Relationship between Increased Mean Corpuscular Volume and Mortality Associated with Cerebral Ischemic Stroke and Ischemic Heart Disease: A Longitudinal Study on 66,294 Taiwanese The gradient relationship between mean corpuscular volume (MCV) and mortality due to ischemic vascular disease has not been researched using a large-scale population-based study. This study evaluated the association between MCV and death attributable to cerebrovascular disease (CVD) and cardiovascular disease

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2018 Scientific reports

8. Storage of blood samples at or above 33℃ leads to rapid appearance of appreciable systemic bias in platelet and mean corpuscular volume related parameters: an important pre-analytical factor in tropical conditions. (PubMed)

Storage of blood samples at or above 33℃ leads to rapid appearance of appreciable systemic bias in platelet and mean corpuscular volume related parameters: an important pre-analytical factor in tropical conditions. There is scant documentation of the stability of common haematological parameters on storage of blood samples under tropical conditions. K2EDTA samples in multiple vials were taken from 20 healthy blood donors, baseline readings taken, and stored at 33°C and 37°C. Readings from (...) the stored vials were taken after 1, 3 and 6 h. The percent change against the baseline readings at each time point for each storage temperature was calculated. Platelet counts showed an unacceptable shift within 1 h at 37°C and 3 h at 33°C; red cell volume related parameters showed an unacceptable shift within 3 h at 37°C and 6 h at 33°C. Haemoglobin, red blood cell count, white blood cell count and mean corpuscular haemoglobin remained stable for 6 h at both temperatures. The unacceptable change

2018 Tropical Doctor

9. Mean Corpuscular Volume as a Predictive Factor of Response to Preoperative Chemoradiotherapy in Locally Advanced Rectal Cancer (PubMed)

Mean Corpuscular Volume as a Predictive Factor of Response to Preoperative Chemoradiotherapy in Locally Advanced Rectal Cancer The aim of this study was to identify if blood routine parameters and serum tumor marker are potential predictive factors for tumor response to preoperative chemoradiotherapy (CRT) in locally advanced rectal cancer.55 locally advanced rectal cancer patients were treated with preoperative CRT in this study. The total dose of preoperative radiotherapy was 45 Gy in 25

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2018 Gastroenterology research and practice

10. Mean Corpuscular Volume and Mortality in Patients with CKD. (PubMed)

Mean Corpuscular Volume and Mortality in Patients with CKD. Mean corpuscular volume is the measure of the average size of the circulatory erythrocyte, and it is principally used as an index for the differential diagnosis of anemia. Recently, mean corpuscular volume has been associated with mortality in many clinical settings. However, the association of mean corpuscular volume with mortality in patients with CKD has not been fully addressed.We conducted a retrospective observational cohort (...) study of 1439 patients with stages 3-5 CKD and baseline mean corpuscular volume values from 2004 to 2012 in a medical center. The study cohort was divided into the high-mean corpuscular volume group and the low-mean corpuscular volume group by the median value (90.8 fl) of mean corpuscular volume. The baseline patient information included demographic data, laboratory parameters, medications, and comorbid conditions. The independent association of mean corpuscular volume with mortality was examined

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2017 Clinical Journal of the American Society of Nephrology

11. Mean Corpuscular Volume

Mean Corpuscular Volume Mean Corpuscular Volume Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Mean Corpuscular Volume Mean (...) Corpuscular Volume Aka: Mean Corpuscular Volume , MCV Cutoffs for Microcytic Anemia , MCV , Mentzer Index From Related Chapters II. Findings: Normal (Units in femtoliters = 10^-15 liters) ral MCV cutoffs vary from age to age MCV cutoffs also vary per reference MCV Normal Range Newborn: 95 to 121 fl Ages 6 months to 2 years: 70 to 86 fl Ages 12 to 18 years Boys: 78 - 98 Girls: 78 - 102 Age over 18 years: 78 to 98 fl MCV Cutoffs for Microcytic Anemia Age 1-2 years: <77 fl (CDC) Age 3-5 years: <79 fl (CDC

2018 FP Notebook

12. Lower mean corpuscular hemoglobin concentration is associated with poorer outcomes in intensive care unit admitted patients with acute myocardial infarction (PubMed)

were evaluated using a Cox hazard regression model and Kaplan-Meier curve analysis.In univariable analysis, increased white blood cell (WBC), neutrophil percentage, mean corpuscular volume (MCV), RDW, potassium and decreased red blood cell (RBC), hemoglobin, mean corpuscular hemoglobin concentration (MCHC), hematocrit and percentage of lymphocyte, monocyte, basophil and eosinophil were significantly associated with hospital mortality. In multivariable analyses, basophil percentage, potassium, WBC (...) Lower mean corpuscular hemoglobin concentration is associated with poorer outcomes in intensive care unit admitted patients with acute myocardial infarction Accumulated studies have shown that hematological parameters [e.g., red blood cell distribution width (RDW), hemoglobin, platelet count] and serum potassium level can impact the prognosis of patients with acute myocardial infarction (AMI). However, no previous study has evaluated the prognostic values of these laboratory tests

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2016 Annals of Translational Medicine

13. Mean Corpuscular Hemoglobin Concentration

hemoglobinu v erytrocytu Hungarian Vörösvértest átlagos haemoglobin , Vörösvértestek átlagos haemoglobin tartalma , Vörösvértest átlagos hemoglobin tartalom , MCH , Vörösvértestek átlagos hemoglobin tartalma Derived from the NIH UMLS ( ) Ontology: Mean corpuscular hemoglobin concentration determination (C0474535) Definition (NCI_CDISC) A quantitative measurement of the mean amount of hemoglobin per erythrocytes in a specified volume of a biological specimen. Definition (NCI) The mean cell hemoglobin (...) concentration (MCHC), which is the average concentration of hemoglobin in a given volume of blood. The MCHC is a calculated value derived from the measurement of hemoglobin and the hematocrit. Definition (MSH) MCHC equals HEMOGLOBIN divided by HEMATOCRIT. Concepts Laboratory Procedure ( T059 ) MSH SnomedCT 165450006 , 103206002 , 142861007 , 37254006 LNC LP17695-5, MTHU013638 English Mean cell haemoglobin concentration , Mean cell hemoglobin concentration , MCHC - NOS (procedure) , mean corpuscular

2018 FP Notebook

14. Changes in the mean corpuscular volume after capecitabine treatment are associated with clinical response and survival in patients with advanced gastric cancer. (PubMed)

Changes in the mean corpuscular volume after capecitabine treatment are associated with clinical response and survival in patients with advanced gastric cancer. Capecitabine is known to increase mean corpuscular volume (MCV). To define the incidence of capecitabine-induced macrocytosis and its association with chemotherapy outcomes, we investigated data of 89 patients with advanced gastric cancer (AGC) who were enrolled in a randomized chemotherapy trial involving capecitabine.Chemotherapy (...) -naïve AGC patients were treated with capecitabine (1,000 mg/m(2)/day on days 1-14) plus cisplatin (75 mg/m(2) on day 1), with or without epirubicin (50 mg/m(2) on day 1). Complete blood counts including MCV were measured at baseline and on day 1 of each 3-week chemotherapy course. Macrocytosis was defined as a MCV increase > 10 fL from baseline. Multivariate Cox proportional hazards models were used for analysis of the impact of clinical and MCV values on chemotherapy outcomes.At baseline, the mean

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2015 Cancer research and treatment : official journal of Korean Cancer Association

15. Mean corpuscular volume of control red blood cells determines the interpretation of eosin-5′-maleimide (EMA) test result in infants aged less than 6 months (PubMed)

Mean corpuscular volume of control red blood cells determines the interpretation of eosin-5′-maleimide (EMA) test result in infants aged less than 6 months Eosin-5'-maleimide (EMA) binding test is a flow cytometric test used to detect hereditary spherocytosis (HS). To perform the test sample from patients, 5-6 reference samples of red blood are needed. Our aim was to investigate how the mean corpuscular volume (MCV) of red blood cells influences on the value of fluorescence of bounded EMA (...) dye and how the choice of reference samples affects the test result. EMA test was performed in peripheral blood from 404 individuals, including 31 children suffering from HS. Mean fluorescence channel of EMA-RBCs was measured with Cytomics FC500 flow cytometer. Mean corpuscular volume of RBCs was assessed with LH750 Beckman Coulter. Statistical analysis was performed using Graph Pad Prism. The correlation Spearman coefficient between mean channel of fluorescence of EMA-RBCs and MCV was r = 0.39, p

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2015 Annals of hematology

16. Change in Erythrocyte Mean Corpuscular Volume During Combination Therapy with Azathioprine and Infliximab Is Associated with Mucosal Healing: A Post hoc Analysis from SONIC. (PubMed)

Change in Erythrocyte Mean Corpuscular Volume During Combination Therapy with Azathioprine and Infliximab Is Associated with Mucosal Healing: A Post hoc Analysis from SONIC. The adequacy of exposure of purine analogs as measured by 6-thioguanine nucleotides concentrations in the setting of combination therapy remains poorly understood. The aim of this study was to investigate the relationship between the mean corpuscular volume (MCV) value (as a surrogate marker of 6-thioguanine nucleotides (...) concentration) and Crohn's disease outcomes in the setting of combination therapy with infliximab.The SONIC trial was a randomized controlled trial comparing infliximab to azathioprine and to infliximab plus azathioprine in 508 Crohn's disease patients. An increase of at least 7 femtoliter (fL) of the MCV (ΔMCV) was used for statistical analysis.At week 26, the mean increase of MCV was similar among patients treated with azathioprine alone (mean of 7.9 fL) or in combination with infliximab (mean of 8.5 fL

2015 Inflammatory Bowel Diseases

17. Relationship of Mean Platelet Volume To MDD: A Retrospective Study (PubMed)

and gender were recruited. We collected peripheral blood samples from both groups and gathered basic data. For comparison of normally distributed data (age, body mass index, lymphocyte count, white blood cell count, red blood cell count, hematocrit, platelet count and mean corpuscular volume) between groups, single t-test were used; and for comparison of non-normally distributed data (Neutrophil count, neutrophil count, platelet/ lymphocyte ratio, hemoglobin, red blood cell distribution width, mean (...) Relationship of Mean Platelet Volume To MDD: A Retrospective Study Results of numerous studies show that major depressive disorder (MDD) is associated with a chronic low-grade inflammation, but the underlying mechanism remains unclear.To compare the results of blood cell analysis of MDD patients with healthy controls, and explore the potential value of it as an indicator of immune-inflammation in MDD, especially the mean platelet volume.103 MDD patients and 106 healthy controls with matched age

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2017 Shanghai archives of psychiatry

18. Relationship between mean corpuscular volume and cognitive performance in older adults. (PubMed)

Relationship between mean corpuscular volume and cognitive performance in older adults. To examine the relationship between erythrocyte mean corpuscular volume (MCV) and cognitive performance over time.Longitudinal.Sample from the Baltimore Longitudinal Study of Aging (BLSA).Eight hundred twenty-seven participants from the BLSA (mean age 67, range 50-96).Mean corpuscular volume and several other blood indices were measured, including hemoglobin, iron, ferritin, vitamin B12, folate, white blood

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2013 Journal of the American Geriatrics Society

19. Multiplicative interaction between mean corpuscular volume and red cell distribution width in predicting mortality of elderly patients with and without anemia. (PubMed)

Multiplicative interaction between mean corpuscular volume and red cell distribution width in predicting mortality of elderly patients with and without anemia. Recent studies have shown that an elevated red cell distribution width (RDW) is an important predictor of adverse outcomes. However, the strength of this biomarker has not been tested in a large outpatient elderly population. Also since increased RDW can be due to a variety of etiologies, additional biomarkers are needed to refine

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2013 American journal of hematology

20. RELATION OF VARIATIONS IN MEAN CORPUSCULAR VOLUME TO NUMBER OF RETICULOCYTES IN PERNICIOUS ANEMIA: The Significance of Increased Bone Marrow Activity in Determining the Mean Size of Red Corpuscles (PubMed)

RELATION OF VARIATIONS IN MEAN CORPUSCULAR VOLUME TO NUMBER OF RETICULOCYTES IN PERNICIOUS ANEMIA: The Significance of Increased Bone Marrow Activity in Determining the Mean Size of Red Corpuscles 16694237 2006 05 31 2018 11 13 0021-9738 13 4 1934 Jul The Journal of clinical investigation J. Clin. Invest. RELATION OF VARIATIONS IN MEAN CORPUSCULAR VOLUME TO NUMBER OF RETICULOCYTES IN PERNICIOUS ANEMIA: The Significance of Increased Bone Marrow Activity in Determining the Mean Size of Red

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1934 Journal of Clinical Investigation

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