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McMurray Test

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121. Genetics of Colorectal Cancer (PDQ®): Health Professional Version

% or greater on MMRpro and MMRpredict are recommended for genetic evaluation referral and testing. Associated Genes and Syndromes Hereditary CRC has two well-described forms: (1) polyposis (including and (AFAP), which are caused by pathogenic variants in the gene; and , which is caused by pathogenic variants in the MUTYH gene); and (2) (often referred to as hereditary nonpolyposis colorectal cancer), which is caused by germline pathogenic variants in DNA MMR genes ( , , , and ) and . Other CRC syndromes (...) individuals with newly diagnosed CRC are evaluated for Lynch syndrome through molecular diagnostic tumor testing assessing MMR deficiency. A is supported, in which all CRC cases are evaluated regardless of age at diagnosis or fulfillment of existing clinical criteria for Lynch syndrome. A more cost-effective approach has been reported whereby all patients aged 70 years or younger with CRC and older patients who meet the revised Bethesda guidelines are tested for Lynch syndrome. Tumor evaluation often

2018 PDQ - NCI's Comprehensive Cancer Database

122. Use of Non-Vitamin K Antagonist Oral Anticoagulants (NOAC) in Non-Valvular Atrial Fibrillation

Drug Interactions ). In patients weighing less than 60 kg or greater than 100 kg, calculate the creatinine clearance (CrCl) and do not depend on the estimated glomerular filtration rate (eGFR) provided by laboratory reports (because weight has not be adjusted). CrCl can be calculated using the (link to calculator: ) according to the patient’s age, weight, and serum creatinine: Coagulation Testing The INR and the activated partial thromboplastin time (aPTT) are used to monitor the anticoagulant (...) effects of warfarin and heparin, respectively. They should NOT be used to measure the anticoagulant effects of NOACs. , Depending on the laboratory reagent used and the timing of the blood draw after a dose of NOAC, the INR and aPTT may or may not be prolonged. Consequently, these tests should not be used to estimate the anticoagulant activity. It is reasonable to assume that some anticoagulant activity is present if either the INR and/or aPTT is elevated, but it is not appropriate to assume

2015 Clinical Practice Guidelines and Protocols in British Columbia

123. Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death

explain 15–25% of sudden arrhythmic death syndrome (SADS) cases. 17 The value of the post-mortem diagnosis in a victim of SCD lies in extending genetic screening to the family members of SADS or SIDS victims. Recent expert consensus documents for the diagnosis and management of inheritable arrhythmias state that the use of a focused molecular autopsy/post-mortem genetic testing should be considered for SCD victims when the presence of channelopathies is suspected. We endorse this recommendation (...) and the effects of various drugs may result in repolarization abnormalities and/or prolongation of the QRS duration. Exercise ECG is most commonly applied to detect silent ischaemia in adult patients with ventricular VAs. Exercise-induced non-sustained VT was reported in nearly 4% of asymptomatic middle-age adults and was not associated with an increased risk of total mortality. 108 Exercise testing in adrenergic-dependent rhythm disturbances, including monomorphic VT and polymorphic VT such as CPVT

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2015 European Society of Cardiology

124. Colorectal Cancer Prevention (PDQ®): Health Professional Version

issues that preclude making general recommendations for their use. These include a paucity of knowledge about the proper dose and duration for these agents, and concern about whether the potential preventive benefits such as a reduction in the frequency or intensity of screening or surveillance could counterbalance long-term risks such as gastrointestinal ulceration and hemorrhagic stroke for the average-risk individual.[ ] Calcium supplements A randomized placebo-controlled trial tested the effect

2018 PDQ - NCI's Comprehensive Cancer Database

125. Classification of Anemias

, sulfacetamide, sulfamethoxazole, sulfanilamide & sulfapyridine. Drug induced Hemolytic anemia: ACEI, acetaminophen, ASA/NSAIDs, cephalosporins, chlorpromazine, chlorpropamide, diclofenac, hydrochlorothiazide, interferon a2a&2b , isoniazid, levodopa, levofloxacin, mefenamic acid, methadone, methyldopa, penicillins, probenecid, procainamide, quinine, quinidine, ribavirin, rifampin, sulfonamides, & tetracycline. (Direct antiglobulin test-DAT or Coomb’s test is used to detect cause of hemolytic anemia) Drug (...) agent ESRD=end-stage renal dx FeSO4=ferrous sulfate Hct=hematocrit HD-CKD=dialysis-CKD HF=heart failure Hgb=hemoglobin HRQL=health-related QOL ITT=intention to treat LFT=liver function tests LVMI=left ventricular mass index LVVI=left ventricular volume index LVCVI=left ventricular cavity volume index MCV=Mean corpuscular volume MI=myocardial infarction ND-CKD=non-dialysis CKD OL=open label pt=patient QALY=quality-adjusted life year QOL=quality of life RCT=randomized control trial RDW=Red cell

2014 RxFiles

126. ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management

. .2390 3.3 Functional capacity. . . . . . . . . . . . . . . . . . . . . . . . .2390 3.4 Risk indices . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2391 3.5 Biomarkers . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2392 3.6 Non-invasive testing. . . . . . . . . . . . . . . . . . . . . . . .2392 3.6.1 Non-invasive testing of cardiac disease . . . . . . . . .2393 3.6.2 Non-invasive testing of ischaemic heart disease. . . .2393 3.7 Invasive coronary angiography (...) failure, hypertension, age =75 (doubled), dia- betes, stroke (doubled)-vascular disease, age 65–74 and sex category (female) CI con?dence interval CI-AKI contrast-induced acute kidney injury CKD chronic kidney disease CKD-EPI Chronic Kidney Disease Epidemiology Collaboration C max maximum concentration CMR cardiovascular magnetic resonance COPD chronic obstructive pulmonary disease CPG Committee for Practice Guidelines CPX/CPET cardiopulmonary exercise test CRP C-reactive protein CRT cardiac

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2014 European Society of Cardiology

127. Hypertrophic Cardiomyopathy

of ventricular morphology and function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2745 5.5.2 Myocardial ?brosis . . . . . . . . . . . . . . . . . . . . . .2746 5.5.3 Late Gadolinium Enhancement and Prognosis . . . . .2746 5.5.4 Differential diagnosis . . . . . . . . . . . . . . . . . . . . .2746 5.6 Nuclear imaging and computerized tomography . . . . . .2747 5.7 Endomyocardial biopsy . . . . . . . . . . . . . . . . . . . . . .2747 5.8 Laboratory tests (...) . . . . . . . . . . . . . . . . . . . . . . . . . . .2747 6. Genetic testing and family screening . . . . . . . . . . . . . . . . . .2747 6.1 Counselling in probands . . . . . . . . . . . . . . . . . . . . . .2748 6.2 Methods for molecular genetic screening in probands . . .2748 6.3 Indications for genetic testing in probands . . . . . . . . . .2748 6.4 Genetic and clinical screening of relatives . . . . . . . . . . .2749 6.4.1 Families with de?nite disease causing genetic mutations 2749 6.4.2 Families without de?nite disease causing genetic

2014 European Society of Cardiology

128. ESC/EACTS Guidelines in Myocardial Revascularisation

-making (Heart Team) . . . . . . .2553 4.3 Timing of revascularization andadhoc percutaneous coronary intervention . . . . . . . . . . . . . . . . . . . . . . . . . .2553 5. Strategies for diagnosis: functional testing and imaging . . . . . .2554 5.1 Non-invasive tests . . . . . . . . . . . . . . . . . . . . . . . . .2554 5.2 Invasive tests . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2554 5.3 Detection of myocardial viability . . . . . . . . . . . . . . . .2555 6. Revascularization (...) April 201918.4.6 Duration of dual antiplatelet therapy after percutaneous coronary intervention . . . . . . . . . . . . . . .2604 18.4.7 Drug interactions: a clopidogrel-related topic . . . .2605 18.4.8 Renal dysfunction . . . . . . . . . . . . . . . . . . . . . .2605 18.4.9 Surgery in patients on dual antiplatelet therapy . . .2606 18.4.10 Antiplatelet therapy monitoring and genetic testing 2608 18.4.11 Patients with hypersensitivity to acetylsalicylic acid 2608 18.4.12 Heparin-induced

2014 European Society of Cardiology

129. Screening and Risk Stratification for Diabetic Foot Ulcers

of the critical appraisal of the included SR, using the AMSTAR tool, 6 is available in Appendix 5, Table A5.1. The clinical efficacy evidence for a DFU screening program identified by the SR consisted of two RCTs and four historically controlled trials. The RCTs were evaluated as having a CONSORT score of 65% for McCabe et al. (1998) 16 and 57% for McMurray et al., 2002. 17 The authors of the SR also state that the RCT by McCabe et al. (1998) 16 did not provide any information concerning baseline (...) characteristics of the populations, the index group was subdivided and reallocated multiple times on the basis of neuropathy and PVD, and the allocation protocol was breached. 5 The end points, blinding, and statistical methods were also unclear. 16,22 The SR provided in the guidelines from the University of Adelaide stated that this RCT had a moderate risk of bias and was of average quality. 10 The other RCT included in this SR, McMurray et al. (2002), 17 had a frequency of follow-up with a large proportion

2014 Canadian Agency for Drugs and Technologies in Health - Rapid Review

130. Apixaban and Rivaroxaban for Stroke Prevention in Atrial Fibrillation

Cardiol. 2013 Oct 26. PubMed: PM24211508 6. Garcia DA, Wallentin L, Lopes RD, Thomas L, Alexander JH, Hylek EM, et al. Apixaban versus warfarin in patients with atrial fibrillation according to prior warfarin use: results from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial. Am Heart J. 2013 Sep;166(3):549-58. PubMed: PM24016506 7. McMurray JJ, Ezekowitz JA, Lewis BS, Gersh BJ, van Diepen S, Amerena J, et al. Left ventricular systolic dysfunction (...) and of bleeding in atrial fibrillation: a secondary analysis of a randomised controlled trial. Lancet. 2012 Nov 17;380(9855):1749-58. PubMed: PM23036896 14. Connolly SJ, Eikelboom J, Joyner C, Diener HC, Hart R, Golitsyn S, et al. Apixaban in patients with atrial fibrillation. N Engl J Med. 2011 Mar 3;364(9):806-17. PubMed: PM21309657 15. Granger CB, Alexander JH, McMurray JJ, Lopes RD, Hylek EM, Hanna M, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011 Sep 15;365(11

2014 Canadian Agency for Drugs and Technologies in Health - Rapid Review

131. Magnetic resonance imaging can increase the diagnostic accuracy in symptomatic meniscal repair patients. (PubMed)

included. All had undergone a primary meniscal repair followed by an MRI and re-arthroscopy due to clinical symptoms of a meniscal lesion. A validated semi-quantitative scoring system was employed for identifying MRI-diagnosed healing failure. The clinical assessment was divided into joint swelling, joint-line tenderness, locking and a positive McMurray's test. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of MRI and positive clinical findings were

2019 Knee Surgery, Sports Traumatology, Arthroscopy

132. The characteristic findings of an inverted-type discoid lateral meniscus tear: a hidden tear pattern. (PubMed)

(inverted group). We age-matched these patients with 12 controls who were extracted from many normal DLM tear cases in the same period (non-inverted group). The assessment items were traumatic history with the onset of pain, the mean duration between the appearance of symptoms and surgery, preoperative knee range of motion (ROM), positive findings on the McMurray test, knee locking or catching, and characteristic MRI findings. These items were compared between the two groups using χ2 and Student's t (...) -tests.All patients in the inverted group had clear trauma with the onset of pain during sports or daily life activities, and 7 of the 12 patients with a non-inverted type of DLM tear had clear trauma. There was a significantly higher rate of traumatic history in the inverted group than in the non-inverted group (P = 0.03). The mean duration between the appearance of symptoms and surgery, preoperative knee ROM, positive findings on the McMurray test, and knee locking or catching were not significantly

2019 BMC Musculoskeletal Disorders

133. Sacubitril/valsartan - Addendum to Commission A15-60

: For a detailed description of the outcome “NMQ hypotension”, see dossier assessment A15-60 [1]. c: Institute’s calculation, Cochran’s Q test. CI: confidence interval; HR: hazard ratio; MedDRA: Medical Dictionary for Regulatory Activities; N: number of analysed patients; n: patients with (at least) one event; NC: not calculable; ND: no data; NMQ: Novartis MedDRA Query; RCT: randomized controlled trial; RR: relative risk; vs.: versus Mortality There was proof of an effect modification by the characteristic (...) - 21_Modul4A_Sacubitril-Valsartan.pdf. 5. Gemeinsamer Bundesausschuss. Stenografisches Wortprotokoll der mündliche Anhörung gemäß 5. Kapitel, § 19 Abs. 2 Verfahrensordnung des Gemeinsamen Bundesausschusses zum Wirkstoff Sacubitril/Valsartan vom 09.05.2016 [online]. [Accessed: 20.05.2016]. URL: Valsartan.pdf. 6. McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR et al. Angiotensin- neprilysin inhibition versus enalapril

2017 Institute for Quality and Efficiency in Healthcare (IQWiG)

134. Systematic guideline search and appraisal, as well as extraction of relevant recommendations, for a DMP "chronic heart failure"

DMP relevant). 4.4.4 Monitoring A total of 6 guidelines provide recommendations on the monitoring of heart failure. One guideline provides the recommendation that stable patients should be reassessed by a medical doctor every 6 months or after shorter intervals in the event of necessary treatment adaptations or a deterioration of their condition (recommendation is potentially DMP relevant). As examinations within the framework of monitoring, 3 guidelines recommend blood and urine tests, control (...) :// 09_Langfassung_Herzinsuffizienz_1_E002BIndex.pdf. 6. Bundesärztekammer, Kassenärztliche Bundesvereinigung, Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften. Nationale VersorgungsLeitlinie: chronische Herzinsuffizenz; Langfassung; Version 7 [online]. 08.2013 [accessed: 08.12.2014]. URL: lang.pdf. 7. McMurray JJV

2017 Institute for Quality and Efficiency in Healthcare (IQWiG)

135. Findings series 41 - Public health implications of the pSoBid study

, participants completed lifestyle and psychological questionnaires and underwent measurement of blood pressure, heart rate, hip, waist and mid-thigh circumference and assessment of lung function. At visit 2, participants were asked to fast before attending, so bloods could be taken for biochemical analyses. Height and weight were measured. After being provided with breakfast, subjects completed a number of cognitive tests. Finally, carotid artery ultrasound, a non-invasive measure of atherosclerosis (...) 21 , the Rosenberg Self-esteem Scale 22 and the Eysenck Personality Questionnaire 23 . A series of cognitive tests were completed and included the Trail Making Test 24 , the Stroop Test 25 , the Choice Reaction Time Test 26 , the Auditory Verbal Learning Test 27 and the National Adult Reading Test 28 . b Magnetic resonance imaging (MRI) is a medical imaging technique most commonly used to visualise detailed internal body structures that do not show up well on x-rays. Public health implications

2014 Glasgow Centre for Population Health

136. Knee pain - assessment

. The McMurray test for meniscal injuries is no longer recommended because of concerns that it exacerbates the injury and its low diagnostic accuracy. Assess for neurovascular damage, including loss of sensation or weakness in the lower leg or foot, absence or asymmetry of pulses, or acute compartment syndrome. Basis for recommendation Basis for recommendation General knee examination recommendations are based on expert opinion in review articles [ ; ], a BMJ Best Practice review [ ] and a textbook (...) to rule in or out a knee disorder [ ]. The Lachman test was found to be an accurate test to rule in or out an anterior cruciate ligament injury [ ], although another systematic review found it to have decreased sensitivity, particularly for partial ruptures [ ]. Expert opinion is that using a combination of tests may be more accurate [ ; ]. The recommendation that the McMurray test is not recommended for meniscal injuries is based on expert opinion from several CKS reviewers that this test can

2017 NICE Clinical Knowledge Summaries

137. Systematic review of needs for medical devices for ageing populations

, including tests used during the course of the study. In many cases, there may be a range of options of devices for a specific indication. The clinical application of the information from these studies in a real-world context may not always be clear, and a specific comment on the comparative safety and effectiveness of the alternative devices was not possible. Although the list of topics was based on the top five causes of losses of DALYs for older people in the Western Pacific Region, regionality has (...) be shifts in research priorities to accommodate the aged population, such as towards minimally invasive technologies or home and self-care devices (3). New medical devices are frequently developed and tested in high-resource settings, and hence their applicability to low- or medium-resource settings needs to be considered. The factors involved in setting priority health care areas and identifying the medical devices needed to address them are many and complex. The focus of this project is to identify


138. Guidelines for the Management of Spontaneous Intracerebral Hemorrhage

information. Also, this Table 1. Applying Classification of Recommendations and Level of Evidence A recommendation with Level of Evidence B or C does not imply that the recommendation is weak. Many important clinical questions addressed in the guidelines do not lend themselves to clinical trials. Although randomized trials are unavailable, there may be a very clear clinical consensus that a particular test or therapy is useful or effective. *Data available from clinical trials or registries about (...) be associated with coagulopathy Physical examination Vital signs A general physical examination focusing on the head, heart, lungs, abdomen, and extremities A focused neurological examination A structured examination such as the National Institutes of Health Stroke Scale can be completed in minutes and provides a quantification that allows easy communication of the severity of the event to other caregivers. GCS score is similarly well known and easily computed. Serum and urine tests Complete blood count

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2015 American Heart Association

139. Heart Failure Management in Skilled Nursing Facilities

to avoidable hospitalizations include lack of on-site primary care clinicians, lack of timely laboratory testing, lack of integration of HF assessment and interventions into nursing care, and large resident to clinical staff ratios. , , , Given the paucity of outcome data for HF patients in SNFs, further studies that provide longitudinal data regarding the range of patient experiences after hospital discharge to a SNF are needed. Comprehensive SNF HF Care Clinical Diagnosis of HF Comprehensive SNF HF care (...) begins with accurate identification of residents diagnosed with HF. The clinical diagnosis of HF may largely rely on data from care before SNF admission. Residents without an HF diagnosis who develop pulmonary congestion or volume overload should have a physical examination, chest radiograph, and blood chemistry tests to confirm congestion and volume overload within the SNF setting if possible. Results from laboratory tests may take 24 hours or longer to return in SNFs; thus, appropriate clinical

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2015 American Heart Association

140. Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence

further research. Throughout, we emphasize that this document is not a comprehensive review of the literature but rather a focus on the major new trials that have led to recent guideline changes in the area of primary prevention of CVD in type 2 diabetes mellitus. New Diagnostic Criteria for Diabetes Mellitus and Prediabetes In 2010, the ADA included A 1c for the first time among the tests recommended for the diagnosis of diabetes mellitus. This recommendation has also been adopted by the European (...) Association for the Study of Diabetes, the World Health Organization, and other professional groups in the United States. Clinical practice recommendations from the ADA now state that an A 1c value of ≥6.5% or previous criteria for fasting glucose (≥126 mg/dL) or 2-hour glucose (≥200 mg/dL) can be used for the diagnosis of diabetes mellitus ( ). In 2010, the ADA also added A 1c to the tests used to identify people with prediabetes, who are at increased risk for type 2 diabetes mellitus. Thus, along

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2015 American Heart Association

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