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1. Mastitis and breast abscess

Mastitis and breast abscess Mastitis and breast abscess - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Mastitis and breast abscess Last reviewed: February 2019 Last updated: January 2019 Summary Breast infection (including infectious mastitis and breast abscess) more commonly affects women aged 15-45 years, especially those who are lactating. Mastitis and breast abscess can occur at any age. Staphylococcus aureus (...) is the most frequent pathogen isolated. Prompt and appropriate management of mastitis usually leads to a timely resolution and prevents complications, such as a breast abscess. Treatment of infectious and non-infectious mastitis includes antibiotic therapy and effective milk removal if lactating. Breast abscess requires removal of pus and antibiotic therapy. Surgical interventions can include aspiration and incision and drainage. It is imperative to identify and treat any underlying co-existent causes

2019 BMJ Best Practice

3. Mastitis and breast abscess

Mastitis and breast abscess Mastitis and breast abscess - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Mastitis and breast abscess Last reviewed: February 2019 Last updated: January 2019 Summary Breast infection (including infectious mastitis and breast abscess) more commonly affects women aged 15-45 years, especially those who are lactating. Mastitis and breast abscess can occur at any age. Staphylococcus aureus (...) is the most frequent pathogen isolated. Prompt and appropriate management of mastitis usually leads to a timely resolution and prevents complications, such as a breast abscess. Treatment of infectious and non-infectious mastitis includes antibiotic therapy and effective milk removal if lactating. Breast abscess requires removal of pus and antibiotic therapy. Surgical interventions can include aspiration and incision and drainage. It is imperative to identify and treat any underlying co-existent causes

2018 BMJ Best Practice

4. Mammary Gland Pathology Subsequent to Acute Infection with Strong versus Weak Biofilm Forming Staphylococcus aureus Bovine Mastitis Isolates: A Pilot Study Using Non-Invasive Mouse Mastitis Model. (PubMed)

Mammary Gland Pathology Subsequent to Acute Infection with Strong versus Weak Biofilm Forming Staphylococcus aureus Bovine Mastitis Isolates: A Pilot Study Using Non-Invasive Mouse Mastitis Model. Biofilm formation by Staphylococcus aureus is an important virulence attribute because of its potential to induce persistent antibiotic resistance, retard phagocytosis and either attenuate or promote inflammation, depending upon the disease syndrome, in vivo. This study was undertaken to evaluate (...) the potential significance of strength of biofilm formation by clinical bovine mastitis-associated S. aureus in mammary tissue damage by using a mouse mastitis model.Two S. aureus strains of the same capsular phenotype with different biofilm forming strengths were used to non-invasively infect mammary glands of lactating mice. Biofilm forming potential of these strains were determined by tissue culture plate method, ica typing and virulence gene profile per detection by PCR. Delivery of the infectious dose

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2017 PLoS ONE

5. Clinical and Cytological Spectrum of Granulomatous Mastitis and Utility of FNAC in Picking up Tubercular Mastitis: An Eight-Year Study (PubMed)

Clinical and Cytological Spectrum of Granulomatous Mastitis and Utility of FNAC in Picking up Tubercular Mastitis: An Eight-Year Study Granulomatous Mastitis (GM) is a rare, benign, inflammatory disease of the breast. It is a well known mimicker of malignancy, clinically and radiologically. Patients are often subjected to number of tests for the right diagnosis. Non-specific Granulomatous Mastitis (NGM) and Tubercular Mastitis (TBM) are chief among the various causes of GM. They are important (...) to be diagnosed early as their treatment varies significantly. Fine Needle Aspiration Cytology (FNAC) is simple, patient friendly and primary investigation modality in cases of lump in breast.To find out the utility of FNAC in differentiating NGM and TBM.All cases of granulomatous mastitis diagnosed on cytology over eight years were retrospectively retrieved. The clinical and radiological history was obtained from the patient file. The slides were stained with haematoxylin and eosin stain as well as Leishman

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2017 Journal of clinical and diagnostic research : JCDR

6. A Rare Cause of Mastitis: Idiopathic Granulomatous Mastitis (PubMed)

A Rare Cause of Mastitis: Idiopathic Granulomatous Mastitis 30038994 2019 02 26 2514-8281 101 1 2017 Jan 10 Journal of the Belgian Society of Radiology J Belg Soc Radiol A Rare Cause of Mastitis: Idiopathic Granulomatous Mastitis. 2 10.5334/jbr-btr.1017 Eyselbergs Michiel M Antwerp University Hospital, BE. Verslegers Inge I Antwerp University Hospital, BE. Van Goethem Mireille M Antwerp University Hospital, BE. Trinh Xuan Bich XB Antwerp University Hospital, BE. Siozopoulou Vasiliki V Antwerp (...) University Hospital, BE. Parizel Paul P Antwerp University Hospital, BE. eng Case Reports 2017 01 10 England J Belg Soc Radiol 101698198 2514-8281 Breast Granulomatous MRI Mastitis ultrasound The authors have no competing interests to declare. 2018 7 25 6 0 2017 1 10 0 0 2017 1 10 0 1 epublish 30038994 10.5334/jbr-btr.1017 PMC5854249 BMC Surg. 2014 Sep 04;14:66 25189179

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2017 Journal of the Belgian Society of Radiology

7. Impact of intramammary inoculation of inactivated Lactobacillus rhamnosus and antibiotics on the milk microbiota of water buffalo with subclinical mastitis. (PubMed)

Impact of intramammary inoculation of inactivated Lactobacillus rhamnosus and antibiotics on the milk microbiota of water buffalo with subclinical mastitis. Water buffalo mastitis represents a major issue in terms of animal health, cost of therapy, premature culling and decreased milk yeld. The emergence of antibiotic resistance has led to investigate strategies to avoid or reduce antibiotics' based therapies, in particular during subclinical mastitis. The use of Generally Regarded As Safe (...) bacteria (GRAS) such as Lactobacillus rhamnosus to restore the unbalance in mammary gland microbiota could provide potential corrective measures. The aim of this study was to investigate the changes in milk microbiota after the intramammary treatment with inactivated cultures of Lactobacillus rhamnosus of mammary gland quarters naturally affected by subclinical mastitis as compared to antibiotic therapy.A number of 43 quarters affected by subclinical mastitis with no signs of clinical inflammation

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2019 PLoS ONE

8. Case Report: Ductal Carcinoma in Situ Within A Granulomatous Mastitis (PubMed)

Case Report: Ductal Carcinoma in Situ Within A Granulomatous Mastitis Granulomatous lobular mastitis is a rare chronic breast disease, firstly described by Kessler and Wolloch in 1972. In this article we present a 35-year-old patient with granulomatous lobular mastitis and in situ ductal carcinoma and discuss clinicopathological characteristics of the disease with literature data. A 35-year-old female patient admitted to the outpatient clinic with a complaint of swelling in right breast ongoing (...) since March 2017. On the basis of physical examination and radiological examinations, antibiotic therapy was initiated considering the inflammatory breast disease and the patient was referred to our general surgery clinic because she did not benefit from treatment. On the recommendation of histopathological correlation, trucut biopsy was performed and reported as granulomatous mastitis. In the histopathological examination of the prepared sections, we found lobule-restricted, non-caseous granulomas

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2018 European journal of breast health

9. Granulomatous Mastitis Concurrence with Breast Cancer (PubMed)

Granulomatous Mastitis Concurrence with Breast Cancer Idiopathic Granulomatous Mastitis (IGM) is a rare, chronic, non-malignant and non-life-threatening breast disease. IGM may mimic carcinoma of the breast. This case report is about concurrence of chronic granulomatous mastitis with breast cancer. The important aspect of this case is that it is the 4th case where IGM and breast cancer are present concurrently.

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2018 European journal of breast health

10. Scoring Idiopathic Granulomatous Mastitis: An Effective System for Predicting Recurrence? (PubMed)

Scoring Idiopathic Granulomatous Mastitis: An Effective System for Predicting Recurrence? Idiopathic granulomatous mastitis is a breast disease without a definitive etiology. There are no definitive classifications, scoring systems or certitudes. The aim of this study is to define the factors related to the recurrence and design a scoring system.Patients who were admitted to the general surgery department with symptoms of granulomatous mastitis were evaluated by ultrasonography and underwent (...) antibiotic therapy. Granulomatous mastitis is diagnosed by core biopsy and treated with steroid therapy. Patients without improvement underwent surgery and were included in the study. In total, 53 patients were included in the study. There were 8 recurrent cases. Factors related with recurrences were defined.Number of births over 2, duration of lactation more than 18 months, body mass index greater than 31, having fistula in physical examination, abscess collection in ultrasonographic examination

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2018 European journal of breast health

11. Efficacy of cefquinome and a combination of cloxacillin and ampicillin for treatment of dairy cows with Streptococcus agalactiae subclinical mastitis. (PubMed)

Efficacy of cefquinome and a combination of cloxacillin and ampicillin for treatment of dairy cows with Streptococcus agalactiae subclinical mastitis. A randomized clinical trial was conducted to assess efficacy of intramammary cloxacillin and ampicillin (CLOXIMM), intramammary cefquinome (CEFIMM), and intramuscular cefquinome (CEFIM) to treat Streptococcus agalactiae intramammary infections (Trial 1). Subsequently, two treatment groups were extended to assess whether CLOXIMM was not inferior (...) of traditional IMM drugs (cloxacillin and ampicillin) to treat S. agalactiae subclinical mastitis.

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2019 PLoS ONE

12. Idiopathic granulomatous mastitis: dilemmas in diagnosis and treatment (PubMed)

Idiopathic granulomatous mastitis: dilemmas in diagnosis and treatment Idiopathic granulomatous mastitis (IGM) is a benign rare inflammatory disease of the breast. Due to its uncommon etiology, diagnosis and treatment is still unknown. Selection of a standard method for diagnosing idiopathic granulomatous mastitis is sophisticated. In view of non-definitive clinical and imaging finding, histopathology is the cornerstone of definitive diagnosis.To determine and help solve the dilemma (...) ) months.According to our findings, histopathology of the disease is fundamental for correct diagnosis. Steroid therapy as a therapeutic method such as prednisolone was an effective and applicable choice in the treatment of idiopathic granulomatous mastitis by decreasing in inflammation.

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2017 Electronic physician

13. Chronic Mastitis in Egypt and Morocco: differentiating between idiopathic granulomatous mastitis and IgG4-related disease (PubMed)

Chronic Mastitis in Egypt and Morocco: differentiating between idiopathic granulomatous mastitis and IgG4-related disease Idiopathic granulomatous mastitis (IGM) is a benign, frequently severe chronic inflammatory lesion of the breast. Its etiology remains unknown and reported cases vary in their presentation and histologic findings with an optimal treatment algorithm yet to be described owing mainly to the disease's heterogeneity. IgG4-related disease (IgG4-RD) is a newly recognized systemic (...) fibroinflammatory condition characterized by a dense lymphoplasmacytic infiltrate with many IgG4-positive plasma cells, storiform fibrosis, and obliterative phlebitis. Immunosuppressive therapy is considered to be an effective first-line therapy for IgG4-RD. We sought to clarify and classify chronic mastitis according to the histologic findings of IgG4-RD mastitis with respect to IGM and to develop a robust diagnostic framework to help select patients for optimal treatment strategies. Using the largest

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2016 The breast journal

14. The effect of individual quarter dry-off in management of subclinical mastitis on udder condition and milk production in organic dairy herds: A randomized field trial. (PubMed)

The effect of individual quarter dry-off in management of subclinical mastitis on udder condition and milk production in organic dairy herds: A randomized field trial. The objective of the study was to evaluate the effect of individual quarter dry-off in management of subclinical mastitis on clinical development, behavior during milking, and short-term production loss. The study was conducted as a controlled randomized trial in 5 commercial organic dairy herds. Seventy cows meeting (...) the inclusion criteria were randomly allocated to 1 of 2 treatments: individual quarter dry-off (QDO) or continued milking. The inclusion criteria constituted an increase in somatic cell count from below to above 400,000 cells/mL at milk recording and identification of a quarter scoring of at least 3 and higher than the remaining quarters at California mastitis testing (scale 1-5). Quarters were evaluated clinically for atrophy, swelling, firmness, signs of pain, and milk leakage, and rectal temperature

2019 Journal of dairy science

15. Evaluation of milk sample fractions for characterization of milk microbiota from healthy and clinical mastitis cows. (PubMed)

Evaluation of milk sample fractions for characterization of milk microbiota from healthy and clinical mastitis cows. Amplicon sequencing technique has been increasingly applied to the clinical setting as a sensitive diagnostic tool. Therefore, it is of great importance to develop a DNA extraction method that accurate isolates DNA from complex host-associated microbiota. Given the multifactorial etiology of clinical mastitis and the diversified lifestyle of bacterial species harboring in milk (...) , here four distinct milk sample fractions: raw whole milk, milk fat, casein-pellet, and casein-pellet + fat from healthy cows and cows with clinical mastitis, were subjected to bead-beating DNA extraction, followed by high-throughput sequencing. We aimed to identify the best approach for characterization of the milk microbiota and detection of mastitis pathogens (Klebsiella spp., Streptococcus spp. and Escherichia coli). DNA from each milk fraction tested was extracted by two commercial kits, which

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2018 PLoS ONE

16. Ductal Lavage for Patients With Nonlactational Mastitis: A Single-Arm, Proof-of-Concept Trial. (PubMed)

Ductal Lavage for Patients With Nonlactational Mastitis: A Single-Arm, Proof-of-Concept Trial. Surgery, steroids, and/or observations alone have been proposed for patients with nonlactational mastitis (NLM), but most of these studies were retrospective. The optimal treatment for these patients remains unclear. This prospective, single-arm, proof-of-concept trial aimed to evaluate the feasibility and safety of ductal lavage as a novel treatment for patients with NLM.Eligible patients with NLM (...) ). There were 21 (65.6%), 4 (12.5%), and 7 (21.9%) patients diagnosed as idiopathic granulomatous mastitis, periductal mastitis, and unspecific NLM, respectively. During the ductal lavage, the median (range) number of cannulated ducts at first attempt was 5 (3-8). Ductal lavage significantly reduced the visual analog score and mastitis score (M-score) (P < 0.01). Within a median follow-up of 15.6 mo, 93.8% (30/32) of patients achieved CR. The median (range) time to CR was 6 (0.5-21) mo. Three patients (10.0

2019 The Journal of surgical research

17. Therapeutic effect of ginsenoside Rg1 on mastitis experimentally induced by lipopolysaccharide in lactating goats. (PubMed)

Therapeutic effect of ginsenoside Rg1 on mastitis experimentally induced by lipopolysaccharide in lactating goats. Escherichia coli is a cause of subclinical and clinical mastitis in dairy cattle and goats, and sometimes causes severe clinical disease that may result in death of the animal. Previous investigation showed that ginsenoside Rg1 extracted from Panax ginseng C.A. Meyer (Araliaceae) has an anti-inflammatory effect on the sepsis induced by E. coli lipopolysaccharide via competitive (...) binding to toll-like receptor 4. We hypothesized that intravenous injection of Rg1 had therapeutic effect on mastitis experimentally induced by intramammary infusion of lipopolysaccharide in lactating goats. In this study, 9 lactating goats were randomly assigned to 1 of the 3 groups: (1) lipopolysaccharide intramammary infusion + saline intravenous injection, (2) lipopolysaccharide intramammary infusion + Rg1 intravenous injection, and (3) saline intramammary administration + saline intravenous

2019 Journal of dairy science

18. Key CMM Combinations in Prescriptions for Treating Mastitis and Working Mechanism Analysis Based on Network Pharmacology. (PubMed)

Key CMM Combinations in Prescriptions for Treating Mastitis and Working Mechanism Analysis Based on Network Pharmacology. Using both data mining and network pharmacology methods, this paper aims to construct a molecule-target-disease network for medicines used for treating mastitis, mine out targets, and signaling pathways related to mastitis and explore the mechanism of Chinese materia medica (CMM) prescriptions in treating mastitis.A total of 131 CMM prescriptions for treating mastitis were (...) collected from clinical practice and related literatures. A database of prescriptions for treating mastitis (DPTM) was then constructed. Based on data mining method, Traditional Chinese Medicine Inheritance Support System (TCMISS) was employed to mine out high-frequency CMM and key CMM combinations in DPTM. Subsequently, TCM Systems Pharmacology Database and Analysis Platform (TCMSP) and Traditional Chinese Medicine Information Database (TCM-ID) were searched for the targets of ingredients of high

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2019 Evidence-based Complementary and Alternative Medicine (eCAM)

19. Corynebacterium kroppenstedtii: a challenging culprit in breast abscesses and granulomatous mastitis. (PubMed)

Corynebacterium kroppenstedtii: a challenging culprit in breast abscesses and granulomatous mastitis. Corynebacterium kroppenstedtii is a difficult pathogen associated with granulomatous mastitis and recurrent breast abscesses. Despite over a dozen studies, there is no guidance on surgical interventions, steroid use, or dosing or duration of antibiotic treatment.Initially seen in predominantly Maori and Pacific Islander multiparous, postlactating women, C. kroppenstedtii breast infection has (...) since been reported throughout the world, including in nulliparous women. Additionally, emerging data suggest that hyperprolactinemia is a modifiable risk factor for these infections. This article reviews a patient case and data from 87 other cases to compile current best practices for diagnosis, treatment, and monitoring, and provides areas for future study.In cases of granulomatous mastitis and breast abscess, especially if recurrent, infection with C. kroppenstedtii should be considered

2019 Current Opinion in Obstetrics and Gynecology

20. Effective Treatment of Bovine Mastitis with Intramammary Infusion of <i>Angelica dahurica</i> and <i>Rheum officinale</i> Extracts. (PubMed)

Effective Treatment of Bovine Mastitis with Intramammary Infusion of Angelica dahurica and Rheum officinale Extracts. Mastitis in dairy cattle is a highly prevalent infectious disease, causing considerable economic loss worldwide. In this study, we used Angelica dahurica and Rheum officinale extracts (designated as Yi-Xiong-Tang, YXT) for mastitis treatment. California mastitis test (CMT) was performed and 67 mastitis udder quarters were identified among 179 lactating dairy cows (...) . These 67 mastitis udder quarters were subjected to treatments by intramammary infusion of YXT twice a day for three consecutive days. The mastitis indicators including clots, lactate dehydrogenase (LDH), TNF-α, IL-6, IL-8, and total viable count of bacteria (TVC) in milk were examined before and after the YXT treatment to evaluate its effectiveness. Levels of mastitis indicators from mastitis udder quarters were elevated. After YXT treatment, normal levels of these indicators were restored: TVC, 2.10

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2019 Evidence-based Complementary and Alternative Medicine (eCAM)

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