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Mannheim Peritonitis Index

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1. Mannheim Peritonitis Index (MPI) and elderly population: prognostic evaluation in acute secondary peritonitis (PubMed)

Mannheim Peritonitis Index (MPI) and elderly population: prognostic evaluation in acute secondary peritonitis Acute Secondary Peritonitis due to abdominal visceral perforation is characterized by high mortality and morbidity risk. Risk stratification allows prognosis prediction to adopt the best surgical treatment and clinical care support therapy. In Western countries elderly people represent a significant percentage of population Aim. Evaluation of Mannheim Peritonitis Index (MPI (...) ) and consideration upon old people.Retrospective study on 104 patients admitted and operated for "Acute Secondary Peritonitis due to visceral perforation". MPI was scored. In our study we want to demonstrate efficacy of MPI and the possibility to consider older age an independent prognostic factor.Mortality was 25.96%. Greatest sensitivity and specificity for the MPI score as a predictor of mortality was at the score of 20. MPI score of <16 had 0.15 times lower risk of mortality compared to patients with MPI

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2017 Il Giornale di chirurgia

2. Mannheim Peritonitis Index

Mannheim Peritonitis Index Mannheim Peritonitis Index Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Mannheim Peritonitis Index (...) Mannheim Peritonitis Index Aka: Mannheim Peritonitis Index , Clinical Scoring System to Predict Mortality in Peritonitis II. Criteria: Tally scores of positive criteria Organ Failure: 7 Diffuse peritonitis: 6 Age older than 50 years old: 5 Female gender: 5 Malignancy: 4 Non-colonic origin: 4 Preoperative duration of peritonitis: 4 Exudate Fecal: 12 Cloudy or purulent: 6 Clear: 0 III. Interpretation Score 0-5: 0% Mortality Score 6-13: 20% Mortality Score 14-21: 13% Mortality Score 22-29: 26% Mortality

2018 FP Notebook

3. Mannheim Peritonitis Index

Mannheim Peritonitis Index Mannheim Peritonitis Index Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Mannheim Peritonitis Index (...) Mannheim Peritonitis Index Aka: Mannheim Peritonitis Index , Clinical Scoring System to Predict Mortality in Peritonitis II. Criteria: Tally scores of positive criteria Organ Failure: 7 Diffuse peritonitis: 6 Age older than 50 years old: 5 Female gender: 5 Malignancy: 4 Non-colonic origin: 4 Preoperative duration of peritonitis: 4 Exudate Fecal: 12 Cloudy or purulent: 6 Clear: 0 III. Interpretation Score 0-5: 0% Mortality Score 6-13: 20% Mortality Score 14-21: 13% Mortality Score 22-29: 26% Mortality

2015 FP Notebook

4. Hartmann's Procedure or Primary Anastomosis for Generalized Peritonitis due to Perforated Diverticulitis: A Prospective Multicenter Randomized Trial (DIVERTI)

on an intention-to-treat basis. The primary end point was mortality rate at 18 months. Secondary outcomes were postoperative complications, operative time, length of hospital stay, rate of definitive stoma, and morbidity.All 102 patients enrolled were comparable for age (p = 0.4453), sex (p = 0.2347), Hinchey stage III vs IV (p = 0.2347), and Mannheim Peritonitis Index (p = 0.0606). Overall mortality did not differ significantly between HP (7.7%) and PA (4%) (p = 0.4233). Morbidity for both resection (...) Hartmann's Procedure or Primary Anastomosis for Generalized Peritonitis due to Perforated Diverticulitis: A Prospective Multicenter Randomized Trial (DIVERTI) About 25% of patients with acute diverticulitis require emergency intervention. Currently, most patients with diverticular peritonitis undergo a Hartmann's procedure. Our objective was to assess whether primary anastomosis (PA) with a diverting stoma results in lower mortality rates than Hartmann's procedure (HP) in patients

2017 EvidenceUpdates

5. Delayed Small-Bowel Anastomosis in Patients With Postoperative Peritonitis

provided by (Responsible Party): Andrey Nikolayevich Zharikov, Altai State Medical University Study Details Study Description Go to Brief Summary: Surgical management results for 114 patients with postoperative peritonitis due to small-bowel perforations, necrosis, and anastomotic leakage were comparatively analyzed. Using the APACHE-II (Acute Physiology, Age, Chronic Health Evaluation) and MPI (Mannheim Peritonitis Index) scoring systems, different surgical approaches were examined in three patient (...) -II (Acute Physiology, Age, Chronic Health Evaluation) and MPI (Mannheim Peritonitis Index) scores, and different surgical approaches were applied to the groups: group I underwent resection of the small intestine to place primary anastomosis; group II was subjected to resection of the small intestine to place delayed anastomosis; and group III went through resection of the small intestine with enterostomy. The surgeon used minimization (including a random element) and stratification by gender, age

2018 Clinical Trials

6. Efficacy and Safety of Rheosorbilact® Solution for Infusion, in a Complex Therapy of Peritonitis

of dysfunction or failure. The MODS score ranges from 0 to 24 points. We evaluate initial MODS score and differences between subsequent scores (MODS scores). A change in the total MPI score vs. baseline score upon admission [ Time Frame: Will be evaluated for the duration of Intensive Care Unit (ICU) stay, at screening (Day 0) and Visit 3 (Day 3) of ICU stay. ] MPI (Mannheim Peritonitis Index) scoring system for predicting the mortality in patients with peritonitis based on analysis of 8 possible risks (...) ) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Male and female aged 18 to 60 years inclusive Purulent peritonitis in two or more anatomical parts of the abdominal cavity diagnosed according to Mannheim Peritonitis Index (MPI) Score from 21 to 29 (no later than 24 hours after primary laparotomy and revision of the abdominal cavity). Informed consent for participation in the study signed by subject's own hand. The baseline value of the SOFA scale ≥ 2 points

2018 Clinical Trials

7. Personalised Medicine With Pentaglobin® Compared With Standard of Care for Treatment of Peritonitis After Infectious Source Control

course of the biomarkers (PCT, IL 6, HLA DR, ADM, Immuneglobulins M, G, A), the SOFA score, the Mannheim Peritonitis Index, the surrogate variables for organ dysfunction and survival according to Heyland et al. 2011 and vital signs. Influence of the biomarkers NF kB1, ADM and pathogen spectrum upon the outcome for the patient. Comparison of the MOF score with other scores, such as the SOFA score, for assessment of organ dysfunction. Study Design Go to Layout table for study information Study Type (...) Simon, Dr. med. Sponsors and Collaborators RWTH Aachen University Biotest Investigators Layout table for investigator information Principal Investigator: Gernot Marx, Prof. Dr. RWTH Aachen University More Information Go to Publications: Kujath P., Rodloff Peritonitis UNI-MED, 2001 ISBN 3-8999-549-5 Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number): Layout table for additonal information Responsible Party: RWTH Aachen University ClinicalTrials.gov

2017 Clinical Trials

8. Hartmann's Procedure or Primary Anastomosis for Generalized Peritonitis due to Perforated Diverticulitis: A Prospective Multicenter Randomized Trial (DIVERTI). (PubMed)

on an intention-to-treat basis. The primary end point was mortality rate at 18 months. Secondary outcomes were postoperative complications, operative time, length of hospital stay, rate of definitive stoma, and morbidity.All 102 patients enrolled were comparable for age (p = 0.4453), sex (p = 0.2347), Hinchey stage III vs IV (p = 0.2347), and Mannheim Peritonitis Index (p = 0.0606). Overall mortality did not differ significantly between HP (7.7%) and PA (4%) (p = 0.4233). Morbidity for both resection (...) Hartmann's Procedure or Primary Anastomosis for Generalized Peritonitis due to Perforated Diverticulitis: A Prospective Multicenter Randomized Trial (DIVERTI). About 25% of patients with acute diverticulitis require emergency intervention. Currently, most patients with diverticular peritonitis undergo a Hartmann's procedure. Our objective was to assess whether primary anastomosis (PA) with a diverting stoma results in lower mortality rates than Hartmann's procedure (HP) in patients

2017 Journal of the American College of Surgeons

9. Hartmann's Procedure or Primary Anastomosis for Generalized Peritonitis due to Perforated Diverticulitis: A Prospective Multicenter Randomized Trial (DIVERTI). (PubMed)

on an intention-to-treat basis. The primary end point was mortality rate at 18 months. Secondary outcomes were postoperative complications, operative time, length of hospital stay, rate of definitive stoma, and morbidity.All 102 patients enrolled were comparable for age (p = 0.4453), sex (p = 0.2347), Hinchey stage III vs IV (p = 0.2347), and Mannheim Peritonitis Index (p = 0.0606). Overall mortality did not differ significantly between HP (7.7%) and PA (4%) (p = 0.4233). Morbidity for both resection (...) Hartmann's Procedure or Primary Anastomosis for Generalized Peritonitis due to Perforated Diverticulitis: A Prospective Multicenter Randomized Trial (DIVERTI). About 25% of patients with acute diverticulitis require emergency intervention. Currently, most patients with diverticular peritonitis undergo a Hartmann's procedure. Our objective was to assess whether primary anastomosis (PA) with a diverting stoma results in lower mortality rates than Hartmann's procedure (HP) in patients

2017 Journal of the American College of Surgeons

10. Scoring Systems for Outcome Prediction of Patients with Perforation Peritonitis (PubMed)

Scoring Systems for Outcome Prediction of Patients with Perforation Peritonitis Peritonitis continues to be one of the major infectious problems confronting a surgeon. Mannheim Peritonitis Index (MPI), Physiological and Operative Severity Score for en Umeration of Mortality (POSSUM) and Morbidity and sepsis score of Stoner and Elebute have been devised for risk assessment and for prediction of postoperative outcome.The aim of this study was to find the accuracy of these scores in predicting (...) outcome in terms of mortality in patients undergoing exploratory laprotomy for perforation peritonitis.The prospective study was carried out in 100 diagnosed cases of perforation at our centre in a single unit over a period of 21 months from December 2012 to August 2014. Study was conducted on all cases of peritonitis albeit primary, tertiary, iatrogenic and those with age less than 12 years were excluded from the study. All the relevant data were collected and three scores were computed from one set

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2016 Journal of clinical and diagnostic research : JCDR

11. Plasma and peritoneal fluid population pharmacokinetics of micafungin in post-surgical patients with severe peritonitis. (PubMed)

score and Mannheim peritonitis index were 72 (43-85) years, 15 (11-36) and 26 (8-37), respectively. On day 1, median (SD) penetration of micafungin into the peritoneal cavity was 30% (30%-40%). A three-compartment model adequately described the data. The mean (SD) estimates for clearance and volume of distribution of the central compartment were 1.27 (0.75) L/h and 9.26 (1.11) L, respectively. In most patients, the PTA in plasma was ≥ 90% for MICs of 0.008-0.016 mg/L for Candida spp. and 0.125-0.25 (...) Plasma and peritoneal fluid population pharmacokinetics of micafungin in post-surgical patients with severe peritonitis. Limited information about the pharmacokinetics of micafungin in the peritoneal cavity is available. The aim of this study was to explore the pharmacokinetics/pharmacodynamics of micafungin in plasma and peritoneal fluid in post-surgical critically ill patients with proven or suspected intra-abdominal fungal infection.Patients were administered 100 mg/day micafungin. Serial

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2015 Journal of Antimicrobial Chemotherapy

12. Prognostic scoring systems-validation and their utility in patients with abdominal sepsis in colon peritonitis (PubMed)

. The prognostic CR-POSSUM scores and Mannheim peritonitis index were calculated by using data from observation sheets. There have been a number of deaths and overall mortality was calculated.There were 58 patients with abdominal sepsis, hospitalized and operated, registering a 17.24% mortality rate. Time from admission until the time of operation was divided between up to 24 hours and over 24 hours, recording 27 (46.55%) cases operated <24 hours and 31 (53, 45%) of patients operated> for 24 hours. Operative (...) severity scores were calculated by taking into account data provided by each surgeon on intraoperative appearance.The results of this study demonstrated that both CR-POSSUM score and Mannheim have a prognostic value for patients with abdominal sepsis in colonic peritonitis, both being surgery scores.

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2014 Journal of medicine and life

13. Elimination of Peritoneal Tumor Cells With Extensive Peritoneal Lavage During Surgery in Patients With Gastric Cancer

Mannheim, Department of Surgery More Information Go to Publications: Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number): Layout table for additonal information Responsible Party: Ulrich Ronellenfitsch, MD, Principal Investigator, Universitätsmedizin Mannheim ClinicalTrials.gov Identifier: Other Study ID Numbers: UMM-EIPL First Posted: November 22, 2011 Last Update Posted: May 2, 2017 Last Verified: May 2017 Keywords provided by Ulrich Ronellenfitsch, MD (...) , Universitätsmedizin Mannheim: gastric cancer extensive intraperitoneal lavage EIPL intraperitoneal tumor cells peritoneal carcinomatosis Additional relevant MeSH terms: Layout table for MeSH terms Adenocarcinoma Stomach Neoplasms Carcinoma Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Gastrointestinal Neoplasms Digestive System Neoplasms Neoplasms by Site Digestive System Diseases Gastrointestinal Diseases Stomach Diseases

2011 Clinical Trials

14. Pancreatic Stone Protein Predicts Outcome in Patients With Peritonitis in the ICU. (PubMed)

Pancreatic Stone Protein Predicts Outcome in Patients With Peritonitis in the ICU. To determine the value of pancreatic stone protein in predicting sepsis-related postoperative complications and death in the ICU.A prospective cohort study of postoperative patients admitted to the ICU. Blood samples for analysis were taken within 3 hours from admission to the ICU including pancreatic stone protein, white blood cell counts, C-reactive protein, interleukin-6, and procalcitonin. The Mannheim (...) Peritonitis Index and Acute Physiology and Chronic Health Evaluation II clinical scores were also determined. Univariate and multivariate analyses were performed to determine the diagnostic accuracy and independent predictors of death in the ICU [Clinicaltrials.gov, NCT01465711].An adult medical-surgical ICU in a teaching hospital in Germany.Ninety-one consecutive postoperative patients with proven diagnosis of secondary peritonitis admitted to the ICU were included in the study from August 17, 2007

2013 Critical Care Medicine

15. Primary anastomosis vs nonrestorative resection for perforated diverticulitis with peritonitis: a prematurely terminated randomized controlled trial. (PubMed)

PRA patients were comparable to 56 nonrestorative colon resection patients for age (P = 0.481), gender (P = 0.190), APACHE III (P = 0.281), Hinchey stage III vs IV (P = 0.394) and Mannheim Peritonitis Index (P = 0.145). There were no differences in operating time (P = 0.231), surgeries performed at night (P = 0.083), open vs laparoscopic approach (P = 0.419) and litres of peritoneal irrigation (P = 0.096). There was no significant difference in mortality (2.9 vs 10.7%; P = 0.247) and morbidity (...) Primary anastomosis vs nonrestorative resection for perforated diverticulitis with peritonitis: a prematurely terminated randomized controlled trial. This randomized controlled trial (RCT) was performed to test the hypothesis that adverse event rates following primary anastomosis (PRA) are not inferior to those following nonrestorative colon resection for perforated diverticulitis with peritonitis.Patients admitted for perforated diverticulitis with peritonitis were randomly assigned to PRA

2012 Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

16. Prospective Comparison of Primary Abdominal Closure and Vacuum Assisted Laparostomy in Treatment of Severe Peritonitis

Volunteers: No Criteria Inclusion Criteria: patients indicated for urgent surgery for suspected acute abdomen with severe peritonitis (meet SIRS criteria or signs of diffuse peritoneal irritation) the diagnose of severe peritonitis is confirmed intraoperatively (Mannheim Peritonitis Index - MPI > 25) patient agrees with inclusion to the study Exclusion Criteria: patients aged < 18 and > 80 years patients with not expected survival longer than 48 hours after surgery patients with different peroperative (...) Prospective Comparison of Primary Abdominal Closure and Vacuum Assisted Laparostomy in Treatment of Severe Peritonitis Prospective Comparison of Primary Abdominal Closure and Vacuum Assisted Laparostomy in Treatment of Severe Peritonitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2012 Clinical Trials

17. Gastrointestinal Stromal Tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

Cancer Institute, Amsterdam and Department of Radiotherapy, Leiden University Medical Centre, Leiden, The Netherlands; 25 Turku University Hospital (Turun Yliopistollinen Keskussairaala), Turlu, Finland; 26 Oxford University Hospitals NHS Foundation Trust, Oxford, UK; 27 Mannheim University Medical Center, Mannheim; 28 Department of Medicine III, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany; 29 Helsinki University Central Hospital (HUCH), Helsinki, Finland; 30 Royal (...) the surgeon to plan the best approach according to the histological diagnosis and avoid sur- gery for diseases which might not bene?t (e.g. lymphomas, mes- enteric ?bromatosis and germ cell tumours). The risk of peritoneal contamination is negligible if the procedure is prop- erly carried out. Moreover, lesions at risk in this regard (e.g. cystic masses) should be biopsied only in specialised centres. Immediate laparoscopic/laparotomic excision is an option on an individualised basis, especially

2018 European Society for Medical Oncology

18. Management of Intra-Abdominal Infection : guidelines by the Surgical Infection Society

ischemia (Grade 1-B). • Do not use routine planned re-laparotomy in higher-risk patients with severe peritonitis when adequate source control can be obtained at the time of the index procedure; treat such patients with on-demand rather than scheduled re-laparotomy (Grade 1-B). • Irrigate with crystalloid fluid to remove visible debris and gross contamination before abdominal closure in patients undergoing laparotomy for IAI, generally limiting lavage to those areas with gross involvement (Grade 2-B). 3 (...) ). Consider patients with at least two physiologic/phenotypic risk factors for an adverse outcome, those having diffuse peritonitis, and those having delayed or inadequate source control as potential higher-risk patients (Grade 2-B). • Identify patients who have been hospitalized for at least 48 hours during the previous 90 days; those residing in a skilled nursing or long-term care facility during the previous 30 days; those who have received intravenous (IV) infusion therapy, wound care, or renal

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2016 Surgical Infection Society

19. Multicentre international trial of laparoscopic lavage for Hinchey III acute diverticulitis (LLO Study). (PubMed)

international study included consecutive patients from 24 centres who underwent laparoscopic lavage from 2005 to 2015.A total of 404 patients were included, 231 of whom had Hinchey III acute diverticulitis. Sepsis control was achieved in 172 patients (74·5 per cent), and was associated with lower Mannheim Peritonitis Index score and ASA grade, no evidence of free perforation, absence of extensive adhesiolysis and previous episodes of diverticulitis. The operation was immediately converted to open surgery (...) Multicentre international trial of laparoscopic lavage for Hinchey III acute diverticulitis (LLO Study). Laparoscopic lavage was proposed in the 1990s to treat purulent peritonitis in patients with perforated acute diverticulitis. Prospective randomized trials had mixed results. The aim of this study was to determine the success rate of laparoscopic lavage in sepsis control and to identify a group of patients that could potentially benefit from this treatment.This retrospective multicentre

2018 British Journal of Surgery

20. Is it possible to reduce the surgical mortality and morbidity of peptic ulcer perforations? (PubMed)

in the study, morbidity was observed in 21 (18.8%), mortality in 11 (9.8%), and no complication was observed in 80 (71.4%), who were discharged with cure. The differences between group for the average values of the perforation diameter and American Society of Anesthesiologists, Acute Physiology and Chronic Health Evaluation II, and Mannheim Peritonitis Index scores were statistically significant (p<0.001 for each). The average values for the group with mortality were significantly higher than those (...) of the other groups.In this study where we investigated risk factors for increased morbidity and mortality in PUPs, there was statistically significant difference between the average values for age, body mass index, perforation diameter, and Acute Physiology and Chronic Health Evaluation II and Mannheim Peritonitis Index scores among the three groups, whereas the amount of subdiaphragmatic free air did not differ.

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2017 Turkish Journal of Surgery

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