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Management of Severe Head Injury

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10681. Trends in head injury outcome from 1989 to 2003 and the effect of neurosurgical care: an observational study. (Abstract)

guidelines, suggesting that treatment in a neurosurgical centre represents an important strategy in the management of severe head injury. (...) Trends in head injury outcome from 1989 to 2003 and the effect of neurosurgical care: an observational study. Case fatality rates after all types of blunt injury have not improved since 1994 in England and Wales, possibly because not all patients with severe head injury are treated in a neurosurgical centre. Our aims were to investigate the case fatality trends in major trauma patients with and without head injury, and to establish the effect of neurosurgical care on mortality after severe head

2005 Lancet

10682. Injuries to polo riders: a prospective evaluation Full Text available with Trip Pro

sports have injury rates much greater than 8/1000 player-game hours, the severity of most injuries occurring in polo was classified as major, with fractures and facial lacerations common. The use of a helmet with a face protector is recommended to decrease injury to players. A doctor experienced in the management of serious trauma should be present at all polo matches. (...) Injuries to polo riders: a prospective evaluation To assess prospectively the incidence, nature, and severity of injuries to polo riders competing in the 1996 Argentine High Polo season.Assessment, documentation, and provision of care for all injuries sustained during the 1996 season by one of the authors. Riders were also surveyed retrospectively for their previous polo injuries.34 riders took part in the study. Nine injuries were sustained prospectively and 55 injuries were reviewed

1999 British Journal of Sports Medicine

10683. Can you tell me how long a patient should refrain from contact and non contact sports following a head injury, both minor and with a history of loss of consciousness?

injury [2] which could be of interest. This discusses grades of severity and the ramifications for sport. This can be read via the URL below. This is based on the American Academy of Neurology guidance [3], which again might be of interest. We’ve reproduced the main summary table below: References 1) 2) 3) Answered 3 March 2008 Follow us: © 2019 Trip Database Ltd. company number 04316414. Trip is proud to be made in the UK. (...) Can you tell me how long a patient should refrain from contact and non contact sports following a head injury, both minor and with a history of loss of consciousness? Can you tell me how long a patient should refrain from contact and non contact sports following a head injury, both minor and with a history of loss of consciousness? - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere

2008 TRIP Answers

10684. Ventilatory management of acute lung injury and acute respiratory distress syndrome. Full Text available with Trip Pro

Ventilatory management of acute lung injury and acute respiratory distress syndrome. The acute lung injury and acute respiratory distress syndrome are critical illnesses associated with significant morbidity and mortality. Mechanical ventilation is the cornerstone of supportive therapy. However, despite several important advances, the optimal strategy for ventilation and adjunctive therapies for patients with acute lung injury and acute respiratory distress syndrome is still evolving.To (...) identify reports of invasive ventilatory and adjunctive therapies in adult patients with acute lung injury and acute respiratory distress syndrome, we performed a systematic English-language literature search of MEDLINE (1966-2005) using the Medical Subject Heading respiratory distress syndrome, adult, and related text words, with emphasis on randomized controlled trials and meta-analyses. EMBASE and the Cochrane Central Register of Controlled Trials were similarly searched. The search yielded 1357

2005 JAMA

10685. Review: mild induced hypothermia does not reduce mortality or severe disability in moderate to severe head injury Full Text available with Trip Pro

Review: mild induced hypothermia does not reduce mortality or severe disability in moderate to severe head injury Review: mild induced hypothermia does not reduce mortality or severe disability in moderate to severe head injury | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username (...) and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: mild induced hypothermia does not reduce mortality or severe disability in moderate to severe head injury Article Text Treatment Review: mild induced

2006 Evidence-Based Nursing

10686. Cerebral Hemodynamic Effects of Hypertonic Solutions in Severely Head-Injured Patients

Cerebral Hemodynamic Effects of Hypertonic Solutions in Severely Head-Injured Patients Cerebral Hemodynamic Effects of Hypertonic Solutions in Severely Head-Injured Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Cerebral Hemodynamic Effects of Hypertonic Solutions in Severely Head-Injured Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00125229 Recruitment Status : Terminated (Dr. Hladky died Sept 2006 prior to study completion) First Posted : July 29, 2005 Last Update Posted

2005 Clinical Trials

10687. Thiopental-induced neutropenia in two patients with severe head trauma. (Abstract)

Thiopental-induced neutropenia in two patients with severe head trauma. Thiopental has been used for decades in the treatment of refractory intracranial hypertension in patients with traumatic and nontraumatic head injuries. Commonly reported adverse effects include hypotension, hypokalemia, respiratory complications, and hepatic dysfunction. Neutropenia has rarely been reported as an adverse effect of thiopental. We witnessed probable thiopental-induced neutropenia in two patients (...) with traumatic brain injuries who developed increased intracranial hypertension that was refractory to standard therapy. Based on a MEDLINE search of published case reports and literature, we propose two mechanisms by which thiopental-related neutropenia might be explained. The first is inhibition of inflammatory mediator nuclear factor-kappa B (NF-kappa B), leading to granulocyte apoptosis. The second mechanism involves inhibition of calcineurin. Although the precise link between these two mechanisms has

2007 Pharmacotherapy

10688. Intravascular cooling for rapid induction of moderate hypothermia in severely head-injured patients: results of a multicenter study (IntraCool). (Abstract)

Intravascular cooling for rapid induction of moderate hypothermia in severely head-injured patients: results of a multicenter study (IntraCool). To evaluate the feasibility, safety and effectiveness of a new method of intravascular temperature management for inducing moderate hypothermia (MHT).Prospective, international-multicenter clinical trial conducted in four university hospitals.In a 2-year period 24 patients with severe head injury and refractory high ICP were treated with MHT (32.5 (...) degrees C) by intravascular methods.Seventeen were males and seven females, with a median age of 25 years (range 15-60). The median Glasgow Coma Scale upon admission was 7 (range 3-13) and the median Injury Severity Score was 22 (range 13-43). A total of 75% of patients presented a diffuse lesion in the pre-enrollment computed tomography. Median time from injury until reaching refractory high ICP was 71.5 h after injury (minimum 14 h, maximum 251 h). Twelve patients (50%) reached this situation within

2008 Intensive Care Medicine

10689. Cerebral hemodynamic responses to blood pressure manipulation in severely head-injured patients in the presence or absence of intracranial hypertension. (Abstract)

Cerebral hemodynamic responses to blood pressure manipulation in severely head-injured patients in the presence or absence of intracranial hypertension. The management of cerebral perfusion pressure (CPP) remains a controversial issue in the critical care of severely head-injured patients. Recently, it has been proposed that the state of cerebrovascular autoregulation should determine individual CPP targets. To find optimal perfusion pressure, we pharmacologically manipulated CPP in a range (...) of 51 mm Hg (median; 25th-75th percentile, 48-53 mm Hg) to 108 mm Hg (102-112 mm Hg) on Days 0, 1, and 2 after severe head injury in 13 patients and studied the effects on intracranial pressure (ICP), autoregulation capacity, and brain tissue partial pressure of oxygen. Autoregulation was expressed as a static rate of regulation for 5-mm Hg CPP intervals based on middle cerebral artery flow velocity. When ICP was normal (26 occasions), there were no major changes in the measured variables when CPP

2004 Anesthesia and Analgesia

10690. The eighth wonder of the world: the mythology of concussion management Full Text available with Trip Pro

The eighth wonder of the world: the mythology of concussion management 10205701 1999 06 09 2018 11 13 0306-3674 33 2 1999 Apr British journal of sports medicine Br J Sports Med The eighth wonder of the world: the mythology of concussion management. 136-7 McCrory P P Olympic Park Sports Medicine Centre, Melbourne, Australia. eng Journal Article England Br J Sports Med 0432520 0306-3674 IM Athletic Injuries complications diagnosis prevention & control therapy Brain Concussion complications (...) diagnosis prevention & control therapy Brain Edema etiology Cognition Disorders etiology Epilepsy, Post-Traumatic etiology Guidelines as Topic Humans Injury Severity Score Memory physiology Recurrence Risk Factors Sports Unconsciousness physiopathology 1999 4 17 1999 4 17 0 1 1999 4 17 0 0 ppublish 10205701 PMC1756145 Lancet. 1975 Nov 22;2(7943):995-7 53547 Am J Public Health. 1983 Dec;73(12):1370-5 6638230 J Neurol Neurosurg Psychiatry. 1990 Apr;53(4):293-6 2341842 Sports Med. 1992 Jul;14(1):64-74

1999 British Journal of Sports Medicine

10691. The role of hypothermia in the management of severe brain injury: a meta-analysis

of hypothermia in the management of severe head injury, compared with normothermia, were eligible for inclusion. In the included studies, the temperature of hypothermia ranged from 32 to 35 degrees C and the duration of hypothermia was between 24 hours and 14 days. The time to target temperature, where reported, ranged from 8 to 15 hours post-injury and the rewarming schedule varied between 12 hours and 5 days. Participants included in the review Studies of participants aged 10 years or older with post (...) the use of hypothermia in the management of severe head injury. CRD commentary The review question and inclusion criteria were clearly defined. Several electronic databases and other relevant sources were used in the search for primary studies. Two reviewers worked independently and were blinded to some study details, which should have minimised the introduction of errors and bias during the study selection and data extraction processes. Sufficient details of the primary studies were provided

2002 DARE.

10692. Hypertonic Saline With Dextran for Treating Hypovolemic Shock and Severe Brain Injury

Hypertonic Saline With Dextran for Treating Hypovolemic Shock and Severe Brain Injury Hypertonic Saline With Dextran for Treating Hypovolemic Shock and Severe Brain Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Hypertonic Saline With Dextran for Treating Hypovolemic Shock and Severe Brain Injury The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00113685 Recruitment Status : Completed First Posted : June 10, 2005 Last Update Posted : February 9, 2016 Sponsor: University of Washington Collaborator

2005 Clinical Trials

10693. Therapeutic Hypothermia for Severe Traumatic Brain Injury in Japan

Therapeutic Hypothermia for Severe Traumatic Brain Injury in Japan Therapeutic Hypothermia for Severe Traumatic Brain Injury in Japan - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Therapeutic Hypothermia (...) Clinical Research Support Unit(J-CRSU) Information provided by (Responsible Party): Tsuyoshi Maekawa, Yamaguchi University Hospital Study Details Study Description Go to Brief Summary: The purpose of this trial is to determine if mild hypothermia therapy, for severe head trauma patients, improves neurological outcome. Condition or disease Intervention/treatment Phase Brain Injuries, Traumatic Procedure: Therapeutic mild hypothermia Phase 3 Detailed Description: Mild hypothermia therapy shows protective

2005 Clinical Trials

10694. Dexanabinol in Severe Traumatic Brain Injury

Dexanabinol in Severe Traumatic Brain Injury Dexanabinol in Severe Traumatic Brain Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Dexanabinol in Severe Traumatic Brain Injury The safety (...) Trauma Centers with severe head injuries. Bleeding into and swelling of these patients' brains may cause compression of vital structures, disability and death. Sometimes surgery is needed. Unfortunately, the investigators have no medication to treat the bad effects of head trauma. Part of the brain damage is due to toxic chemicals (including one called glutamate) that are released by the damaged nerves. Dexanabinol may prevent some of the bad effects of glutamate on the brain and may protect

2005 Clinical Trials

10695. Hypertonic Resuscitation Following Severe Traumatic Brain Injury (TBI)

Hypertonic Resuscitation Following Severe Traumatic Brain Injury (TBI) Hypertonic Resuscitation Following Severe Traumatic Brain Injury (TBI) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Hypertonic (...) Abbreviated Injury Scores (AIS) Greater Than or Equal to 4 (Head AIS≥4) Assessed to Have Glasgow Outcome Scale-Extended (GOSE)≤4 at 6 Months: Imputed Analysis [ Time Frame: 6 months after injury ] The Abbreviated Injury Scale (AIS) ranks injuries on a scale of 1 to 6, with 1 being minor, 2 moderate, 3 serious, 4 severe, 5 critical and 6 an unsurvivable injury. A priori secondary analyses included the subgroup of participants in each intervention group with a head AIS≥4, which is a diagnostic indicator

2006 Clinical Trials

10696. Intensive Rehabilitation of Patients With Severe Traumatic Brain Injury

Intensive Rehabilitation of Patients With Severe Traumatic Brain Injury Intensive Rehabilitation of Patients With Severe Traumatic Brain Injury - Development of a Didactic Model - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Intensive Rehabilitation of Patients With Severe Traumatic Brain Injury - Development of a Didactic Model The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00419939 Recruitment Status : Completed First Posted : January 9, 2007 Last Update Posted : June 21, 2011 Sponsor: University

2007 Clinical Trials

10697. Effect of Passive Gait Training on the Cortical Activity in Patients With Severe Traumatic Brain Injury.

Effect of Passive Gait Training on the Cortical Activity in Patients With Severe Traumatic Brain Injury. Effect of Passive Gait Training on the Cortical Activity in Patients With Severe Traumatic Brain Injury. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) and oral stimulation develops new connections in the brain and thereby stimulates consciousness and behaviour. Elliot et al shows improvement in level of consciousness due to postural changes from a lying position to a standing posture in 8 of 12 patients using Wessex Head Injury Matrix. Passive movements result in proprioceptive stimulation; the effect of which is close to that achieved by physiological voluntary activity. PET and fMRI studies show that passive movements activate several areas

2007 Clinical Trials

10698. Problems With Morphine Use in Patients With a Severe Brain Injury

Problems With Morphine Use in Patients With a Severe Brain Injury Problems With Morphine Use in Patients With a Severe Brain Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Problems With Morphine Use (...) in Patients With a Severe Brain Injury The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00196131 Recruitment Status : Unknown Verified September 2006 by Dalhousie University. Recruitment status was: Active, not recruiting First Posted : September 20, 2005 Last Update Posted : April 10, 2008 Sponsor

2005 Clinical Trials

10699. Phase II clinical trial of moderate hypothermia after severe traumatic brain injury in children. (Abstract)

stratification by age to moderate HYPO (32-33 degrees C) treatment in conjunction with standardized head injury management versus NORM in a multicenter trial. An additional 27 patients were entered into a parallel single-institution trial of excluded patients because of late transfer or consent (delayed in transfer >6 h but within 24 h of admission), unknown time of injury (e.g., child abuse), and adolescence (e.g., aged 13-18 yr). Assessments of safety included mortality, infection, coagulopathy (...) Phase II clinical trial of moderate hypothermia after severe traumatic brain injury in children. To determine whether moderate hypothermia (HYPO) (32-33 degrees C) begun in the early period after severe traumatic brain injury (TBI) and maintained for 48 hours is safe compared with normothermia (NORM) (36.5-37.5 degrees C).After severe (Glasgow Coma Scale score < or =8) nonpenetrating TBI, 48 children less than 13 years of age admitted within 6 hours of injury were randomized after

2005 Neurosurgery Controlled trial quality: uncertain

10700. Effects of selective brain cooling in patients with severe traumatic brain injury: a preliminary study. Full Text available with Trip Pro

Effects of selective brain cooling in patients with severe traumatic brain injury: a preliminary study. We prospectively investigated non-invasive selective brain cooling (SBC) in patients with severe traumatic brain injury. Sixty-six in-patients were randomized into three groups. In one group, brain temperature was maintained at 33 - 35 degrees C by cooling the head and neck (SBC); in a second group, mild systemic hypothermia (MSH; rectal temperature 33 - 35 degrees C) was produced (...) and control groups, respectively. Complications were managed without severe sequelae. Non-invasive SBC was safe and effective.

2006 The Journal of international medical research Controlled trial quality: uncertain

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