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Management of Severe Head Injury

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10661. Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer

Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies (...) Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details

2000 Clinical Trials

10662. Bevacizumab and Erlotinib in Treating Patients With Recurrent or Metastatic Head and Neck Cancer

Bevacizumab and Erlotinib in Treating Patients With Recurrent or Metastatic Head and Neck Cancer Bevacizumab and Erlotinib in Treating Patients With Recurrent or Metastatic Head and Neck Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) keratopathy, aniridia, severe chemical burns, neutrophilic keratitis) Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception No prior allergic reactions to compounds of similar chemical or biologic composition to bevacizumab or other study agents No known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies No significant traumatic injury within the past 28 days No other concurrent uncontrolled illness No psychiatric

2003 Clinical Trials

10663. Erlotinib Plus Docetaxel in Treating Patients With Locally Advanced, Metastatic, or Recurrent Head and Neck Cancer

Erlotinib Plus Docetaxel in Treating Patients With Locally Advanced, Metastatic, or Recurrent Head and Neck Cancer Erlotinib Plus Docetaxel in Treating Patients With Locally Advanced, Metastatic, or Recurrent Head and Neck Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Erlotinib Plus Docetaxel in Treating Patients With Locally Advanced, Metastatic, or Recurrent Head and Neck Cancer The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00055770 Recruitment Status : Completed First Posted : March 7

2003 Clinical Trials

10664. Salivary Gland Surgery Before Radiation Therapy in Preventing Radiation-Caused Xerostomia in Patients With Head and Neck Cancer

Salivary Gland Surgery Before Radiation Therapy in Preventing Radiation-Caused Xerostomia in Patients With Head and Neck Cancer Salivary Gland Surgery Before Radiation Therapy in Preventing Radiation-Caused Xerostomia in Patients With Head and Neck Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) gland transfer in patients with head and neck cancer. Determine the rate and severity of radiation-induced xerostomia after this surgery in these patients. Determine the pattern of recurrence, disease-free survival, and overall survival of patients treated with this surgery followed by radiotherapy. Determine the quality of life of patients treated with this regimen. OUTLINE: This is a multicenter study. Patients undergo surgical transfer of the submandibular salivary gland to the submental space

2003 Clinical Trials

10665. Iseganan Hydrochloride in Preventing Oral Mucositis in Patients Who Are Undergoing Radiation Therapy for Head and Neck Cancer

Iseganan Hydrochloride in Preventing Oral Mucositis in Patients Who Are Undergoing Radiation Therapy for Head and Neck Cancer Iseganan Hydrochloride in Preventing Oral Mucositis in Patients Who Are Undergoing Radiation Therapy for Head and Neck Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) . It is not yet known if iseganan hydrochloride is effective in preventing oral mucositis. PURPOSE: Randomized phase III trial to determine the effectiveness of iseganan hydrochloride in preventing oral mucositis in patients who are receiving radiation therapy for head and neck cancer. Condition or disease Intervention/treatment Phase Head and Neck Cancer Oral Complications of Radiation Therapy Radiation Toxicity Drug: iseganan HCl oral solution Procedure: management of therapy complications Phase 3 Detailed

2001 Clinical Trials

10666. [Monocular blindness following blunt head trauma]. (Abstract)

[Monocular blindness following blunt head trauma]. An uncommon, devastating complication of blunt head trauma is monocular blindness. We present a 40-year-old man who complained of visual loss in the right eye a few days after minor closed head trauma. Electrophysiologic study (VEP) proved severe damage to the right optic nerve, most probably due to transection of the nerve. Based on the assumption that optic nerve injury might be analogous to spinal cord injury, we used methylprednisolone (...) : a loading dose of 30 mg/kg was followed 2 hours later by 15 mg/kg, which was then given every 6 hours for 48 hours. Surgical decompression of the bony optic canal was not performed. There are no good data to guide our decision-making. A prospective randomized trial is required to provide definitive management guidelines in this severe and dramatic injury.

1993 Harefuah

10667. Minor head trauma in children: an intervention to decrease functional morbidity. (Abstract)

correlated with parental anxiety. In managing children with minor head trauma, pediatricians and emergency department physicians must focus their discharge instructions on the parent's anxiety, emphasize the minor severity of the injury, and urge that the children return to their usual routine. (...) Minor head trauma in children: an intervention to decrease functional morbidity. Minor head trauma is common among children and evokes strong parental reaction. Parents often rush the child to an emergency department or consult their pediatrician by telephone despite the minor nature of the injury. In a previous report we showed that children with minor head trauma appear to have limitations in their usual daily activities and a high rate of school absenteeism. This study was a prospective

1987 Pediatrics Controlled trial quality: uncertain

10668. Head cooling with mild systemic hypothermia in anesthetized piglets is neuroprotective. (Abstract)

Head cooling with mild systemic hypothermia in anesthetized piglets is neuroprotective. Hypothermia is potentially therapeutic in the management of neonatal hypoxic-ischemic brain injury. However, not all studies have shown a neuroprotective effect. It is suggested that the stress of unsedated hypothermia may interfere with neuroprotection. We propose that selective head cooling (SHC) combined with mild total-body hypothermia during anesthesia enhances local neuroprotection while minimizing (...) the occurrence of systemic side effects and stress associated with unsedated whole-body cooling. Our objective was to determine whether SHC combined with mild total-body hypothermia while anesthetized for a period of 24 hours reduces cerebral damage in our piglet survival model of global hypoxia-ischemia. Eighteen anesthetized piglets received a 45-minute global hypoxic-ischemic insult. The pigs were randomized either to remain normothermic or to receive SHC. We found that the severity of the hypoxic

2003 Annals of Neurology

10669. Antiepileptic drug prophylaxis in severe traumatic brain injury

of the American Academy of Neurology Bernard S. Chang , Daniel H. Lowenstein First published January 14, 2003, DOI: https://doi.org/10.1212/01.WNL.0000031432.05543.14 Bernard S. Chang Daniel H. Lowenstein Practice parameter: Antiepileptic drug prophylaxis in severe traumatic brain injury Bernard S. Chang , Daniel H. Lowenstein Neurology Jan 2003, 60 (1) 10-16; DOI: 10.1212/01.WNL.0000031432.05543.14 Citation Manager Formats Make Comment See Comments Downloads 39137 Share Abstract Objective: To review (...) the prophylactic use of antiepileptic drugs (AEDs) in patients with severe traumatic brain injury (TBI). TBI is a common neurologic disorder, accounting for about 1.1 million emergency department visits and one hospitalization per 1,000 people each year in the United States. Among all patients with head trauma who seek medical attention, about 2% develop post-traumatic seizures, although the number varies widely depending primarily on injury severity. About 12% of patients with severe TBI develop post

2003 American Academy of Neurology

10670. Therapy for Reading Problems in Adults After Brain Injury

Therapy for Reading Problems in Adults After Brain Injury Therapy for Reading Problems in Adults After Brain Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Therapy for Reading Problems in Adults (...) Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Study Details Study Description Go to Brief Summary: Adults who sustain brain damage due to stroke, head injury, or traumatic surgery may develop difficulty reading. This study examines the effectiveness of behavior-based programs to improve reading ability in these individuals. Condition or disease Intervention/treatment Phase Dyslexia, Acquired Brain Injuries Cerebrovascular Accident Behavioral: Cognitive Therapy

2003 Clinical Trials

10671. Prospective Memory in Children With Traumatic Brain Injury

Prospective Memory in Children With Traumatic Brain Injury Prospective Memory in Children With Traumatic Brain Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Prospective Memory in Children (...) about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 9 Years to 18 Years (Child, Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria English speaker Minimum birth weight of 2500 grams (5.5 lbs) and 37 weeks' gestation Additional Inclusion Criteria for Children with Traumatic Brain Injury Head injury resulting

2003 Clinical Trials

10672. Genotype Influence on Recovery After Traumatic Brain Injury

, including traumatic brain injury. It is proposed that the accuracy of prediction of outcome after head injury will be significantly increased by inclusion of APOE genotype alone, or in combination with other variables such as severity of head injury, cognitive, electroencephalographic or neuroradiologic measures, or treatment strategies. Study Design Go to Layout table for study information Study Type : Observational Official Title: The Influence of APOE Genotype on Recovery After Traumatic Brain Injury (...) research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 17 Years to 55 Years (Child, Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Patients enrolled in the DVHIP are subject to the following recruitment criteria: Mild, moderate or severe closed head injury, where the cut off between mild and moderate is defined by GCS<12. PTA>24 hrs or - foca cerebral contusion on CT/MRI or Loss

2001 Clinical Trials

10673. Progesterone Treatment of Blunt Traumatic Brain Injury

Progesterone Treatment of Blunt Traumatic Brain Injury Progesterone Treatment of Blunt Traumatic Brain Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Progesterone Treatment of Blunt Traumatic Brain (...) and 12 Exclusion Criteria: Spinal cord injury Penetrating head trauma Cardiopulmonary arrest upon ECC arrival Status Epilepticus upon ECC arrival Systolic BP < 90mmHG upon ECC arrival Pulse Ox of < 90 (or pO2 < 60) Prisoners or incarcerated individuals Past Hx of significant intercranial pathology Pregnant females Blood alcohol level > 250 mg/dl Non-English speakers (a Spanish version of the ICF is currently being developed) Allergy(s) to soy, egg, or progesterone Active breast or reproductive organ

2002 Clinical Trials

10674. Magnesium Sulfate For Brain Injury

is to determine whether magnesium sulfate, given within 8 hours of a moderate or severe traumatic brain injury improves survival, decreases the number of people developing seizures, improves the survivors' mental and psychological functioning, including the ability to return to daily life, live independently, and return to work or school. Condition or disease Intervention/treatment Phase Brain Injuries Head Injury Brain Concussion Drug: magnesium sulfate Phase 3 Detailed Description: The purpose of the study (...) Magnesium Sulfate For Brain Injury Magnesium Sulfate For Brain Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Magnesium Sulfate For Brain Injury The safety and scientific validity of this study

2000 Clinical Trials

10675. Rock-Climbing Injuries in Yosemite National Park Full Text available with Trip Pro

and severity quantified. The National Park Service rescued 27% of the climbers. Injured climbers were characteristically male (88%) and experienced (mean 5.9 years) and typically fell while leading climbs (66%). Among 451 injuries, 50% were to the skin or subcutaneous tissues, while 28% involved the lower extremity and were predominantly fractures. In terms of each climber's most severe injury (n = 220), 45% involved the lower extremities (30% from the ankle alone). Head injury or hypothermia caused 12 (...) of 13 fatalities, showing the lowest case-fatality rate reported to date among injured climbers (6%). Rescue personnel successfully managed airways in victims of head injuries, anticipated and treated complications of hypothermia, and stabilized fractures. Victims requiring immediate extensive surgical intervention or blood transfusion usually died before rescue could be effected.

1988 Western Journal of Medicine

10676. Management of flail chest. Full Text available with Trip Pro

sodium succinate and colloid infusion in an intensive care unit. In addition to these measures, the group 2 patients underwent endotracheal intubation and assisted mechanical ventilation with a volume respirator that provided continuous positive airway pressure and positive end-expiratory pressure. Of the 57 group 2 patients 36 required prolonged ventilation, eventually through a tracheostomy, because of severe head injury, pneumonia, severe facial injury, quadriplegia, pre-existing lung disease (...) Management of flail chest. This paper compares the management of two groups of patients with flail chest. The 25 patients in group 1 had a flail chest without other significant injuries or shock, whereas the 57 in group 2 had a flail chest with multiple injuries, shock or both. The group 1 patients were treated with repeated multiple intercostal nerve blocks or high segmental epidural analgesia, oxygen, intensive chest physiotherapy, fluid restriction, furosemide diuretics, methylprednisolone

1983 Canadian Medical Association Journal

10677. Standardized management of intracranial pressure: a preliminary clinical trial. (Abstract)

Standardized management of intracranial pressure: a preliminary clinical trial. To test a standardized protocol for management of intracranial pressure (ICP) after severe head injury (i.e., traumatic brain injury), consistent with published guidelines.We compared prospective use of a standardized protocol for ICP management in 12 patients with severe head injuries and retrospective ICP management using preprinted hospital orders in combination with ad hoc physician orders in 12 historical (...) control patients with severe head injuries. With the standardized protocol, flow-chart decision logic diagrams were applied at patient bedside by critical care practitioners, with nursing shift review.ICP and its variation during the first 6 intensive care unit days was less for the standardized protocol- than for the preprinted order-managed group (p <0.001), indicating better process control with the standardized protocol. ICP exceeded 25 mm Hg for less time for the standardized protocol group (182

1999 Journal of Trauma

10678. Field-side and prehospital management of the spine-injured athlete. (Abstract)

Field-side and prehospital management of the spine-injured athlete. Rapid on-field diagnosis and early stabilization can help to optimize the outcomes of spinal injury, which can have devastating consequences. Several basic principles will guide the rescuer through this process. Preinjury planning should include appointing a team leader, assessing the athletes' equipment, acquiring appropriate equipment to facilitate stabilization, and establishing lines of communication to emergency medical (...) services (EMS). When an athlete is down, the team leader should proceed to quickly assess airway, breathing, circulation, level of consciousness, and activation of EMS. This should be followed by stabilization of the head and neck, a coordinated log roll, and ultimately complete spinal immobilization for transport. Specific techniques for stabilizing the cervical spine, removing the facemask, log rolling the athlete, and lifting the athlete, will improve outcome. The helmet and shoulder pads should

2005 Current Sports Medicine Reports

10679. Evaluating the role of botulinum toxin in the management of focal hypertonia in adults. Full Text available with Trip Pro

toxin or placebo was injected with EMG guidance after multidisciplinary assessment. The modified Ashworth scale of spasticity, percentage passive range of joint motion, subjective rating of problem severity, the Rivermead motor assessment scale, a timed 10 metre walk (lower limb patients), nine hole peg test (upper limb patients), and a modified goal attainment scale were used as outcome measures. The patients were 52 adults; 34 male, 18 female; mean age 40.31, range 16-79 years; mean duration (...) of symptoms 35 months (range 3 months to 22 years). Diagnoses included cerebrovascular accidents (23), head injury (12), incomplete spinal cord injury (six), tumour (five), cerebral palsy (three), and anoxic episodes (three).For each variable an overall score for the treatment period was computed by summing the scores from the 3, 6, 9, and 12 week assessments. These overall scores were significantly better in the treated group for the Ashworth scale, percentage passive range of movement, Rivermead lower

2000 Journal of neurology, neurosurgery, and psychiatry Controlled trial quality: uncertain

10680. Medical outcome after immediate computed tomography or admission for observation in patients with mild head injury: randomised controlled trial. Full Text available with Trip Pro

for observation, there was a considerable delay in time to treatment in those who required surgery. None of the patients with normal findings on immediate computed tomography had complications later. Patients' satisfaction with the two strategies was similar.The use of computed tomography in the management of patients with mild head injury is feasible and leads to similar clinical outcomes compared with observation in hospital.ISRCTN81464462. (...) Medical outcome after immediate computed tomography or admission for observation in patients with mild head injury: randomised controlled trial. To compare immediate computed tomography during triage for admission with observation in hospital in patients with mild head injury.Multicentre, pragmatic, non-inferiority randomised trial.39 acute hospitals in Sweden.2602 patients (aged > or = 6) with mild head injury.Immediate computed tomography or admission for observation.Dichotomised extended

2006 BMJ Controlled trial quality: predicted high

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