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Management of Severe Head Injury

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10601. Double Blind Study of Vigabatrin for the Treatment of Cocaine Dependence

life threatening or progressive medical illness other than addiction that may compromise subject safety or study conduct. Have a history of traumatic head injury. Be mandated by a court to obtain treatment for cocaine dependence. Have been treated for cocaine addiction, or abstained from cocaine use for a significant period, within the 6 months preceding screening. Be unable to complete the study protocol because of probable incarceration or relocation from the clinical area. Have AIDS (although (...) Double Blind Study of Vigabatrin for the Treatment of Cocaine Dependence Double Blind Study of Vigabatrin for the Treatment of Cocaine Dependence - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Double Blind

2007 Clinical Trials

10602. Transcranial Magnetic Stimulation (TMS) for Individuals With Tourette's Syndrome

, defined as a total Y-GTSS total motor tic or phonic tic score > 20, despite treatment with an adequate trial of medications (defined as a failure to respond to a trial of commonly used medications for TS such as clonidine, guanfacine, or neuroleptic medications, given at recommended dosage and duration based on the clinician's judgment) Persistent high level of tic severity for 4 months despite efforts to control the tics using medications, or the presence of self injurious tics Duration of the index (...) Transcranial Magnetic Stimulation (TMS) for Individuals With Tourette's Syndrome Transcranial Magnetic Stimulation (TMS) for Individuals With Tourette's Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2007 Clinical Trials

10603. Examining Cognitive Function and Brain Abnormalities in Adults With Sickle Cell Disease

for enrollment as community controls into the study: Adult between the ages of 21 and 55 African descent Proficient/fluent in English Capable of giving informed consent for the protocol Exclusion Criteria: Individuals who meet any of the following criteria are disqualified from enrollment in the case group of the study: Overt stroke Previous evidence of an abnormal MRI or CT other than small peri-ventricular or watershed lesions History of head injury that resulted in neurological symptoms or medical visit (...) Examining Cognitive Function and Brain Abnormalities in Adults With Sickle Cell Disease Examining Cognitive Function and Brain Abnormalities in Adults With Sickle Cell Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2007 Clinical Trials

10604. Transcranial Magnetic Stimulation for Treating Women With Chronic Widespread Pain

, or depression Current use of proconvulsant medications (e.g., bupropion) Metal in the body that would prevent magnetic resonance imaging (MRI) or TMS (e.g., aneurysm clips, pacemakers, neurostimulators) History of head injury associated with loss of consciousness for more than 15 minutes, brain surgery, or lithium toxicity History of bipolar disorder, schizophrenia, obsessive compulsive disorder, panic disorder, or post-traumatic stress disorder Current substance abuse or dependence Active suicidal intent (...) Transcranial Magnetic Stimulation for Treating Women With Chronic Widespread Pain Transcranial Magnetic Stimulation for Treating Women With Chronic Widespread Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2007 Clinical Trials

10605. Apremilast Safety and PK Study in Recalcitrant Plaque Psoriasis

3.0, grades: 1 = mild, 2 = moderate, 3 = severe, 4 = life threatening, 5 = death. Adverse event (AE) = any noxious, unintended, or untoward medical occurrence occurring at any dose that may appear or worsen in a participant during the course of a study, including new intercurrent illness, worsening concomitant illness, injury, or any concomitant impairment of participant's health, including laboratory test values, regardless of etiology. Serious adverse event (SAE) = any AE which: results in death (...) disease severity. Erythema, thickness, and scaling are scored on a scale of 0 (none) to 4 (very severe) on 4 anatomic regions of the body: head, trunk, upper limbs, and lower limbs. Degree of involvement on each of the 4 anatomic regions is scored on a scale of 0 (no involvement) to 6 (90% to 100% involvement). The total qualitative score (sum of erythema, thickness, and scaling scores) was multiplied by the degree of involvement for each anatomic region and then multiplied by a constant. These values

2007 Clinical Trials

10606. Biomarker Study of Acamprosate in Schizophrenia

of mental retardation/severe neurological disorder/head injury with loss of consciousness DSM-IV diagnosis of substance dependence in previous six months/abuse in the previous three months (except nicotine) Serious suicidal risk in the previous six months History of renal failure/creatinine clearance of less than 50mL/min Current treatment with clozapine Contraindication to MRI scanning. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you (...) Biomarker Study of Acamprosate in Schizophrenia Biomarker Study of Acamprosate in Schizophrenia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Biomarker Study of Acamprosate in Schizophrenia The safety

2008 Clinical Trials

10607. Improving Sedation of Children Undergoing Procedures in the Emergency Department

will be excluded if they have: closed head injury with loss of consciousness, abnormal neurologic exam relative to baseline status, severe developmental delay or baseline neurologic deficits, severe trauma with suspected internal injuries, acute or chronic respiratory conditions, or renal, cardiac or hepatic abnormalities. Variables of interest will include level of sedation prior to and during the procedure (using an activity scale and a modified CHEOPS scale) (McGrath 1985), time to adequate sedation (...) : No Criteria Inclusion Criteria: Laceration in need of repair with sutures, with no other major injuries Age >=6 months and < 7 years No meal within the last 2 hours Exclusion Criteria: Closed head injury associated with loss of consciousness Abnormal neurologic exam, relative to baseline status Significant developmental delay or baseline neurologic deficit Severe trauma with suspected internal injuries Acute or chronic respiratory condition Acute or chronic renal, cardiac or hepatic abnormalities Allergy

2008 Clinical Trials

10608. Cognitive Effects of Bariatric Surgery

Volunteers: No Sampling Method: Non-Probability Sample Study Population Participants will be recruited from the bariatric and weight loss programs of affiliated clinical centers. Criteria Specific criteria for bariatric surgery patients include: Inclusion Criteria 25-65 years of age Enrolled in LABS project English-speaking Exclusion Criteria History of neurological disorder or injury (e.g. dementia, stroke, seizures) Moderate or severe head injury (defined as >10 minutes loss of consciousness; Alexander (...) Cognitive Effects of Bariatric Surgery Cognitive Effects of Bariatric Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Cognitive Effects of Bariatric Surgery The safety and scientific validity

2008 Clinical Trials

10610. Repetitive Transcranial Magnetic Stimulation for Treating Depression: A Functional Magnetic Resonance Imaging Study

satisfactory improvement in depression after two or more adequate trials of antidepressant medications. MEDICAL EXCLUSIONS: Patients newly diagnosed with thyroid dysfunction History of drug and/or ETOH dependence History of seizures History of head injury with loss of consciousness > 5 minutes Any implantable metal object in the skull or near their head Any implantable devices such as a cardiac pacemaker, vagal nerve stimulator, etc. Positive urine pregnancy test Severe migraine headaches uncontrolled (...) Repetitive Transcranial Magnetic Stimulation for Treating Depression: A Functional Magnetic Resonance Imaging Study Repetitive Transcranial Magnetic Stimulation for Treating Depression: A Functional Magnetic Resonance Imaging Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2009 Clinical Trials

10611. Dual Antiplatelet Therapy Tailored on the Extent of Platelet Inhibition

Eligible for Study: 20 Years to 90 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Unstable or NSTEMI Exclusion Criteria: Previous bleeding events which have required blood transfusion PT- INR >1.5 Platelet count ≤ 100000/ mm3 Hb < 10 g/dl Previous TIA/stroke (ischemic or hemorrhagic or unknown) Body weight < 60 Kg Creatinine levels ≥ 4 mg/dl Cerebral neoplasia Recent major trauma/surgery/head injury (within 3 previous weeks (...) Dual Antiplatelet Therapy Tailored on the Extent of Platelet Inhibition Dual Antiplatelet Therapy Tailored on the Extent of Platelet Inhibition - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Dual

2008 Clinical Trials

10612. Factor VII, Prothrombin Complex Concentrate, and Fresh Frozen Plasma in Warfarin-Related Intracranial Hemorrhage

in surgical patients, severe multiple trauma with ongoing bleeding, intracranial bleeding < 4 hours since symptom onset, traumatic head injury with evidence of expanding bleed, retroperitoneal bleed, and life-threatening bleeding due to idiopathic coagulopathy. To our knowledge, these two products have never been clinically compared head to head for the reversal of warfarin in the setting of intracranial hemorrhage. The rFVIIa (Novoseven) guidelines are based off of national data and utilize a dose range (...) Factor VII, Prothrombin Complex Concentrate, and Fresh Frozen Plasma in Warfarin-Related Intracranial Hemorrhage Factor VII, Prothrombin Complex Concentrate, and Fresh Frozen Plasma in Warfarin-Related Intracranial Hemorrhage - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2008 Clinical Trials

10613. Optimization of IV Ketamine for Treatment Resistant Depression

risk; Women who are either pregnant or nursing; Serious, unstable medical illnesses including hepatic, renal, gastroenterologic (including gastroesophageal reflux disease), respiratory (including obstructive sleep apnea, or history of difficulty with airway management during previous anesthetics), cardiovascular (including ischemic heart disease and uncontrolled hypertension), endocrinologic, neurologic (including history of severe head injury), immunologic, or hematologic disease; Clinically (...) years in both pediatric and adult patients. Beyond its well-established role in anesthesia and pain management, there is emerging evidence that ketamine may have rapid antidepressant properties for patients with severe mood disorders. In this study we are investigating whether ketamine can have an antidepressant effect compared to midazolam. Midazolam has similar anesthetic effects compared to ketamine but has not been shown to be an antidepressant, and is therefore acting as an active control

2008 Clinical Trials

10614. Role of the Sensory Experience in Generating Motor Tics in Tourette Syndrome

Role of the Sensory Experience in Generating Motor Tics in Tourette Syndrome Role of the Sensory Experience in Generating Motor Tics in Tourette Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Role (...) be 18-65 years of age, of any race, gender, or handedness. EXCLUSION CRITERIA: Inability to stop taking all central-acting medications, including those used to treat tics, for at least one week prior to the study Current use of coumadin, heparin, or lovenox Any additional movement disorder, including tremor, myoclonus, or dystonia A diagnosis of major depression or bipolar disorder Frequent or severe headaches Any history of or current experience of hallucinations Any history of a seizure

2008 Clinical Trials

10615. Hypothermia for Cardiac Arrest in Paediatrics

. Neuromuscular blockers will be administered as needed intravenously in both groups of patients to prevent shivering. Experimental: 2 Other: Hypothermia Patients randomized to the Hypothermia arm (esophageal temp 33º to 34 °C) will be cooled rapidly using the cooling protocol developed for the Hypothermia Paediatric Head Injury Trial. A temperature probe will be placed in the esophagus and its position confirmed using a chest radiograph. Patients will be placed on a servo-controlled cooling blanket (...) Hypothermia for Cardiac Arrest in Paediatrics Hypothermia for Cardiac Arrest in Paediatrics - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Hypothermia for Cardiac Arrest in Paediatrics The safety

2008 Clinical Trials

10616. Pregnenolone for Cognitive and Negative Symptoms in Schizophrenia

weeks; No benzodiazepine use in the past twelve hours prior to cognitive testing; The patient cohort will be enriched for cognitive symptoms (Composite BACS scores = 0-3 standard deviations below the mean, assessed at the screening visit). Exclusion Criteria: Subjects with a DSM-IV/DSM-IV TR diagnosis of alcohol or substance dependence (other than nicotine) within the last month; Subjects with a history of significant head injury/trauma, as defined by one or more of the following: Loss (...) of consciousness (LOC) for more than 1 hour, Recurring seizures resulting from the head injury, Clear cognitive sequelae of the injury, Cognitive rehabilitation following the injury; Subjects with unstable medical illness or neurological illness (seizures, CVA); Patients with hormone-sensitive tumors (such as breast, uterine, or prostate cancer); Clinically significant abnormalities in physical examination , ECG, or laboratory assessments; Pregnant women or women of child-bearing potential, who are either

2008 Clinical Trials

10617. CDP-Choline and Working Memory After TBI: A Neuroimaging Study

-Choline, the patterns in neuroimaging findings and cognitive testing results for individuals with TBI will more closely resemble results observed for healthy individuals. We hope that what we learn from this study will be helpful in the future treatment of individuals with head injury. Condition or disease Intervention/treatment Phase Brain Injuries Drug: CDP-Choline Drug: Placebo Phase 2 Detailed Description: Despite the prevalence of working memory deficits following traumatic brain injury (TBI (...) injury (TBI). The study sample will consist of 48 subjects: A group of 24 individuals who have sustained moderate to severe TBI, and a group of 24 healthy controls. Each group will be divided into a placebo and treatment group. The project will utilize functional Magnetic Resonance Imaging (fMRI) to investigate the cerebral neurophysiological effects of treatment with CDP-Choline. A working memory task (N-Back) will be employed during fMRI sessions. In addition, the effects of treatment with CDP

2008 Clinical Trials

10618. International Study to Predict Optimised Treatment

or discontinuation. Use of any medication which is known to be contraindicated with Escitalopram, Sertraline, or Venlafaxine XR (refer to the product package insert for each drug). Known medical condition, disease or neurological disorder which might, in the opinion of investigator/s, interfere with the assessments to be made in the study or put subjects at increased risk when exposed to optimal doses of the drug treatment. History of head injury with loss of consciousness for at least 10 minutes. Recent/current (...) International Study to Predict Optimised Treatment International Study to Predict Optimised Treatment - in Depression - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. International Study to Predict Optimised

2008 Clinical Trials

10619. Escitalopram in Adult Patients With Major Depressive Disorder

disorder. Patients who are considered a suicide risk Patients with a history of seizures (including seizure disorder), stroke, significant head injury, central nervous system tumors, or any other condition that predisposes patients to a risk for seizure. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study (...) Escitalopram in Adult Patients With Major Depressive Disorder Escitalopram in Adult Patients With Major Depressive Disorder - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Escitalopram in Adult Patients

2008 Clinical Trials

10620. Ciprofloxacin on Burned Patients

for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Moderate to severe burnt patients defined as burning of 20 to 60% of total body surface according to rule of nine, II deep degree and III degree according to Full-Thickness Burn model, Hospitalization for burning injury since at least 72h during hyper metabolic phase Active infections microbiological confirmed Signed informed (...) Ciprofloxacin on Burned Patients Ciprofloxacin on Burned Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Ciprofloxacin on Burned Patients The safety and scientific validity of this study

2008 Clinical Trials

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