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Management of Severe Head Injury

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10601. Methylphenidate (Ritalin) and Memory/Attention in Traumatic Brain Injury (TBI)

Methylphenidate (Ritalin) and Memory/Attention in Traumatic Brain Injury (TBI) Methylphenidate (Ritalin) and Memory/Attention in Traumatic Brain Injury (TBI) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Age: Individuals aged 18-65 who sustained a mild to severe TBI 4 months prior to study entry. TBI: Subjects must sustain a traumatic blow to the head, resulting in either alteration of level of consciousness (manifested by being dazed and confused or having amnesia for the event) or loss of consciousness (LOC). Duration of LOC will be estimated by using all available information including patient and witness reports

2007 Clinical Trials

10602. Stepped Preventive Care to Reduce the Impact of Acute Pediatric Injury

Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Age 8 to 17 Admitted to hospital for treatment of unintentional injury Sufficient English fluency to participate in an interview Family has access to a telephone (for telephone follow-up contacts) Exclusion criteria: Child's medical status or cognitive functioning precludes participating in an interview Child has moderate to severe head injury, defined as Glasgow Coma Score (GCS) <= 12 Child's injury involved family (...) Stepped Preventive Care to Reduce the Impact of Acute Pediatric Injury Stepped Preventive Care to Reduce the Impact of Acute Pediatric Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Stepped

2007 Clinical Trials

10603. Affect Recognition: Enhancing Performance of Persons With Acquired Brain Injury (ABI)

for eligibility information Ages Eligible for Study: 18 Years to 65 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Age between eighteen and sixty-five years old. At minimum, one year post-injury. Glasgow Coma Score (GCS) of 12 or less, or stroke with hemi-paresis signifying a moderate to severe acquired brain injury. A TBI that resulted in either a closed or open head injury or a stroke that resulted in severe disability Perform at least (...) Affect Recognition: Enhancing Performance of Persons With Acquired Brain Injury (ABI) Affect Recognition: Enhancing Performance of Persons With Acquired Brain Injury (ABI) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2006 Clinical Trials

10604. Depression and Traumatic Brain Injury

Depression and Traumatic Brain Injury Depression and Traumatic Brain Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Depression and Traumatic Brain Injury The safety and scientific validity (...) Library of Medicine related topics: related topics: available for: Arms and Interventions Go to Intervention Details: Drug: citalopram (celexa) 20(1 tablet)-50(2 1/2 tablets) mg/day for a period of 6 or 10 weeks Outcome Measures Go to Primary Outcome Measures : - Hamilton Depression Rating Scale (HAM-D) [ Time Frame: Baseline, 6 weeks and 10 weeks (if applicable) ] Secondary Outcome Measures : Beck Depression Inventory (BDI), Rivermead Head Injury Follow-up Questionnaire (RHFQ), General Health

2005 Clinical Trials

10605. Safety of Autologous Stem Cell Treatment for Traumatic Brain Injury in Children

Safety of Autologous Stem Cell Treatment for Traumatic Brain Injury in Children Safety of Autologous Stem Cell Treatment for Traumatic Brain Injury in Children - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) Phase 1 Detailed Description: Traumatic brain injury (TBI) contributes to 50% of all trauma deaths. The mortality rate for children following severe TBI (Glasgow Coma Scale < 9) ranges from 14-24%. There is currently no therapy to reverse the primary injury associated with TBI. Bone marrow precursor cells (BMPC) or bone marrow mononuclear cellular fractions of bone marrow contain mesenchymal stem cells (MSC) and hematopoetic stem cells (HSC). These cells are a component of bone marrow

2005 Clinical Trials

10606. Excitatory Amino Acids and Activated Microglia After Traumatic Brain Injury: a (R)-[11C]PK11195 PET Study

-D-Aspartate (NMDA) receptors, leads to excessive influx of calcium through receptor gated ion-channels, causing metabolic derangement and finally cell death. Although the exact role of EEA in patients who have suffered severe head injury remains to be established, it has been shown that sustained high intracranial pressure (ICP) and poor outcome are significantly correlated to high levels of EEA using microdialysis. Disadvantages of microdialysis are that it can only be used to evaluate (...) Excitatory Amino Acids and Activated Microglia After Traumatic Brain Injury: a (R)-[11C]PK11195 PET Study Excitatory Amino Acids and Activated Microglia After Traumatic Brain Injury: a (R)-[11C]PK11195 PET Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2005 Clinical Trials

10607. Patient-Centered Collaborative Care for Preventing Post-Traumatic Stress Disorder After Traumatic Injury

the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: English-speaking Admitted to Harborview Medical Center with injuries sufficiently severe to require inpatient admission Experienced a traumatic injury Exhibits symptoms of PTSD while in the hospital ward Exclusion Criteria: History of head, spinal, or other (...) Patient-Centered Collaborative Care for Preventing Post-Traumatic Stress Disorder After Traumatic Injury Patient-Centered Collaborative Care for Preventing Post-Traumatic Stress Disorder After Traumatic Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2005 Clinical Trials

10608. Inflammation and the Host Response to Injury (Trauma)

Inflammation and the Host Response to Injury (Trauma) Inflammation and the Host Response to Injury (Trauma) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Inflammation and the Host Response to Injury (...) contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 16 Years and older (Child, Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Sampling Method: Non-Probability Sample Study Population Acute hospitalized blunt trauma patients Criteria Inclusion criteria for enrollment in the trauma study are as follows: Blunt trauma without isolated head injury Absence of traumatic

2005 Clinical Trials

10609. A Study of Blood Pressure and Blood Supply to the Brain in Persons With a Spinal Cord Injury.

A Study of Blood Pressure and Blood Supply to the Brain in Persons With a Spinal Cord Injury. A Study of Blood Pressure and Blood Supply to the Brain in Persons With a Spinal Cord Injury. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) blood pressure (Vasotec). We will determine how persons with a spinal cord injury are able to maintain blood flow to the brain (not get dizzy) as they assume a more upright position and their blood pressure decreases. Condition or disease Intervention/treatment Phase Orthostatic Hypotension Spinal Cord Injuries Drug: 1.25 mg enalaprilat IV Other: Head up tilt (HUT) Not Applicable Detailed Description: Individuals with tetraplegia lack normal sympathetic nervous system regulation of blood pressure

2005 Clinical Trials

10610. Effects of Hypothermia Upon Outcomes After Acute Traumatic Brain Injury

Effects of Hypothermia Upon Outcomes After Acute Traumatic Brain Injury Effects of Hypothermia Upon Outcomes After Acute Traumatic Brain Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effects (...) : The University of Texas Health Science Center, Houston Collaborator: National Institute of Neurological Disorders and Stroke (NINDS) Information provided by (Responsible Party): Guy Clifton, The University of Texas Health Science Center, Houston Study Details Study Description Go to Brief Summary: Induction of hypothermia to < 35˚C by < 2.5 hours after severe traumatic brain injury, reaching 33˚C by 4 hours after injury and maintained for 48 hours in patients aged 16-45 will result in an increased number

2005 Clinical Trials

10611. Comparison Between Different Types of Oxygen Treatment Following Traumatic Brain Injury

to maintain a PaO2 of 70 mm Hg or greater. History of severe pulmonary disease, such as COPD or asthma. Unstable fracture (spine, pelvis, femur, etc) preventing placement into the HBO chamber. Patients placed in barbiturate coma during initial management due to the potential effect barbiturates have on cerebral metabolism. Age range < 16 years or > 65 years. Coagulopathy. Pregnancy. Severe mental retardation or prior severe head injury. High velocity penetrating injury to the head,(e.g. gunshot wound (...) Comparison Between Different Types of Oxygen Treatment Following Traumatic Brain Injury Comparison Between Different Types of Oxygen Treatment Following Traumatic Brain Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2005 Clinical Trials

10612. Effect of rosuvastatin on amnesia and disorientation after traumatic brain injury (NCT003229758). (Abstract)

as demonstrated by computed tomography (CT) scan. We excluded those patients with recent head injury or severe disability; administration of known drugs as modifiers of statin metabolism; multisystemic trauma; prior use of mannitol, barbiturate, corticosteroids, indomethacin or calcium antagonists; surgical or isolated lesion in brainstem; allergy to statins; previous hepatopathy or myopathy; previous management in another clinic; or pregnancy. Each patient received the same treatment and was randomly (...) Effect of rosuvastatin on amnesia and disorientation after traumatic brain injury (NCT003229758). Amnesia is a common sequela following traumatic brain injury (TBI), for which there is no current treatment. Pleiotropic effects of statins have demonstrated faster recovery of spatial memory after TBI in animals. We conducted a double-blind randomized clinical trial add-on of patients with TBI (16-50 years of age), with Glasgow Coma Scale (GCS) scores of 9-13, and intracranial lesions

2008 Journal of neurotrauma Controlled trial quality: predicted high

10613. Association between implementation of clinical practice guidelines and outcome for traumatic brain injury. (Abstract)

Association between implementation of clinical practice guidelines and outcome for traumatic brain injury. Traumatic brain injury (TBI) is the leading cause of death in the population under 40 years of age in Western countries, and the same was true for Latvia in 1999. This indicated a strong need to improve the management of TBI. The Latvian Society of Neurosurgeons in collaboration with related societies created a dedicated working group, and the Guidelines for Medical Management of TBI (...) in Latvia (Guidelines) were developed in 2001. This study aimed to assess the association between implementation of the Guidelines and the outcome of TBI patients.The Guidelines were printed and distributed to relevant clinical units and teaching institutions. To assess the impact of the Guidelines on the outcome of TBI, Latvian medical statistics were researched. All patients admitted to emergency departments and registered as either discharged or dead with a diagnosis of head trauma from 1998 to 2004

2007 World Journal of Surgery

10614. Internal carotid artery stenting for blunt carotid artery injuries with an associated pseudoaneurysm. (Abstract)

traumatic intracranial hemorrhage. AC (heparin drip) or AP therapy (clopidogrel or aspirin or both) was initiated in all patients within 48 hours of diagnosis of BCI. Time from admission to AC or AP was 21 +/- 9.5 hours (mean +/- SD). Mortality rate was 18% (2 of 11). One death was attributed to severe brain injury. The other was attributed to a stroke from the carotid injury. No patient had radiologic progression of traumatic intracranial hemorrhage on head computed tomography despite AP or AC. One (...) Internal carotid artery stenting for blunt carotid artery injuries with an associated pseudoaneurysm. Blunt carotid artery injuries (BCI) are being recognized and treated with increasing frequency because of improved screening protocols. Recent advances in endovascular techniques using microcoils, angioplasty, and stenting offer a new treatment strategy for those patients with traumatic pseudoaneurysms (PA) (BCI and PA). Experience with these techniques is limited because of the rarity

2008 Journal of Trauma

10615. Timeline to operative intervention for solid organ injuries in children. (Abstract)

(age <15) with a single abdominal SOI (kidney, liver, spleen). Children with significant associated head injury (Abbreviated Injury Score; AIS >2) were excluded. Data abstracted included age, organ injury and severity (ICD-9, AIS), and operative procedures. Survival analysis methods were used to evaluate equality of hazard rates (indicating rate of operative intervention by hour).For the period of review, the NTDB contained 2,013 children with a single SOI including 1,813 eligible for review (...) Timeline to operative intervention for solid organ injuries in children. Nonoperative management of solid organ injuries (SOI) in children is now the standard of care. Little is know regarding the time to failure for those children requiring operative intervention. We sought to delineate this timeline to operative intervention for the subset of single solid organ injured patients requiring laparotomy.The National Trauma Data Bank (NTDB) was queried for the period 1991 to 2003 for all children

2006 Journal of Trauma

10616. The diagnostic accuracy of the Revised Westmead PTA Scale as an adjunct to the Glasgow Coma Scale in the early identification of cognitive impairment in patients with mild traumatic brain injury. Full Text available with Trip Pro

The diagnostic accuracy of the Revised Westmead PTA Scale as an adjunct to the Glasgow Coma Scale in the early identification of cognitive impairment in patients with mild traumatic brain injury. Assessment of patients with mild traumatic brain injury (mTBI) is predominantly done using the Glasgow Coma Scale (GCS). While the GCS is universally accepted for assessment of severity of traumatic brain injury, it may not be appropriate to rely on the GCS alone when assessing patients with mTBI (...) for reasons other than head trauma was also assessed. All patients were assessed using the GCS, R-WPTAS and a battery of neuropsychological tests.Patients with mTBI scored poorly compared with control patients on all measures. The R-WPTAS showed greater concurrent validity with the neuropsychological measures than the GCS and significantly increased prediction of group membership of patients with mTBI with cognitive impairment.The R-WPTAS significantly improves diagnostic accuracy in identifying patients

2008 Neurosurgery and Psychiatry

10617. The long-distance tertiary air transfer and care of tsunami victims: injury pattern and microbiological and psychological aspects. (Abstract)

Staphylococcus aureus, Aeromonas hydrophilia, Pseudomonas species, and Candida albicans. Apart from these findings, all patients displayed severe signs of posttraumatic stress response.Individuals who survived their initial injuries and who were evacuated to Europe had traumatic injuries to head, chest, and limbs that were often contaminated with highly resistant bacteria. (...) The long-distance tertiary air transfer and care of tsunami victims: injury pattern and microbiological and psychological aspects. On December 26, 2004, a giant earthquake shocked Southeast Asia, triggering deadly flood waves (tsunami) across the Indian Ocean. More than 310,000 people have been reported dead and millions left destitute. Shortly thereafter, European governments organized airborne home transfer of most severely injured tourists using MedEvac aircraft. On arrival, patients were

2005 Critical Care Medicine

10618. Hypopituitarism following traumatic brain injury (TBI). (Abstract)

Hypopituitarism following traumatic brain injury (TBI). Traumatic brain injury (TBI) is the commonest cause of death and disability in young adults living in industrialised countries. Recently, several studies have shown that hypopituitarism is a common complication of head trauma, with a prevalence of at least 25% among patients who were studied months or years following injury. This remarkably high frequency has changed the traditional concept of hypopituitarism being a rare complication (...) of TBI, and suggests that most cases of posttraumatic hypopituitarism remain undiagnosed and untreated in clinical practice. It is therefore reasonable to infer that posttraumatic hypopituitarism may have an important contribution to the high physical and neuropsychiatric morbidity seen in patients with head injury. This article discusses the published reports on neuroendocrine dysfunction in TBI patients and the natural history of this disorder. The potential impact of posttraumatic hypopituitarism

2007 British Journal of Neurosurgery

10619. Injury patterns in clashes between citizens and security forces during forced evacuation. Full Text available with Trip Pro

settlers. 229 injured (174 settlers and 55 security personnel) were cared for at six receiving hospitals. A total of 16 were evacuated by aeromedical evacuation, including one severely head-injured policeman. Settlers used sticks, stones and cement blocks, whereas police used mounted riders, batons and shields. Head injuries were the most common injuries among settlers (50%), whereas extremity injuries dominated among security forces members (72.7%).Large-scale clashes between state security forces (...) Injury patterns in clashes between citizens and security forces during forced evacuation. Clashes between state security forces and civilian populations can lead to mass casualty incidents (MCI), challenging emergency medical service (EMS) systems, hospitals and medical management systems. In January 2006, clashes erupted between Israeli security forces and settlers, around the forced evacuation of the Amona outpost.Data collected during the events and in subsequent formal debriefings were

2008 Emergency Medicine Journal

10620. Methylprednisolone was associated with an increase in death after head injury Full Text available with Trip Pro

Methylprednisolone was associated with an increase in death after head injury Methylprednisolone was associated with an increase in death after head injury | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts (...) Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Methylprednisolone was associated with an increase in death after head injury Article Text Treatment Methylprednisolone was associated with an increase in death after head injury Free Hilaire J Thompson , PhD , RN, CNRN , Asha Bakshi

2006 Evidence-Based Nursing

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