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Male Infertility

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1. Male factor infertility

Male factor infertility Male factor infertility - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Male factor infertility Last reviewed: February 2019 Last updated: March 2018 Summary Presence of abnormal semen parameters in the male partner of a couple unable to achieve conception after 1 year of unprotected intercourse. Male factor alone contributes to 20% of cases of infertile couples and to an additional 30% to 40 (...) % in combination with other factors. Most cases are of unknown aetiology. Diagnosed if abnormal semen parameters in 2 semen analyses separated by 1 month. Sperm functional assays, endocrine tests, genetic testing, and imaging can be helpful. Treatment should be targeted to the aetiological factors whenever possible. Assisted reproductive techniques are often the fastest and most effective method to achieve pregnancy regardless of the aetiology. Definition The clinical definition of male factor infertility

2018 BMJ Best Practice

2. Male Infertility

-analytic study. Andrology, 2014. 2: 794. 149. Schopohl, J., et al. Comparison of gonadotropin-releasing hormone and gonadotropin therapy in male patients with idiopathic hypothalamic hypogonadism. Fertil Steril, 1991. 56: 1143. 150. Andersson, A.M., et al. Impaired Leydig cell function in infertile men: a study of 357 idiopathic infertile men and 318 proven fertile controls. J Clin Endocrinol Metab, 2004. 89: 3161. 151. Lanfranco, F., et al. Klinefelter’s syndrome. Lancet, 2004. 364: 273. 152. Manning (...) . Ultrasound of the male genital tract in relation to male reproductive health. Human Reprod Update, 2015. 21: 56. 14. WHO, WHO Laboratory Manual for the Examination and Processing of Human Semen, in 5th edn. 2010. 15. Hauser, R., et al. Fertility in cases of hypergonadotropic azoospermia. Fertil Steril, 1995. 63: 631. 16. Martin-du-Pan, R.C., et al. Increased follicle stimulating hormone in infertile men. Is increased plasma FSH always due to damaged germinal epithelium? Hum Reprod, 1995. 10: 1940. 17

2019 European Association of Urology

3. Male Infertility

-analytic study. Andrology, 2014. 2: 794. 149. Schopohl, J., et al. Comparison of gonadotropin-releasing hormone and gonadotropin therapy in male patients with idiopathic hypothalamic hypogonadism. Fertil Steril, 1991. 56: 1143. 150. Andersson, A.M., et al. Impaired Leydig cell function in infertile men: a study of 357 idiopathic infertile men and 318 proven fertile controls. J Clin Endocrinol Metab, 2004. 89: 3161. 151. Lanfranco, F., et al. Klinefelter’s syndrome. Lancet, 2004. 364: 273. 152. Manning (...) . Ultrasound of the male genital tract in relation to male reproductive health. Human Reprod Update, 2015. 21: 56. 14. WHO, WHO Laboratory Manual for the Examination and Processing of Human Semen, in 5th edn. 2010. 15. Hauser, R., et al. Fertility in cases of hypergonadotropic azoospermia. Fertil Steril, 1995. 63: 631. 16. Martin-du-Pan, R.C., et al. Increased follicle stimulating hormone in infertile men. Is increased plasma FSH always due to damaged germinal epithelium? Hum Reprod, 1995. 10: 1940. 17

2018 European Association of Urology

4. Diagnostic evaluation of sexual dysfunction in the male partner in the setting of infertility: a committee opinion

- and-sterility/posts/36354-26626 INTRODUCTION Sexual dysfunctionisacommoncondi- tion among men of reproductive age. It can be signi?cantly worsened by the stress of infertility. It is important to elicit this information and provide the appropriate referral. This document will presentdiagnosis,evaluation, andtreat- ment of the most common sexual dysfunction issues seen by fertility pro- viders. These issues drive patients to seek care and offer an opportunity to improve male somatic health (...) million in 2025 (2).It is present in 18%–89% of men with male infertility (3–6). The prevalence of ED in infertile men is signi?cantly higher than in fertile controls (6). Having an erection is a necessary piece of natural conception and, often, for intrauterine insemination (IUI) or in vitro fertilization (IVF). ED may be indicative of serious health comorbidities. Men with ED withoutahistoryofcardiovasculardis- ease have a 45% increased risk of hav- ing a subsequent cardiovascular event within 5

2018 Society for Assisted Reproductive Technology

6. The effectiveness of ICSI versus conventional IVF in couples with non-male factor infertility: study protocol for a randomised controlled trial. Full Text available with Trip Pro

The effectiveness of ICSI versus conventional IVF in couples with non-male factor infertility: study protocol for a randomised controlled trial. Does ICSI result in a higher live birth rate as compared with conventional IVF in couples with non-male factor infertility?ICSI is primarily indicated for severe male factor infertility. While the use of ICSI for couples with non-male factor infertility has been increasing worldwide, this is not supported by data from randomised controlled trials (...) . Evidence from non-randomised studies suggest no benefit from ICSI compared with conventional IVF in non-male factor infertility, if not a harm.This randomised, open-label, multi-centre trial aims to compare the effectiveness of one ICSI cycle and one conventional IVF cycle in infertile couples with non-male factor infertility. A total of 1064 couples will be randomly allocated to an ICSI group and a conventional IVF group. The estimated duration of the study is 30 months.Eligible couples are those

2019 Human reproduction open Controlled trial quality: predicted high

7. The effect of metabolic syndrome on male reproductive health: A cross-sectional study in a group of fertile men and male partners of infertile couples. Full Text available with Trip Pro

The effect of metabolic syndrome on male reproductive health: A cross-sectional study in a group of fertile men and male partners of infertile couples. This study aimed to determine the effect of metabolic syndrome (MS) on the reproductive function in fertile (FM) and male partners of infertile couples (MPIC). We performed a cross-sectional study formatting two study groups: partners of pregnant women (n = 238; mean age 32.0) as FM and male partners of infertile couples (n = 2642; mean age 32.6 (...) ) as MPIC. A standard semen analysis was performed and clinical, laboratory and lifestyle data were analysed. The adapted NCEP-ATPIII criteria were used to define MS. 12.2% of FM and 17.8% of MPIC had MS. In both groups, men with MS were older, they were centrally obese and had higher triglycerides, systolic and diastolic blood pressure and decreased HDL cholesterol values as compared to men without MS. However, glucose concentrations as well as fasting insulin levels were significantly higher only

2018 PLoS ONE

8. Resistance exercise modulates male factor infertility through anti-inflammatory and antioxidative mechanisms in infertile men: A RCT. (Abstract)

Resistance exercise modulates male factor infertility through anti-inflammatory and antioxidative mechanisms in infertile men: A RCT. Inflammation and oxidative stress appear to be involved in the pathogenesis of male factor infertility. Exercise training has been shown to strengthen antioxidant defenceses and attenuate inflammation across body fluids, organs and tissues. However, the effect of resistance exercise training upon male factor infertility is unknown. Our aim was to investigate (...) the effects of resistance exercise training on markers of male reproduction and reproductive performance in infertile patients.This study evaluated the changes in seminal oxidative stress status, inflammatory biomarkers, semen parameters, sperm DNA integrity and pregnancy rate following 24 weeks of resistance exercise in infertile patients. A total of 1228 sedentary infertile patient (aged 25-40 years) were screened and 430 were randomized to exercise (EX, n = 216) and non-exercise (NON-EX, n = 214

2018 Life sciences Controlled trial quality: uncertain

9. Genetic and epigenetic profiling of the infertile male. Full Text available with Trip Pro

Genetic and epigenetic profiling of the infertile male. Evaluation of reproductive quality of spermatozoa by standard semen analysis is often inadequate to predict ART outcome. Men may be prone to meiotic error and have higher proportion of spermatozoa with fragmented chromatin, capable of affecting the conceptus' health. In men with unexplained infertility, supplementary tests may be pivotal to gain insight into the paternal contribution to the zygotic genome. A total of 113 consenting men (...) were included in the study, with an additional 5 donor specimens used as control. Among study participants, 87 were screened for sperm aneuploidy by fluorescent in situ hybridization (FISH) and ranked according to their increasing age. A total of 18 men were assessed by whole exome sequencing and categorized according to their reproductive outcome as either fertile or infertile. Another set of men (n = 13) had their gene expression analyzed by RNA-seq and were profiled according

2019 PLoS ONE

10. Knowledge gaps in male infertility: a reproductive endocrinology and infertility perspective Full Text available with Trip Pro

Knowledge gaps in male infertility: a reproductive endocrinology and infertility perspective Reproductive research has moved forward at a remarkable pace. Some of these advances are the result of a separation between male and female specialties, allowing focused study in specific areas of the field. However, the different training programs between male and female fertility specialists has created an environment in which some discoveries are not put in the greater context of clinical care (...) plausibility to account for subfertility of some male partners. However, until well defined thresholds for predicting outcomes in different treatment scenarios are available, changes in sperm DNA fragmentation testing is not an adequate outcome for measuring the utility of interventions. The biggest limitation for these tests remains their analysis of bulk semen. Tests allowing interrogation of the reproductive competence of a given sperm, while allowing that sperm to be used in assisted reproductive

2018 Translational andrology and urology

11. Male infertility, azoozpermia and cryptozoospermia incidence among three infertility clinics in Turkey Full Text available with Trip Pro

admitted to three separate infertility clinics in Turkey for infertility investigation and analyze the outcomes of these patients.A total of 9733 men, who have been admitted to 3 infertility clinics in Turkey due to infertility between March 2011 and October 2016, were included in the study. Male infertility, azoozpermia and cryptozoospermia incidence were calculated according to WHO criteria.Male factor infertility was determined in 3114 (32%) of the patients including cases with azoospermia (...) and cryptozoospermia. Azoospermia cases were observed in 570 (5.85%) and cryptozoospermia in 850 (8.73%) men. Azoospermic, and cryptozoospermic patients constitute 18.3%, and 27.2% of the male infertility cases. Sperm retrieval rates in diagnostic or oocyte pick-up plus testicular sperm extraction groups were found to be comparable (16.39%, and 41.3%, respectively).The data obtained may help to estimate the number of in vitro fertilization cycles and testicular sperm extraction cases, to determine social security

2018 Turkish journal of urology

12. Women’s perceptions and experiences of the challenges in the process of male infertility treatment: A qualitative study Full Text available with Trip Pro

Women’s perceptions and experiences of the challenges in the process of male infertility treatment: A qualitative study Despite the fact that both men and women are equally subject to infertility, it is usually women who bear the burden of treatment and its consequences, even in cases of male infertility. Therefore, it is more necessary to recognize their health problems in order to help them.To explore women's perceptions and experiences of the challenges they face in the process of male (...) infertility treatment.This qualitative study was conducted during 2014-2015 using content analysis. Thirty semi-structured interviews were conducted with women whose husbands suffered from male infertility. Purposive sampling was conducted until data saturation was achieved. All interviews were recorded, transcribed and analyzed using conventional content analysis adopted by Graneheim and Lundman.From data analysis, the major category of "treatment-related stresses" and four subcategories of "high

2017 Electronic physician

13. Male Infertility

attempting to conceive a subsequent child. Three percent of women remain involuntarily childless, while 6% of parous women are not able to have as many children as they would wish [5]. Infertility affects both men and women. In 50% of involuntarily childless couples, a male-infertility-associated factor is found together with abnormal semen parameters. A fertile partner may compensate for the fertility problem of the man and thus infertility usually manifests if both partners have reduced fertility [4 (...) ]. Male fertility can be reduced as a result of [4]: • congenital or acquir ed ur ogenital abnormalities; • malignancies; • ur ogenital tract infections; • incr eased scr otal temperatur e (e.g. as a consequence of varicocele); • endocrine disturbances; • genetic abnormalities; • immunological factors. In 30-40% of cases, no male-infertility-associated factor is found (idiopathic male infertility). These men present with no previous history of diseases affecting fertility and have normal findings

2015 European Association of Urology

14. Diagnostic evaluation of the infertile male: a committee opinion

?cation and treatment of correctable conditions willimprovethemalepartner'sfertility and allow conception to be achieved naturally. Detection of certain genetic causes of male infertility provides the opportunity to inform affected couples about the risk of transmitting genetic abnormalities that may affect the health of offspring, may affect the chance for successful treatment, and can help to guide treatment options. Evaluation of the infertile man also is aimed at identifying any underlying medical (...) femalepartneris>35yearsold(4).Men having concerns about their future fertility also merit evaluation. Ataminimum,theinitialscreening evaluation of the male partner of an infertile couple should include a repro- ductive history and analysis of at least onesemensample.Iftheinitialevalua- tionisabnormal,thenreferraltosome- one experienced in male reproduction is recommended. Reproductive History Thereproductivehistoryshouldinclude: 1)coitalfrequencyandtiming;2)dura- tion of infertility and previous fertility; 3

2015 Society for Assisted Reproductive Technology

15. Male factor infertility and lack of openness about infertility as risk factors for depressive symptoms in males undergoing assisted reproductive technology treatment in Italy. Full Text available with Trip Pro

Male factor infertility and lack of openness about infertility as risk factors for depressive symptoms in males undergoing assisted reproductive technology treatment in Italy. To investigate the association between male factor infertility and openness to discussing assisted reproductive technology (ART) treatment with levels of depression among men undergoing infertility treatment.Cross-sectional.Not applicable.Three hundred forty participants (170 men and their partners) undergoing ART (...) treatments.Administration of a set of questionnaires.Depressive symptoms were detected by means of the Zung Depression Self-Rating Scale. Participants' willingness to share their infertility treatment experience with other people was assessed by means of self-report questionnaires.In this study, 51.8% of males chose not to discuss their ART treatments with people other than their partner. In addition, the decision to discuss or not discuss the ART treatments with others was significantly associated with men's

2017 Fertility and Sterility

16. Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia. Full Text available with Trip Pro

Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia. Motile cilia and sperm flagella share an evolutionarily conserved axonemal structure. Their structural and/or functional defects are associated with primary ciliary dyskinesia (PCD), a genetic disease characterized by chronic respiratory-tract infections and in which most males are infertile due to asthenozoospermia. Among the well-characterized (...) axonemal protein complexes, the outer dynein arms (ODAs), through ATPase activity of their heavy chains (HCs), play a major role for cilia and flagella beating. However, the contribution of the different HCs (γ-type: DNAH5 and DNAH8 and β-type: DNAH9, DNAH11, and DNAH17) in ODAs from both organelles is unknown. By analyzing five male individuals who consulted for isolated infertility and displayed a loss of ODAs in their sperm cells but not in their respiratory cells, we identified bi-allelic mutations

2019 American Journal of Human Genetics

17. MNS1 variant associated with situs inversus and male infertility. Full Text available with Trip Pro

MNS1 variant associated with situs inversus and male infertility. Ciliopathy disorders due to abnormalities of motile cilia encompass a range of autosomal recessive conditions typified by chronic otosinopulmonary disease, infertility, situs abnormalities and hydrocephalus. Using a combination of genome-wide SNP mapping and whole exome sequencing (WES), we investigated the genetic cause of a form of situs inversus (SI) and male infertility present in multiple individuals in an extended Amish (...) being unaffected, consistent with an autosomal recessive mode of inheritance. This study identifies an MNS1 variant as a cause of laterality defects and male infertility in humans, mirroring findings in Mns1-deficient mice which also display male infertility and randomisation of left-right asymmetry of internal organs, confirming a crucial role for MNS1 in nodal cilia and sperm flagella formation and function.

2019 European Journal of Human Genetics

18. IMSI procedure improves clinical outcomes and embryo morphokinetics in patients with different aetiologies of male infertility. (Abstract)

IMSI procedure improves clinical outcomes and embryo morphokinetics in patients with different aetiologies of male infertility. Our objective was to evaluate the effect of IMSI on embryo kinetics and clinical outcomes in patients with different aetiologies of male infertility. A total of 150 couples with different aetiologies of male infertility were randomly divided into ICSI and IMSI treatment groups (n = 75). ICSI was done accordingly. For IMSI group, the sperm selection was done using MSOME (...) different aetiologies (p > 0.05). The rates of chemical pregnancy and implantation (37.8% and 38.2% respectively) were insignificantly higher in OAT patients compare to others (p > 0.05). Also, the clinical pregnancy and live birth rates (32% and 32% respectively) were insignificantly higher in teratozoospermia (T) cases. Sperm selection with MSOME parameters and IMSI can improve the embryo morphokinetics and clinical outcomes in couples with male factor infertility, especially for OAT and T patients.©

2019 Andrologia Controlled trial quality: uncertain

19. Oxidation reduction potential: a new biomarker of male infertility. Full Text available with Trip Pro

Oxidation reduction potential: a new biomarker of male infertility. Oxidative stress is considered a major etiology for male infertility, more specifically idiopathic infertility. The causes of seminal oxidative stress can be intrinsic, such as varicocele or due to the presence of active leukocytes and immature germ cells. Reported external causes are smoking, alcohol or exposure to environmental toxins. Traditional methods to determine the seminal oxidative stress do not evaluate this status

2019 Panminerva medica

20. Smartphone-based home screening tests for male infertility. (Abstract)

Smartphone-based home screening tests for male infertility. Diagnostic testing for male infertility has traditionally been limited to andrology labs. The advent of home-based semen testing has the potential to allow patients to perform testing in the comfort of their home and screen those who need a formal evaluation. An extensive review of the literature was performed. There are several FDA-approved devices for home semen testing. The mechanism of the test and the results provided differ (...) by test. The existing tests are limited in their diagnostic capabilities but may fill a niche for men who do not have access to andrology lab testing or prefer home testing.

2019 Panminerva medica

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