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Male Infertility

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1. Male factor infertility

Male factor infertility Male factor infertility - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Male factor infertility Last reviewed: February 2019 Last updated: March 2018 Summary Presence of abnormal semen parameters in the male partner of a couple unable to achieve conception after 1 year of unprotected intercourse. Male factor alone contributes to 20% of cases of infertile couples and to an additional 30% to 40 (...) % in combination with other factors. Most cases are of unknown aetiology. Diagnosed if abnormal semen parameters in 2 semen analyses separated by 1 month. Sperm functional assays, endocrine tests, genetic testing, and imaging can be helpful. Treatment should be targeted to the aetiological factors whenever possible. Assisted reproductive techniques are often the fastest and most effective method to achieve pregnancy regardless of the aetiology. Definition The clinical definition of male factor infertility

2018 BMJ Best Practice

2. Male Infertility

Male Infertility Male Infertility | Uroweb › Male Infertility Male Infertility To access the pdfs & translations of individual guidelines, please as EAU member. Non-EAU members can view the web versions. To become an EAU member, click . A. Jungwirth (Chair), T. Diemer (Vice-chair), Z. Kopa, C. Krausz, S. Minhas, H. Tournaye TABLE OF CONTENTS REFERENCES 1. Dohle, G.R., et al. EAU Guidelines on Male Infertility. Eur Urol, 2005. 48: 703. 2. Jungwirth, A., et al. European Association of Urology (...) guidelines on Male Infertility: the 2012 update. Eur Urol, 2012. 62: 324. 3. Guyatt, G.H., et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ, 2008. 336: 924. 4. Guyatt, G.H., et al. What is “quality of evidence” and why is it important to clinicians? BMJ, 2008. 336: 995. 5. Phillips B, et al. Oxford Centre for Evidence-based Medicine Levels of Evidence. Updated by Jeremy Howick March 2009. 1998. 6. Guyatt, G.H., et al. Going from evidence

2019 European Association of Urology

3. Diagnostic evaluation of sexual dysfunction in the male partner in the setting of infertility: a committee opinion

Diagnostic evaluation of sexual dysfunction in the male partner in the setting of infertility: a committee opinion Diagnostic evaluation of sexual dysfunctioninthemalepartnerinthe setting of infertility: a committee opinion PracticeCommitteeoftheAmericanSocietyforReproductiveMedicineinCollaborationWiththeSocietyfor Male Reproduction and Urology American Society for Reproductive Medicine, Birmingham, Alabama It is the responsibility of the clinician to assess for the presence of erectile (...) - and-sterility/posts/36354-26626 INTRODUCTION Sexual dysfunctionisacommoncondi- tion among men of reproductive age. It can be signi?cantly worsened by the stress of infertility. It is important to elicit this information and provide the appropriate referral. This document will presentdiagnosis,evaluation, andtreat- ment of the most common sexual dysfunction issues seen by fertility pro- viders. These issues drive patients to seek care and offer an opportunity to improve male somatic health

2018 Society for Assisted Reproductive Technology

4. Male Infertility

Male Infertility Male Infertility | Uroweb › Male Infertility Male Infertility To access the pdfs & translations of individual guidelines, please as EAU member. Non-EAU members can view the web versions. To become an EAU member, click . A. Jungwirth (Chair), T. Diemer (Vice-chair), Z. Kopa, C. Krausz, S. Minhas, H. Tournaye TABLE OF CONTENTS REFERENCES 1. Dohle, G.R., et al. EAU Guidelines on Male Infertility. Eur Urol, 2005. 48: 703. 2. Jungwirth, A., et al. European Association of Urology (...) guidelines on Male Infertility: the 2012 update. Eur Urol, 2012. 62: 324. 3. Guyatt, G.H., et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ, 2008. 336: 924. 4. Guyatt, G.H., et al. What is “quality of evidence” and why is it important to clinicians? BMJ, 2008. 336: 995. 5. Phillips B, et al. Oxford Centre for Evidence-based Medicine Levels of Evidence. Updated by Jeremy Howick March 2009. 1998. 6. Guyatt, G.H., et al. Going from evidence

2018 European Association of Urology

5. Potential effects of male obesity and nutritional factors on sperm disorders and idiopathic male infertility

Potential effects of male obesity and nutritional factors on sperm disorders and idiopathic male infertility Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

6. The effectiveness of ICSI versus conventional IVF in couples with non-male factor infertility: study protocol for a randomised controlled trial. (PubMed)

The effectiveness of ICSI versus conventional IVF in couples with non-male factor infertility: study protocol for a randomised controlled trial. Does ICSI result in a higher live birth rate as compared with conventional IVF in couples with non-male factor infertility?ICSI is primarily indicated for severe male factor infertility. While the use of ICSI for couples with non-male factor infertility has been increasing worldwide, this is not supported by data from randomised controlled trials (...) . Evidence from non-randomised studies suggest no benefit from ICSI compared with conventional IVF in non-male factor infertility, if not a harm.This randomised, open-label, multi-centre trial aims to compare the effectiveness of one ICSI cycle and one conventional IVF cycle in infertile couples with non-male factor infertility. A total of 1064 couples will be randomly allocated to an ICSI group and a conventional IVF group. The estimated duration of the study is 30 months.Eligible couples are those

2019 Publication 4890926 Controlled trial quality: predicted high

7. Male factor infertility and lack of openness about infertility as risk factors for depressive symptoms in males undergoing assisted reproductive technology treatment in Italy. (PubMed)

Male factor infertility and lack of openness about infertility as risk factors for depressive symptoms in males undergoing assisted reproductive technology treatment in Italy. To investigate the association between male factor infertility and openness to discussing assisted reproductive technology (ART) treatment with levels of depression among men undergoing infertility treatment.Cross-sectional.Not applicable.Three hundred forty participants (170 men and their partners) undergoing ART (...) treatments.Administration of a set of questionnaires.Depressive symptoms were detected by means of the Zung Depression Self-Rating Scale. Participants' willingness to share their infertility treatment experience with other people was assessed by means of self-report questionnaires.In this study, 51.8% of males chose not to discuss their ART treatments with people other than their partner. In addition, the decision to discuss or not discuss the ART treatments with others was significantly associated with men's

2017 Fertility and Sterility

8. Knowledge gaps in male infertility: a reproductive endocrinology and infertility perspective (PubMed)

Knowledge gaps in male infertility: a reproductive endocrinology and infertility perspective Reproductive research has moved forward at a remarkable pace. Some of these advances are the result of a separation between male and female specialties, allowing focused study in specific areas of the field. However, the different training programs between male and female fertility specialists has created an environment in which some discoveries are not put in the greater context of clinical care (...) plausibility to account for subfertility of some male partners. However, until well defined thresholds for predicting outcomes in different treatment scenarios are available, changes in sperm DNA fragmentation testing is not an adequate outcome for measuring the utility of interventions. The biggest limitation for these tests remains their analysis of bulk semen. Tests allowing interrogation of the reproductive competence of a given sperm, while allowing that sperm to be used in assisted reproductive

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2018 Translational andrology and urology

9. Resistance exercise modulates male factor infertility through anti-inflammatory and antioxidative mechanisms in infertile men: A RCT. (PubMed)

Resistance exercise modulates male factor infertility through anti-inflammatory and antioxidative mechanisms in infertile men: A RCT. Inflammation and oxidative stress appear to be involved in the pathogenesis of male factor infertility. Exercise training has been shown to strengthen antioxidant defenceses and attenuate inflammation across body fluids, organs and tissues. However, the effect of resistance exercise training upon male factor infertility is unknown. Our aim was to investigate (...) the effects of resistance exercise training on markers of male reproduction and reproductive performance in infertile patients.This study evaluated the changes in seminal oxidative stress status, inflammatory biomarkers, semen parameters, sperm DNA integrity and pregnancy rate following 24 weeks of resistance exercise in infertile patients. A total of 1228 sedentary infertile patient (aged 25-40 years) were screened and 430 were randomized to exercise (EX, n = 216) and non-exercise (NON-EX, n = 214

2018 Life sciences Controlled trial quality: uncertain

10. Male infertility, azoozpermia and cryptozoospermia incidence among three infertility clinics in Turkey (PubMed)

Male infertility, azoozpermia and cryptozoospermia incidence among three infertility clinics in Turkey Semen parameters are directly correlated with the infertility of the male. Incidence rates of male factor infertility, azoospermia and cryptozoospermia differ according to many factors such as geographic region, age, occupation and body weight. The aim of the present study is to determine the incidence of male factor infertility, azoospermia and cryptozoospermia among patients who have been (...) admitted to three separate infertility clinics in Turkey for infertility investigation and analyze the outcomes of these patients.A total of 9733 men, who have been admitted to 3 infertility clinics in Turkey due to infertility between March 2011 and October 2016, were included in the study. Male infertility, azoozpermia and cryptozoospermia incidence were calculated according to WHO criteria.Male factor infertility was determined in 3114 (32%) of the patients including cases with azoospermia

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2018 Turkish journal of urology

11. Women’s perceptions and experiences of the challenges in the process of male infertility treatment: A qualitative study (PubMed)

Women’s perceptions and experiences of the challenges in the process of male infertility treatment: A qualitative study Despite the fact that both men and women are equally subject to infertility, it is usually women who bear the burden of treatment and its consequences, even in cases of male infertility. Therefore, it is more necessary to recognize their health problems in order to help them.To explore women's perceptions and experiences of the challenges they face in the process of male (...) infertility treatment.This qualitative study was conducted during 2014-2015 using content analysis. Thirty semi-structured interviews were conducted with women whose husbands suffered from male infertility. Purposive sampling was conducted until data saturation was achieved. All interviews were recorded, transcribed and analyzed using conventional content analysis adopted by Graneheim and Lundman.From data analysis, the major category of "treatment-related stresses" and four subcategories of "high

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2017 Electronic physician

12. Does ICSI improve live birth rates when compared to conventional IVF in non-male infertility?

Does ICSI improve live birth rates when compared to conventional IVF in non-male infertility? Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2019 PROSPERO

13. Effects of physical exercises on reproductive function and reproductive outcomes in male infertility: a systematic review and meta-analysis of randomized controlled trials

Effects of physical exercises on reproductive function and reproductive outcomes in male infertility: a systematic review and meta-analysis of randomized controlled trials Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2019 PROSPERO

14. A novel copy number variation in CATSPER2 causes idiopathic male infertility with normal semen parameters. (PubMed)

A novel copy number variation in CATSPER2 causes idiopathic male infertility with normal semen parameters. Are genetic abnormalities in CATSPER (cation channel of sperm) genes associated with idiopathic male infertility with normal semen parameters and, if so, how do they affect male fertility?A novel copy number variation (CNV) in CATSPER2 causes idiopathic male infertility with normal semen parameters by disrupting the ability of sperm to penetrate viscous media, undergo hyperactivation (...) and respond to progesterone.CATSPER is the principle Ca2+ channel mediating extracellular Ca2+ influx into spermatozoa. Although several case reports have suggested a causal relationship between CATSPER disruption and human male infertility, whether genetic abnormalities in CATSPER genes are associated with idiopathic male infertility with normal semen parameters remains unclear.Spermatozoa were obtained from men attending the reproductive medical center at Jiangxi Provincial Maternal and Child Health

2019 Human Reproduction

15. Tobacco smoking and semen quality in infertile males: a systematic review and meta-analysis. (PubMed)

Tobacco smoking and semen quality in infertile males: a systematic review and meta-analysis. Nowadays, the total number of couples visiting an infertility clinic is on the rise. Tobacco smoking is considered one of the major factors leading to male infertility. In this study, we aimed to systematically investigate the impact of tobacco smoking on semen quality in infertile male participants.Online databases (Cochrane Central database of Randomized Controlled Trials and the databases of MEDLINE (...) generated to represent the results.Sixteen studies with a total number of 10,823 infertile male participants (5257 smokers and 5566 non-smokers) were included. Results of this analysis showed oligozoospermia to be significantly higher in smokers (RR: 1.29, 95% CI: 1.05-1.59; P = 0.02). Morphological defect of spermatozoa (MD: 2.44, 95% CI: 0.99-3.89; P = 0.001) was also significantly higher in smokers whereby significant head (MD: 1.76, 95% CI: 0.32-3.20; P = 0.02), neck (MD: 1.97, 95% CI: 0.75-3.18; P

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2019 BMC Public Health

16. Ibuprofen linked to male infertility? It’s pure speculation

Ibuprofen linked to male infertility? It’s pure speculation Ibuprofen linked to male infertility? It’s pure speculation - HealthNewsReview.org Note to our followers: Our nearly 13-year run of daily publication of new content on HealthNewsReview.org came to a close at the end of 2018. Publisher Gary Schwitzer and other contributors may post new articles periodically. But all of the 6,000+ articles we have published contain lessons to help you improve your critical thinking about health care (...) interventions. And those will be still be alive on the site for a couple of years. 6093 Posts Menu January 10, 2018 Ibuprofen linked to male infertility? It’s pure speculation Posted By Categories , , Tags , Mary Chris Jaklevic has freelanced for HealthNewsReview.org since 2016 and recently joined the staff as a full-time health care journalist. She tweets as @mcjaklevic. At least 10 news organizations rushed this week to cover a asserting that the widely used painkiller ibuprofen might cause male

2018 HealthNewsReview

17. A systematic review and standardized clinical validity assessment of male infertility genes. (PubMed)

A systematic review and standardized clinical validity assessment of male infertility genes. Which genes are confidently linked to human monogenic male infertility?Our systematic literature search and clinical validity assessment reveals that a total of 78 genes are currently confidently linked to 92 human male infertility phenotypes.The discovery of novel male infertility genes is rapidly accelerating with the availability of next-generating sequencing methods, but the quality of evidence (...) for gene-disease relationships varies greatly. In order to improve genetic research, diagnostics and counseling, there is a need for an evidence-based overview of the currently known genes.We performed a systematic literature search and evidence assessment for all publications in Pubmed until December 2018 covering genetic causes of male infertility and/or defective male genitourinary development.Two independent reviewers conducted the literature search and included papers on the monogenic causes

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2019 Human Reproduction

18. The relevance of MTHFR C677T, A1298C, and MTRR A66G polymorphisms with response to male infertility in Asians: A meta-analysis. (PubMed)

The relevance of MTHFR C677T, A1298C, and MTRR A66G polymorphisms with response to male infertility in Asians: A meta-analysis. Although published studies have reported the association between MTHFR C677T (rs 1801133), A1298C (rs 1801131), and MTRR A66G (rs1801394) polymorphisms and male infertility in Asian populations, the results are conflicting. In order to accurately evaluate the relevance, a meta-analysis was performed.We searched for potential studies in 4 databases, containing PubMed (...) , 12 studies of MTHFR A1298C polymorphism and 4 studies of MTRR A66G polymorphism. The results indicated that MTHFR C677T, A1298C, and MTRR A66G polymorphisms were significantly associated with male infertility in Asian populations (Dominant model: MTHFR CC + CT vs TT: OR = 0.60, 95% CI (0.53, 0.67), P <.00001; MTHFR AA + AC vs CC: OR = 0.62, 95% CI (0.49, 0.79), P = .0001; MTRR AA + AG vs GG: OR = 0.60, 95% CI (0.45, 0.81), P = .001. Recessive model: MTHFR CC vs CT + TT: OR = 0.67, 95% CI (0.61

2019 Medicine

19. Non-Robertsonian translocations involving chromosomes 13, 14, or 15 in male infertility: 28 cases and a review of the literature. (PubMed)

Non-Robertsonian translocations involving chromosomes 13, 14, or 15 in male infertility: 28 cases and a review of the literature. For genetic counseling of male carriers of chromosomal translocations, the specific chromosomes and breakpoints involved in the translocation are relevant to know. The structural chromosomal abnormalities may lead to abnormal sperm counts, infertility, and miscarriage. These are related to the specific chromosomes and breakpoints involved in the translocation (...) . To date, over 200 cases of non-Robertsonian translocation in male carriers have been described that involve chromosomes 13, 14, or 15.This study reports of 28 male carriers from our clinic with balanced reciprocal translocations of chromosome 13, 14, or 15, and a literature review of 201 cases. The 28 male carriers from our clinic were diagnosed by cytogenetic analyses: 19 subjects suffered from pregestational infertility and 9 from gestational infertility. The most common translocations were t(7;13

2019 Medicine

20. Introduction: Surgical treatment of male infertility: a state-of-the-art overview. (PubMed)

Introduction: Surgical treatment of male infertility: a state-of-the-art overview. Surgical treatments offer effective solutions for many couples experiencing male factor infertility. This Views and Reviews collection of articles offers a state-of-the-art overview of the surgical procedures commonly used to treat impaired male reproductive health.Copyright © 2019. Published by Elsevier Inc.

2019 Fertility and Sterility

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