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Malaria Chemoprophylaxis

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101. The risk of malaria in travelers to India. (PubMed)

The risk of malaria in travelers to India. Several countries have reported a decline in malaria cases imported by travelers returning from India.We collected data on imported malaria for the period 1992 to 2005 from nine countries. Traveler statistics denominator data were obtained from the Indian Ministry of Tourism.The malaria case numbers declined from 93 cases per 100,000 travelers in 1992 to 19 cases per 100,000 travelers in 2005. The proportion of Plasmodium falciparum decreased steadily (...) throughout the years. The proportion of Plasmodium vivax accounts for more than 80% of all cases of malaria in travelers to India. Deaths due to malaria were rare; only the UK and the United States reported deaths, a total of 16, between 1992 and 2005. The high-risk areas for malaria in India can be clearly identified using endemic malaria data. High-risk states are Chhattisgarh, Orissa, Jharkhand, West Bengal, Goa (mainly P vivax), and the states east of Bangladesh.The decreasing incidence of malaria

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2017 Journal of Travel Medicine

102. Variability in malaria prophylaxis prescribing across europe: a delphi method analysis. (PubMed)

Variability in malaria prophylaxis prescribing across europe: a delphi method analysis. The indications for prescribing malaria chemoprophylaxis lack a solid evidence base that results in subjectivity and wide variation of practice across countries and among professionals.European experts in travel medicine, who are members of TropNetEurop, participated in a survey conducted using the Delphi method. This technique aims at evaluating and developing a consensus through iterations (...) that improving the evidence base on efficacy and tolerability and risk of malaria for prescribing chemoprophylaxis is needed as is further discussion across Europe to achieve harmonization of prescribing practice.

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2017 Journal of Travel Medicine

103. Sterile protection against human malaria by chemoattenuated PfSPZ vaccine. (PubMed)

-attenuated, cryopreserved PfSPZ ('PfSPZ Vaccine'); or by infectious PfSPZ inoculated by mosquitoes to volunteers taking chloroquine or mefloquine (chemoprophylaxis with sporozoites). We assessed immunization by direct venous inoculation of aseptic, purified, cryopreserved, non-irradiated PfSPZ ('PfSPZ Challenge') to malaria-naive, healthy adult volunteers taking chloroquine for antimalarial chemoprophylaxis (vaccine approach denoted as PfSPZ-CVac). Three doses of 5.12 × 104 PfSPZ of PfSPZ Challenge at 28 (...) Sterile protection against human malaria by chemoattenuated PfSPZ vaccine. A highly protective malaria vaccine would greatly facilitate the prevention and elimination of malaria and containment of drug-resistant parasites. A high level (more than 90%) of protection against malaria in humans has previously been achieved only by immunization with radiation-attenuated Plasmodium falciparum (Pf) sporozoites (PfSPZ) inoculated by mosquitoes; by intravenous injection of aseptic, purified, radiation

2017 Nature Controlled trial quality: uncertain

104. Efficacy of standardized extract of Hibiscus sabdariffa L. (Malvaceae) in Improving Iron Status of Adults in Malaria Endemic Area: A Randomized controlled trial. (PubMed)

when concurrently used with malaria chemoprophylaxis in malaria endemic areas.Copyright © 2017 Elsevier Ireland Ltd. All rights reserved. (...) Efficacy of standardized extract of Hibiscus sabdariffa L. (Malvaceae) in Improving Iron Status of Adults in Malaria Endemic Area: A Randomized controlled trial. Indigenous community of Mkuranga district have been using aqueous extract of H. sabdariffa L. for treating anemia. However, there have been neither safety nor efficacy studies to validate this medicinal product in anemia.The purpose of this study was to establish efficacy and safety of standardized aqueous extract of H. sabdariffa L

2017 Journal of Ethnopharmacology Controlled trial quality: uncertain

105. Sanaria PfSPZ Challenge With Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Trial to Determine Safety and Protective Efficacy of Sanaria PfSPZ Challenge With Concurrent Pyrimethamine Treatment That Inhibits Development of Asexual B...

. Condition or disease Intervention/treatment Phase Malaria Drug: Chloroquine (CQ) Drug: Pyrimethamine (PYR) Biological: Sanaria PfSPZ Challenge (NF54) Phase 1 Detailed Description: Human studies have shown that immunization by the bite PfSPZ-infected mosquitoes under drug coverage with chloroquine, an approach called chemoprophylaxis with sporozoites (CPS), infection treatment vaccination (ITV), or chemoprophylaxis vaccination (CVac) can provide high level, long term protection against homologous (...) will contribute to understanding the targets and mechanisms of immunity against Pf malaria infection. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 57 participants Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Prevention Official Title: Sanaria PfSPZ Challenge With Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Trial to Determine Safety and Protective

2015 Clinical Trials

106. Safety, Tolerability, and Compliance with Long-Term Antimalarial Chemoprophylaxis in American Soldiers in Afghanistan. (PubMed)

% of soldiers reported use of bed nets and skin repellents, respectively. Compliance with long-term malaria prophylaxis was poor, and there were substantial tolerability issues based on these anonymous survey results, though fewer with MQ than doxycycline. Given few long-term antimalarial chemoprophylaxis options, there is an unmet medical need for new antimalarials safe for long-term use. © The American Society of Tropical Medicine and Hygiene. (...) Safety, Tolerability, and Compliance with Long-Term Antimalarial Chemoprophylaxis in American Soldiers in Afghanistan. Long-term antimalarial chemoprophylaxis is currently used by deployed U.S. military personnel. Previous small, short-term efficacy studies have shown variable rates of side effects among patients taking various forms of chemoprophylaxis, though reliable safety and tolerability data on long-term use are limited. We conducted a survey of troops returning to Fort Drum, NY

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2015 American Journal of Tropical Medicine & Hygiene

107. Malaria prophylaxis

, mefloquine, proguanil, Malarone® (atovaquone-proguanil combination) and doxycycline. Choice of medication for effective chemoprophylaxis is guided by the existing patterns of parasite resistance in the area of travel, the possibility of adverse maternal side effects and patient-specific medical history. Please refer to the specific UKTIS monographs on individual antimalarials for further information. Considering the maternal and fetal risks posed by gestational malaria infection, antimalarials should (...) Malaria prophylaxis MALARIA PROPHYLAXIS IN PREGNANCY 0344 892 0909 MALARIA PROPHYLAXIS IN PREGNANCY (Date of issue: February 2019 , Version: 3 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient information leaflet on is available at . Summary Malaria is caused by a protozoan parasite, Plasmodium

2014 UK Teratology Information Service

108. Target Antigens Induced by Plasmodium Falciparum Sporozoite Immunization Under Chemoprophylaxis

with a homologous parasite by immunization with Plasmodium parasites while taking chloroquine chemoprophylaxis (ChemoProphylaxis and Sporozoites, CPS-immunization). The unprecedented efficacy of CPS-immunization makes it a unique model to identify pre-erythrocytic target antigens for the development of a subunit vaccine. Identification of antigens that play a significant role in the development of sterile protection against malaria will provide a basis for the development and evaluation of more effective sub (...) Target Antigens Induced by Plasmodium Falciparum Sporozoite Immunization Under Chemoprophylaxis Target Antigens Induced by Plasmodium Falciparum Sporozoite Immunization Under Chemoprophylaxis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2014 Clinical Trials

109. Safety and Protective Efficacy of Intravenous Immunization With Cryopreserved Plasmodium Falciparum Sporozoites Under Chemoprophylaxis

: Benjamin Mordmüller, MD Institute of Tropical Medicine, University of Tuebingen More Information Go to Publications of Results: Layout table for additonal information Responsible Party: Sanaria Inc. ClinicalTrials.gov Identifier: Other Study ID Numbers: TUCHMI-002 2013-003900-38 ( EudraCT Number ) First Posted: April 16, 2014 Last Update Posted: May 15, 2017 Last Verified: February 2016 Keywords provided by Sanaria Inc.: Malaria Plasmodium falciparum malaria Antimalarial chemoprophylaxis PfSPZ (...) Safety and Protective Efficacy of Intravenous Immunization With Cryopreserved Plasmodium Falciparum Sporozoites Under Chemoprophylaxis Safety and Protective Efficacy of Intravenous Immunization With Cryopreserved Plasmodium Falciparum Sporozoites Under Chemoprophylaxis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning

2014 Clinical Trials

110. Chemoprophylaxis and Plasmodium Falciparum NF54 Sporozoite Immunization Challenged by Heterologous Infection

countries. Ultimately, the key to malaria control, and hopefully eradication, would be an effective vaccine. Though a number of vaccine-candidates have entered the pipeline of pre-clinical and clinical development, they have yet to achieve the level of efficacy necessary for effective malaria prevention. It has been shown previously that if healthy human volunteers taking chloroquine chemoprophylaxis are repeatedly exposed to Plasmodium parasites through the bites of infected mosquitoes, they are fully (...) protected against a later challenge infection with a 'homologous' (genetically similar) Plasmodium parasite. This process is known as ChemoProphylaxis and Sporozoites, or CPS-immunization. One of the obstacles to developing an effective vaccine is the genetic heterogeneity of malaria parasites. To further consider the development of whole-parasite based vaccines against malaria and in order to better understand the protective immunity induced by CPS-immunization, it is essential to investigate whether

2014 Clinical Trials

111. A Challenge Study to Assess the Safety, Immunogenicity and Efficacy of a Malaria Vaccine Candidate

steroids are allowed. Administration of long-acting immune-modifying drugs at any time during the study period (e.g. infliximab). Chronic use of antibiotics with antimalarial effects (e.g. tetracyclines for dermatologic patients, sulfa for recurrent urinary tract infections, etc.). History of malaria chemoprophylaxis within 60 days prior to vaccination. History of allergic disease or reactions likely to be exacerbated by any component of the vaccine. Any history of anaphylaxis in relation (...) A Challenge Study to Assess the Safety, Immunogenicity and Efficacy of a Malaria Vaccine Candidate A Challenge Study to Assess the Safety, Immunogenicity and Efficacy of a Malaria Vaccine Candidate - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove

2016 Clinical Trials

112. Use of Malaria Rapid Diagnostic Tests as a Decision Aid for the Management of Fever by International Travelers

of these febrile illness episodes. Its objective is to evaluate the clinical use of malaria rapid diagnostic tests (RDT) by travelers or their peers during travel, as a decision aid for the management of febrile illness in the tropics. If the study demonstrates that malaria can be ruled out safely by travelers themselves using a RDT, a combination of self/peer testing with SBET may become an alternative to antimalarial chemoprophylaxis in travel medicine. Condition or disease Intervention/treatment Fever (...) Use of Malaria Rapid Diagnostic Tests as a Decision Aid for the Management of Fever by International Travelers Use of Malaria Rapid Diagnostic Tests as a Decision Aid for the Management of Fever by International Travelers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2016 Clinical Trials

113. Seasonality and shift in age-specific malaria prevalence and incidence in Binko and Carrière villages close to the lake in Selingué, Mali. (PubMed)

), but the incidence remained high until December. Surprisingly, the risk of clinical malaria was two- to nine-fold higher among children 5-9 years old compared to younger children.A shift in the peak of clinical episodes from children under 5-9 years of age calls for expanding control interventions, such as seasonal malaria chemoprophylaxis targeting the peak transmission months. (...) Seasonality and shift in age-specific malaria prevalence and incidence in Binko and Carrière villages close to the lake in Selingué, Mali. Malaria transmission in Mali is seasonal and peaks at the end of the rainy season in October. This study assessed the seasonal variations in the epidemiology of malaria among children under 10 years of age living in two villages in Selingué: Carrière, located along the Sankarani River but distant from the hydroelectric dam, and Binko, near irrigated rice

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2016 Malaria journal

114. Pre-infection administration of asiatic acid retards parasitaemia induction in Plasmodium berghei murine malaria infected Sprague-Dawley rats. (PubMed)

Pre-infection administration of asiatic acid retards parasitaemia induction in Plasmodium berghei murine malaria infected Sprague-Dawley rats. Malaria prevention has remained a critical area in the absence of efficacious vaccines against malaria. Drugs currently used as chemotherapeutics are also used in chemoprophylaxis increasing possible drug resistance. Asiatic acid is a natural phytochemical with oxidant, antioxidant and anti-inflammatory properties with emerging anti-malarial potential (...) preserved food and water intake as well as increase in percentage weight gain of infected animals. In pre-infection treated animals, the pre-patent period was extended to day 6 from 72 h. Asiatic acid suppressed parasitaemia while oral chloroquine (30 mg/kg) did not influence malaria induction.Per-oral, pre-infection, asiatic acid administration influenced parasitaemia patency and parasitaemia progression, food, water, and weight gain percentage. This may suggest possible chemoprophylaxis effects

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2016 Malaria journal

115. Epidemiology and clinical features of imported malaria in East London. (PubMed)

described and risk factors associated with severe falciparum malaria were explored.In total, 133 patients with laboratory-confirmed malaria were identified including three requiring critical care admission but no deaths. The median age at presentation was 41 years (IQR 30-50). The majority of patients were males (64.7%, 86/133) and had Black or Black British ethnicity (67.5%, 79/117). West Africa was the most frequent region of travel (70.4%, 76/108). Chemoprophylaxis use was poor (25.3%, 20/79 (...) Epidemiology and clinical features of imported malaria in East London. Malaria is the most common imported tropical disease in the United Kingdom (UK). The overall mortality is low but inter-regional differences have been observed.We conducted a 2-year retrospective review of clinical and laboratory records of patients with malaria attending three acute hospitals in East London from 1 April 2013 through 31 March 2015. Epidemiological and clinical characteristics of imported malaria were

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2016 Journal of Travel Medicine

116. The prevalence of malaria in people living with HIV in Yaounde, Cameroon. (PubMed)

The prevalence of malaria in people living with HIV in Yaounde, Cameroon. Coinfection with malaria and HIV is common in Sub-Saharan Africa. In the advent of a decline in the global incidence of malaria, it is important to generate updated data on the burden of malaria in people living with HIV (PLWHIV). This study was designed to determine the prevalence of malaria in PLWHIV in Yaounde, Cameroon, as well determine the association between CD4 (+) T cell count and malaria in the study (...) population.In a cross sectional study performed between April 2015 and June 2016, 355 PLWHIV were enrolled and blood samples were collected for analysis. Complete blood count was performed using an automated haematology analyser (Mindray®, BC-2800) and CD4 (+) T cell count was performed using a flow cytometer (BD FASCount™). Giemsa-stained blood films were examined to detect malaria parasite. The Pearson's chi-square, student's T-test, ANOVA, and correlation analysis were all performed as part

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2016 BMC Public Health

117. Historical Review: Problematic Malaria Prophylaxis with Quinine. (PubMed)

Historical Review: Problematic Malaria Prophylaxis with Quinine. Quinine, a bitter-tasting, short-acting alkaloid drug extracted from cinchona bark, was the first drug used widely for malaria chemoprophylaxis from the 19th century. Compliance was difficult to enforce even in organized groups such as the military, and its prophylaxis potential was often questioned. Severe adverse events such as blackwater fever occurred rarely, but its relationship to quinine remains uncertain. Quinine

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2016 American Journal of Tropical Medicine & Hygiene

118. Malaria

Presentation within the first month of return from travel to endemic region Delayed presentation beyond 2 months may occur with the use of chemoprophylaxis Initial prodrome Malaise Next (>50% of patients) Shaking chills Next Drowsiness Lethargy Other symptoms Myalgias More severe in Muscle tenderness More severe in and s Back pain VI. Signs for 1-8 hours recurs Plasmodium Vivax: 48 hour intervals (Tertian Fever) Plasmodium Malariae: 72 hour intervals (Quartan Fever) Plasmodium Falciparum: Variable (...) when patient is febrile Image Rapid blood dipstick testing (when smear not available) Tests HRP-2 detection (only detects P. falciparum) LDH detection (detects all 4 Malaria types) Precautions Decreased with low levels of mia Examples: Patients who took chemoprophylaxis, or prior exposure Negative rapid tests should be confirmed with blood smears Malaria PCR Detects low levels of parsites in blood (<5 s/ul) Distinguishes between plasmodium species May be used to monitor response to treatment at 5-8

2018 FP Notebook

119. Epidemiological and entomological studies of a malaria outbreak among French armed forces deployed at illegal gold mining sites reveal new aspects of the disease's transmission in French Guiana. (PubMed)

and P. vivax were tested by both enzyme-linked immunosorbent assay and real-time PCR.Seventy-two P. vivax malaria cases were reported (three were mixed P. falciparum/P. vivax infections), leading to a global attack rate of 26.5% (72/272). Lack of compliance with vector control measures and doxycycline chemoprophylaxis was reported by patients. Two illegal gold mining sites located in remote areas in the primary forest were identified as places of contamination. In all, 595 Anopheles females were (...) Epidemiological and entomological studies of a malaria outbreak among French armed forces deployed at illegal gold mining sites reveal new aspects of the disease's transmission in French Guiana. In December 2010, a Plasmodium vivax malaria outbreak occurred among French forces involved in a mission to control illegal gold mining in French Guiana. The findings of epidemiological and entomological investigations conducted after this outbreak are presented here.Data related to malaria cases

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2016 Malaria journal

120. UK Malaria Treatment Guidelines 2016. (PubMed)

be considered. 23. An acute attack of malaria does not confer protection from future attacks: individuals who have had malaria should take effective anti-mosquito precautions and chemoprophylaxis during future visits to endemic areas.Copyright © 2016 The British Infection Association. Published by Elsevier Ltd. All rights reserved. (...) UK Malaria Treatment Guidelines 2016. 1.Malaria is the tropical disease most commonly imported into the UK, with 1300-1800 cases reported each year, and 2-11 deaths. 2. Approximately three quarters of reported malaria cases in the UK are caused by Plasmodium falciparum, which is capable of invading a high proportion of red blood cells and rapidly leading to severe or life-threatening multi-organ disease. 3. Most non-falciparum malaria cases are caused by Plasmodium vivax; a few cases are caused

2016 Journal of Infection

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