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Malaria Chemoprophylaxis

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61. How can interventions that target forest-goers be tailored to accelerate malaria elimination in the Greater Mekong Subregion? A systematic review of the qualitative literature. Full Text available with Trip Pro

and the characteristics of these measures. In contrast, anti-malarial drugs, for example, as chemoprophylaxis, hold promise but require further evaluation. (...) How can interventions that target forest-goers be tailored to accelerate malaria elimination in the Greater Mekong Subregion? A systematic review of the qualitative literature. Despite decreases in incidence and related mortality, malaria remains a major public health challenge in the Greater Mekong Sub-region (GMS). The emergence of artemisinin resistance threatens these gains and has prompted efforts to accelerate elimination in the region. In the GMS, transmission now clusters in hotspots

2019 Malaria journal

62. Chemotherapy and Chemoprophylaxis of Malaria Full Text available with Trip Pro

Chemotherapy and Chemoprophylaxis of Malaria 14904985 2004 02 15 2018 12 01 0007-1447 1 4758 1952 Mar 15 British medical journal Br Med J Chemotherapy and chemoprophylaxis of malaria; clinical trials in 500 cases and mass prophylaxis in a hyperendemic area. 568-74 CHAUDHURI R N RN CHAKRAVARTY N K NK RAI CHAUDHURI M N MN JANARDAN POTI S S eng Journal Article England Br Med J 0372673 0007-1447 OM Chemoprevention Humans Malaria therapy 5221:35569:224 MALARIA/therapy 1952 3 15 1952 3 15 0 1 1952 3

1952 British medical journal

63. Chemoprophylaxis for Malaria Full Text available with Trip Pro

Chemoprophylaxis for Malaria 18730679 2010 06 28 2010 06 28 0008-1264 116 2 1972 Feb California medicine Calif Med Chemoprophylaxis for malaria. 51-2 Chin J J eng Journal Article United States Calif Med 0410260 0008-1264 1972 2 1 0 0 1972 2 1 0 1 1972 2 1 0 0 ppublish 18730679 PMC1518218

1972 California Medicine

64. Chemoprophylaxis of malaria. Full Text available with Trip Pro

Chemoprophylaxis of malaria. 791446 1977 01 29 2018 11 13 0007-1447 2 6046 1976 Nov 20 British medical journal Br Med J Chemoprophylaxis of malaria. 1215-6 eng Editorial England Br Med J 0372673 0007-1447 0 Antimalarials 88463U4SM5 Sulfadoxine 886U3H6UFF Chloroquine S61K3P7B2V Proguanil Z3614QOX8W Pyrimethamine AIM IM Adult Antimalarials administration & dosage Chloroquine therapeutic use Humans Malaria prevention & control Plasmodium falciparum Proguanil therapeutic use Pyrimethamine

1976 British medical journal

65. Chemoprophylaxis of malaria. Full Text available with Trip Pro

Chemoprophylaxis of malaria. 326335 1977 08 12 2013 11 21 0007-1447 1 6075 1977 Jun 11 British medical journal Br Med J Chemoprophylaxis of malaria. 1535 Johnson F A FA eng Letter England Br Med J 0372673 0007-1447 0 Hemoglobin, Sickle 886U3H6UFF Chloroquine AIM IM Chloroquine therapeutic use Hemoglobin, Sickle metabolism Humans Malaria prevention & control Plasmodium falciparum 1977 6 11 1977 6 11 0 1 1977 6 11 0 0 ppublish 326335 PMC1607227

1977 British medical journal

66. Chemoprophylaxis of malaria. Full Text available with Trip Pro

Chemoprophylaxis of malaria. 837161 1977 04 30 2018 11 13 0007-1447 1 6058 1977 Feb 12 British medical journal Br Med J Chemoprophylaxis of malaria. 447 Bergson V V eng Letter England Br Med J 0372673 0007-1447 0 Antimalarials 0 Drug Combinations 88463U4SM5 Sulfadoxine Z3614QOX8W Pyrimethamine AIM IM Antimalarials administration & dosage therapeutic use Drug Combinations Humans Malaria prevention & control Pyrimethamine therapeutic use Sulfadoxine therapeutic use 1977 2 12 1977 2 12 0 1 1977 2

1977 British medical journal

67. Falciparum malaria despite chemoprophylaxis. Full Text available with Trip Pro

Falciparum malaria despite chemoprophylaxis. 376057 1979 09 01 2013 11 21 0007-1447 1 6174 1979 May 19 British medical journal Br Med J Falciparum malaria despite chemoprophylaxis. 1351 Bentley S J SJ eng Letter England Br Med J 0372673 0007-1447 0 Drug Combinations 886U3H6UFF Chloroquine 8W5C518302 Dapsone Z3614QOX8W Pyrimethamine AIM IM Chloroquine therapeutic use Dapsone therapeutic use Drug Combinations Humans Malaria prevention & control Plasmodium falciparum Pyrimethamine therapeutic use

1979 British medical journal

68. Falciparum malaria despite chemoprophylaxis. Full Text available with Trip Pro

Falciparum malaria despite chemoprophylaxis. 380749 1979 10 24 2013 11 21 0007-1447 1 6177 1979 Jun 09 British medical journal Br Med J Falciparum malaria despite chemoprophylaxis. 1565 Moody P P eng Letter England Br Med J 0372673 0007-1447 886U3H6UFF Chloroquine S61K3P7B2V Proguanil AIM IM Chloroquine adverse effects Female Fetal Diseases chemically induced Humans Malaria prevention & control Plasmodium falciparum Pregnancy Pregnancy Complications, Infectious prevention & control Proguanil

1979 British medical journal

69. Malaria. Chemoprophylaxis and chemotherapy. Full Text available with Trip Pro

Malaria. Chemoprophylaxis and chemotherapy. 4927912 1971 05 26 2018 11 13 0007-1447 2 5753 1971 Apr 10 British medical journal Br Med J Malaria. Chemoprophylaxis and chemotherapy. 95-8 Peters W W eng Journal Article Review England Br Med J 0372673 0007-1447 0 Antimalarials 0 Pyrimidines 0 Sulfonamides 0 Triazines 220236ED28 Amodiaquine 886U3H6UFF Chloroquine 8W5C518302 Dapsone A7V27PHC7A Quinine MVR3634GX1 Primaquine S61K3P7B2V Proguanil Z3614QOX8W Pyrimethamine AIM IM Amodiaquine therapeutic (...) use Antimalarials therapeutic use Chloroquine therapeutic use Dapsone therapeutic use Drug Resistance, Microbial Drug Synergism Humans Malaria drug therapy prevention & control Plasmodium falciparum drug effects Primaquine therapeutic use Proguanil therapeutic use Pyrimethamine therapeutic use Pyrimidines therapeutic use Quinine therapeutic use Sulfonamides therapeutic use Triazines therapeutic use 59 1971 4 10 1971 4 10 0 1 1971 4 10 0 0 ppublish 4927912 PMC1795523 JAMA. 1967 Jan 16;199(3):173-7

1971 British medical journal

70. Chemoprophylaxis of malaria. Full Text available with Trip Pro

Chemoprophylaxis of malaria. 318895 1977 03 15 2018 11 13 0007-1447 1 6052 1977 Jan 01 British medical journal Br Med J Chemoprophylaxis of malaria. 49-50 Peters W W eng Letter England Br Med J 0372673 0007-1447 0 Antimalarials AIM IM Antimalarials therapeutic use Humans Malaria prevention & control Plasmodium vivax 1977 1 1 1977 1 1 0 1 1977 1 1 0 0 ppublish 318895 PMC1603647 Ann Trop Med Parasitol. 1975 Jun;69(2):141-5 1155986

1977 British medical journal

71. Malaria

Malaria Malaria - NICE CKS Share Malaria: Summary Malaria is a life-threatening illness caused by infection of red blood cells by Plasmodium parasites. Transmission of malaria to humans occurs through the bite of infected female Anopheles mosquitoes. Several species of Plasmodium cause malaria in humans: Plasmodium falciparum — responsible for the majority of malaria related deaths worldwide. Plasmodium vivax and Plasmodium ovale — these species have dormant liver stages which can cause (...) ‘relapses’ of malaria months or years after initial infection. Plasmodium malariae — if untreated can cause lifelong chronic infection. Plasmodium knowlesi — a malaria parasite of monkeys in South-East Asia which can cause severe and sometimes fatal illness in humans. If malaria is identified promptly, appropriate treatment is given and no organ dysfunction has occurred, most people make a rapid and complete recovery. If malaria treatment is delayed or inappropriate, severe or fatal malaria can develop

2017 NICE Clinical Knowledge Summaries

72. A comparative study of azithromycin and sulphadoxine-pyrimethamine as prophylaxis against malaria in pregnancy. (Abstract)

A comparative study of azithromycin and sulphadoxine-pyrimethamine as prophylaxis against malaria in pregnancy. The benefit of malaria prophylaxis in pregnancy is threatened by emergence of Plasmodium falciparum resistance to antimalarial agents for chemoprophylaxis and treatment.This study aimed to compare the effectiveness of azithromycin (AZ) with sulphadoxine-pyrimethamine (SP) for malaria prevention.A prospective comparative study of antenatal clinic attendees at the University College (...) Hospital, Ibadan, Nigeria. Participants were randomised to receive SP or AZ.The subjects were antenatal attendees and Samples for malaria parasitaemia were collected and repeated at follow-up visits; maternal peripheral blood film, placental and cord blood samples were collected at delivery.Chi-square test and t-test in a per-protocol analysis.Of 200 participants (100 in each group), 166 (83.0%) completed the study: 86 (86.0%) of SP and 80 (80.0%) of AZ groups, respectively (P = 0.26). Four (4.7

2018 The Nigerian Postgraduate Medical Journal Controlled trial quality: uncertain

73. Safety, Tolerability, Immunogenicity and Protective Efficacy of PfSPZ Vaccine and PfSPZ-CVac in Indonesian Adults Against Naturally-Transmitted Malaria

to Brief Summary: The study is a single site, double-blind, randomized, placebo-controlled clinical trial that will assess the safety, tolerability, immunogenicity and vaccine efficacy (VE) of PfSPZ Vaccine and PfSPZ-CVac against naturally occurring malaria in Indonesian soldiers deployed to eastern Indonesia. Condition or disease Intervention/treatment Phase Malaria Biological: PfSPZ Vaccine Biological: PfSPZ Challenge under chloroquine (CQ) chemoprophylaxis Other: Normal Saline Phase 2 Detailed (...) Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Prevention Official Title: Safety, Tolerability, Immunogenicity and Protective Efficacy Against Naturally-Transmitted Malaria in Eastern Indonesia of Two Plasmodium Falciparum Sporozoite Vaccines, Sanaria® PfSPZ Vaccine and Sanaria® PfSPZ-CVac: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial in Healthy Indonesian Adults Estimated Study Start Date : March 2019 Estimated Primary Completion Date

2018 Clinical Trials

74. Co-morbidity of malnutrition with falciparum malaria parasitaemia among children under the aged 6–59 months in Somalia: a geostatistical analysis Full Text available with Trip Pro

MUAC measurement in surveys. Shared spatial distribution and distinct hotspots present opportunities for targeted seasonal chemoprophylaxis and other forms of malaria prevention integrated within nutrition programmes. (...) Co-morbidity of malnutrition with falciparum malaria parasitaemia among children under the aged 6–59 months in Somalia: a geostatistical analysis Malnutrition and malaria are both significant causes of morbidity and mortality in African children. However, the extent of their spatial comorbidity remains unexplored and an understanding of their spatial correlation structure would inform improvement of integrated interventions. We aimed to determine the spatial correlation between both wasting

2018 Infectious diseases of poverty

75. Malaria Surveillance — United States, 2015 Full Text available with Trip Pro

Malaria Surveillance — United States, 2015 Malaria in humans is caused by intraerythrocytic protozoa of the genus Plasmodium. These parasites are transmitted by the bite of an infective female Anopheles species mosquito. The majority of malaria infections in the United States occur among persons who have traveled to regions with ongoing malaria transmission. However, malaria is occasionally acquired by persons who have not traveled out of the country through exposure to infected blood (...) . Although the number of malaria cases diagnosed in the United States has been increasing since the mid-1970s, the number of cases decreased by 208 from 2014 to 2015. Among the regions of acquisition (Africa, West Africa, Asia, Central America, the Caribbean, South America, Oceania, and the Middle East), the only region with significantly fewer imported cases in 2015 compared with 2014 was West Africa (781 versus 969). Plasmodium falciparum, P. vivax, P. ovale, and P. malariae were identified in 67.4

2018 MMWR Surveillance Summaries

76. Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization Full Text available with Trip Pro

protective as immunization with non-attenuated sporozoites under chemoprophylaxis. Both immunization regimens delayed the development of blood-stage parasites, but differences in cellular and humoral immune mechanisms were observed. Single-dose whole-parasite vaccination might serve as a relatively simple and feasible immunization approach to prevent life-threatening cerebral malaria. (...) Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization Cerebral malaria is a life-threatening complication of Plasmodia infection and a major cause of child mortality in Sub-Saharan Africa. We report that protection from experimental cerebral malaria in the rodent model is obtained by a single intravenous or subcutaneous whole-parasite immunization. Whole-parasite immunization with radiation-attenuated sporozoites was equally

2018 Scientific reports

77. Severe imported malaria in children in France. A national retrospective study from 1996 to 2005. Full Text available with Trip Pro

malaria cases, a stay in a Sahelian region, lack of chemoprophylaxis, age <2 years or thrombocytopenia <100 x 10^3/mm^3 predicted adverse outcomes. Except for the hyperparasitemia threshold of 4%, the main WHO 2000 criteria for severe malaria reliably predicted adverse outcomes. In our study, the threshold of parasitemia most predictive of a poor outcome was 8%.In imported pediatric malaria, children younger than 2 years deserve particular attention. The main WHO 2000 criteria for severity (...) Severe imported malaria in children in France. A national retrospective study from 1996 to 2005. Malaria is a leading cause of imported febrile illnesses in pediatric travelers, but few studies have addressed severe imported pediatric malaria. We aimed to determine the risk factors and the features of imported pediatric severe malaria.We conducted a retrospective, descriptive study using the French National Reference Center for Imported Malaria database, in children aged 0-15 years who were

2017 PLoS ONE

78. Changes in malaria epidemiology in Germany, 2001-2016: a time series analysis. Full Text available with Trip Pro

malaria infections were reportedly acquired in Thailand between 2012 and 2016. Total numbers of malaria notifications among native Germans and residents with migration background showed an increasing trend since 2007. Chemoprophylaxis use was reported for 24.3% (1695/6984) of cases and showed a declining trend. Native German cases took significantly more frequently chemoprophylaxis than cases with migration background (32.6% vs. 17.9%; p < 0.001).The steep rise in vivax malaria notifications in 2014 (...) and 2015 was mainly due to newly arriving refugees from Eritrea but also from other countries of the Horn of Africa and South Asia. Clinicians should include malaria in their differential diagnosis in case of a febrile illness in the respective population and consider vivax malaria even if arrival to Germany dates back several months. Over the past 10 years, malaria notifications among native Germans and residents with migration background showed an increasing trend. Use of chemoprophylaxis

2018 Malaria journal

79. Status of imported malaria on Réunion Island in 2016. Full Text available with Trip Pro

analysed according to historical data and to the exchanges with malaria-affected areas (estimated by airport data).Form 2013 to 2016, 95 imported malaria cases have been detected in Reunion Island: 42% of cases occurred in the area of repartition of Anopheles arabiensis, but Anopheles mosquitoes were present only around seven cases including one gametocyte carrier. No autochthonous or introduced case has occurred during this period. The lack of chemoprophylaxis or poor adherence was found (...) , which travel to malaria endemic countries (mainly Madagascar) to visit their friends and relatives (VFRs) represent a high-risk group of contracting malaria. VFRs, low adherence to pre-travel recommendations, in particular, the compliance on the use of chemoprophylaxis are the main drivers of imported malaria in Reunion Island. Furthermore as previously described, some general practitioners in Reunion Island are always not sufficiently aware of the official recommendations for prescriptions

2018 Malaria journal

80. Humanized DRAGA mice immunized with Plasmodium falciparum sporozoites and chloroquine elicit protective pre-erythrocytic immunity. Full Text available with Trip Pro

Humanized DRAGA mice immunized with Plasmodium falciparum sporozoites and chloroquine elicit protective pre-erythrocytic immunity. Human-immune-system humanized mouse models can bridge the gap between humans and conventional mice for testing human vaccines. The HLA-expressing humanized DRAGA (HLA-A2.HLA-DR4.Rag1KO.IL2RγcKO.NOD) mice reconstitute a functional human-immune-system and sustain the complete life cycle of Plasmodium falciparum. Herein, the DRAGA mice were investigated for immune (...) responses following immunization with live P. falciparum sporozoites under chloroquine chemoprophylaxis (CPS-CQ), an immunization approach that showed in human trials to confer pre-erythrocytic immunity.The CPS-CQ immunized DRAGA mice (i) elicited human CD4 and CD8 T cell responses to antigens expressed by P. falciparum sporozoites (Pfspz) and by the infected-red blood cells (iRBC). The Pfspz-specific human T cell responses were found to be systemic (spleen and liver), whereas the iRBCs-specific human T

2018 Malaria journal

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