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Malaria Chemoprophylaxis

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541. Counselling travellers about malaria chemoprophylaxis. (PubMed)

Counselling travellers about malaria chemoprophylaxis. 6478355 1984 11 09 2018 11 13 0008-4409 131 7 1984 Oct 01 Canadian Medical Association journal Can Med Assoc J Counselling travellers about malaria chemoprophylaxis. 715-6 Keystone J S JS Lawee D D McIntyre L L Spence H H eng Letter Canada Can Med Assoc J 0414110 0008-4409 0 Antimalarials AIM IM Antimalarials therapeutic use Counseling Humans Malaria prevention & control Physicians Travel 1984 10 1 1984 10 1 0 1 1984 10 1 0 0 ppublish

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1984 Canadian Medical Association Journal

542. Malaria prophylaxis. Toxicity of mefloquine is similar to that of other chemoprophylaxis. (PubMed)

Malaria prophylaxis. Toxicity of mefloquine is similar to that of other chemoprophylaxis. 7677878 1995 08 24 2018 11 13 0959-8138 311 6998 1995 Jul 15 BMJ (Clinical research ed.) BMJ Malaria prophylaxis. Toxicity of mefloquine is similar to that of other chemoprophylaxis. 191; author reply 192 Croft A A eng Clinical Trial Comment Letter Randomized Controlled Trial England BMJ 8900488 0959-8138 886U3H6UFF Chloroquine S61K3P7B2V Proguanil TML814419R Mefloquine AIM IM BMJ. 1995 Mar 18;310(6981 (...) ):709-14 7711540 Chloroquine adverse effects Double-Blind Method Humans Malaria prevention & control Mefloquine adverse effects Proguanil adverse effects 1995 7 15 1995 7 15 0 1 1995 7 15 0 0 ppublish 7677878 PMC2550245 BMJ. 1994 Jan 29;308(6924):286-7 8124114 Drug Saf. 1993 Apr;8(4):295-311 8481216 Clin Pharmacol Ther. 1979 Sep;26(3):372-9 466930 Lancet. 1995 Apr 22;345(8956):1049 7723515 BMJ. 1995 Mar 18;310(6981):709-14 7711540

1995 BMJ (Clinical research ed.) Controlled trial quality: uncertain

543. Combination of mefloquine with sulfadoxine-pyrimethamine compared with two sulfadoxine-pyrimethamine combinations in malaria chemoprophylaxis. (PubMed)

Combination of mefloquine with sulfadoxine-pyrimethamine compared with two sulfadoxine-pyrimethamine combinations in malaria chemoprophylaxis. 2863679 1985 10 24 2015 06 16 0140-6736 2 8457 1985 Sep 28 Lancet (London, England) Lancet Combination of mefloquine with sulfadoxine-pyrimethamine compared with two sulfadoxine-pyrimethamine combinations in malaria chemoprophylaxis. 694-5 Win K K Thwe Y Y Lwin T T TT Win K K eng Clinical Trial Comparative Study Journal Article Randomized Controlled (...) Trial Research Support, Non-U.S. Gov't England Lancet 2985213R 0140-6736 0 Antimalarials 0 Drug Combinations 0 Quinolines 0 Sulfanilamides 88463U4SM5 Sulfadoxine TML814419R Mefloquine Z3614QOX8W Pyrimethamine AIM IM Adolescent Adult Antimalarials administration & dosage therapeutic use Clinical Trials as Topic Drug Combinations Drug Resistance, Microbial Drug Therapy, Combination Humans Malaria parasitology prevention & control Male Mefloquine Plasmodium falciparum isolation & purification

1985 Lancet (London, England) Controlled trial quality: uncertain

544. Malaria chemoprophylaxis in travellers to east Africa: a comparative prospective study of chloroquine plus proguanil with chloroquine plus sulfadoxine-pyrimethamine. (PubMed)

Malaria chemoprophylaxis in travellers to east Africa: a comparative prospective study of chloroquine plus proguanil with chloroquine plus sulfadoxine-pyrimethamine. As malaria caused by Plasmodium falciparum has become resistant to chloroquine alternative drug regimens need to be developed. The prophylactic efficacy against malaria and the side effects of chloroquine phosphate 500 mg weekly with proguanil hydrochloride 200 mg daily was compared with the efficacy of chloroquine 500 mg weekly (...) with sulfadoxine 500 mg-pyrimethamine 25 mg weekly in a randomised study of Scandinavian travellers to Kenya and Tanzania during 1984-5. A total of 767 subjects (416 male and 351 female; 384 taking chloroquine phosphate with proguanil hydrochloride and 383 taking chloroquine with sulfadoxine-pyrimethamine) completed a diary on the breakthrough of malaria and the side effects of treatment while taking the drugs. They were also asked to make thick blood films when symptoms like those of malaria occurred, which

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1988 British medical journal (Clinical research ed.) Controlled trial quality: uncertain

545. The effectiveness of chemoprophylaxis against malaria for non-immune migrant workers in eastern Thailand. (PubMed)

The effectiveness of chemoprophylaxis against malaria for non-immune migrant workers in eastern Thailand. A randomized, double-blind field trial was carried out to compare the effectiveness of mefloquine plus sulfadoxine-pyrimethamine (MSP) with that of sulfadoxine-pyrimethamine (SP) in chemoprophylaxis against malaria. The study was conducted in 193 migrant workers in the eastern rural areas of Thailand which are known to be highly endemic for multidrug-resistant Plasmodium falciparum

1990 Transactions of the Royal Society of Tropical Medicine and Hygiene Controlled trial quality: uncertain

546. The effect of short-term malaria chemoprophylaxis on the immune response of semi-immune adult volunteers. (PubMed)

The effect of short-term malaria chemoprophylaxis on the immune response of semi-immune adult volunteers. In 17 semi-immune adult volunteers, chemoprophylaxis with 300 mg chloroquine base weekly for six months was found to be effective in suppressing malaria. However, following 3 months of chemoprophylaxis, a significant reduction of IFA titres was seen lasting up to 2 months after chloroquine withdrawal. There was resurgence of malaria in the post-intervention phase. 2 months after drug (...) withdrawal, serum concentrations of IgG and factor B were significantly reduced. 3 months after initiation of chloroquine prophylaxis, a temporary but significant decrease of IgG and IgM serum concentrations was found with a corresponding decline in the number of B-lymphocytes and regulatory T-cells. These returned to normal at 6 months of chemoprophylaxis. Our findings suggest that short-term malaria chemoprophylaxis may significantly interfere with humoral and cell-mediated immunity in areas

1990 East African medical journal Controlled trial quality: uncertain

547. Malaria chemoprophylaxis using proguanil/dapsone combinations on the Thai-Cambodian border. (PubMed)

Malaria chemoprophylaxis using proguanil/dapsone combinations on the Thai-Cambodian border. The Thai-Cambodian border is a difficult area in which to provide adequate malaria chemoprophylaxis because of multiple drug-resistant Plasmodium falciparum. In 1990-1991, Thai soldiers were randomly selected to receive proguanil (200 mg/day) combined with dapsone (4 mg or 12.5 mg/day) (n = 184) or pyrimethamine/dapsone (12.5 mg and 100 mg/week) (n = 177). Doxycycline (100 mg/day) was given to men (...) . Hematologic toxicity was not observed with the proguanil/dapsone combination. We conclude that proguanil/dapsone is not a useful alternative for malaria chemoprophylaxis on the Thai-Cambodian border.

1992 The American journal of tropical medicine and hygiene Controlled trial quality: uncertain

548. A malaria control trial using insecticide-treated bed nets and targeted chemoprophylaxis in a rural area of The Gambia, west Africa. 5. Design and implementation of the trial. (PubMed)

A malaria control trial using insecticide-treated bed nets and targeted chemoprophylaxis in a rural area of The Gambia, west Africa. 5. Design and implementation of the trial. A large-scale malaria intervention programme using insecticide-treated bed nets and chemoprophylaxis administered to children was introduced into a rural area of The Gambia. The operation was carried out using the existing primary health care (PHC) service in the region. Training of the village health workers (...) heavier fabrics tended to absorb more insecticide than those made from lighter materials. Four months after dipping, 89% of the insecticide had been lost from treated nets. This was probably due mainly to women washing their nets, an activity carried out on average once every 2 months during the rainy season. The high number of insecticide-treated bed nets in the study area demonstrated that a malaria control programme operated through a PHC system can be implemented successfully.

1993 Transactions of the Royal Society of Tropical Medicine and Hygiene Controlled trial quality: uncertain

549. Malaria in infants whose mothers received chemoprophylaxis: response to amodiaquine therapy. (PubMed)

Malaria in infants whose mothers received chemoprophylaxis: response to amodiaquine therapy. In October 1988, a project was implemented for assessing the malaria chemoprophylactic efficacy of weekly chloroquine (CQ) and daily proguanil (PROG) during pregnancy in Muheza-Tanzania. Resultant CQ and PROG-cohorts of infants were followed up for prompt diagnosis and treatment of malaria. Infections were primarily treated with 25 mg base amodiaquine/kg over 3 days. By September 1990, 49 and 60 infants (...) from PROG and CQ cohorts respectively had completed one year follow up. Thirty-five (71%) infants of PROG and 44 (73%) for CQ-cohort were infected with malaria before 3 months of age. The one year mean infection episode rates were 7 (PROG-cohort) and 6.6 (CQ-cohort). Amodiaquine cleared 209 (80%) of PROG's total infections and 224 (81%) for CQ-cohort, and significantly reduced the infection load among clearance failures. Clearance failures had high pre-treatment parasite densities whilst post

1992 Tropical and geographical medicine Controlled trial quality: uncertain

550. [Mefloquine chemoprophylaxis of malaria in the Brazilian Amazonia]. (PubMed)

[Mefloquine chemoprophylaxis of malaria in the Brazilian Amazonia]. In a randomised double-blind study 122 volunteers living in an endemic malarious area in Amazonian Rondônia state were divided into 4 groups to study malaria suppression. . The first group received 500 mg of mefloquine every month, group II 250 mg every two weeks, group III a tablet of Fansidar (500 mg sulphadoxine + 25mg pyrimethamine) a week and group IV placebo. Acute attacks of malaria occurred in one individual in group I

1994 Revista da Sociedade Brasileira de Medicina Tropical Controlled trial quality: uncertain

551. Malaria chemoprophylaxis, birth weight and child survival. (PubMed)

Malaria chemoprophylaxis, birth weight and child survival. Study of the effects of malaria chemoprophylaxis given during pregnancy on birthweight and investigation of the influence of birthweight on child survival suggest that, in a rural area of The Gambia, chemoprophylaxis given during pregnancy might reduce infant mortality by about one-fifth in the children of primigravidae but by less than 5% in the children of multigravidae. In malaria endemic areas, primigravidae should be protected (...) against malaria not only for their own sake but also for that of their infants.

1993 Transactions of the Royal Society of Tropical Medicine and Hygiene Controlled trial quality: uncertain

552. Malaria chemoprophylaxis, infection of the placenta and birth weight in Gambian primigravidae. (PubMed)

Malaria chemoprophylaxis, infection of the placenta and birth weight in Gambian primigravidae. A randomized, double blind, placebo-controlled community based trial of Maloprim (pyrimethamine 12.5 mg+dapsone 100 mg) administered to primigravid pregnant women by Traditional Birth Attendants was carried out in a rural area of The Gambia, West Africa. Placental histology showed less malaria infection in women who received chemoprophylaxis than in those who received placebo. The birth weight (...) of children born to women who received chemoprophylaxis was increased by an average of 153 g. Within the treatment groups, there were no significant differences in the birthweights of babies born to women who had histological evidence of malaria infection of the placenta compared to those who had no malaria infection. This study confirms the beneficial effect of malaria prophylaxis for primigravid pregnant women but questions the mechanism by which malaria affects foetal development.

1994 The Journal of tropical medicine and hygiene Controlled trial quality: predicted high

553. The influence of Maloprim chemoprophylaxis on cellular and humoral immune responses to Plasmodium falciparum asexual blood stage antigens in schoolchildren living in a malaria endemic area of Mozambique. (PubMed)

The influence of Maloprim chemoprophylaxis on cellular and humoral immune responses to Plasmodium falciparum asexual blood stage antigens in schoolchildren living in a malaria endemic area of Mozambique. We examined the impact of chemoprophylaxis on the cellular and humoral immune responses to polypeptides of the asexual Plasmodium falciparum blood stage antigens, the glutamate rich protein GLURP and Pf155/RESA, both of which in previous field studies have been identified as potentially (...) season, both during the period of chemoprophylaxis and during the follow-up. The antibody response rate to the GLURP was lower in the Maloprim group than in the placebo group during the intervention phase. The lymphoproliferative response rate to the malaria antigens was significantly lower at the end of the rainy season than at the end of the dry season, but the difference between the experimental group and the control group of schoolchildren was not statistically significant. These results suggest

1994 Acta tropica Controlled trial quality: uncertain

554. Hyperpigmented dermal macules in children following the administration of Maloprim for malaria chemoprophylaxis. (PubMed)

Hyperpigmented dermal macules in children following the administration of Maloprim for malaria chemoprophylaxis. The occurrence of an unexpected side effect following the use of Maloprim (pyrimethamine/dapsone) for malaria chemosuppression in 3-59 months old children in Sierra Leone is reported. As part of a trial of chemoprophylaxis and insecticide-impregnated bed nets, 2000 children received either Maloprim or placebo; 4% of children who received Maloprim fortnightly for more than 3 months (...) was noted. Hyperpigmented lesions similar to those reported in this study have been described previously in patients with leprosy treated with dapsone, and the dapsone component of Maloprim is the likely cause of the skin reactions seen in children given this drug for malaria chemoprophylaxis.

1997 Transactions of the Royal Society of Tropical Medicine and Hygiene Controlled trial quality: uncertain

555. Humoral immune response to tetanus-diphtheria vaccine given during extended use of chloroquine or primaquine malaria chemoprophylaxis. (PubMed)

Humoral immune response to tetanus-diphtheria vaccine given during extended use of chloroquine or primaquine malaria chemoprophylaxis. Immune suppression resulting from prolonged chemoprophylaxis and potential drug-vaccine interaction were investigated within the context of a randomized placebo-controlled trial that compared daily primaquine or weekly chloroquine administration for malaria prevention. After 11 months of prophylaxis, adult male subjects received a tetanus-diphtheria (Td

1998 The Journal of infectious diseases Controlled trial quality: uncertain

556. Randomised trial of alternative malaria chemoprophylaxis strategies among pregnant women in Kigoma, Tanzania: I. Rationale and design. (PubMed)

Randomised trial of alternative malaria chemoprophylaxis strategies among pregnant women in Kigoma, Tanzania: I. Rationale and design. The objective of the study was to assess the effectiveness of alternative strategies of malaria chemoprophylaxis on the reduction of malaria episodes and prevalence of parasitaemia among pregnant women in Kigoma urban district in western Tanzania.Randomised antimalarial prophylactic trial.The study was conducted in an urban maternal and child health (MCH) clinic (...) in Kigoma town.All pregnant women attending antenatal care services at Kigoma urban MCH clinic were eligible. Informed consent was sought from each pregnant woman for participation in the study. INTERVENTION MEASURES: The intervention measures were intermittent and continuous malaria chemoprophylaxis using chloroquine and proguanil.Reduction of malaria episodes and parasitaemia and haemoglobin levels among participating pregnant women in Kigoma urban district.Baseline data indicates that the overall

2000 East African medical journal Controlled trial quality: uncertain

557. Tolerability of doxycycline monohydrate salt vs. chloroquine-proguanil in malaria chemoprophylaxis. (PubMed)

Tolerability of doxycycline monohydrate salt vs. chloroquine-proguanil in malaria chemoprophylaxis. The resistance of Plasmodium falciparum to the chloroquine-proguanil association (C/P) as antimalarial chemoprophylaxis is becoming increasingly common in Africa. Daily oral doxycycline hyclate 100 mg is effective as malaria prophylaxis. But the hyclate salt's adverse effects combined with the capsule's galenic form are incompatible with good chemoprophylaxis compliance. We conducted a randomized (...) group study of 522 French soldiers deployed in Gabon and Chad for 4 months to determine the tolerability of short-term malaria chemoprophylaxis with a 100-mg daily tablet of a monohydrate doxycycline salt compared with a daily C/P capsule. At days 7 and 120, compliance was better in the doxycycline group [respectively 98.5%vs. 73.9% (P < 0.001) and 90.5%vs. 74% (P < 0.001)]. No major event (evacuation, hospitalization) was related to the medications. Epigastralgia, diarrhoea, urticaria, mouth ulcers

2002 Tropical medicine & international health : TM & IH Controlled trial quality: uncertain

558. A malaria control trial using insecticide-treated bed nets and targeted chemoprophylaxis in a rural area of The Gambia, west Africa. 2. Mortality and morbidity from malaria in the study area. (PubMed)

A malaria control trial using insecticide-treated bed nets and targeted chemoprophylaxis in a rural area of The Gambia, west Africa. 2. Mortality and morbidity from malaria in the study area. Background data on child mortality and morbidity from malaria were obtained in a new study area in the centre of The Gambia, south of the river, chosen as the site for a malaria intervention trial. Infant and child mortality rates were 120 and 41 per 1000 respectively. Results obtained using post-mortem (...) questionnaires suggested that malaria was an uncommon cause of death in children under the age of one year but responsible for about 40% of deaths in children aged 1-4 years. Ninety-two percent of deaths attributed to malaria occurred during or immediately after the rainy season. Parasite and spleen rates in children aged 1-5 years at the end of the malaria transmission season were 66% and 64% respectively. Malariometric indices were similar in primary health care (PHC) villages, selected as sites

1993 Transactions of the Royal Society of Tropical Medicine and Hygiene

559. Mortality and morbidity from malaria after stopping malaria chemoprophylaxis. (PubMed)

Mortality and morbidity from malaria after stopping malaria chemoprophylaxis. Gambian children who had received malaria chemoprophylaxis for a variable period of time during their first 5 years of life were followed to determine whether they experienced a rebound in mortality or in morbidity from malaria during the period after chemoprophylaxis was stopped. The risk of dying between the ages of 5 years, when chemoprophylaxis was stopped, and 10 years was no higher among children who had (...) received chemoprophylaxis with Maloprim (pyrimethamine plus dapsone) for some period during their first 5 years of life than among children who had received placebo (21 vs. 24 deaths) and the beneficial effect of chemoprophylaxis on mortality observed during the first 5 years of life was sustained. The incidence of clinical attacks of malaria during the year after medication was stopped was significantly higher among children who had previously received Maloprim for several years than among children

1996 Transactions of the Royal Society of Tropical Medicine and Hygiene

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