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Malaria Chemoprophylaxis

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541. Tolerability of malaria chemoprophylaxis in non-immune travellers to sub-Saharan Africa: multicentre, randomised, double blind, four arm study. Full Text available with Trip Pro

Tolerability of malaria chemoprophylaxis in non-immune travellers to sub-Saharan Africa: multicentre, randomised, double blind, four arm study. To compare the tolerability of malaria chemoprophylaxis regimens in non-immune travellers.Randomised, double blind, study with placebo run-in phase.Travel clinics in Switzerland, Germany, and Israel.Proportion of participants in each treatment arm with subjectively moderate or severe adverse events.623 non-immune travellers to sub-Saharan Africa: 153

2003 BMJ Controlled trial quality: predicted high

542. RCT Iron Supplementation and Malaria Chemoprophylaxis for Prevention of Severe Anemia and Malaria in Tanzanian Infants

RCT Iron Supplementation and Malaria Chemoprophylaxis for Prevention of Severe Anemia and Malaria in Tanzanian Infants RCT Iron Supplementation and Malaria Chemoprophylaxis for Prevention of Severe Anemia and Malaria in Tanzanian Infants - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. RCT Iron Supplementation and Malaria Chemoprophylaxis for Prevention of Severe Anemia and Malaria in Tanzanian Infants The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00497471 Recruitment Status : Terminated (Follow

2007 Clinical Trials

543. Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants. (Abstract)

Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants. Malaria and anaemia, especially that due to iron deficiency, are two leading causes of morbidity worldwide. Little is known about the relative contribution of Plasmodium falciparum infection and iron deficiency to the aetiology of anaemia in malaria-endemic areas. We undertook a randomised comparison of different strategies for control (...) . supplementation was given from 8 to 24 weeks of age, and the weekly chemoprophylaxis from 8 to 48 weeks. The frequency of severe anaemia (packed-cell volume < 25%) and malaria episodes was assessed through a combination of passive case detection and cross-sectional surveys.The groups that received iron supplementation had a lower frequency of severe anaemia than those that did not receive iron (0.62 vs 0.87 cases per person-year; protective efficacy 28.8% [95% CI 6.3-45.8). Iron supplementation had no effect

1997 Lancet Controlled trial quality: predicted high

544. Cost considerations of malaria chemoprophylaxis including use of primaquine for primary or terminal chemoprophylaxis. (Abstract)

Cost considerations of malaria chemoprophylaxis including use of primaquine for primary or terminal chemoprophylaxis. The costs of mefloquine, chloroquine, doxycycline, primaquine, and atovaquone/proguanil are calculated for various durations of exposure to malaria. The cost is included for detecting glucose 6-phosphate dehydrogenase (G6PD) deficiency before administering primaquine for primary or terminal prophylaxis. For durations of exposure ranging from 3 to 730 days, if no terminal (...) prophylaxis is given, doxycycline (generic) is the least expensive regimen. Compared with doxycycline hyclate, chloroquine costs three to four times more, and primaquine, after screening for G6PD, costs about eight times more. Atovaquone/proguanil is less expensive than mefloquine for a 3-day exposure, but more expensive for 7 or more days. When terminal chemoprophylaxis with primaquine for 14 days is used in addition to doxycycline, mefloquine, chloroquine, or atovaquone/proguanil, primaquine alone

2006 American Journal of Tropical Medicine & Hygiene

545. Malaria prophylaxis. Toxicity of mefloquine is similar to that of other chemoprophylaxis. (Abstract)

Malaria prophylaxis. Toxicity of mefloquine is similar to that of other chemoprophylaxis. 7677878 1995 08 24 2018 11 13 0959-8138 311 6998 1995 Jul 15 BMJ (Clinical research ed.) BMJ Malaria prophylaxis. Toxicity of mefloquine is similar to that of other chemoprophylaxis. 191; author reply 192 Croft A A eng Clinical Trial Comment Letter Randomized Controlled Trial England BMJ 8900488 0959-8138 886U3H6UFF Chloroquine S61K3P7B2V Proguanil TML814419R Mefloquine AIM IM BMJ. 1995 Mar 18;310(6981 (...) ):709-14 7711540 Chloroquine adverse effects Double-Blind Method Humans Malaria prevention & control Mefloquine adverse effects Proguanil adverse effects 1995 7 15 1995 7 15 0 1 1995 7 15 0 0 ppublish 7677878 PMC2550245 BMJ. 1994 Jan 29;308(6924):286-7 8124114 Drug Saf. 1993 Apr;8(4):295-311 8481216 Clin Pharmacol Ther. 1979 Sep;26(3):372-9 466930 Lancet. 1995 Apr 22;345(8956):1049 7723515 BMJ. 1995 Mar 18;310(6981):709-14 7711540

1995 BMJ (Clinical research ed.) Controlled trial quality: uncertain

546. Combination of mefloquine with sulfadoxine-pyrimethamine compared with two sulfadoxine-pyrimethamine combinations in malaria chemoprophylaxis. (Abstract)

Combination of mefloquine with sulfadoxine-pyrimethamine compared with two sulfadoxine-pyrimethamine combinations in malaria chemoprophylaxis. 2863679 1985 10 24 2015 06 16 0140-6736 2 8457 1985 Sep 28 Lancet (London, England) Lancet Combination of mefloquine with sulfadoxine-pyrimethamine compared with two sulfadoxine-pyrimethamine combinations in malaria chemoprophylaxis. 694-5 Win K K Thwe Y Y Lwin T T TT Win K K eng Clinical Trial Comparative Study Journal Article Randomized Controlled (...) Trial Research Support, Non-U.S. Gov't England Lancet 2985213R 0140-6736 0 Antimalarials 0 Drug Combinations 0 Quinolines 0 Sulfanilamides 88463U4SM5 Sulfadoxine TML814419R Mefloquine Z3614QOX8W Pyrimethamine AIM IM Adolescent Adult Antimalarials administration & dosage therapeutic use Clinical Trials as Topic Drug Combinations Drug Resistance, Microbial Drug Therapy, Combination Humans Malaria parasitology prevention & control Male Mefloquine Plasmodium falciparum isolation & purification

1985 Lancet (London, England) Controlled trial quality: uncertain

547. Effects of pyrimethamine versus proguanil in malarial chemoprophylaxis in children with sickle cell disease: a randomized, placebo-controlled, open-label study. Full Text available with Trip Pro

Effects of pyrimethamine versus proguanil in malarial chemoprophylaxis in children with sickle cell disease: a randomized, placebo-controlled, open-label study. Malarial chemoprophylaxis is essential for patients with homozygous sickle cell disease (SCD) who live in areas where malaria is endemic. Endemic regions include most sub-Saharan African countries and Southeast Asia.This study compared the efficacy and tolerability of pyrimethamine with that of proguanil and placebo in the prevention (...) of malaria and the complications of Plasmodium falciparum infection (hepatomegaly, splenomegaly, bone pain crisis, hemolytic crisis) in children with SCD.In this single-center, open-label study conducted in Nigeria, children aged 1 to 16 years with SCD were randomly assigned to receive tablets of pyrimethamine (0.5 mg/kg·wk), proguanil (1.5 mg/kg·d), or placebo (vitamin C, 7 mg/kg·d) for 9 months as prophylaxis from February to December (which includes the rainy season), the period of greatest malarial

2003 Current therapeutic research, clinical and experimental Controlled trial quality: uncertain

548. The effects of malaria chemoprophylaxis given by traditional birth attendants on the course and outcome of pregnancy. (Abstract)

The effects of malaria chemoprophylaxis given by traditional birth attendants on the course and outcome of pregnancy. A trial of malaria chemoprophylaxis given by traditional birth attendants was undertaken in a rural area of The Gambia where access to antenatal clinics is difficult. Women received one or more doses of Maloprim or placebo from a traditional birth attendant during 1049 of 1208 pregnancies (87%) recorded in 16 villages over a 3-year period. Primigravidae who received Maloprim had (...) a lower parasite rate and a significantly higher mean packed cell volume than primigravidae who received placebo, and their babies were significantly heavier (6% low birth weight vs 22%). In multigravidae chemoprophylaxis reduced malaria parasitaemia but it had no beneficial effect on haemoglobin level and much less effect on birth weight than was observed in primigravidae. However, the mean birth weight of babies born to grandemultigravidae who received chemoprophylaxis was significantly higher than

1990 Transactions of the Royal Society of Tropical Medicine and Hygiene

549. The use of immunofluorescence to evaluate the efficacy of malarial chemoprophylaxis. (Abstract)

The use of immunofluorescence to evaluate the efficacy of malarial chemoprophylaxis. 338 subjects occupationally exposed to high levels of malaria transmission were randomly assigned to three groups. Group A received one tablet of mefloquine (250 mg) and one tablet of sulfadoxine-pyrimethamine once a week, group B received two tablets of sulfadoxine-pyrimethamine once a week and group C received one tablet of sulfadoxine-pyrimethamine (each containing sulfadoxine 500 mg and pyrimethamine 25 mg (...) ) twice a week. Blood films for malaria parasites and filter paper strips for serological study were taken before and at 5 and 12 months after the chemoprophylaxis. The advantages and inherent limitation of the slide positivity rate and the usefulness of geometric mean reciprocal titre for the assessment of the efficacy of the chemoprophylaxis were discussed.

1987 Transactions of the Royal Society of Tropical Medicine and Hygiene Controlled trial quality: uncertain

550. Malaria chemoprophylaxis in travellers to east Africa: a comparative prospective study of chloroquine plus proguanil with chloroquine plus sulfadoxine-pyrimethamine. Full Text available with Trip Pro

Malaria chemoprophylaxis in travellers to east Africa: a comparative prospective study of chloroquine plus proguanil with chloroquine plus sulfadoxine-pyrimethamine. As malaria caused by Plasmodium falciparum has become resistant to chloroquine alternative drug regimens need to be developed. The prophylactic efficacy against malaria and the side effects of chloroquine phosphate 500 mg weekly with proguanil hydrochloride 200 mg daily was compared with the efficacy of chloroquine 500 mg weekly (...) with sulfadoxine 500 mg-pyrimethamine 25 mg weekly in a randomised study of Scandinavian travellers to Kenya and Tanzania during 1984-5. A total of 767 subjects (416 male and 351 female; 384 taking chloroquine phosphate with proguanil hydrochloride and 383 taking chloroquine with sulfadoxine-pyrimethamine) completed a diary on the breakthrough of malaria and the side effects of treatment while taking the drugs. They were also asked to make thick blood films when symptoms like those of malaria occurred, which

1988 British medical journal (Clinical research ed.) Controlled trial quality: uncertain

551. The effectiveness of chemoprophylaxis against malaria for non-immune migrant workers in eastern Thailand. (Abstract)

The effectiveness of chemoprophylaxis against malaria for non-immune migrant workers in eastern Thailand. A randomized, double-blind field trial was carried out to compare the effectiveness of mefloquine plus sulfadoxine-pyrimethamine (MSP) with that of sulfadoxine-pyrimethamine (SP) in chemoprophylaxis against malaria. The study was conducted in 193 migrant workers in the eastern rural areas of Thailand which are known to be highly endemic for multidrug-resistant Plasmodium falciparum

1990 Transactions of the Royal Society of Tropical Medicine and Hygiene Controlled trial quality: uncertain

552. Malarial chemoprophylaxis and the healing of periodontal lesions. (Abstract)

Malarial chemoprophylaxis and the healing of periodontal lesions. A randomized study was carried out using 92 patients (39 taking a malarial chemoprophylactic agent and 53 not taking a chemoprophylactic agent) to investigate the rate of healing of ulcerative periodontitis after treatment. The chemoprophylaxis group who had been on 300 mg chloroquine weekly for at least one year and the non-chemoprophylaxis group who had not been on the regimen for at least one year were involved in the study (...) which examined the global efficacy and assessment for pain relief over a period of 12 weeks after treatment for ulcerative periodontitis. A detailed, symtomatic and clinical assessment was made at biweekly intervals. Relief from pain was higher for the non-chemoprophylaxis group (94.2% vs. 46.2%, p less than 0.05). The global efficacy was statistically significant for the non-chemoprophylaxis group (87% vs. 38.4%, p less than 0.05). The outcome of treatment was not influenced by factors

1991 Clinical preventive dentistry Controlled trial quality: uncertain

553. Compliance with malaria chemoprophylaxis over a five-year period among children in a rural area of The Gambia. (Abstract)

Compliance with malaria chemoprophylaxis over a five-year period among children in a rural area of The Gambia. We have reviewed a malaria chemoprophylaxis programme in which Maloprim (pyrimethamine and dapsone) has been administered fortnightly by village health workers (VHWs) to approximately 1500 children each year aged 6-59 months resident in 15 primary health care villages in a rural area of The Gambia over 5 years. Reasonable levels of compliance with chemoprophylaxis have been maintained (...) no compensation from the villagers for administering chemoprophylaxis. The administration of a drug to prevent illness in children was complementary to the curative service provided by VHWs. The chemoprophylactic was widely acceptable and nearly all mothers stated that the tablets were good for their children's health. However, knowledge of the specific purpose of chemoprophylaxis in the prevention of malaria was limited. Improvements in the programme which may result in higher levels of compliance

1990 The Journal of tropical medicine and hygiene

554. The effect of short-term malaria chemoprophylaxis on the immune response of semi-immune adult volunteers. (Abstract)

The effect of short-term malaria chemoprophylaxis on the immune response of semi-immune adult volunteers. In 17 semi-immune adult volunteers, chemoprophylaxis with 300 mg chloroquine base weekly for six months was found to be effective in suppressing malaria. However, following 3 months of chemoprophylaxis, a significant reduction of IFA titres was seen lasting up to 2 months after chloroquine withdrawal. There was resurgence of malaria in the post-intervention phase. 2 months after drug (...) withdrawal, serum concentrations of IgG and factor B were significantly reduced. 3 months after initiation of chloroquine prophylaxis, a temporary but significant decrease of IgG and IgM serum concentrations was found with a corresponding decline in the number of B-lymphocytes and regulatory T-cells. These returned to normal at 6 months of chemoprophylaxis. Our findings suggest that short-term malaria chemoprophylaxis may significantly interfere with humoral and cell-mediated immunity in areas

1990 East African medical journal Controlled trial quality: uncertain

555. Malaria chemoprophylaxis, infection of the placenta and birth weight in Gambian primigravidae. (Abstract)

Malaria chemoprophylaxis, infection of the placenta and birth weight in Gambian primigravidae. A randomized, double blind, placebo-controlled community based trial of Maloprim (pyrimethamine 12.5 mg+dapsone 100 mg) administered to primigravid pregnant women by Traditional Birth Attendants was carried out in a rural area of The Gambia, West Africa. Placental histology showed less malaria infection in women who received chemoprophylaxis than in those who received placebo. The birth weight (...) of children born to women who received chemoprophylaxis was increased by an average of 153 g. Within the treatment groups, there were no significant differences in the birthweights of babies born to women who had histological evidence of malaria infection of the placenta compared to those who had no malaria infection. This study confirms the beneficial effect of malaria prophylaxis for primigravid pregnant women but questions the mechanism by which malaria affects foetal development.

1994 The Journal of tropical medicine and hygiene Controlled trial quality: predicted high

556. Hyperpigmented dermal macules in children following the administration of Maloprim for malaria chemoprophylaxis. (Abstract)

Hyperpigmented dermal macules in children following the administration of Maloprim for malaria chemoprophylaxis. The occurrence of an unexpected side effect following the use of Maloprim (pyrimethamine/dapsone) for malaria chemosuppression in 3-59 months old children in Sierra Leone is reported. As part of a trial of chemoprophylaxis and insecticide-impregnated bed nets, 2000 children received either Maloprim or placebo; 4% of children who received Maloprim fortnightly for more than 3 months (...) was noted. Hyperpigmented lesions similar to those reported in this study have been described previously in patients with leprosy treated with dapsone, and the dapsone component of Maloprim is the likely cause of the skin reactions seen in children given this drug for malaria chemoprophylaxis.

1997 Transactions of the Royal Society of Tropical Medicine and Hygiene Controlled trial quality: uncertain

557. Humoral immune response to tetanus-diphtheria vaccine given during extended use of chloroquine or primaquine malaria chemoprophylaxis. (Abstract)

Humoral immune response to tetanus-diphtheria vaccine given during extended use of chloroquine or primaquine malaria chemoprophylaxis. Immune suppression resulting from prolonged chemoprophylaxis and potential drug-vaccine interaction were investigated within the context of a randomized placebo-controlled trial that compared daily primaquine or weekly chloroquine administration for malaria prevention. After 11 months of prophylaxis, adult male subjects received a tetanus-diphtheria (Td

1998 The Journal of infectious diseases Controlled trial quality: uncertain

558. Counselling travellers about malaria chemoprophylaxis. Full Text available with Trip Pro

Counselling travellers about malaria chemoprophylaxis. 6478355 1984 11 09 2018 11 13 0008-4409 131 7 1984 Oct 01 Canadian Medical Association journal Can Med Assoc J Counselling travellers about malaria chemoprophylaxis. 715-6 Keystone J S JS Lawee D D McIntyre L L Spence H H eng Letter Canada Can Med Assoc J 0414110 0008-4409 0 Antimalarials AIM IM Antimalarials therapeutic use Counseling Humans Malaria prevention & control Physicians Travel 1984 10 1 1984 10 1 0 1 1984 10 1 0 0 ppublish

1984 Canadian Medical Association Journal

559. Chemoprophylaxis against malaria in Papua New Guinea: a trial of amodiaquine and a combination of dapsone and pyrimethamine. (Abstract)

Chemoprophylaxis against malaria in Papua New Guinea: a trial of amodiaquine and a combination of dapsone and pyrimethamine. A placebo-controlled chemoprophylaxis trial was carried out in 1980 in 318 semi-immune school children in the Madang area of Papua New Guinea, where there was a high prevalence of strains of Plasmodium falciparum resistant to 4-aminoquinolines. Since prophylaxis with amodiaquine at 5 mg/kg weekly had failed, amodiaquine at a dose of 10mg/kg weekly and Maloprim (half (...) counts by either drug regimen. Chemoprophylaxis as a component of an integrated malaria control program should not be overlooked, provided that compliance can be maintained. However, in this particular case the principal purpose of the study had been to evaluate the proposed chemoprophylactic regimens in school children before embarking on an intervention study in young children. As a result of this study it was decided not to go ahead with the chemoprophylactic intervention in young children

1992 Papua and New Guinea medical journal

560. Malaria in infants whose mothers received chemoprophylaxis: response to amodiaquine therapy. (Abstract)

Malaria in infants whose mothers received chemoprophylaxis: response to amodiaquine therapy. In October 1988, a project was implemented for assessing the malaria chemoprophylactic efficacy of weekly chloroquine (CQ) and daily proguanil (PROG) during pregnancy in Muheza-Tanzania. Resultant CQ and PROG-cohorts of infants were followed up for prompt diagnosis and treatment of malaria. Infections were primarily treated with 25 mg base amodiaquine/kg over 3 days. By September 1990, 49 and 60 infants (...) from PROG and CQ cohorts respectively had completed one year follow up. Thirty-five (71%) infants of PROG and 44 (73%) for CQ-cohort were infected with malaria before 3 months of age. The one year mean infection episode rates were 7 (PROG-cohort) and 6.6 (CQ-cohort). Amodiaquine cleared 209 (80%) of PROG's total infections and 224 (81%) for CQ-cohort, and significantly reduced the infection load among clearance failures. Clearance failures had high pre-treatment parasite densities whilst post

1992 Tropical and geographical medicine Controlled trial quality: uncertain

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